Patents Assigned to The University of Liverpool
  • Publication number: 20210162731
    Abstract: The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 3, 2021
    Applicants: Howmedica Osteonics Corp., The University Of Liverpool
    Inventors: William O'Neill, Christopher J. Sutcliffe, Eric Jones, Robin Stamp
  • Publication number: 20210123036
    Abstract: Provided are peptides, and conjugates comprising targeting peptides and payloads. The peptides comprise a plurality of modules corresponding to at least one of module 1, module 2, or module 3 of the collagen binding domain of a gelatinase, or a gelatin-binding fragment or variant thereof. The gelatinase may be MMP-2. The conjugates may be therapeutic or non-therapeutic. Medical uses of the peptides or therapeutic conjugates, and pharmaceutical compositions comprising these, are also provided, as are nucleic acids encoding the peptides.
    Type: Application
    Filed: March 29, 2019
    Publication date: April 29, 2021
    Applicant: THE UNIVERSITY OF LIVERPOOL
    Inventor: Anthony Hollander
  • Publication number: 20210086266
    Abstract: A method of 3D printing comprises: providing a layer of a powder bed; jetting a functional binder onto selected parts of said layer, wherein said binder infiltrates into pores in the powder bed and locally fuses particles of the powder bed in situ; sequentially repeating said steps of applying a layer of powder on top and selectively jetting functional binder, multiple times, to provide a powder bed bonded at selected locations by printed functional binder; and taking the resultant bound 3D structure out of the powder bed.
    Type: Application
    Filed: August 1, 2018
    Publication date: March 25, 2021
    Applicant: The University of Liverpool
    Inventors: Kate Black, Paul Chalker, Christopher John Sutcliffe
  • Patent number: 10919944
    Abstract: The present invention relates to vaccines comprising a ShK domain of a filarial nematode protein. These vaccines may be used for the prevention and/or treatment of filarial nematode infections. The invention also relates to novel proteins comprising a ShK domain of a filarial nematode protein and pharmaceutical compositions. The invention may be used for the prevention and/or treatment of filarial nematode infections in canine subjects, and also in human subjects.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: February 16, 2021
    Assignees: The University of Liverpool, Edinburgh University
    Inventors: Ben Makepeace, David Taylor, Simon Babayan, Stuart Armstrong, Mark Blaxter
  • Patent number: 10788309
    Abstract: Embodiments of the present invention provide a method and apparatus for frequency-domain optical interferometry imaging. Embodiments of the invention include an apparatus comprising a line-shaping optical element for directing optical radiation into a line illumination, an imaging optical element for receiving optical radiation comprising radiation reflected from a target sample and a reference point associated with the target sample, and a detection unit for measuring common path interferences between a plurality of reflections from the target sample and the reference point. Embodiments of the invention include a method comprising directing radiation into a line illumination, directing the line illumination towards a target sample, receiving radiation reflected from the target sample at a detection unit, and measuring common path interferences between a plurality of reflections at the target sample and a reference point.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: September 29, 2020
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Yaochun Shen, Yalin Zheng, Yue Dong, Samuel Lawman
  • Patent number: 10716673
    Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: July 21, 2020
    Assignees: Howmedica Osteonics Corp., The University Of Liverpool
    Inventors: Eric Jones, Christopher J. Sutcliffe, Robin Stamp
  • Patent number: 10710052
    Abstract: Porous materials (such as organic polyamine cage compounds) and methods of stabilising porous materials which are otherwise prone to pore-collapse are described. Such stabilisation is accomplished through the use of molecular ties to create bridges between reactive groups of a (potentially) porous material to thereby strengthen and stabilise the porous structure. The chemistry involved in, and the results of, the stabilisation of porous materials to provide a new sorption composition comprising the very materials which are generally prone to pore-collapse are also described.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 14, 2020
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Andy Cooper, Ming Liu
  • Patent number: 10689297
    Abstract: The present invention relates to new multiferroic materials. More particularly, the present invention relates to new multiferroic single phase ceramic materials as well as to thin films formed from these materials, methods of preparing these materials and their use as multiferroic materials in electronic components and devices.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: June 23, 2020
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Matthew J. Rosseinsky, Pranab Mandal, Jonathan Alaria, John Claridge, Michael Pitcher
  • Patent number: 10688470
    Abstract: A host material may be used for the separation of elements or compounds, wherein the host material is an organic molecular solid with suitable cavities for accommodating a guest material to be separated, and with interconnections between the cavities to allow the guest material to diffuse through the host material, and wherein said interconnections are closed for a proportion of the time or have a static pore limiting diameter which is smaller than the static dimension of the guest material. Applications include separations of rare gases, chiral molecules, and alkanes. One class of suitable host materials may be made by imine condensation.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: June 23, 2020
    Assignee: University of Liverpool
    Inventors: Andrew Cooper, Thomas Hasell, Daniel Holden, Michael Briggs, Linjiang Chen
  • Publication number: 20200190237
    Abstract: A method of preparing a branched polymer comprises the free radical polymerisation of a multivinyl monomer in the presence of a chain transfer agent, using a source of radicals, wherein the extent of propagation is controlled relative to the extent of chain transfer to prevent gelation of the polymer. The average length of each vinyl polymer chain within the product is short.
    Type: Application
    Filed: April 26, 2018
    Publication date: June 18, 2020
    Applicant: The University of Liverpool
    Inventors: Steve Rannard, Pierre Chambon, Savannah Cassin
  • Publication number: 20200181335
    Abstract: A method of preparing a polymer comprises the use of free radical vinyl polymerisation to form carbon-carbon backbone segments of the polymer, wherein the longest chains in the polymer comprise vinyl polymer chains interspersed with other chemical groups and/or chains. The product has the characteristics of a step-growth polymer comprising a mixture of polyfunctional step-growth monomer residues formed by vinyl polymerization.
    Type: Application
    Filed: April 26, 2018
    Publication date: June 11, 2020
    Applicant: The University of Liverpool
    Inventors: Steve Rannard, Pierre Chambon, Savannah Cassin
  • Patent number: 10675251
    Abstract: Particles comprising a branched polymer and either a block copolymer or a linear dendritic hybrid represent a category of useful materials. They may be used in for example drug delivery applications. They may be prepared by a method comprising the steps of: dissolving the branched polymer and block copolymer or linear dendritic hybrid, and optionally other component(s), in a solvent to form a solution; adding said solution to a different liquid; and removing said solvent to form a dispersion of co-precipitated particles.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 9, 2020
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Steve Rannard, Jane Ford, Hannah Rogers, Pierre Chambon, Marco Giardiello, Andrew Owen, Neil Kitteringham
  • Patent number: 10614176
    Abstract: Aspects of the present disclosure relate generally to preparing models of three-dimensional structures. In particular, a model of a three-dimensional structure constructed of porous geometries is prepared. A component file including a porous CAD volume having a boundary is prepared. A space including the porous CAD volume is populated with unit cells. The unit cells are populated with porous geometries having a plurality of struts having nodes on each end. The space is populated with at least one elongated fixation element extending beyond the boundary to produce an interlocking feature enabling assembly or engagement with a mating structure.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 7, 2020
    Assignees: Howmedica Osteonics Corp., The University Of Liverpool
    Inventors: Nicholas Nai Guang Dong, Matthew P. Poggie, Robert W. Klein, Eric Jones, Christopher J. Sutcliffe, Joe Robinson, Dan Jones, Lewis Mullen, Robin Stamp
  • Patent number: 10603279
    Abstract: The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: March 31, 2020
    Assignee: The University of Liverpool
    Inventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith, James Long
  • Publication number: 20200086625
    Abstract: The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Applicant: The University Of Liverpool
    Inventors: William O'Neill, Christopher J. Sutcliffe, Eric Jones, Robin Stamp
  • Patent number: 10561609
    Abstract: The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: February 18, 2020
    Assignee: The University of Liverpool
    Inventors: Alison J. Foster, James Long, Steven P. Rannard, Dong Wang, David J. Duncalf, Andrew Owen
  • Patent number: 10525688
    Abstract: The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 7, 2020
    Assignees: Howmedica Osteonics Corp., The University Of Liverpool
    Inventors: William O'Neill, Christopher J. Sutcliffe, Eric Jones, Robin Stamp
  • Patent number: 10463618
    Abstract: An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: November 5, 2019
    Assignee: The University of Liverpool
    Inventors: Steve Rannard, Andrew Owen, James Hobson, Neill Liptrott, Pierre Chambon
  • Patent number: 10463610
    Abstract: The present invention relates to novel pharmaceutical formulations. More specifically, the present invention relates to novel pharmaceutical formulations that are suitable for intraocular administration. The present invention also relates to the use of these formulations for the treatment of collagenic eye disorder such as, for example, the treatment of keratoconus.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: November 5, 2019
    Assignee: The University of Liverpool
    Inventors: Rachel L. Williams, Colin E. Willoughby
  • Patent number: 10449198
    Abstract: The present invention relates to a method of treating pain in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate: wherein Q is as defined herein.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: October 22, 2019
    Assignee: The University of Liverpool
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala