Abstract: The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.

Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.

Abstract: A method of delivery of fluid through a computer controlled fluid network, the network including: regulators to control the flow of fluid to deliver a predetermined amount thereof to at least one customer; a first control system for opening and closing the regulators, which collects data based on timed measurements of fluid levels upstream and downstream of respective regulators and the opening positions of respective regulators, using data analysis to provide models for prediction of fluid levels between regulators; a second control system that is a supervisory layer interacting with the first control system to provide adjustments to the controlling of the regulators based on constraint and future flow load; and a third control system interacting with the first and second control systems, which processes fluid delivery requests from the at least one customer to provide a flow load delivery schedule based on the hydraulic capacity of the network.

Abstract: The present invention relates to compounds that are useful as metal ligands and which contain a moiety capable of binding to a biological entity and methods of making these compounds. These compounds are of interest as they can be bound to a biological entity and then coordinated with a suitable metallic radionuclide. The coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging.

Abstract: This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity and surface forces in such processes.

Abstract: A method of obtaining information about at least one target, includes transmitting a stepped frequency signal, obtaining a return radar signal corresponding to the transmitted stepped frequency signal from at least one target, bandpass filtering the return radar signal based on the frequencies of the transmitted frequency signal, converting the bandpass filtered return radar signal to a digital bandpass filtered return radar signal, and digitally mixing the digital bandpass filtered return radar signal with a digital mixing signal related to the stepped frequency signal to obtain information about the at least one target.

Abstract: The present invention relates to isolated Porphyromanas gingivalis polypeptides and nucleotides. The polypeptides include an amino acid sequence selected from the group consisting of: SEQ. ID. NO. 110; SEQ. ID. NO. 111; SEQ. ID. NO. 112; SEQ. ID. NO. 113; SEQ ID NO: 120; SEQ. ID. NO. 123; SEQ. ID. NO. 124; SEQ. ID. NO. 125; SEQ. ID. NO. 130; SEQ. ID. NO. 131; SEQ. ID. NO. 132; SEQ. ID. NO. 133; SEQ. ID. NO. 135; SEQ. ID. NO. 136; SEQ. ID. NO. 137; SEQ. ID. NO. 138; SEQ. ID. NO. 143; SEQ. ID. NO. 144; SEQ. ID. NO. 145; SEQ. ID. NO. 146; SEQ. ID. NO. 147; SEQ. ID. NO. 148; and amino acid sequences at least 95% identical thereto.

Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.

Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Abstract: The present invention generally relates to the field of water treatment, and in particular to industrial processes which generate aqueous solutions containing thiocyanate (SCN). The invention particularly relates to processes for treating aqueous solutions containing SCN and more specifically treatment processes to extract and remove SCN from said aqueous solutions.

Abstract: The present invention relates to compounds and compositions useful as antioxidants and in particular to selenium containing compounds of formula (I): wherein n is 1, 2, or 3; m is 2, 3, 4, or 5; and each R] is independently —(optionally substituted C1-C3 alkylene) p-OH, where p is 0 or 1, or a salt thereof. The invention also relates to the use of these seleno-compounds in the treatment of diseases or conditions associated with increased levels of oxidants produced by myeloperoxidase (MPO), such as for instance, atherosclerosis.

Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.

Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.

Abstract: Processes for the continuous production of conjugated polymers are disclosed. The processes provide excellent control over reaction parameters and are highly reproducible. The conjugated polymers find use in heterojunction devices.

Abstract: There is disclosed a material processing method wherein a material is fed between a pair of opposed moving surfaces which converge such that a nip is defined therebetween, whereby the material is drawn into the nip to be compressed or compacted between the surfaces, and thence output from between the surfaces, the method comprising subjecting the material to an asymmetric and/or non uniform flow condition between the surfaces to effect shearing in the material in a direction generally parallel to the direction of flow of the material between the surfaces.

Abstract: The present disclosure provides a method of monitoring a property of a sample, such as a nanoscopic property of the sample. The method comprises the steps of providing a quantum probe having a quantum state and exposing the quantum probe to the sample in a manner such that the property of the sample, in the proximity of the quantum probe, affects quantum coherence of the quantum probe. The method also comprises detecting a rate of quantum decoherence of the quantum probe to monitor the property of the sample. Further the present disclosure provides an apparatus for monitoring a property of a sample.

Abstract: The present invention provides a purified multimeric complex from P. gingivalis. The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than about 300 kDa.

Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Abstract: The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3;1,4)-?-D-glucan synthases. The present invention provides, among other things, methods for influencing the level of (1,3;1,4)-?-D-glucan produced by a cell and nucleic acid and amino acid sequences which encode (1,3;1,4)-?-D-glucan synthases.