Patents Assigned to The University of Chicago
  • Patent number: 12291738
    Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: May 6, 2025
    Assignees: The University of Chicago, EMD Millipore Corporation
    Inventors: David A. Schwartz, Jimmy Williams, Xinfang Zhao, Chunfang Zhao, William B. Busa, Stephen J. Kron, Amy Catherine Flor
  • Patent number: 12292893
    Abstract: A radiology workstation (24) includes at least one display component (30, 32); at least one user input device (28); and at least one microprocessor (26, 34) programmed to generate a contextual ranking of clinical codes for a context received via the at least one user input device (28) and to display information pertaining to the contextual ranking on the display component (30, 32) of the radiology workstation (24). The contextual ranking is computed by the microprocessor from (i) statistics of occurrences of the clinical codes in radiology reports contained in a radiology reports database (10) and satisfying the context and (ii) statistics of the clinical codes in problem lists contained in a problem lists database and satisfying the context.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: May 6, 2025
    Assignees: Koninklijke Philips N.V., The University of Chicago
    Inventors: Merlijn Sevenster, Paul Joseph Chang, Amir Mohammad Tahmasebi Maraghoosh
  • Patent number: 12281060
    Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: April 22, 2025
    Assignees: The University of Chicago, The United States of America, as Represented by the Secretary, Department of Health and Human Services, President and Fellows of Harvard College, IIT Research Institute, Beth Israel Deaconess Medical Center Inc.
    Inventors: Julian Solway, Nickolai Dulin, Diane Luci, David Maloney, Chan Young Park, Jeffrey Fredberg, David McCormick, Ramaswamy Krishnan
  • Patent number: 12280038
    Abstract: Described herein are novel ?- and ?-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: April 22, 2025
    Assignees: The University of Chicago, IIT Research Institute
    Inventors: Michael J. Kates, Nanduri R. Prabhakar, David L. McCormick, Miguel Muzzio
  • Patent number: 12280066
    Abstract: Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
    Type: Grant
    Filed: December 15, 2023
    Date of Patent: April 22, 2025
    Assignee: The University of Chicago
    Inventors: Deng Pan, Masha Kocherginsky, Suzanne D. Conzen
  • Publication number: 20250122255
    Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Applicants: The University of Chicago, Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.
    Inventors: Ernst Lengyel, Matthias Mann, Marion Curtis, Fabian Coscia
  • Publication number: 20250122240
    Abstract: The present disclosure provides macrocyclic and macrobicyclic peptides with secondary structures that are stabilized over the corresponding non-cyclic peptides. The macrocyclic and macrobicyclic peptides are formed from peptides with adduct-forming, complementary reactive side chain moieties.
    Type: Application
    Filed: October 28, 2024
    Publication date: April 17, 2025
    Applicant: The University of Chicago
    Inventors: Raymond E. MOELLERING, Jeffrey E. MONTGOMERY
  • Patent number: 12276710
    Abstract: A method for quantum spin amplification includes spin-polarizing an ensemble of quantum spins in an initial spin state to generate a transversely-polarized sensing spin state. The quantum spins identically have an upper energy state and a lower energy state. The sensing spin state accumulates a phase shift that transforms the sensing spin state into a phase-accumulated spin state having first and second transverse polarization components. The phase-accumulated spin state is transformed into an intermediate spin state by rotating the first transverse polarization component into a longitudinal polarization component of the intermediate spin state. The ensemble is then coupled to an auxiliary mode, during which the intermediate spin state evolves such that the second transverse polarization component is amplified into an amplified transverse polarization. This amplified transverse polarization is then measured.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: April 15, 2025
    Assignee: The University of Chicago
    Inventors: Aashish Clerk, Martin Koppenhöfer, Peter Groszkowski
  • Patent number: 12276654
    Abstract: Disclosed, in part, are methods and compositions for evaluating two or more target proteins from the same family through the use of a molecular construct that contains a targeting group and a retrieval tag. The method can, in some aspects, quantify the activity and function of the proteins of interest, visualize active enzymes at the subcellular and intercellular scale, and increase dynamic range via signal amplification.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 15, 2025
    Assignee: The University of Chicago
    Inventors: Raymond E. Moellering, Gang Li
  • Publication number: 20250090588
    Abstract: In aspects, the present disclosure provides a method of treating or preventing premature ovarian insufficiency or polycystic ovary syndrome in a female mammal, the method comprising, consisting essentially of, or consisting of administering to the female mammal an effective amount of (i) mesenchymal stem cells (MSCs) or secretome from MSCs, wherein the MSCs overexpress (a) miR144, (b) BMP-2, (c) TGF?1, (d) IL-10, or (e) any combination of (a), (b), (c) and (d); (ii) exosomes produced by MSCs, wherein the MSCs overexpress (a) miR144, (b) BMP-2, (c) TGF?1, (d) IL-10, or (e) any combination of (a), (b), (c) and (d); and/or (iii) exosomes comprising one or more effectors, wherein the one or more effectors comprises, consists essentially of, or consists of (a) miR144, (b) BMP-2, (c) TGF?1, (d) IL-10, or (e) any combination of (a), (b), (c) and (d), and wherein the amount of the effector per exosome is greater than the amount of the effector per exosome when produced by unmodified MSCs.
    Type: Application
    Filed: July 6, 2022
    Publication date: March 20, 2025
    Applicant: The University of Chicago
    Inventors: Ayman Al-Hendy, Hang-Soo Park
  • Patent number: 12240890
    Abstract: Provided herein are compositions and methods for treating and/or preventing pathogenic fungal infection and for maintenance of microbiome commensalism. In particular, provided herein are compositions comprising modified peptide YY (PYY) peptides and therapeutic and/or prophylactic methods of use thereof.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: March 4, 2025
    Assignee: The University of Chicago
    Inventors: Eugene B. Chang, Joseph F. Pierre, Katharine A. Harris
  • Publication number: 20250064989
    Abstract: Radioisotope-labeled small molecule activity-based probes that target the cancer associated serine hydrolase neutral cholesterol ester hydrolase 1 (NCEH1) are described. The probes can undergo a reaction with the NCEH1, resulting in covalent bonding of a portion of the probe molecule to the NCEH1. Also described are methods of labeling NCEH1 in biological samples, such as cells or tissue, and methods of visualizing tumors using the radioisotope-labeled NCEH1 probes as tracer compounds, either alone or in combination with assessing the efficacy of a cancer treatment or potential cancer treatment.
    Type: Application
    Filed: November 8, 2024
    Publication date: February 27, 2025
    Applicant: The University of Chicago
    Inventors: Raymond E. Moellering, Jae Won Chang
  • Patent number: 12226227
    Abstract: The present disclosure provides methods for diagnosing and determining the disease progression of neurodegenerative disorders in patients using neurophysiological biomarkers.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: February 18, 2025
    Assignee: The University of Chicago
    Inventors: Naoum P. Issa, Kourosh Rezania
  • Patent number: 12227769
    Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: February 18, 2025
    Assignees: The University of Chicago, Nationwide Children's Hospital, The Ohio State University
    Inventors: Jianrong Li, Mark E. Peeples, Chuan He, Stefan Niewiesk, Mijia Lu, Miaoge Xue, Zijie Zhang, Boxuan Zhao
  • Publication number: 20250052960
    Abstract: Systems and methods for generating and manipulating a guided electromagnetic wave in a waveguide are provided. The optical system includes a waveguide, such as a two-dimensional waveguide, and an optical element disposed adjacent the surface of the waveguide. To generate the guided electromagnetic wave, a converging laser beam is generated and coupled to the waveguide by steering the converging laser beam towards an edge of the waveguide and with a beam center trajectory approximately parallel to a surface of the waveguide.
    Type: Application
    Filed: August 8, 2024
    Publication date: February 13, 2025
    Applicant: The University of Chicago
    Inventors: Jiwoong Park, Hanyu Hong, Myungjae Lee
  • Patent number: 12186402
    Abstract: Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: January 7, 2025
    Assignee: The University of Chicago
    Inventors: Jeffrey A. Hubbell, Ruyi Wang, D. Scott Wilson, Cathryn R. Nagler, Catherine Plunkett
  • Patent number: 12188084
    Abstract: Methods, compositions and kits are provided to amplify an amount of genomic methylated DNA that can be subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: January 7, 2025
    Assignee: The University of Chicago
    Inventors: Chuan He, Boxuan Simen Zhao, Pradnya Narkhede, Chang Liu, Xiaolong Cui
  • Patent number: 12180267
    Abstract: Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith.
    Type: Grant
    Filed: June 15, 2023
    Date of Patent: December 31, 2024
    Assignee: The University of Chicago
    Inventors: Patrick Wilson, Yaoqing Chen, Haley L. Dugan
  • Patent number: 12174225
    Abstract: Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: December 24, 2024
    Assignee: The University of Chicago
    Inventors: Gary Wolfowicz, Samuel James Whiteley, David Daniel Awschalom
  • Publication number: 20240415851
    Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.
    Type: Application
    Filed: March 14, 2024
    Publication date: December 19, 2024
    Applicants: The University of Chicago, The United States of America, as Represented by the Secretary, Department of Health and Human, President and Fellows of Harvard College, IIT Research Institute, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Julian SOLWAY, Nickolai DULIN, Marsha ROSNER, Gokhan MUTLU, Diane LUCI, David MALONEY, Chan Young PARK, Jeffrey FREDBERG, David MCCORMICK, Ramaswamy KRISHNAN