Patents Assigned to The University of Oregon
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Publication number: 20180015442Abstract: Disclosed herein is a material comprising a functionalized solid support surface, wherein the functionalization comprises a thioalkylene linker bound to the support surface and the thioalkylene linker is coupled to a moiety derived from a ligand, wherein the ligand includes a terminal alkenyl and at least one first functional group configured to bind to at least one predetermined target species.Type: ApplicationFiled: July 14, 2017Publication date: January 18, 2018Applicants: University of Oregon, Battelle Memorial InstituteInventors: Kara Nell, Darren W. Johnson, Jonathan Pittman, Wilaiwan Chouyyok, Raymond Shane Addleman, Marvin G. Warner
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Patent number: 9867795Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.Type: GrantFiled: November 21, 2016Date of Patent: January 16, 2018Assignees: The UAB Research Foundation, The State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
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Publication number: 20180009829Abstract: Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.Type: ApplicationFiled: July 18, 2017Publication date: January 11, 2018Applicant: University of OregonInventors: James E. Hutchison, Edward W. Elliott, III, Zachary Kennedy, Patrick Haben
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Publication number: 20170369456Abstract: Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.Type: ApplicationFiled: September 7, 2017Publication date: December 28, 2017Applicant: University of OregonInventors: Darren W. Johnson, Mary Collins
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Publication number: 20170350870Abstract: A method for detecting for the presence of H2S or HS? anion in a system, comprising contacting a sample from the system with a compound, or a protonate or salt thereof, having a structure represented by: wherein Y represents an aromatic group or a substituted aromatic group; n is 1 or 2; R is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, amido, aryloxy, cyano, hydroxyl, or sulfonyl; R1 is H, substituted lower alkyl, lower alkyl, substituted aralkyl or aralkyl; R2 is selected from H, acyl, substituted aralkyl, aralkyl, phosphonyl, —SO2R3; —C(O)R5; —C(O)OR7 or —C(O)NR9R10; R3; R5; R7; R9 and R10 are each independently selected from H, substituted lower alkyl, lower alkyl, substituted aralkyl, aralkyl, substituted aryl or aryl.Type: ApplicationFiled: June 2, 2017Publication date: December 7, 2017Applicant: University of OregonInventors: Michael M. Haley, Michael Pluth, Darren W. Johnson, Sean Fontenot
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Patent number: 9790192Abstract: Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.Type: GrantFiled: November 18, 2015Date of Patent: October 17, 2017Assignee: University of OregonInventors: Darren W. Johnson, Mary Collins
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Publication number: 20170292115Abstract: Disclosed herein are bacterial proteins that increase pancreatic beta (?) cell number and/or proliferation, methods of increasing ? cell number and/or proliferation using such proteins, and methods of treating or inhibiting diabetes in a subject by administering such proteins to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as any one of SEQ ID NOs: 1-7, or fragments thereof. Recombinant vectors including a nucleic acid encoding the protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to any one of SEQ ID NOs: 1-7 or fragments thereof) operably linked to a heterologous promoter are also disclosed. Also disclosed are methods of identifying compounds that increase ? cell number and/or proliferation by determining the effect of test compounds on ? cell number or proliferation in zebrafish pancreas.Type: ApplicationFiled: September 23, 2015Publication date: October 12, 2017Applicant: University of OregonInventors: Jennifer Hampton, Karen Guillemin
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Patent number: 9773988Abstract: A compound having a structure represented by formula I: wherein each R1 is independently H, alkynyl or substituted alkynyl; each R2 is independently H, alkynyl or substituted alkynyl; each R3 is independently alkyl or halogen; each R4 is independently H, alkyl, or halogen; each R5 is independently H or halogen; n is 0 or 1; and m is 0 or 1, provided that if n is 0 then m is 0, and if n is 1 then m is 1.Type: GrantFiled: April 6, 2016Date of Patent: September 26, 2017Assignee: University of OregonInventors: Michael M. Haley, Gabriel Rudebusch
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Patent number: 9771380Abstract: Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.Type: GrantFiled: February 27, 2015Date of Patent: September 26, 2017Assignee: University of OregonInventors: James E. Hutchison, Edward W. Elliott, III, Zachary Kennedy, Patrick Haben
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Patent number: 9723817Abstract: Disclosed herein are devices, systems, and methods for measuring an electropharyngeogram (EPG) in living organisms. In some embodiments, the devices and systems disclosed herein include an array for sorting and immobilizing an organism (such as a nematode) for measurement of an EPG and/or optical imaging. Also disclosed are methods for identifying therapeutic or toxic compounds utilizing the disclosed devices and systems. In some embodiments, the methods include screening for compounds with anthelmintic activity, toxicity (for example HERG channel blockers), or candidate drugs for treatment of a variety of human and/or animal diseases.Type: GrantFiled: November 9, 2012Date of Patent: August 8, 2017Assignee: State of Oregon Acting by and through the State Board of Higher Education on behalf of the University of OregonInventor: Shawn Lockery
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Patent number: 9728344Abstract: An electrical double layer capacitor (EDLC) energy storage device is provided that includes at least two electrodes and a redox-enhanced electrolyte including two redox couples such that there is a different one of the redox couples for each of the electrodes. When charged, the charge is stored in Faradaic reactions with the at least two redox couples in the electrolyte and in a double-layer capacitance of a porous carbon material that comprises at least one of the electrodes, and a self-discharge of the energy storage device is mitigated by at least one of electrostatic attraction, adsorption, physisorption, and chemisorption of a redox couple onto the porous carbon material.Type: GrantFiled: April 21, 2015Date of Patent: August 8, 2017Assignees: Oregon State University, The Regents of the University of California, University of OregonInventors: Galen Stucky, Brian Evanko, Nicholas Parker, David Vonlanthen, David Auston, Shannon Boettcher, Sang-Eun Chun, Xiulei Ji, Bao Wang, Xingfeng Wang, Raghu Subash Chandrabose
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Publication number: 20170173558Abstract: A method, device, article of manufacture and apparatus are disclosed for binding successive layers of a “guest specie” such as an atom, cation, anion, organic molecule, and/or pathogen to a substrate or multiple different substrates. Possible substrates include materials with a porous nature; macro, micro and nano porous materials are all candidates. The adsorbent capacity of a substrate is extended by coordinating a layer of bi- or multi-functional ligand (L) to an adsorbed atom or ion or molecule or pathogen, which is then coordinate to a second layer of adsorbed atom or ion or molecule or pathogen.Type: ApplicationFiled: December 28, 2016Publication date: June 22, 2017Applicants: Crystal Clear Technologies, Inc., University of OregonInventors: Darren Johnson, Melanie Pitt, James Harris
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Patent number: 9664696Abstract: Disclosed herein are embodiments of H2S-reactive compounds, or compositions thereof, which can be used to determine the presence of H2S, and in some embodiments quantify H2S. Also disclosed herein are methods of using the H2S-reactive compounds. The methods can use colorimetric, chemiluminescent, or bioluminescent testing methods to determine the presence of and/or amount of H2S in a sample.Type: GrantFiled: May 30, 2014Date of Patent: May 30, 2017Assignee: University of OregonInventors: Michael D. Pluth, T. Spencer Bailey, Leticia A. Montoya, Taylor F. Pearce
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Patent number: 9649207Abstract: Real-time control of a prosthetic device using EMG-based locomotion state classification computes a histogram [208] of a time-frequency spectrogram [206] of the EMG data [200] sampled from muscles, classifies the histogram using if-else rules [212] as representing a locomotion steady state [216] or locomotion transition state [214] in the prosthetic device, and controls the prosthetic device using the computed transitions between locomotion modes. The classification may be based on a comparison of feature values [210] derived from the histogram and stored feature values derived from histograms of known locomotion states. Alternatively, the classification may be based on matching scores calculated from the histogram and stored histograms of known locomotion states.Type: GrantFiled: July 7, 2014Date of Patent: May 16, 2017Assignee: University of OregonInventors: Michael Hahn, Deepak Joshi
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Publication number: 20170096457Abstract: Disclosed herein are methods of treating or inhibiting inflammation in a subject by administering an anti-inflammatory protein to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1 or fragments thereof. Also disclosed are methods of identifying anti-inflammatory compounds by determining the effect of test compounds on inflammation in zebrafish gut. In some embodiments, germ-free zebrafish or zebrafish inoculated with a single defined bacterial strain are contacted with one or more test compounds and a marker of inflammation in the gut is measured and compared to a control. Recombinant vectors including a nucleic acid encoding the anti-inflammatory protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to SEQ ID NO: 1 or fragments thereof) operably linked to a heterologous promoter are also disclosed.Type: ApplicationFiled: May 15, 2015Publication date: April 6, 2017Applicant: University of OregonInventors: Karen Guillemin, Annah Rolig
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Patent number: 9594267Abstract: A system and method includes a laser to create a control laser signal and a laser to create a probe laser signal. A resonator creates an acoustic signal adjacent the control laser signal and the probe laser signal. A resulting coherent interaction between the control laser signal and the probe laser signal creates a Brillouin scattering induced transparency in one direction and maintains opacity in an opposite direction.Type: GrantFiled: October 1, 2015Date of Patent: March 14, 2017Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE UNIVERSITY OF OREGONInventors: Gaurav Bahl, JunHwan Kim, Hailin Wang, Mark Kuzyk
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Patent number: 9522156Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.Type: GrantFiled: February 10, 2016Date of Patent: December 20, 2016Assignees: The UAB Research Foundation, The State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
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Patent number: 9517945Abstract: Methods for making metal oxide nanoparticles, including mixed metal oxides and core-shell metal oxide nanoparticles, are disclosed. A solution comprising a metal carboxylate and a carboxylic acid is combined with a solvent comprising an alcohol heated to a temperature ?250° C. for an effective period of time to form metal oxide nanoparticles. The metal may be a group IIIA metal, a group IVA metal, a transition metal, or a combination thereof. A metal oxide shell may be deposited onto metal oxide nanoparticles by dispersing the metal oxide nanoparticles in an alcohol, adding a metal carboxylate, and maintaining the reaction at a temperature ?200° C. for an effective period of time to form core-shell nanoparticles. The nanoparticles may have a relative size dispersity of ?20%, and may further comprise a plurality of carboxylic acid, carboxylate, and/or alcohol ligands coordinated to the nanoparticles' outer surfaces.Type: GrantFiled: November 27, 2013Date of Patent: December 13, 2016Assignee: University of OregonInventors: Daisuke Ito, James E. Hutchison
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Patent number: 9513406Abstract: Disclosed embodiments concern a soluble functionalized nanoparticle suitable for use with polymerizable components, such as monomers (or polymers thereof), used to make gradient optical polymer nanocomposites. In particular disclosed embodiments, the nanoparticle is functionalized with one or more surface ligands that promote the solubility and dispersion of the nanoparticle in the disclosed monomer. Also disclosed herein are embodiments of a method for making the functionalized nanoparticle as well as embodiments of a composition comprising the functionalized nanoparticles.Type: GrantFiled: July 17, 2013Date of Patent: December 6, 2016Assignee: University of OregonInventors: Richard Chartoff, Casey Check
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Publication number: 20160301021Abstract: A compound having a structure represented by formula I: wherein each R1 is independently H, alkynyl or substituted alkynyl; each R2 is independently H, alkynyl or substituted alkynyl; each R3 is independently alkyl or halogen; each R4 is independently H, alkyl, or halogen; each R5 is independently H or halogen; n is 0 or 1; and m is 0 or 1, provided that if n is 0 then m is 0, and if n is 1 then m is 1.Type: ApplicationFiled: April 6, 2016Publication date: October 13, 2016Applicant: University of OregonInventors: Michael M. Haley, Gabriel Rudebusch