Abstract: Certain embodiments are directed to methods of treating LLT1 expressing cancer by administering to a subject having an LLT1 expressing cancer an LLT1 inhibitor.

Abstract: Systems and methods for copper etch monitoring and control are described. Certain embodiments include utilizing thin-film cells to measure the absorbance of a copper etch solution to determine the etch rate of the solution. In another embodiment, a method of controlling etch rate of a copper etch solution includes detecting characteristics of the copper etch solution utilizing a sensor device, e.g., flow cell and/or attenuated total reflection probe, calculating, based on the detected characteristics of the copper etch solution, the etch rate of the copper etch solution, and adjusting the etch rate of the copper etch solution in response to the calculated etch rate deviating from a specified value.

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: switchable optical filter that is based on carrier injection induced semiconductor to metal phase transition (SMT) of vanadium oxide-based (e.g., VO2) thin films may reversibly change from optically transparent to opaque while undergoing such phase transition. Electrical carrier injection may be established by an electric field or by photoexcitation. The SMT may also be induced by a combination of applying an electric field and optical flux. Such a switchable optical filter, when inserted in the optical path of an optical radiation sensor, may be used to control and/or limit high power optical beams, such as a laser beam impinging on one or more sensor elements. Since the SMT may be configured to occur at ultrafast time scales (e.g., approximately 100 femtoseconds), it may also act as a beam shutter and/or as a fast optical beam modulator.

Abstract: Direct pixel-by-pixel phase engineering in a SLM is an effective method for the holographic fabrication of graded photonic super-quasi-crystals with desired disorder and graded photonic super-crystals with rectangular unit-cells. Multiple levels of filling fractions of dielectric in the crystal have been created in the graded regions. Fabrication of these graded photonic super-crystals and super-quasi-crystals with small feature size is possible, using a laser projection system consisting of integrated spatial light modulator and reflective optical element.

Abstract: A soft-landing (SL) instrument for depositing ions onto substrates using a laser ablation source is described herein. The instrument of the instant invention is designed with a custom drift tube and a split-ring ion optic for the isolation of selected ions and is capable of operating at atmospheric pressure. The drift tube allows for the separation and thermalization of ions formed after laser ablation through collisions with an inert bath gas that allow the ions to be landed at energies below 1 eV onto substrates. The split-ring ion optic is capable of directing ions toward the detector or a landing substrate for selected components.

Abstract: An interconnect and a method of making an interconnect between one or more features on a substrate comprises: sputtering a noble metal-copper eutectic thin film under controlled power on an oxide grown or deposited on a substrate; and forming an amorphous alloy structure from the noble metal-copper eutectic thin film in the shape of the interconnect and the interconnect comprising no grain or grain boundaries without temperature sensitive resistivity.

Abstract: An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule detector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may introduce heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or tetrahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified one or more target VOCs. The output may include information that quantitates a concentration of the one or more target VOCs with respect to a source of the breath sample.

Abstract: The present invention includes a composition and method for the treatment of an eye disease comprising a therapeutically effective amount of an autophagy stimulator that treats or slows the progression of the eye disease by enhancing or stimulating autophagy or correcting an autophagy deficiency.

Abstract: The present invention provides amorphous bi-functional catalytic aluminum metallic glass particles having an aluminum metallic glass core and 2 or more transition metals disposed on the surface of the aluminum metallic glass core to form amorphous bi-functional aluminum metallic glass particles with catalytic activity.

Abstract: The present invention related to compounds, compositions, methods of use, and processes for preparing compound which are useful as deterrents for terrestrial arthropods and marine organisms.

Abstract: A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic, wherein the PAL gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host organism. A method of treating the metabolic disease of PKU by oral administration and ingestion of a GMP is also provided.

Abstract: An apparatus and method for laser-assisted machining (LAM) of non-monolithic composite bone material is described. A high intensity focused laser beam conducts bone material removal in extremely short time duration without causing any thermal (necrosis) and mechanical damage to the material surrounding the bone-laser interaction region. A computer associated with the apparatus for machining bone preferably employs a Multiphysics computational modeling approach which takes into account physical phenomena such as heat transfer, fluid flow, convection mixing, and surface tension when determining bone target volume, calculating material properties of the multicomponent and multicomposition composite bone material, determining parameters for the laser-assisted machining based on the material properties, and performing the laser-assisted cutting/shaping/machining of bone.

Abstract: The invention includes supercapacitors and methods of making supercapacitor by fabricating transition metal dichalcogenide (MX2) layers using a combination of magnetron sputtering followed by chemical vapor deposition.

Abstract: The amount of proanthocyanidins (PAs) found in cells of plants can be engineered or adjusted through regulation of transcription factors that affect PA biosynthesis. Increasing expression of genes encoding TT2-type MYB transcription factors, including homologs of AtTT2 of Arabidopsis thaliana such as GHMYB36 or GHMYB IO of cotton plants or GmTT2A or GmTT2B of soybean plants, leads to increased PA content. Expression of these genes can be increased through any suitable methods, including mutation of the genes and transformation of plant cells to include exogenous genes resulting in increased expression.

Abstract: A phosphorescent chemosensor based on A Gold(I) complex stabilized in an aqueous polymer media. The complex exhibits strong red emission (?max ˜690 nm) in solutions and is sensitive to sub-ppm/nM levels of silver ions. On addition of silver salt to the polymer-complex, a bright-green emissive adduct with peak maximum within 475-515 nm is developed. The silver adduct exhibits a four-fold increase in quantum yield (0.19±0.02) compared to polymer-complex alone (0.05±0.01), along with a corresponding increase in phosphorescence lifetime. The polymer-complex also exhibits sensitivity to higher concentrations (e.g., >1 mM) of other metal ions such as Tl+, Pb2+, and Gd3+. The sensing methodology is simple, fast, and convenient, and the results can be detected by the naked eye. Addition of EDTA restores the red emission of the complex. The complex can distinguish between silver ions and silver nanoparticles and can be used to remediate silver ions from the environment.

Abstract: Direct pixel-by-pixel phase engineering in a SLM is an effective method for the holographic fabrication of graded photonic super-quasi-crystals with desired disorder and graded photonic super-crystals with rectangular unit-cells. Multiple levels of filling fractions of dielectric in the crystal have been created in the graded regions. Fabrication of these graded photonic super-crystals and super-quasi-crystals with small feature size is possible, using a laser projection system consisting of integrated spatial light modulator and reflective optical element.

Abstract: A dimpled stent design has geometrical characteristics, namely dimple width and depth, which generate dimple site specific turbulence and thrust within the blood flow to reduce or eliminate restenosis. The dimpled stent design is produced by laser processing of the stent material to produce different sizes, which may be predicted by a Multiphysics computational model, placements, and spatial layouts of dimples in the stent.

Abstract: Adjustments to the amount of soluble and insoluble proanthocyanidins (PAs) in plants can be accomplished through regulation of leucoanthocyanidin reductase (LAR) functionality. Reducing LAR functionality increases epicatechin polymerization, leading to greater amounts of insoluble PAs and effects on astringency and other characteristics.

Abstract: Electrochemical synthesis and electrodeposition of corrosion resistant metal-ionic clay nanocomposite coatings. The coatings comprise a zinc-aluminum based layered double hydroxide nanoplatelets incorporated into a nickel matrix. The coatings can be deposited onto such as a metal surface by way of electrodeposition. Electrodeposition of the corrosive resistant coatings described here have an average platelet size of about 631±43 nm and crystallite size from about 25 nm to about 45 nm.