Abstract: Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

Abstract: Provided herein is technology relating to immunoisolation of cells and tissues, including, but not exclusively, to compositions, methods, and kits for encapsulating cells and/or tissues within an immunoisolating device to protect the cells/or tissues from host immune rejection.

Abstract: A computer-implemented method is presented for quantifying hydration in a subject. The method includes: receiving a heart rate signal indicative of heart rate of the subject; extracting features from the heart rate signal, where one or more of the extracted features include a frequency domain representation of the heart rate signal; constructing a feature vector from the extracted features; and quantifying hydration status of the subject as a percent of body weight of the subject by classifying the feature vector using machine learning, where percentages of body weight are expressed in increments on the order of one percent or less.

Abstract: Devices and techniques for continuously monitoring pressure and simultaneously monitoring changes in blood flow, vascular resistance, and/or vascular behavior are provided. The techniques are employed in measuring intracranial pressure (ICP), while simultaneously measuring cerebral blood flow and/or cerebrovascular resistance or behavior. A sensor device includes an optical and piezoelectric sensing assembly integrated into a deployable ICP monitoring device.

Abstract: A microscale collector and injector device comprises a microscale passive pre-concentrator (?PP) and a microscale progressively-heated injector (?PHI). The ?PP devices comprises first and second substrate portions, a first collection material, a ?PP heater, and an outlet. The first substrate portion defines an array of microscale diffusion channels. The first and second substrate portions cooperate to define a first compartment in fluid communication with the diffusion channels. The first collection material is disposed within the first compartment, at least partially surrounding the outlet. The ?PP heater is disposed in thermal communication with the second substrate portion. The ?PHI device comprises third and fourth substrate portions, a second collection material, and a plurality of ?PHI heaters. The third and fourth substrate portions cooperate to define a second compartment. The second collection material is disposed within the second compartment.

Abstract: Building blocks, wall structures made therefrom, building systems made therefrom, structures made therefrom, and methods of constructing a structure therewith, are described.

Abstract: A system includes a navigation antenna configured to receive first satellite signals transmitted from a first type of satellite in a first frequency band and second satellite signals transmitted from a second type of satellite in a second frequency band and generate RHCP signal responses based on the first and second satellite signals, a plurality of science antennas configured to receive the first satellite signals in the first frequency band and the second satellite signals in the second frequency band as reflected from a ground surface and generate LHCP signal responses and RHCP signal responses based on the first and second satellite signals, and a receiver module including a processing module and a plurality of receivers coupled between the navigation antenna and the plurality of science antennas and the processing module. The processing module is configured to generate telemetry data based on the received LHCP and RHCP signal responses.

Abstract: The present application can provide a preparation method capable of preparing a desired polymer or conductive polymer film with excellent polymerization efficiency and conversion rates without consumption or modulation in the polymerization process, and a polymer and a conductive polymer film formed by the method. The present application can provide a method for preparing a polymer or a conductive polymer film having a desired level of transparency and conductivity, wherein desired physical properties such as solubility in a solvent or resistance to a solvent are effectively imparted thereto as necessary, and a polymer and a conductive polymer film formed by the method.

Abstract: In one aspect, a system and method for aligning hip replacement prostheses comprises an acetabular liner having an inner concave surface and an outer convex surface. The acetabular liner includes at least two magnetic sensors arranged in a spatially distributed manner. The system and method also include a prosthetic femoral component comprising a femoral head component. The femoral head component and the acetabular liner component are shaped such that a ball and socket joint is formed when the femoral head component comes into contact with the inner concave surface of the acetabular liner. While the ball-and-socket joint is formed, and in at least some orientations of the femoral head component relative to the acetabular liner component, a contact point on an external surface of the femoral head component contacts the inner concave surface. The femoral head component includes at least one permanent magnet.

Abstract: A dual-polarized antenna is presented for 5G mobile communications. The antenna includes two discrete elements—a folded dipole and a folded monopole, which generate two orthogonal polarizations. Parasitic elements are used to realize higher-band operation. In one example, the antenna covers both the 28 GHz band and the 39 GHz band. The entire structure is designed on an ultra-thin four-layer laminate and is intended to be incorporated along the edges of smartphones to enable 5G operation.

Abstract: Provided herein are microscope surveillance systems and methods. In particular, provided herein are modular, multi-functional microscope surveillance systems and methods suitable for use in incubators and other environments.

Abstract: A microfluidic device for use with a microfluidic delivery system, such as an organic vapor jet printing device, includes a glass layer that is directly bonded to a microfabricated die and a metal plate via a double anodic bond. The double anodic bond is formed by forming a first anodic bond at an interface of the microfabricated die and the glass layer, and forming a second anodic bond at an interface of the metal plate and the glass layer, where the second anodic bond is formed using a voltage that is lower than the voltage used to form the first anodic bond. The second anodic bond is formed with the polarity of the voltage reversed with respect to the glass layer and the formation of the first anodic bond. The metal plate includes attachment features that allow removal of the microfluidic device from a fixture.

Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.

Abstract: In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed—even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function.

Abstract: A composite material is provided. The composite material includes a hydrogel matrix having a three-dimensional geometry and fibers embedded and substantially uniformly distributed within the three-dimensional hydrogel matrix. The fibers have a substantially circular cross-sectional geometry and are anisotropically aligned. Methods of making and using the composite material are also provided.

Abstract: A method of increasing light emission efficiency in an organic light emitting diode (OLED) eliminates or reduces at least one waveguide mode selected from the group consisting of: transverse electric (TE0) mode, transverse magnetic (TM1) mode, and combinations thereof by disposing an ultrathin electrically conductive transparent metallic electrode having a first polarity within the OLED. The OLED has a transparent substrate on which the ultrathin electrically conductive transparent metallic electrode is disposed. It also has an emissive active assembly for generating photons defining first and second opposite sides. A conductive transparent metallic electrode is disposed along the first side. A second transparent electrode having a second polarity opposite to the first polarity disposed adjacent to the second side of emissive active assembly. The methods include increasing an external quantum efficiency of the organic light emitting diode to ?about 20%. OLEDs with such a design are also contemplated.

Abstract: A system is presented for analyzing and interpreting histologic images. The system includes an imaging device and a diagnostic module. The imaging device captures an image of a tissue sample at an optical section of the tissue sample, where the tissue sample has a thickness larger than the optical section. The system may further include an image interpretation subsystem located remotely from the imaging device and configured to receive the images from the imaging device. The diagnostic module is configured to receive the images for the tissue sample from the imaging device and generates a diagnosis for the tissue sample by applying a machine learning algorithm to the images. The diagnostic module may be interface directly with the imaging device or located remotely at the image interpretation subsystem.

Abstract: The present disclosure relates to compositions capable of absorbing UVA and UVB light. In particle, the present disclosure relates to UV screening compositions comprising at least a portion of LITE-1 polypeptides which are capable of absorbing UV light (e.g., UV-A and/or UV-B light).

Abstract: Provided herein are compositions and methods for treating cancer. In particular, provided herein are compositions, methods, and uses of targeted therapy to treat cancer (e.g., prostate cancer) in subjects with CDK12 mutations.

Abstract: The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used in methods for the treatment of a wide variety of cancers and other diseases associated with one or more of MLL1, MLL2, MLL fusion proteins, and menin.