Patents Assigned to The University of Melbourne
  • Analyte detection assay
    Patent number: 8617824
    Abstract: A rapid and sensitive analyte detection assay is based on whispering gallery modes of fluorescently labelled microspheroidal particles. Ligands for the analyte, such as nucleic acids, are anchored to the particles. The fluorescent labels may comprise fluorophores or quantum dots. In the latter case, the particles may comprise melamine formaldehyde. The assay may be used to detect analytes in aqueous samples.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: December 31, 2013
    Assignees: Genera Biosystems Limited, The University of Melbourne
    Inventors: Karl Frederick Poetter, Edin Nuhiji, Paul Mulvaney
  • Stabilized calcium phosphate complexes
    Patent number: 8609071
    Abstract: The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralization.
    Type: Grant
    Filed: November 24, 2005
    Date of Patent: December 17, 2013
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Ionic complexes
    Patent number: 8603988
    Abstract: The present invention provides a phosphopeptide or phosphoprotein (PP) stabilized amorphous calcium phosphate or amorphous calcium fluoride phosphate complex having a calcium ion greater than about 30 moles of calcium per mole of PP.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: December 10, 2013
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • SYNTHETIC PEPTIDE CONSTRUCTS FOR THE DIAGNOSIS AND TREATMENT OF PERIODONTIS ASSOCIATED WITH PORPHYROMONAS GINGIVALIS
    Publication number: 20130309179
    Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.
    Type: Application
    Filed: March 28, 2013
    Publication date: November 21, 2013
    Applicant: The University of Melbourne
    Inventors: Eric Charles Reynolds, Neil Martin O'BRIEN-SIMPSON, Nada SLAKESKI
  • Pain treatment
    Publication number: 20130243791
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: May 28, 2013
    Publication date: September 19, 2013
    Applicant: The University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • Non-steroidal compounds
    Patent number: 8536157
    Abstract: The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: September 17, 2013
    Assignee: The University of Melbourne
    Inventors: Alastair Stewart, Martin Banwell, Brenda Leung, Anu Augustine, Jacki Kitching, Thomasz Bilski
  • Temperature sensitive vaccine strain of and uses thereof
    Patent number: 8524252
    Abstract: The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute (Australia) under accession number NM04/41259, which strain is temperature sensitive and attenuated, a vaccine comprising such strains and methods and uses thereof.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: September 3, 2013
    Assignees: Bioproperties Pty Ltd., The University of Melbourne
    Inventors: Rima Youil, Youssef Abs El-Osta, Glenn Browning, Phillip Markham
  • Process for the preparation of a cross-linked multilayer film
    Patent number: 8496997
    Abstract: The present invention provides a process for the preparation of a multilayer film, in particular, a cross-linked multilayer macromolecular film.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: July 30, 2013
    Assignee: The University of Melbourne
    Inventors: Francesco Caruso, Greg Guanghua Qiao, Anton Richard Blencowe, Tor Kit Goh, Luke Andrew Connal, Georgina Kate Such
  • Synthetic peptide constructs for the diagnosis and treatment of Periodontitis associated with
    Patent number: 8431688
    Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: April 30, 2013
    Assignee: The University of Melbourne
    Inventors: Eric C. Reynolds, Neil Martin O'Brien-Simpson, Nada Slakeski
  • Incremental stimulation sound processor
    Patent number: 8260429
    Abstract: In one aspect of the invention, a cochlear implant constructed and arranged to successively generate stimulation signals each comprising at least one stimulus pulse such that said successive stimulation signals incrementally build a neural excitation pattern that accurately reflects a received sound. In one embodiment, each said successive stimulation signal is generated based on the cumulative effect of all previous stimulus pulses, thereby compensating for finite spatial spreading of individual stimulus pulses as well as for the temporal integration of the neural excitation pattern along the neural pathways.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: September 4, 2012
    Assignees: The University of Melbourne, Bionic Ear Institute, Cochlear Limited
    Inventors: Peter J. Blamey, Bonar Dickson, Brett A. Swanson
  • MODIFIED PEPTIDE SUBSTRATE
    Publication number: 20120208225
    Abstract: The invention provides novel reagents and methodologies for detecting free versus bound enzyme. It is particularly useful to detect thrombin when it is not bound to A2M in the presence of thrombin bound to A2M by using a modified substrate that is sterically hindered from reacting with the bound thrombin.
    Type: Application
    Filed: February 16, 2012
    Publication date: August 16, 2012
    Applicants: The University of Melbourne, McMaster University
    Inventors: Leslie R. Berry, Vera Ignjatovic, Paul T. Monagle, Anthony K. Chan
  • Method of treating rheumatoid arthritis with antibodies to M-CSF
    Patent number: 8142777
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: March 27, 2012
    Assignee: The University of Melbourne
    Inventors: John Hamilton, Ian Keith Campbell
  • Modified peptide substrate
    Patent number: 8138308
    Abstract: The invention provides novel reagents and methodologies for detecting free versus bound compounds. It is particularly useful to detect thrombin when it is not bound to A2M in the presence of thrombin bound to A2M by using a modified substrate that is sterically hindered from reacting with the bound thrombin.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: March 20, 2012
    Assignees: McMaster University, The University of Melbourne
    Inventors: Leslie R. Berry, Vera Ignjatovic, Paul T. Monagle, Anthony K. Chan
  • Method and apparatus for envelope detection and enhancement of pitch cue of audio signals
    Patent number: 8135152
    Abstract: A method and apparatus for detecting an envelope of an audio signal, and a method and apparatus for enhancing the pitch cue of an audio signal perceived by a cochlear implant patient where the audio signal is processed and input to an implant device of the recipient. The methods and apparatuses use techniques such as filtering, rectifying, detecting peak values, sampling, resetting, comparing and multiplying various signals to detect the envelope or enhance the pitch cue of the audio signal.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: March 13, 2012
    Assignees: Cochlear Limited, The University of Melbourne
    Inventors: Brett A. Swanson, Peter J. Blamey, Hugh J. McDermott, James F. Patrick
  • HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS
    Publication number: 20120059188
    Abstract: The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation.
    Type: Application
    Filed: December 19, 2008
    Publication date: March 8, 2012
    Applicants: The University of Melbourne, Fibrotech Therapeutics Pty Ltd
    Inventors: Darren James Kelly, Spencer John Williams, Steven Zammit
  • polypeptides and nucleotides
    Patent number: 8129500
    Abstract: The present invention relates to isolated Porphyromonas gingivalis polypeptides and nucleotides. The polypeptides include an amino acid sequence selected from the group consisting of: SEQ. ID. NO. 110; SEQ. ID. NO. 111; SEQ. ID. NO. 112; SEQ. ID. NO. 113; SEQ ID NO: 120; SEQ. ID. NO. 123; SEQ. ID. NO. 124; SEQ. ID. NO. 125; SEQ. ID. NO. 130; SEQ. ID. NO. 131; SEQ. ID. NO. 132; SEQ. ID. NO. 133; SEQ. ID. NO. 135; SEQ. ID. NO. 136; SEQ. ID. NO. 137; SEQ. ID. NO. 138; SEQ. ID. NO. 143; SEQ. ID. NO. 144; SEQ. ID. NO. 145; SEQ. ID. NO. 146; SEQ. ID. NO. 147; SEQ. ID. NO. 148; and amino acid sequences at least 95% identical thereto.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: March 6, 2012
    Assignees: CSL Limited, The University of Melbourne
    Inventors: Bruce C. Ross, Ian G. Barr, Michelle A. Patterson, Catherine T. Agius, Linda J. Rothel, Mai B. Margetts, Dianna M. Hocking, Elizabeth A. Webb
  • Porous polymer blend structures
    Patent number: 8044108
    Abstract: A porous polymer blend, and a method of producing a porous polymer blend from at least two immiscible polymers. The at least two immiscible polymer being blended together and exhibiting the absence of complete phase separation. The method of producing a porous polymer blend comprising: forming a liquid composition comprising at least two immiscible polymers dissolved in a common solvent; subjecting the liquid composition to a reduction in temperature to cause at least two immiscible polymers to phase separate into a common polymer rich phase and a common polymer poor phase; solidifying the at least two immiscible polymers in the common polymer rich phase so as to avoid complete phase separation of the at least two immiscible polymers; and removing the common polymer pore phase to provide a blend of the at least two immiscible polymers having a porous morphology.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: October 25, 2011
    Assignees: The University of Queensland, The University of Melbourne
    Inventors: Justin John Cooper-White, Yang Cao, Andrew Stewart Rowlands
  • Process for the preparation of a cross-linked multilayer film
    Publication number: 20110250353
    Abstract: The present invention provides a process for the preparation of a multilayer film, in particular, a cross-linked multilayer macromolecular film.
    Type: Application
    Filed: March 10, 2011
    Publication date: October 13, 2011
    Applicant: The University of Melbourne
    Inventors: Francesco Caruso, Greg Guanghua Qiao, Anton Richard Blencowe, Tor Kit Goh, Luke Andrew Connal, Georgina Kate Such
  • IMMUNOPOTENTIATING COMPOSITION
    Publication number: 20110217366
    Abstract: The present invention provides an immunopotentiating composition which comprises an antigen or antigen-inducing substance, and a carrier comprising a biocompatible material for effectively increasing an immune response derived from an antigen. The present invention further provides a method of producing an antibody by administering said immunopotentiating composition to a mammal or bird, thereby modulating the immune response in said mammal or bird and recovering the antibody produced.
    Type: Application
    Filed: May 17, 2011
    Publication date: September 8, 2011
    Applicants: Dainippon Sumitomo Pharma Co., Ltd., The University of Melbourne, KONEN CO., LTD.
    Inventors: Keiji FUJIOKA, Akihiko Sano, Shunji Nagahara, Malcolm Roy Brandon, Andrew Donald Nash, Shari Lofthouse
  • Diagnostics and treatments of periodontal disease
    Publication number: 20110213129
    Abstract: This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell association protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
    Type: Application
    Filed: March 16, 2011
    Publication date: September 1, 2011
    Applicant: The University of Melbourne
    Inventors: Eric Charles Reynolds, Peter Singh Bhogal, Nada Slakeski