Abstract: Crimean-Congo hemorrhagic fever (CCHF) virus replicon particles (VRP) are described. These VRP are capable of undergoing a single round of virus replication, but are unable to produce new particles or spread to neighboring cells due to the lack of the glycoprotein-encoding M genome segment. In some instances, the VRP contain one or more mutations in the viral ovarian tumor domain protease encoded by the L genome segment or heterologous antigens within its S genome segment. The VRP are shown to elicit a protective immune response against lethal CCHF virus challenge in an animal model.

Abstract: The present invention provides genetically engineered strains of the Bordetella species to include one or more mutations preventing expression of the gene encoding the Bordetella Sigma Regulator (also referred to as “bsr,” “btrS,” and “brpL”), compositions and vaccines thereof, and the use of such engineered strains in methods to protect against Bordetella spp, including but not limited to Bordetella bronchiseptica, B. pertussis, B. parapertussis, B. homelsii, or B. avium. In some aspects, the present invention provides the Bordetella bronchiseptica strain RB50?bsr, compositions and vaccines thereof, and the use of Bordetella bronchiseptica strain RB50?fer in methods to protect against Bordetella spp, including but not limited to Bordetella bronchiseptica, B. pertussis, B. parapertussis, B. homelsii, or B. avium.

Abstract: The present disclosure provides for modified antibiotic compounds, methods of making modified antibiotic compounds, methods of use, products including modified antibiotic compounds, and the like. The modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule, such as S-nitroso-N-acetylpenicillamine covalently attached to ampicillin.

Abstract: Various examples are provided related to wireless charging of electric vehicles. In one example, a wireless charging system includes a transmitter pad including a primary coil supplied by a power source, and alignment control circuitry configured to determine an alignment condition of the transmitter pad with respect to a receiver pad of an electric vehicle. In another example, a wireless charging system includes a receiver pad including a secondary coil; and alignment processing circuitry configured to determine an alignment condition of the receiver pad with respect to a transmitter pad comprising a primary coil supplied by a power source. In another example, a method includes measuring output voltages of a plurality of auxiliary coils mounted on a secondary coil located over a primary coil of the wireless charging system and determining a lateral misalignment between the primary and secondary coils using the output voltages.

Abstract: Herein provided is a new runner-type peanut variety designated ‘Georgia-18RU’ as well as the seeds, plants and derivatives of the new peanut variety ‘Georgia-18RU’. Also provided are tissue cultures of the new peanut variety ‘Georgia-18RU’ and the plants regenerated therefrom. Methods for producing peanut plants by crossing the new peanut variety ‘Georgia-18RU’ with itself or another peanut variety (such as another runner-type peanut variety) and plants produced by such methods are also provided. ‘Georgia-18RU’ is a unique runner-type peanut cultivar having a combination of high level of tomato spotted wilt virus (TSWV) resistance and leaf scorch resistance caused by Leptosphaerulina crassiasca (Séchet) Jackson and Bell, and high yield. ‘Georgia-18RU’ provides a medium maturity runner-type peanut cultivar with a prominent main stem, medium green foliage, medium-large runner seed size, and pink seedcoat color.

Abstract: Provided herein is a programmable RNA-activated DNA endonuclease activity associated with a Cmr complex. In one embodiment, the enzyme is a general double-stranded DNA endonuclease. Also provided is a programmable RNA endonuclease activity associated with a Cmr complex. In one embodiment, a Cmr2 protein present in a Cmr complex includes a mutation that reduces RNA-activated DNAse activity of the Cmr complex. In one embodiment, a Cmr4 protein present in a Cmr complex includes a mutation that reduces the RNase activity of the Cmr complex. Compositions including components of a Cmr complex and a CRISPR-RNA, and an optional activating RNA, are provided. Also provided are methods for using the compositions, and genetically engineered cells that include components of a Cmr complex and a CRISPR-RNA, and an optional activating RNA.

Abstract: Provided herein are antibodies and related polypeptides that bind specifically to CEACAM6. The antibodies and/or polypeptides can be configured as bispecific T cell engagers. The antibodies and/or polypeptides can also be configured as chimeric antigen receptors. Also provided are methods of detection and treatment of cancer, for example, pancreatic cancer, using the antibodies and related polypeptides herein.

Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.

Abstract: Articles having anti-fogging characteristics, coating compositions providing anti-fogging characteristics, and methods for applying coating compositions with anti-fogging characteristics are described. The coating compositions give a surface or article an anti-fogging characteristic. Articles having such anti-fogging characteristics include those having optical clarity, such as eyewear.

Abstract: Nanofiber spinning apparatuses and methods for making core-sheath materials using touch spinning are provided. The apparatus includes at least one rotating plate with an aperture through which a core yarn passes and at least one post contacting the rotating plate. A speed control device can be configured to control rotation of the rotating plate, and a dispensing device can be configured to dispense a nanofiber-forming material onto the post. To make a core-sheath yarn a core yarn is passed through an aperture in a rotating plate having at least one post. The post is contacted with a nanofiber-forming material the rotating plate is rotated to draw a fiber of nanofiber-forming material from the post to wrap the fiber around the core yarn.

Abstract: The present disclosure provides engineered photosynthetic cells and organisms, methods for engineering photosynthetic cells and organisms with increased extracellular electron transport, photo-bioelectrochemical cells (PBECs), anodes for a PBECs and/or photosynthetic microbial fuel cells (PMFCs), methods of generating an electrical current with PBECs, and methods and systems for generating H2 fuel.

Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.

Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.

Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.

Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1797’, characterized by a combination of early season flowering and ripening, large berries with good color and flavor, high quality fruit production in conventional production areas, and a chilling requirement of about 200-300 hours below about 45° F.

Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1493’, characterized by a combination of early season flowering and ripening, large berries with good color and flavor, high quality fruit production in conventional production areas, and a chilling requirement of about 350-450 hours below about 45° F.

Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-1872’, characterized by a combination of early season flowering and ripening, large berries with good flavor and firmness, high quality fruit production in conventional production areas, and a low chilling requirement of about 150-200 hours below about 45° F.

Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-920’, characterized by a combination of early-to-mid season ripening; large berries with good scar and flavor and high fruit quality; moderately vigorous growth suited to home gardens, soft pink flowers at opening, bronze coloring to newly emerging foliage, berries transitioning from pink hued to sky-blue during ripening; and a chilling requirement of about 500-550 hours below about 45° F.

Abstract: A new and distinct cultivar of Vaccinium plant named ‘TH-889’, characterized by a combination of later season flowering and ripening; large berries with unique, vibrant light blue color and good flavor and firmness; vigorous growth; compact form; attractive fall foliage color; and a chilling requirement of about 500-600 hours below about 45° F.