Patents Assigned to The University of Georgia Research Foundation, Inc.
  • Patent number: 9968671
    Abstract: The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the southeast United States. The invention is directed to these novel group 1 and group 2 avian reoviruses, diagnostic assays using antibodies and/or nucleotide- or amino acid-specific components of such viruses, such as the S1 gene encoding the sigma C protein, and to vaccines that protect chickens from disease caused by such viruses.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: May 15, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Holly S. Sellers
  • Patent number: 9954619
    Abstract: Various examples are provided for jamming avoidance response (JAR), and photonic implementations thereof. In one example, a method includes generating optical pulses that correspond to raising envelope of a beat signal associated with an interference signal and a reference signal; generating optical spikes that correspond to positive zero crossing points of the reference signal; providing a phase output that indicates whether the beat signal is leading or lagging the reference signal, the phase output based at least in part upon the optical spikes; and determining an adjustment to the reference frequency based at least in part upon the optical pulses and the phase output. In another example, a JAR system includes a photonic P-unit to generate the optical pulses; a photonic ELL/T-unit to generate the optical spikes; a photonic TS unit to provide the phase output; and a logic unit to determine the adjustment to the reference frequency.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 24, 2018
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Mable P. Fok, Ryan Toole
  • Patent number: 9943590
    Abstract: This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 17, 2018
    Assignees: The Trustees of the University of Pennsylvania, University of Georgia Research Foundation, Inc.
    Inventors: Donald A. Harn, Jr., Yvonne Paterson, Lisa McEwen
  • Patent number: 9944854
    Abstract: The present disclosure describes methods and compositions for reducing and/or preventing soil water repellency. Embodiments of methods of reducing soil water repellency (SWR) of the present disclosure include applying to an area of groundcover a composition including an effective amount of at least one isolated enzyme capable of degrading or altering organic matter associated with SWR, where the SWR of the area of groundcover is reduced after treatment with the enzyme composition.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: April 17, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Qingguo Huang, Robert N. Carrow, Paul L. Raymer
  • Patent number: 9938312
    Abstract: The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: April 10, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Geert-Jan Boons, Zhen Wang
  • Patent number: 9932297
    Abstract: 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: April 3, 2018
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Geert-Jan Boons, Jun Guo, Xinghai Ning, Margaretha Wolfert
  • Patent number: 9930065
    Abstract: Systems and methods for event path traceback may utilize a processor and a path traceback and categorization (ATC) module in communication with the processor. The processor may be configured to perform processing associated with receiving network traffic from a network. The ATC module may be configured to perform processing associated with identifying an event within the network traffic, tracing a sequence of network transactions related to the event, and outputting an annotated event path (AMP) including data about the event and the sequence of network transactions related to the event. Performing processing associated with tracing the sequence of network transactions may comprise reconstructing a sequence of transactions within the network traffic that led to the event while filtering out unrelated traffic within the network traffic.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 27, 2018
    Assignees: University of Georgia Research Foundation, Inc., Dambala, Inc.
    Inventors: Terry Lee Nelms, Roberto Perdisci
  • Patent number: 9926612
    Abstract: Provided are lectenz molecules, which are mutated carbohydrate processing enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: March 27, 2018
    Assignees: University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
    Inventors: Robert J. Woods, Loretta Yang
  • Publication number: 20180066004
    Abstract: Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based compound. Upon reduction, the mitochondrial targeting moieties are released resulting in a Pt(II) therapeutic agent. Pt(IV) compounds including a mitochondria targeting moiety can be included in nanoparticles. The compounds or nanoparticles can be used to treat, for example, cancer.
    Type: Application
    Filed: April 8, 2015
    Publication date: March 8, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Shanta Dhar, Rakesh Pathak, Sean Marrache
  • Patent number: 9907822
    Abstract: This disclosure describes, in one aspect, a composition that includes a transgenic pathogen that expresses a heterologous pathogen associated molecular pattern (PAMP). In some embodiments, the pathogen may be attenuated. In some embodiments, the pathogen can include T. cruzi. In another aspect, this disclosure describes a method of treating an infection in a subject. Generally, the method includes administering to the subject, in an amount effective to treat the infection, a pathogen genetically modified to express a pathogen-associated molecular pattern (PAMP) not natively expressed by the pathogen.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: March 6, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Rick Tarleton, Samarchith Kurup
  • Publication number: 20180063059
    Abstract: The present invention relates to 2?-Fluoro-6?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.
    Type: Application
    Filed: May 31, 2017
    Publication date: March 1, 2018
    Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Chung K. Chu, Jianing Wang
  • Patent number: 9901616
    Abstract: Nanoparticles include a core and one or more targeting moieties, as well as one or more contrast agents or one or more therapeutic agents. The contrast agents or therapeutic agents may be contained or embedded within the core. If the nanoparticle includes therapeutic agents, the agents are preferably released from the core at a desired rate. The core may be biodegradable and may release the agents as the core is degraded or eroded. The targeting moieties preferably extend outwardly from the core so that they are available for interaction with cellular components, which interactions will target the nanoparticles to the appropriate cells, such as apoptotic cells; organelles, such as mitochondria; or the like. The targeting moieties may be tethered to the core or components that interact with the core.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: February 27, 2018
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Shanta Dhar, Sean Marrache
  • Publication number: 20180044644
    Abstract: Compositions, methods of use and methods of manufacture are provided for PIV5-based amplifying VLP (AVLP) that can deliver an expressible heterologous nucleotide sequence in target cells without producing progeny, and which demonstrate useful safety and therapeutic efficacy in multiple animal and human health applications, such as vaccination, gene therapy and cancer therapy.
    Type: Application
    Filed: April 28, 2016
    Publication date: February 15, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventor: Biao He
  • Patent number: 9879117
    Abstract: Structures having a polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, and the like, are disclosed.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: January 30, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jason J. Locklin, Vikram Dhende
  • Patent number: 9873126
    Abstract: Embodiments of the present disclosure provide for devices, methods for separating particles, and the like.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: January 23, 2018
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Leidong Mao, Taotao Zhu, Mark A. Eiteman
  • Publication number: 20180014440
    Abstract: A pecan tree distinguished by the following unique combination of characteristics: Consistent and acceptable fruit production, small fruit cluster, early nut maturity, large nut producing mammoth kernels with excellent color, and high resistance to scab fungus.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 11, 2018
    Applicant: University of Georgia Research Foundation, Inc.
    Inventor: Darrell Sparks
  • Patent number: 9861652
    Abstract: 2?-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: January 9, 2018
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Dennis C. Liotta, Chung K. Chu, J. Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H. Hong
  • Publication number: 20170360540
    Abstract: A method, apparatus and system for delivery of live or attenuated viral and bacterial vaccines to fowl are described.
    Type: Application
    Filed: December 21, 2015
    Publication date: December 21, 2017
    Applicant: The University of Georgia Research Foundation, Inc .
    Inventors: Mark W Jackwood, Brian Jordan
  • Patent number: 9844196
    Abstract: The present invention is in the field of plant breeding and aphid resistance. More specifically, the invention includes a method for breeding soybean plants containing quantitative trait loci that are associated with resistance to aphids, Aphis glycines. The invention further includes method for monitoring the introgression quantitative trait loci (QTL) conferring aphid resistance into elite germplasm in a breeding program.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: December 19, 2017
    Assignees: Monsanto Technology LLC, University of Georgia, Research Foundation, Inc.
    Inventors: Vergel Concibido, James Narvel, Jennifer Yates, Henry Roger Boerma
  • Patent number: 9839213
    Abstract: Embodiments of the present disclosure, in one aspect, relate to polymer compositions, methods of making polymer compositions, structures having the polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, materials, methods of attaching materials, and the like.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 12, 2017
    Assignee: THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventor: Jason J. Locklin