Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

Abstract: A method for synthesizing diacylglycerol, comprising the following steps: (1) mixing an oil, a lipase and a solvent, and carrying out a hydrolysis reaction to obtain a hydrolyzate; and (2) under the action of a diacylglycerol lipase, performing an esterification reaction on the hydrolyzate obtained in step (1) with glycerol; the lipase in step (1) is lipase MAS1 or MAS1-H108A.

Abstract: Fluidic systems, devices and methods are provided for separating and sequestering particles from a fluid flow within traps in a fluidic chip is provided. The fluidic platform is particularly suited for parallel live zebrafish embryo studies providing automated zebrafish embryo trapping and flow through culture as well as whole mount zebrafish antibody staining functions. The zebrafish on a chip testing platform uses a chaotic hydrodynamic trapping process to trap and retain zebrafish embryos in a consistent body orientation (i.e., head pointed inward) without any external adjustments. The system and apparatus can also be adapted to be a multifunctional concentration gradient generator (CGG) that can be used to automatically immobilize dechorionated zebrafish embryos and generate chemical gradients for acute fish embryo toxicity (FET) tests.

Abstract: This application relates to a data storage method, a reading method, an apparatus, a storage medium, and a program product. The data storage method is applied to a processor and includes: (S1) obtaining event data; (S2) processing the event data, to obtain a plurality of data blocks and a plurality of corresponding metadata blocks, where each data block includes a part of processed event data, and each metadata block includes a start time, an end time, a quantity, and a compression manner of event data in a data block corresponding to the metadata block, and a storage address of the data block; and (S3) storing the plurality of data blocks into a first storage area, and storing the plurality of metadata blocks into a second storage area.

Abstract: A supercapacitor including a gel electrolyte and two electrodes having a substrate, date stone activated carbon, a conductive carbon compound different from the date stone activated carbon, and a binding compound. A mixture of the date stone activated carbon, the conductive carbon compound, and the binding compound partially coats a surface of the substrate. The two electrodes are assembled in a symmetrical layered configuration with the surfaces coated with the mixture facing each other. The gel electrolyte is present between the surfaces coated with the mixture to form the supercapacitor. The gel electrolyte is a mixture of H2SO4, polyvinyl alcohol, and anthraquinone. Particles of the date stone activated carbon have a nanosheet morphology, and the nanosheets are stacked on top of each other to form a hierarchical structure.

Abstract: A method of manufacturing a color-routing element, may include: generating an initial pattern; performing blurring on the initial pattern to generate a reference pattern; performing edge detection on the reference pattern to generate at least one comparison pattern reflecting a process error; performing a simulation to obtain at least one color-routing figure of merit based on the reference pattern and the at least one comparison pattern; updating the initial pattern based on a calculation result of the at least one color-routing figure of merit; generating the updated initial pattern as a target pattern of the color-routing element; and manufacturing the color-routing element based on the target pattern.

Abstract: The present disclosure provides compounds of Formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analog, prodrug, or polymorph thereof, and uses thereof. The present disclosure also provides pharmaceutical compositions comprising, as an active ingredient, the compound of Formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analog, prodrug, or polymorph thereof, and uses thereof. The series of compounds designed and synthesized in the present disclosure can effectively prevent and/or treat diseases or disorders associated with NAMPT.

Abstract: The invention provides a targeted recycling method for waste battery, which comprises the following steps: the positive electrode strip of the waste battery is broken to obtain the broken product; In a carbon monoxide atmosphere, the broken product is pyrolyzed to obtain the pyrolysis product, and then the pyrolysis product is magnetically separated to obtain the magnetic separation product to achieve valuable metal recovery; The pyrolysis gas of the pyrolysis is passed into an alkaline solution to obtain a Li-rich solution and realize Li recovery.

Abstract: An information processing method, an information processing system, and a recording medium are provided.

Abstract: The present disclosure is directed to method for the generation and use of regulatory T cells (Tregs) in the prevention and treatment of graft/transplant rejection. In particular, the method employs engineered CAR Treg cells that protect transplanted materials from rejection.

Abstract: The present invention relates to methods and compositions for transplanting non-lymphoid tissues into lymphoid organs. It may be used to cultivate organ tissues including for the purpose of supplementing or reconstituting organ function. Tissues that may be propagated in this manner include but are not limited to lung, kidney, thyroid, intestine, and brain.

Abstract: The present disclosure relates generally to novel recombinant coronavirus-based fusion proteins (“RBDs-IgG Fc protein” and “RBDs protein”) and vaccine compositions using the same, in which the fusion proteins comprise tandemly arranged coronaviruses receptor binding domains (RBDs). The present disclosure further provides methods and kits for immunizing a subject using the compositions.

Abstract: A method for assessing differentiation potential of cells in a culture broth in the differentiation of pluripotent stem cells into neural cells of the midbrain floor plate region, comprising: measuring a concentration of NT-3 in a culture supernatant in a culture broth obtained by culturing the pluripotent stem cells in a medium containing an inducer of differentiation into the neural cells of the midbrain floor plate region; comparing the measured concentration of NT-3 with a reference concentration; and when the concentration of NT-3 is equal to or more than the reference concentration, assessing the cells in the culture broth as capable of differentiating into the neural cells of the midbrain floor plate region, wherein the culture supernatant is a culture supernatant collected from the culture broth at any time from 48 hours to 240 hours after the start of culture of the pluripotent stem cells.

Abstract: Provided is a solvent extraction method for a petroleum sludge/oil sand assisted by a particle dispersant, including: mixing a solution dissolved with the particle dispersant and the petroleum sludge/oil sand to obtain a mixture, and subjecting the mixture to solvent extraction and separation to obtain a solid phase particle and an oil-carrying liquid phase; wherein the particle dispersant includes one compound selected from the group consisting of a polyoxyethylene alkyl ether carboxylic acid, a polyoxypropylene polyoxyethylene alkyl ether carboxylic acid, and dodecylbenzene sulfonic acid; and a solvent used in the solution dissolved with the particle dispersant comprises one or more selected from the group consisting of cycloalkane and toluene.

Abstract: The present invention relates to peptides derived from COVID-19 virus envelope protein and spike protein. The invention further relates to polynucleotides and vectors encoding said peptides, and antibodies and chimeric antigen receptors that bind to said peptides. The invention also relates to methods of diagnosis and prediction of conditions in a subject which leverage recognition of said peptides, such as by antigen-specific T cells.

Abstract: The invention discloses an AlCrVTiSiON nano-gradient coating with surface pre-oxidation and a preparation method thereof, belonging to the technical field of coatings. The AlCrVTiSiON nano gradient coating is prepared by arc ion plating technology, wherein the target materials are selected from metal Cr target, V target, AlCrSi target and AlTiSi target. In order to further improve the heat resistance of the coating and increase the cutting amount during service, the AlCrVTiSiON nano-gradient coating with O element content increasing from inside to outside was formed. The prepared coating has good heat resistance, which is suitable for high-speed cutting and improves processing efficiency.

Abstract: A machine-readable medium includes instructions. The instructions, when read and executed by a processor, cause the processor to, at a client, receive an instruction to authenticate use of a server application through a host, obtain login credentials for the server application on the host, generate a machine-readable code to represent the login credentials, and display the machine-readable code to log in to the server application through the host.

Abstract: A method includes preparing an alkyl-modified graphene oxide, injecting the modified graphene oxide into a well, and inhibiting acid-induced corrosion of a steel surface in the well with the modified graphene oxide. A composition includes an alkyl-modified graphene oxide having one or more alkyl functional group covalently bonded to a graphene core through an oxygen-containing linking group. A method of preparing modified graphene oxide includes mixing graphite powder with an oxidant to provide a mixture, adding the mixture to an acid solution including H2SO4, H3PO4, or a combination thereof to provide graphene oxide, and reacting the graphene oxide with an alkyl halide by nucleophilic substitution to provide the alkyl-modified graphene oxide.

Abstract: A high performance laminated aluminum alloy manufacturing method includes: combining and fixing a front plate, a middle plate, and a rear plate, performing hot roll-bonding to obtain a laminated aluminum alloy; conducting solid solution and quenching treatment on the laminated aluminum alloy; carrying out underwater stirring friction treatment on the quenched laminated aluminum alloy; after aging heat treatment, the laminated aluminum alloy with high ballistic resistance and high interfacial bonding strength is obtained. The method uses underwater stirring friction treatment on quenched laminated aluminum alloy to break the original interlayer structure, forming a three-dimensional spatial structure composed of a stirring zone and a structural interlocked zone, and the interlayer bonding strength of the laminated aluminum alloy is greatly improved.

Abstract: A memory device according to various example embodiments includes a memory cell array having a plurality of memory cells connected to word lines and bit lines; and an error correction circuit configured to perform error correction on data read from the memory cell array, wherein the error correction circuit is configured to perform at least one of a 1-bit error correction operation, a 2-bit error detection operation, or a 3-bit error detection operation using a parity check matrix, and the parity check matrix is configured so that columns are arranged in an order of odd-odd-even degree, and leading one (LO) of each row is arranged in a stepped structure.