Patents Assigned to The University of Chicago
  • Patent number: 11912970
    Abstract: Microfluidic devices, systems, and methods.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: February 27, 2024
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Ce Zhang, Savas Tay
  • Patent number: 11913081
    Abstract: A proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: February 27, 2024
    Assignee: The University of Chicago
    Inventors: Bryan C. Dickinson, Jinyue Pu, Julia Zinkus
  • Publication number: 20240059760
    Abstract: Aspects of the present disclosure relate to polypeptides that specifically bind to a SARS-CoV-2 spike protein, and to methods of use for treatment, prevention, and diagnosis of a SARS-CoV-2 infection. Certain aspects are directed to antibodies and fragments thereof, including Fabs, configured to bind to various epitopes within the receptor binding domain (RBD) of a SARS-CoV-2 spike protein. Compositions, kits, and methods for detection of SARS-CoV-2 are also disclosed.
    Type: Application
    Filed: November 1, 2021
    Publication date: February 22, 2024
    Applicant: The University of Chicago
    Inventors: Anthony KOSSIAKOFF, Tomasz SLEZAK
  • Patent number: 11905555
    Abstract: The methods, compositions, and kits of the disclosure provide a novel approach for a whole genome, unbiased DNA analysis method that can be performed on limited amounts of DNA. can be used to analyze DNA to determine its modification status. Aspects of the disclosure relate to a method for amplifying bisulfite-treated deoxyribonucleic acid (DNA) molecules comprising: (a) ligating an adaptor to the DNA molecules, wherein the adaptor comprises a RNA polymerase promoter comprising bisulfite-protected cytosines; (b) treating the ligated DNA molecules with bisulfite; (c) hybridizing the bisulfite-treated DNA molecules with a primer; (d) extending the hybridized primer to make double stranded DNA; and (e) in vitro transcribing the double-stranded DNA to make RNA.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: February 20, 2024
    Assignee: The University of Chicago
    Inventors: Chuan He, Ji Nie, Xiao-Long Cui
  • Publication number: 20240052006
    Abstract: Aspects of the present disclosure provide methods and compositions for treatment of autoimmune disorders including, for example, multiple sclerosis and rheumatoid arthritis. Also disclosed are methods for promoting wound healing. Certain aspects are directed to antiinflammatory cytokines operatively linked to an albumin protein. Further aspects relate to methods for delivering an anti-inflammatory cytokine to a lymph node.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 15, 2024
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Jeffrey A HUBBELL, Eiji YUBA, Elyse WATKINS, Jun ISHIHARA, Ako ISHIHARA, Erica BUDINA, Abigail LAUTERBACH
  • Patent number: 11898195
    Abstract: Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: February 13, 2024
    Assignees: The University of Chicago, The National Centre for Biological Sciences
    Inventors: Yamuna Krishnan, Saheli Halder
  • Patent number: 11896935
    Abstract: Polymeric membranes are modified via SIS to promote membrane resilience, prolong membrane lifetime, and mitigate fouling. Modified membranes include an inorganic material within an outer portion of the modified membrane and a polymeric core that remains unmodified by the inorganic material. The polymer may be removed leaving an inorganic material patterned from an initial unmodified polymeric membrane.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: February 13, 2024
    Assignees: UCHICAGO ARGONNE, LLC, UNIVERSITY OF CHICAGO
    Inventors: Seth B. Darling, Jeffrey W. Elam, Ruben Waldman
  • Publication number: 20240043534
    Abstract: The engineered polypeptide comprising modified Fab constant regions and/or protein G Fab binding domains provide advanced affinity reagents that can be used in cell biology applications as well as for therapeutic applications. Accordingly, aspects of the disclosure relate to a polypeptide comprising a constant region of an antibody light chain, wherein the constant region comprises a substitution/deletion of amino acids corresponding to positions 16-20 of SEQ ID NO:1 of the constant region with the amino acids LRT.
    Type: Application
    Filed: October 14, 2020
    Publication date: February 8, 2024
    Applicant: The University of Chicago
    Inventors: Anthony KOSSIAKOFF, Tomasz SLEZAK, Elena DAVYDOVA, Edwin ARAUZ-DIAZ
  • Publication number: 20240044896
    Abstract: Aspects of the disclosure are directed to methods, systems, and compositions for detecting antibodies capable of binding to angiotensin II. Certain aspects comprise detection of antibodies capable of binding to angiotensin II in a sample from a subject, where the subject has or has had a coronavirus infection, such as a SARS-CoV-2 infection. Also disclosed are vaccine compositions comprising a portion of SARS-CoV-2 Spike protein, where such compositions do not induce generation of angiotensin II-binding antibodies.
    Type: Application
    Filed: December 9, 2021
    Publication date: February 8, 2024
    Applicant: The University of Chicago
    Inventors: Melody SWARTZ, Priscilla BRIQUEZ, Jeffrey HUBBELL
  • Patent number: 11890286
    Abstract: Methods and compositions for treating cancer are disclosed.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 6, 2024
    Assignee: The University of Chicago
    Inventors: Ali Ekram Yesilkanal, Marsha Rosner
  • Patent number: 11886379
    Abstract: A computing system includes a quantum processor with qubits, a classical memory including a quantum program defining a plurality of instructions in a source language, and a classical processor configured to: (i) receive a circuit of gates representing a quantum program for a variational algorithm in which computation is interleaved with compilation; (ii) identify a plurality of blocks, each block includes a subcircuit of gates, leaving one or more remainder subcircuits of the circuit of gates outside of the plurality of blocks; (iii) pre-compile each block of the plurality of blocks with a pulse generation program to generate a plurality of pre-compiled blocks including control pulses configured to perform the associated block on the quantum processor; and (iv) iteratively execute the quantum program using the pre-compiled blocks as static during runtime and recompiling the one or more remainder subcircuits on the classical processor at each iteration of execution.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: January 30, 2024
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Pranav Gokhale, Yongshan Ding, Thomas Propson, Frederic T. Chong
  • Patent number: 11883444
    Abstract: Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection.
    Type: Grant
    Filed: July 15, 2022
    Date of Patent: January 30, 2024
    Assignee: The University of Chicago
    Inventors: Cathyrn R. Nagler, Gabriel Nunez, Yun-Gi Kim
  • Patent number: 11883417
    Abstract: Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: January 30, 2024
    Assignee: The University of Chicago
    Inventors: Deng Pan, Masha Kocherginsky, Suzanne D. Conzen
  • Publication number: 20240025961
    Abstract: Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13R?2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy cells. Exemplary specific binding molecules are bispecific binding molecules that comprise a fragment of an IL13R?2 binding molecule and a peptide providing a second function providing a signaling function of the signaling domain of a T cell signaling protein, a peptide modulator of T cell activation, or an enzymatic component of a labeling system. Also provided are polynucleotides encoding such a specific binding molecule (e.g., bispecific binding molecule), vectors, host cells, pharmaceutical compositions and methods of preventing, treating or ameliorating a symptom associated with a cancer disease such as a solid tumor disease (e.g., glioblastoma multiforme).
    Type: Application
    Filed: May 1, 2023
    Publication date: January 25, 2024
    Applicants: The University of Chicago, Baylor College of Medicine
    Inventors: Irina V. BALYASNIKOVA, Maciej S LESNIAK, Stephen M.G. GOTTSCHALK
  • Patent number: 11881391
    Abstract: Methods and systems for fabricating a film, such as, for example, a photocathode, having a tailored band structure and thin-film components that can be tailored for specific applications, such as, for example photocathode having a high quantum efficiency, and simple components fabricated by those methods.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: January 23, 2024
    Assignees: Radiation Monitoring Devices, Inc., University of Chicago, Brookhaven Science Associates, LLP
    Inventors: Harish B. Bhandari, Vivek V. Nagarkar, Olena E. Ovechkina, Henry J. Frisch, Klaus Attenkofer, John M. Smedley
  • Publication number: 20240016943
    Abstract: In aspects, the invention provides a polypeptide construct comprising (a) a first polypeptide comprising an amino acid sequence derived from a basic helix of a transcription factor protein that comprises a basic helix-loop-helix domain; and (b) a second polypeptide comprising an amino acid sequence derived from a helix that extends in the C-terminal direction from the end of the loop of a basic helix-loop-helix domain of a transcription factor protein that comprises a basic helix-loop-helix domain; wherein the first polypeptide and the second polypeptide are linked through an interpolypeptide covalent linkage. Additional aspects of the invention are as described herein.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 18, 2024
    Applicant: The University of Chicago
    Inventors: Raymond E. MOELLERING, Thomas E. Speltz, Sean SHANGGUAN
  • Publication number: 20240018216
    Abstract: The current application describes various compositions and methods for the production of FN3-based binding proteins with improved stability properties. Aspects of the disclosure relate to polypeptides comprising a variant fibronectin type III (FN3) domain from Sulfolobus tokodaii or Pyrococcus horikoshii comprising one or more amino acid substitutions or insertions in a loop region of FN3, in a non-loop region of FN3, or in both.
    Type: Application
    Filed: May 4, 2023
    Publication date: January 18, 2024
    Applicant: The University of Chicago
    Inventors: Shohei KOIDE, Shun-Ichi TANAKA, Akiko KOIDE
  • Patent number: 11872635
    Abstract: Methods for forming samples of noble metal bipyramid nanocrystals having very low size and shape polydispersities from samples of mixed noble metal nanocrystals are provided. The samples include those comprising high purity, substantially monodisperse, plasmonic gold bipyramid nanocrystals. Also provided are methods of growing secondary twinned metal nanocrystals using the noble metal bipyramid nanocrystals as seed particles. Like the seed bipyramid nanocrystals from which they are grown, the secondary nanocrystals are twinned nanocrystals and may also be characterized by very low size and shape polydispersities. Secondary twinned nanocrystals grown by these methods include enlarged metal bipyramid nanocrystals and nanocrystals with anisotropic “dumbbell” shapes having a variety of tip geometries. Methods for using noble metal bipyramid nanocrystals as plasmonic heaters to heat reaction solutions via plasmonic-photothermal radiation-to-heat conversion are also provided.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: January 16, 2024
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Yossi Weizmann, Kyle Gibson, Jung-Hoon Lee, Zoya Cheglakov
  • Publication number: 20240011085
    Abstract: The methods, compositions, and kits of the disclosure provide a novel approach for a whole genome, unbiased DNA analysis method that can be performed on limited amounts of DNA. can be used to analyze DNA to determine its modification status. Aspects of the disclosure relate to a method for amplifying bisulfite-treated deoxyribonucleic acid (DNA) molecules comprising: (a) ligating an adaptor to the DNA molecules, wherein the adaptor comprises a RNA polymerase promoter comprising bisulfite-protected cytosines; (b) treating the ligated DNA molecules with bisulfite; (c) hybridizing the bisulfite-treated DNA molecules with a primer; (d) extending the hybridized primer to make double stranded DNA; and (e) in vitro transcribing the double-stranded DNA to make RNA.
    Type: Application
    Filed: November 21, 2022
    Publication date: January 11, 2024
    Applicant: The University of Chicago
    Inventors: Chuan HE, Ji NIE, Xiao-Long CUI
  • Publication number: 20240000787
    Abstract: In aspects, the present disclosure provides a method of treating or preventing a uterine leiomyosarcoma in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of an inhibitor of bromodomain-containing protein 9 (BRD9).
    Type: Application
    Filed: June 30, 2023
    Publication date: January 4, 2024
    Applicant: The University of Chicago
    Inventors: Qiwei Yang, Ayman Al-Hendy