Patents Assigned to The University of Liverpool
-
Patent number: 9180010Abstract: Aspects of the present disclosure relate generally to preparing models of three-dimensional structures. In particular, a model of a three-dimensional structure constructed of porous geometries is prepared. A component file including a porous CAD volume having a boundary is prepared. A space including the porous CAD volume is populated with unit cells. The unit cells are populated with porous geometries having a plurality of struts having nodes on each end. The space is populated with at least one elongated fixation element extending beyond the boundary to produce an interlocking feature enabling assembly or engagement with a mating structure.Type: GrantFiled: September 14, 2012Date of Patent: November 10, 2015Assignees: Howmedica Osteonics Corp., The University Of LiverpoolInventors: Nicholas Nai Guang Dong, Matthew P. Poggie, Robert W. Klein, Eric Jones, Christopher J. Sutcliffe, Joe Robinson, Dan Jones, Lewis Mullen, Robin Stamp
-
Publication number: 20150299380Abstract: Polymers exhibiting solubility, conjugation and microporosity are processable and useful for a variety of applications. The polymers comprise repeating units which are linked together to form rigid macromolecular structures which do not exhibit space-efficient packing. The polymers may comprise aromatic structures, e.g. fused aromatic structures and/or multiply bonded aromatic structures, and may comprise solubilising groups such as for example branched alkyl groups or siliyl groups.Type: ApplicationFiled: November 4, 2013Publication date: October 22, 2015Applicant: The University of LiverpoolInventors: Andrew Cooper, David Adams, Ge Cheng, Tom Hasell
-
Publication number: 20150272984Abstract: The present invention relates to the use of agents (including heparin derivatives) for the prevention and/or treatment of CNS damage.Type: ApplicationFiled: November 1, 2013Publication date: October 1, 2015Applicants: THE UNIVERSITY OF LIVERPOOL, THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOWInventors: Jeremy Ewan Turnbull, Scott Ernest Guimond, Sophie Marie Thompson, Susan Carol Barnett, Jennifer Rosemary Higginson
-
Patent number: 9140326Abstract: A structure for bending transversal elastic waves around a zone to isolate of a plate, has an anisotropic Young's modulus and/or a heterogeneous mass density. The wavelengths of the elastic waves to bend are large with respect to the thickness of the plate and small with respect to the other dimensions of the plate. The structure is made by defining a meshing of a peripheral zone surrounding the zone to isolate; dividing the peripheral zone into several elementary rings and several elementary angular sectors; and forming, in each mesh delimited by an elementary angular sector and an elementary ring, a structural element in a material having a Young's modulus and/or a mass density different than those of the material forming the plate, the dimensions of the meshes and of the structural elements in the plane of the plate being less than half the wavelengths of the elastic waves to bend.Type: GrantFiled: September 13, 2011Date of Patent: September 22, 2015Assignees: Centre National de la Recherche Scientifique, Université Paul Cézanne Aix-Marseille III, University of LiverpoolInventors: Stéphane Enoch, Mohamed Farhat, Sébastien Guenneau, Alexander Movchan
-
Publication number: 20150258735Abstract: The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.Type: ApplicationFiled: March 27, 2015Publication date: September 17, 2015Applicants: HOWMEDICA OSTEONICS CORP., THE UNIVERSITY OF LIVERPOOLInventors: William O'Neill, Christopher J. Sutcliffe, Eric Jones, Robin Stamp
-
Patent number: 9135374Abstract: Aspects of the present disclosure relate generally to preparing models of three-dimensional structures. In particular, a model of a three-dimensional structure constructed of porous geometries is prepared. A component file including a porous CAD volume having a predefined portion of a boundary. A space including the porous CAD volume is populated with unit cells overlapping the predefined portion of the boundary. The unit cells are populated with porous geometries having a plurality of struts having nodes on each end. At least a first strut overlaps the predefined portion of the boundary and has a length, a first node outside the porous CAD volume, and a second node inside the porous CAD volume. All struts entirely outside the porous CAD volume are removed. After removal of the struts entirely outside the porous CAD volume, each of the remaining struts is connected to a node at each end thereof.Type: GrantFiled: April 6, 2012Date of Patent: September 15, 2015Assignees: Howmedica Osteonics Corp., The University Of LiverpoolInventors: Eric Jones, Christopher J. Sutcliffe, Joe Robinson, Dan Jones, Lewis Mullen
-
Publication number: 20150223494Abstract: The invention concerns the use of a food additive including a sweetener in the feed or the drink of a ruminant animal to reduce the impact of stressful conditions on intestinal mucosa quality.Type: ApplicationFiled: August 29, 2013Publication date: August 13, 2015Applicants: PANCOSMA SA, UNIVERSITY OF LIVERPOOLInventors: David Bravo, Soraya P. Shirazi-Beechey
-
Patent number: 8992703Abstract: The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.Type: GrantFiled: September 6, 2012Date of Patent: March 31, 2015Assignees: Howmedica Osteonics Corp., The University of LiverpoolInventors: William O'Neill, Christopher J. Sutcliffe, Eric Jones, Robin Stamp
-
Patent number: 8968641Abstract: The present invention relates to a process for producing porous metallic materials comprising the steps of: (a) miming metallic particles with a carbonate additive and a binder, wherein the quantity of carbonate additive in the mixture is in the range of 40 to 90 vol % and compressing the mixture beyond the yield strength of the metallic particles; (b) heating the mixture to a first temperature sufficient to evaporate the binder; (c) heating and maintaining the temperature of the mixture to a second temperature sufficient to sinter the metallic particles but insufficient to decompose or melt the carbonate additive; (d) removing the carbonate additive from the sintered porous metallic material; and optionally (e) heating and maintaining the temperature of the porous metallic material to a third temperature greater than the second temperature so as to enhance the sintering. The present invention also relates to metallic materials produced by such a process.Type: GrantFiled: May 19, 2005Date of Patent: March 3, 2015Assignee: The University of LiverpoolInventor: Yuyuan Zhao
-
Publication number: 20140249643Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.Type: ApplicationFiled: May 13, 2014Publication date: September 4, 2014Applicants: The University of Liverpool, Howmedica Osteonics Corp.Inventors: Eric Jones, Christopher J. Sutcliffe, Robin Stamp
-
Publication number: 20140249239Abstract: A method for preparing a conjugated microporous polymer comprises the coupling of an alkynyl aryl monomer having a plurality of terminal alkyne groups with an iodo- or bromo-aryl monomer having a plurality of halogen atoms in the presence of a palladium (0) catalyst. The conjugated microporous polymer comprises nodes comprising at least one aryl unit and struts comprising at least one alkyne unit and at least one aryl unit, wherein a node is bonded from its aryl unit or units to at least two struts via alkyne units. Such polymers are useful in numerous areas such as separations, controlled release, gas storage and supports for catalysts.Type: ApplicationFiled: March 7, 2014Publication date: September 4, 2014Applicant: The University of LiverpoolInventors: Andrew Cooper, Jiaxing Jiang, Neil Campbell, Fabing Su, Abbie Trewin
-
Patent number: 8809409Abstract: A method for preparing a conjugated microporous polymer comprises the coupling of an alkynyl aryl monomer having a plurality of terminal alkyne groups with an iodo-or bromo-aryl monomer having a plurality of halogen atoms in the presence of a palladium (0) catalyst. The conjugated microporous polymer comprises nodes comprising at least one aryl unit and struts comprising at least one alkyne unit and at least one aryl unit, wherein a node is bonded from its aryl unit or units to at least two struts via alkyne units. Such polymers are useful in numerous areas such as separations, controlled release, gas storage and supports for catalysts.Type: GrantFiled: August 15, 2008Date of Patent: August 19, 2014Assignee: The University of LiverpoolInventors: Andrew Cooper, Jiaxing Jiang, Neil Campbell, Fabing Su, Abbie Trewin
-
Publication number: 20140220140Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.Type: ApplicationFiled: September 7, 2012Publication date: August 7, 2014Applicant: THE UNIVERSITY OF LIVERPOOLInventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
-
Publication number: 20140220141Abstract: The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.Type: ApplicationFiled: September 7, 2012Publication date: August 7, 2014Applicant: THE UNIVERSITY OF LIVERPOOLInventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith
-
Publication number: 20140212501Abstract: The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof.Type: ApplicationFiled: September 7, 2012Publication date: July 31, 2014Applicant: THE UNIVERSITY OF LIVERPOOLInventors: Marco Norman Giardiello, Thomas Oliver McDonald, Andrew Owen, Steven Paul Rannard, Philip John Martin, Darren Lee Smith, James Long
-
Patent number: 8748109Abstract: This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for detecting particular serum biomarkers that can be used in the detection, assessment and/or diagnosis of organ (e.g. liver) or tissue (e.g. skin) injury.Type: GrantFiled: July 5, 2010Date of Patent: June 10, 2014Assignee: The University of LiverpoolInventors: Daniel Antoine, Dominic Williams, Kevin Park
-
Patent number: 8728387Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.Type: GrantFiled: December 6, 2005Date of Patent: May 20, 2014Assignees: Howmedica Osteonics Corp., The University of LiverpoolInventors: Eric Jones, Christopher J. Sutcliffe, Robin Stamp
-
Patent number: 8722830Abstract: The present invention relates to a branched vinyl polymer carrying dendrons made from monofunctional vinyl monomers and branched by virtue of difunctional vinyl monomers so that there is on average one branch or fewer per polymer chain to avoid gelation. The polymer may be made by chain-growth polymerization of predominantly monofunctional vinyl monomers in the presence of difunctional vinyl monomers and dendron units.Type: GrantFiled: March 13, 2013Date of Patent: May 13, 2014Assignee: The University of LiverpoolInventors: Jonathan Weaver, Steven Rannard, Gwenaelle Bonzi, Andrew Cooper
-
Publication number: 20140081110Abstract: The invention provides methods for diagnosing and treating asthma in subjects in need thereof but can be applied to other conditions where abnormal electrophysiology underlies dysfunctional organ contractility.Type: ApplicationFiled: June 4, 2012Publication date: March 20, 2014Applicants: University of Liverpool, Children's Hospital Los AngelesInventor: Edwin C. Jesudason
-
Patent number: 8673880Abstract: A pharmaceutical composition for use in the prevention and/or treatment of a neurodegenerative disorder comprising a compound comprised of one or more disaccharide units, the or each disaccharide unit comprising a uronate moiety linked to a glucosamine moiety, wherein the 2-O atom of the uronate moiety is substituted with a hydrogen atom, the 6-O atom of the glucosamine moiety is substituted with a sulphate group and the 2-N atom of the glucosamine moiety is substituted with an atom or group other than a sulphate group. The composition is particularly preferred for use in the prevention and/or treatment of Alzheimer's disease.Type: GrantFiled: May 23, 2007Date of Patent: March 18, 2014Assignee: The University Of LiverpoolInventors: Jeremy Turnbull, Edwin Yates, Susannah Patey