Patents Assigned to The University of Chicago
  • Patent number: 10888569
    Abstract: The disclosure relates to improved therapeutic methods for treating cancer patients. The methods include a method for treating cancer in a subject comprising administering an effective amount of a BACH1 inhibitor and an ETC inhibitor to the subject. Further aspects of the disclosure relate to a method for treating cancer in a subject comprising: administering a first therapeutic regimen comprising an ETC inhibitor to the subject after a biological sample from the subject was determined to have a decreased or substantially the same level of expression of BACH1 relative to a control sample or to a cut-off value; wherein the first therapeutic regimen excludes a BACH1 inhibitor; or administering a second therapeutic regimen comprising a BACH1 inhibitor and an ETC inhibitor to the subject after a biological sample from the subject was determined to have an increased level of expression of BACH1 relative to a control sample or a cut-off value.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: January 12, 2021
    Assignee: The University of Chicago
    Inventors: Marsha Rosner, Jiyoung Lee
  • Publication number: 20200400723
    Abstract: Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence.
    Type: Application
    Filed: February 13, 2019
    Publication date: December 24, 2020
    Applicant: The University of Chicago
    Inventors: Gary Wolfowicz, Samuel James Whiteley, David Daniel Awschalom
  • Patent number: 10857220
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve coagulase Domains 1-2 and variants thereof.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: December 8, 2020
    Assignee: The University of Chicago
    Inventors: Molly McAdow, Andrea Dedent, Alice Cheng, Carla Emolo, Dominique Missiakas, Olaf Schneewind
  • Patent number: 10856835
    Abstract: Phantoms for use in calibrating a dual energy imaging system and methods for their use. The phantoms include a body having at least first and second portions arranged in a through-thickness direction of the body. The first portion defines an anterior surface of the body and contains a first material simulating soft tissue and a second material simulating bone. The second portion contains a third material simulating lung tissue and at least a first object embedded in the third material and formed of a fourth material simulating tumor tissue. The first and second portions of the body are configured such that the second material in the first portion superimposes the first object in the second portion in the through-thickness direction of the body relative to the anterior surface thereof.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 8, 2020
    Assignee: Loyola University Chicago
    Inventors: John C. Roeske, Rakesh Patel, Maksat Haytmyradov
  • Patent number: 10851169
    Abstract: Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13R?2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy cells. Exemplary specific binding molecules are bispecific binding molecules that comprise a fragment of an IL13R?2 binding molecule and a peptide providing a second function providing a signaling function of the signaling domain of a T cell signaling protein, a peptide modulator of T cell activation, or an enzymatic component of a labeling system. Also provided are polynucleotides encoding such a specific binding molecule (e.g., bispecific binding molecule), vectors, host cells, pharmaceutical compositions and methods of preventing, treating or ameliorating a symptom associated with a cancer disease such as a solid tumor disease (e.g., glioblastoma multiforme).
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 1, 2020
    Assignee: The University of Chicago
    Inventors: Irina V. Balyasnikova, Maciej S. Lesniak
  • Patent number: 10829526
    Abstract: Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising DNA encoding a variant inducible heat shock protein 70 (HSP70i) having a mutation in the dendritic cell binding region thereof (HSP70i435-447) or an isolated variant gene product in the form of HSP70i with a modification in the dendritic cell activating region thereof (HSP70i435-447).
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: November 10, 2020
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: I. Caroline Le Poole, Jose Alejandro Guevara, Andrew Zloza
  • Patent number: 10815531
    Abstract: Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: October 27, 2020
    Assignee: The University of Chicago
    Inventors: Yan Zheng, Yuanyuan Zha, Robbert M. Spaapen, Thomas F. Gajewski
  • Patent number: 10818849
    Abstract: The present disclosure relates to ?-substituted perylene diimide (PDI) derivatives as small molecular and polymerized electron acceptors in organic photovoltaic cells.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: October 27, 2020
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Donglin Zhao, Qinghe Wu, Luping Yu, Zhengxu Cai
  • Publication number: 20200332371
    Abstract: A proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.
    Type: Application
    Filed: June 6, 2017
    Publication date: October 22, 2020
    Applicant: The University of Chicago
    Inventors: Bryan C. DICKINSON, Jinyue PU, Julia ZINKUS
  • Patent number: 10806694
    Abstract: Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photosensitizer or a derivative thereof can form a bridging ligand of the MOF. Further optionally, the MOF can comprise inorganic nanoparticles in the cavities or channels of the MOF or can be used in combination with an inorganic nanoparticle. Also described are methods of using MOFs and/or inorganic nanoparticles in photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, or in radiotherapy-radiodynamic therapy, either with or without the co-administration of one or more immunotherapeutic agent and/or one or more chemotherapeutic agent.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: October 20, 2020
    Assignee: The University of Chicago
    Inventors: Wenbin Lin, Chunbai He, Kuangda Lu, Kaiyuan Ni, Guangxu Lan
  • Patent number: 10806602
    Abstract: A cam system for an assistive device and related methods are disclosed. The cam system may comprise a cam profile and a cam follower. The cam profile has a curved outer edge comprising a concave portion. The cam follower is positioned within the concave portion when the assistive device is in an equilibrium position. The assistive device may further comprise a spring that deflects in response to a force applied by the cam system. The assistive device may have a sliding element to adjust the stiffness of the spring in deflection. The assistive device may take the form of a prosthesis or an orthosis.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: October 20, 2020
    Assignees: Rehabilitation Institute of Chicago, Northwestern University
    Inventors: Elliott J. Rouse, Max K. Shepherd
  • Patent number: 10803347
    Abstract: An encoder artificial neural network (ANN) may be configured to receive an input image patch and produce a feature vector therefrom. The encoder ANN may have been trained with a first plurality of domain training images such that an output image patch visually resembling the input image patch can be generated from the feature vector. A generator ANN may be configured to receive the feature vector and produce a generated image patch from the first feature vector. The generator ANN may have been trained with feature vectors derived from a first plurality of domain training images and a second plurality of generative training images such that the generated image patch visually resembles the input image patch but is constructed of a newly-generated image elements visually resembling one or more image patches from the second plurality of generative training images.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: October 13, 2020
    Assignee: The University of Chicago
    Inventor: Jason Salavon
  • Patent number: 10801029
    Abstract: The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the ?-sarcoglycan gene in patients suffering from Limb-Girdle Muscular Dystrophy-2C (LGM-D2C) or in patients at risk of such a disease. The invention also provides methods of preventing or treating muscular dystrophy. e.g., LGMD2C, by exon skipping in the gamma sarcoglycan gene using antisense polynucleotides. Accordingly, in some aspects the invention provides an isolated antisense oligonucleotide, wherein the oligonucleotide specifically hybridizes to an exon target region of a ?-sarcoglycan RNA. In another aspect, the invention provides a method of inducing exon-skipping of a gamma sarcoglycan RNA, comprising delivering an antisense oligonucleotide or a composition to a cell.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: October 13, 2020
    Assignees: THE UNIVERSITY OF CHICAGO, NORTHWESTERN UNIVERSITY
    Inventors: Elizabeth McNally, Eugene Wyatt
  • Publication number: 20200319204
    Abstract: One aspect of the present invention describes materials and methods of quantitatively measuring the density or percent occupancy of DNA binding proteins such as histones, histone variants, histone post translational modifications and transcription factors in chromatin at given DNA loci. One embodiment measures a factor's average quantity at specific gene loci, and controls for a number of pitfalls concerning antibody quality and handling issues. Other embodiments include calibrating and quantifying chromatin immunoprecipitation assays, assessing an affinity reagent specificity, as well as required reagents and their formulation in kits. Another embodiment allows for the diagnosis of a condition or disease by measuring the density of a histone modification at a genomic locus.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Alexander J. Ruthenburg, Adrian Grzybowski, Chen Zhonglei
  • Patent number: 10794898
    Abstract: Methods for identifying a compound that alters fluorescence resonance energy transfer (FRET) of a protein. The methods include use of a genetically engineered cell that includes a target protein. The target protein includes one or more heterologous domains. In one embodiment, a target protein includes two heterologous domains, and in another embodiment, the target protein includes a heterologous domain and the cell further includes a second protein that includes a heterologous domain. A heterologous domain may include a chromophore or an amino acid to which a fluorescent dye attaches. The fluorescence lifetime of one or more chromophore, one or more fluorescent dye, or the combination thereof, is measured after contacting the cell with a compound A difference between the fluorescence lifetime in the presence of the test compound and the fluorescence lifetime in the absence of the test compound indicates that the test compound alters the FRET of the target protein.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: October 6, 2020
    Assignees: Regents of the University of Minnesota, Loyola University Chicago
    Inventors: David D. Thomas, Simon Joseph Gruber, Razvan L. Cornea, Gregory David Gillispie, Kurt C. Peterson, Seth Louis Robia
  • Patent number: 10789738
    Abstract: An apparatus and method are provided for computed tomography (CT) imaging to reduce artifacts due to objects outside the field of view (FOV) of a reconstructed image. The artifacts are suppressed by using an iterative reconstruction method to minimize a cost function that includes a de-emphasis operator. The de-emphasis operator operates in the data domain, and minimizes the contributions of data inconsistencies arising from attenuation due to objects outside the FOV. This can be achieved by penalizing images that manifest indicia of artifacts due to outside objects especially those outside objects have high-attenuation densities and minimizing components of the data inconsistency likely attributable to the outside object.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: September 29, 2020
    Assignees: THE UNIVERSITY OF CHICAGO, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Xiaochuan Pan, Zheng Zhang, Dan Xia, Yu-Bing Chang, Jingwu Yao, Joseph Manak
  • Patent number: 10789939
    Abstract: This disclosure generally relates to a word counting device. Specifically, this disclosure generally relates to a wearable word counter device. The word counter device includes a microphone to receive speech input. The word counter device further includes a light sensor to receive data representative of an amount of light in an environment of the word counter device. The word counter device also includes an accelerometer to receive data representative of an amount of movement of the word counter device or the wearer of the word counter device.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: September 29, 2020
    Assignee: The University of Chicago
    Inventors: Alvin Lacson, Jill Desmond, Andy Turk, Jon Boggiano, Jonathan Simon
  • Patent number: 10780045
    Abstract: Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays and/or scintillation. Optionally, the photosensitizer or a derivative thereof can form a bridging ligand of the MOF. Further optionally, the MOF can comprise inorganic nanoparticles in the cavities or channels of the MOF or can be used in combination with an inorganic nanoparticle. Also described are methods of using MOFs and/or inorganic nanoparticles in photodynamic therapy or in X-ray induced photodynamic therapy, either with or without the co-administration of one or more immunotherapeutic agent and/or one or more chemotherapeutic agent.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: September 22, 2020
    Assignee: The University of Chicago
    Inventors: Wenbin Lin, Chunbai He, Kuangda Lu
  • Patent number: 10759834
    Abstract: Methods and compositions are provided concerning polypeptides with modifications that increase its binding affinity for the Fab region of an antibody. Methods include using the polypeptides for isolating, detecting, purifying, measuring and quantifying Fab polypeptides. Other embodiments concern kits, compositions, and solid supports containing the polypeptides and for using the polypeptides for isolating, detecting, purifying, measuring and quantifying Fab polypeptide.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 1, 2020
    Assignee: The University of Chicago
    Inventors: Anthony A. Kossiakoff, Lucas J. Bailey
  • Patent number: 10751324
    Abstract: Provided herein is technology relating to treating and/or ameliorating TNF? cytotoxicity and particularly, but not exclusively, to compositions, methods, and kits for specifically modulating BCL-2-associated death promoter (BAD) activity, for example, by modulating the activity of Src and/or p190GAP.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: August 25, 2020
    Assignee: The University of Chicago
    Inventor: Anning Lin