Patents Assigned to The University of Georgia Research Foundation, Inc.
  • Publication number: 20190169664
    Abstract: Host cells are metabolically engineered to consume glucose and glycerol simultaneously, and to divert glucose from catabolic to anabolic pathways without adversely affecting glucose uptake.
    Type: Application
    Filed: May 5, 2017
    Publication date: June 6, 2019
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Yajun YAN, Yifei WU, Xinxiao SUN, Yuheng LIN
  • Patent number: 10307435
    Abstract: Disclosed are compositions, articles, and method for enhancing exercise performance in a subject. The method involves contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period sufficient to cause a cephalic phase response in the subject.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 4, 2019
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Jamie A. Cooper
  • Patent number: 10266859
    Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: April 23, 2019
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Yajun Yan, Yuheng Lin
  • Patent number: 10260054
    Abstract: Genetically engineered organophosphorus acid anhydrolases (OPAA) with improved catalytic efficiency and relaxed stereospecificity are provided. The variants typically include a mutation at the residue corresponding to H343 of wildtype Alteromonas sp. OPAA. The mutation allows the OPAA enzyme to effectively process both VR enantiomers. The OPAA optionally include one or more mutations selected the residues corresponding to Y212, V342, and I215 of wildtype Alteromonas sp. OPAA which improve the enzyme's catalytic efficiency for VX and VR. A particularly preferred OPAA includes mutations at the residues corresponding Y212F, V342L, I215Y, and H343D relative to wildtype Alteromonas sp. OPAA. Compositions including an effective amount of OPAA to increase hydrolysis of an organophosphate, and methods of use thereof for treating subjects exposed to an organophosphate, or a surface or liquid contaminated with an organophosphate are also provided.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: April 16, 2019
    Assignees: University of Georgia Research Foundation, Inc., The United States of America, as represented by the Secretary of the Army
    Inventors: Scott Pegan, Steven P. Harvey
  • Publication number: 20190104660
    Abstract: A new variety of Citrus ichangensis x C. maxima plant named ‘Tift2-16’ produces fruit with a reduced number of seeds, making it valuable as a backyard fruit tree. Also, it is a desirable tree for landscaping.
    Type: Application
    Filed: October 3, 2017
    Publication date: April 4, 2019
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Wayne W. Hanna, Brian M. Schwartz
  • Patent number: 10238062
    Abstract: The present invention is in the field of plant breeding and aphid resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are associated with resistance to aphids, Aphis glycines. The invention further includes method for monitoring the introgression quantitative trait loci (QTL) conferring aphid resistance into elite germplasm in a breeding program.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 26, 2019
    Assignees: Monsanto Technology LLC, University of Georgia Research Foundation, Inc.
    Inventors: Vergel Concibido, James Narvel, Jennifer Yates, Henry Roger Boerma
  • Patent number: 10231383
    Abstract: Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLAVATA3/ESR (CLE) peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: March 19, 2019
    Assignees: The Curators of the University of Missouri, Cornell University, North Carolina State University, Iowa State University Research Foundation, Inc., University of Georgia Research Foundation, Inc., The United States of America, as represented by the Secretary of Agriculture
    Inventors: Melissa G. Mitchum, Amy Replogle, Jianying Wang, Xiaohong Wang, Shiyan Chen, Ping Lang, Eric L. Davis, Thomas J. Baum, Richard S. Hussey
  • Patent number: 10227617
    Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: March 12, 2019
    Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., NORTH CAROLINA STATE UNIVERSITY
    Inventors: Michael W. W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Lynette Pries Lipscomb, Gerrit Jan Schut
  • Patent number: 10196616
    Abstract: An altered avian NDV that contains the coding sequence of avian interleukin-4 (IL-4), or a portion thereof, in the reverse orientation suppresses in-ovo IL-4 production via RNAi when administered to embryonic birds. An immunogenic composition containing this altered NDV is included in this invention. The altered avian NDV can, optionally contain a polynucleotide encoding a heterologous antigen from a heterologous avian pathogen and can produce said heterologous antigen in-ovo.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: February 5, 2019
    Assignees: The United States of America, as represented by the Secretary of Agriculture, University of Georgia Research Foundation, Inc.
    Inventors: Claudio L. Afonso, Valerie C. Marcano, Nany Stivalis Cardenas Garcia, Qingzhong Yu, Tonya L. Taylor
  • Patent number: 10174132
    Abstract: The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesis, are combined in numerous ways to produce a range of oligosaccharides.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: January 8, 2019
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Geert-Jan Boons, Andre Venot, Sailaja Arungundram, Kanar al-Mafraji
  • Publication number: 20190008081
    Abstract: A new variety of Miscanthus sinensis plant named ‘M77’ produces a reduced number of seeds, making it less invasive.
    Type: Application
    Filed: June 28, 2017
    Publication date: January 3, 2019
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Wayne W. Hanna, Brian M. Schwartz
  • Patent number: 10147505
    Abstract: The present invention provides method of classifying a subject into a necrotizing meningoencephalitis (NME) disease risk group. The method may include assessing the presence of one or more marker (e.g., SNPs or risk loci) in a sample from the subject. For example, detection of the presence of one or more markers that are associated with an increased risk of NME can indicate that the subject should be classified into a risk group.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: December 4, 2018
    Assignees: The Translational Genomics Research Institute, University of Georgia Research Foundation, Inc.
    Inventors: Matthew Huentelman, Scott Schatzberg, Renee Barber
  • Patent number: 10137188
    Abstract: Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: November 27, 2018
    Assignees: University of Georgia Research Foundation, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Thermo Fisher Scientific, Inc.
    Inventors: Jon Michael Karpilow, Mark Steven Oberste, Ralph A. Tripp, Stephen M. Tompkins
  • Patent number: 10138306
    Abstract: A method of producing methacrylic acid using a hydrotalcite catalyst and subcritical water is described.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: November 27, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: James Kastner, Maryam Pirmoradi
  • Publication number: 20180338399
    Abstract: A new and distinct muscadine grape plant characterized by purple berries; self-fertile flowers; berries that separate with a high percentage of dry stem scars; berries that are very large in size; and very productive vines with high total and usable yields.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 22, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventor: Patrick J. Conner
  • Publication number: 20180327714
    Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.
    Type: Application
    Filed: November 16, 2016
    Publication date: November 15, 2018
    Applicants: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., ARUNA BIOMEDICAL, INC.
    Inventors: Steven L. Stice, Robin Lynn Webb, Tracy A. Stice
  • Patent number: 10125116
    Abstract: Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: November 13, 2018
    Assignees: Brandeis University, University of Georgia Research Foundation, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Lizbeth K. Hedstrom, Gregory D. Cuny, Deviprasad R. Gollapalli, Sivapriya Kirubakaran, Sushil K. Maurya, Boris Striepen, Suresh K. Gorla, Corey R. Johnson, Mandapati Kavitha, Jihan Khan
  • Patent number: PP30014
    Abstract: A new and distinct muscadine grape plant characterized by purple berries; self-fertile flowers; berries that separate with a high percentage of dry stem scars; berries that are very large in size; and very productive vines with high total and usable yields.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 25, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Patrick J. Conner
  • Patent number: PP30227
    Abstract: A pecan tree distinguished by the following unique combination of characteristics: Large nut size, good kernel quality, moderately early harvest date, and excellent resistance to the scab fungus (Fusicladosporium effusum).
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: February 26, 2019
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Patrick J. Conner
  • Patent number: PP30402
    Abstract: A new variety of Miscanthus sinensis plant named ‘M77’ produces a reduced number of seeds, making it less invasive.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: April 16, 2019
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Wayne W. Hanna, Brian M. Schwartz