Abstract: The present invention relates to 2?-Fluoro-6?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.

Abstract: Systems and methods for quantitatively assessing collision risk of bodies, such as vehicles, and severity of a conflict between the bodies are disclosed. A method may comprise receiving image data associated with bodies. Based on the image data, an affinity (proneness) to collision of the bodies may be determined. Based on the determined affinity (proneness) to collision, a proximity (closeness) of collision of the bodies may be determined. Based on the determined proximity (closeness) of collision of the bodies, a collision risk of the bodies may be determined. The determined collision risk may be transmitted to a computing device, such as via a user interface. The determined collision risk may be used to control operations of a traffic control device or an autonomous vehicle.

Abstract: Herein provided is a new runner-type peanut variety designated ‘Georgia-18RU’ as well as the seeds, plants and derivatives of the new peanut variety ‘Georgia-18RU’. Also provided are tissue cultures of the new peanut variety ‘Georgia-18RU’ and the plants regenerated therefrom. Methods for producing peanut plants by crossing the new peanut variety ‘Georgia-18RU’ with itself or another peanut variety (such as another runner-type peanut variety) and plants produced by such methods are also provided. ‘Georgia-18RU’ is a unique runner-type peanut cultivar having a combination of high level of tomato spotted wilt virus (TSWV) resistance and leaf scorch resistance caused by Leptosphaerulina crassiasca (Séchet) Jackson and Bell, and high yield. ‘Georgia-18RU’ provides a medium maturity runner-type peanut cultivar with a prominent main stem, medium green foliage, medium-large runner seed size, and pink seedcoat color.

Abstract: The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/US/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to rMuVIowa/US/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuV?SH) and/or incapable of expressing the V protein (rMuV?V).

Abstract: A simple controllable set-up for drawing single filament nanofibers from polymer solutions or melts using a rotating rod or a set of rods (round brush) is described. The set-up can be assembled in a few minutes and applied to fabricate customized nanofiber scaffolds and meshes for various applications. The resulting fiber diameter is controlled precisely in the range 40 nm to 5 ?m by adjusting the rotational speed and polymer concentration. Owing to the simple design and capability to manipulate single nanofibers, the spinning set-up can be used to wind a single filament into unidirectional, orthogonal or randomly oriented 2D and 3D meshes with controlled density, thickness and combinations of different fibers and materials in the scaffolds. The method is scalable and can be implemented easily for laboratory and industrial manufacturing.

Abstract: The carbohydrate processing enzyme PNGase F was catalytically inactivated through mutation. Additional mutations yielded a catalytically inactive carbohydrate-binding protein with lectin-like properties including high affinity and specificity N-linked glycans, O-linked glycans, or both.

Abstract: The invention provides a new convergent approach for the synthesis of 2?-fluoro-6?-methylene-carbocyclic adenosine (FMCA) and 2?-fluoro-6?-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R, 4R)-3-tert-butoxy-4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.

Abstract: The present disclosure relates to a stretchable fiber optic sensor that can measure tension, bending, and torsion direction of an object. The fiber optic sensor includes an optical fiber with a fiber Bragg grating (FBG) embedded in a sinusoidal configuration at an off-center position of a deformable substrate.

Abstract: Compositions and methods for modulating HIF-2? to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2? inhibitor. The HIF-2? inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.

Abstract: Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.

Abstract: Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.

Abstract: The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.

Abstract: A method, apparatus and system for delivery of live or attenuated viral and bacterial vaccines to fowl are described.

Abstract: Herein provided is a new soybean variety designated ‘G13LL-44’ as well as the seeds, plants and derivatives of the new soybean variety ‘G13LL-44’. Also provided are tissue cultures of the new soybean variety ‘G13LL-44’ and the plants regenerated therefrom. Methods for producing soybean plants by crossing the new soybean variety ‘G13LL-44’ with itself or another soybean variety and plants produced by such methods are also provided. ‘G13LL-44’ is a MG VII line with glufosinate tolerance technology, and with resistance to race 3 of the soybean cyst nematode and frogeye leaf spot, and moderate resistance to southern root-knot nematode. ‘G13LL-44’ yielded 1.4 bu/ac (2.3%) greater than its recurrent parent ‘G00-3213’, across 11 environments and 0.5 bu/ac more than the high-yielding check cultivar ‘AG738 RR’. ‘G13LL-44’ provides a high yielding glufosinate tolerant soybean cultivar with superior nematode resistance.

Abstract: A new Ilex plant named ‘RutHol4’ is characterized by a combination of an attractive pyramidal growth habit, potential for use in containers or as a small hedge.

Abstract: A new and distinct cultivar of Abelia plant named ‘00-BC-46-4’, characterized by a combination of attractive foliage, compact form, large flower panicles, heavy blooming, and low maintenance requirements.

Abstract: A new and distinct cultivar of Abelia plant named ‘99-6-7’, characterized by a combination of large flower panicles of pink/purple flowers and sepals, earliness to flower, and heavy blooming from May to September.

Abstract: A new cultivar of Ilex plant named ‘RutHol2’ is characterized by a combination of its compact, rounded growth habit, its resistance to damage from spider mites, its need for little pruning, its burgundy color new growth, and its ability to be used in large containers with other plants.

Abstract: A new Ilex plant named ‘RutHol3’ is characterized by a combination of its upright, narrow growth habit, its attractive burgundy new growth, its glossy green mature foliage, its quick growth and resistance to spider mites.

Abstract: A new Hibiscus plant named ‘RutHib3’ is characterized by a combination of good form, medium vigor, green/reddish foliage, magenta flowers with a red-purple eye, and good tolerance of Hibiscus sawfly and leaf spot pathogens.