Abstract: A novel high torque density double stator permanent magnet electric machine is provided. An outer stator is provided which has complex teeth and optionally can have windings every tooth or every other tooth. A rotor is provided having a plurality of magnet receivers, each with a complex topology. Magnets are provided in the rotor which are tangentially magnetized with alternating polarities and a complex topology to increase torque density. An inner stator is provided having a plurality of teeth with complex topologies. Windings are provided around every tooth or every other tooth, alternatively. Air-gaps are provided between the outer stator and the rotor and between the rotor and inner stator. The air-gap between the inner stator and the rotor is smaller than the air-gap between the outer stator and the rotor. A lower current density in certain windings improves thermal response without comprising average torque.

Abstract: Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.

Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.

Abstract: In the system and method disclosed, an ultrahigh vacuum (UHV) scanning tunneling microscope (STM) tip is used to selectively desorb hydrogen atoms from the Si(100)-2X1:H surface by injecting electrons at a negative sample bias voltage. A new lithography method is disclosed that allows the STM to operate under imaging conditions and simultaneously desorb H atoms as required. A high frequency signal is added to the negative sample bias voltage to deliver the required energy for hydrogen removal. The resulted current at this frequency and its harmonics are filtered to minimize their effect on the operation of the STM's feedback loop. This approach offers a significant potential for controlled and precise removal of hydrogen atoms from a hydrogen-terminated silicon surface and thus may be used for the fabrication of practical silicon-based atomic-scale devices.

Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize coiled yarns/polymer fibers and can be either neat or comprising a guest. In some embodiments, the actuator system includes a twisted and coiled polymer fiber actuator, and at least one of (i) wire connections that enable electrical heating of the twisted and coiled polymer fiber actuator, (ii) a radiation source and radiation pathway that enables photothermal heating of the twisted and coiled polymer fiber actuator, and (iii) a delivery system for delivering chemicals whose reaction produces heating of the twisted and coiled polymer fiber actuator.

Abstract: A system and method are provided for accurately recognizing actions and estimating action intensity. To enable the system to deal with the uncertainty and varied nature inherent in action recognition and intensity indexing, the system is a hybrid system that combines the concept of fuzzy logic and deep recurrent neural networks. The methodology is an attentive neuro-fuzzy system designed to recognize qualitative differences in human actions and to self-adapt to different intensities. The model of the system and method utilizes recurrent neural networks to detect actions from spatio-temporal patterns of human poses, in tandem with an adaptive fuzzy inference system to learn the various human motions used to perform actions with different intensities and then estimate the action's intensity. The integrated model can successfully learn the unique way a specific action with a certain intensity is performed and can estimate the intensity of the respective action.

Abstract: Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.

Abstract: A gait training system has a motor connected to a first linkage system by an actuator. The first linkage system has multiple linkage members connected to multiple joints and an endpoint that is configured to produce a cyclic gait motion when the motor is activated. First and second linkage members have an adjustable length. A method of customizing a gait pattern on a gait training system is also described.

Abstract: Composition and methods for detection of Coccidioidomycosis.

Abstract: Described herein are low or no-cobalt materials useful as electrode active materials in a cathode for lithium or lithium-ion batteries. For example, compositions of matter are described herein, such as electrode active materials that can be incorporated into an electrode, such as a cathode. The disclosed electrode active materials exhibit high specific energy and voltage, and can also exhibit high rate capability and/or long operational lifetime.

Abstract: Certain embodiments are directed to methods and compositions for preventing or treating bacterial infections. In certain embodiments the compositions comprise thioredoxin inhibitors, and/or thioredoxin-like inhibitors.

Abstract: The present invention includes compositions and methods of for treating plants infected with fungal pathogens by contacting an infected plant or plant at risk of infection with a fungicidal composition comprising an fungicide selected from copper compound such as copper octanoate or copper hydroxide, or a triazole fungicide such as myclobutanil, propiconazole, tebuconazole or epoxiconazole, an enhancer selected from apyrase inhibitors, e.g., N-(m-tolyl)-[1, 1?-biphenyl]-4-sulfonamide, S-heptyl 2-oxo-2H-chromene-3-carbothioate, 3-(N-(4-bromophenyl) sulfamoyl)-N-(3-nitrophenyl) benzamide, or (E)-3-methyl-N-(1-(naphthalen-2-yl) ethylidene) benzohydrazide and, optionally, a phytologically-acceptable inert carrier.

Abstract: The present invention includes a method of macrophage phenotype profiling for the assessment, determination, and stratification of risk of development of fibrosis and/or cirrhosis within the liver, and treatment thereof, comprising the steps of: (a) obtaining a liver biopsy sample from a subject; (b) using fluorescently labeled antibodies to analyze the sample, by laboratory assay, for marker identification and expression comparison of one or more macrophage profiling markers relative to the level of expression of a macrophage profiling marker in at least one control or standard sample, and (c) using spectral analysis to correlate the fluorescent signal generated by the macrophage profiling marker/antibody complex to the risk of developing fibrosis and/or cirrhosis, and treating with anti-viral agents or changes in diet, weight loss, or reduction of fat consumption.

Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRI) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.

Abstract: The disclosure relates to compositions and methods of preventing or treating a subject suffering from opioid toxicity or overdose. The method comprises administering to a patient in need of treatment an effective amount of methocinnamox.

Abstract: Methods of preparing and using a metal-organic framework (MOF) are provided herein, including methods of using an MOF comprising a repeat unit of the formula [ML]n, wherein M is a divalent metal ion and L is a ligand of the formula: The MOFs provided herein may be used in the separation of two or more molecules from each other. In some embodiments, the molecules are ethylene and ethane. In some embodiments, UTSA-280 may be synthesized from calcium oxide (CaO) or calcium hydroxide (Ca(OH)2) and squaric acid (SA) through mechanochemical synthesis.

Abstract: The present invention includes compositions and methods for treating an autoimmune disorder or a cancer in a subject in need thereof, the method comprising: administering an effective amount of a composition comprising an oligonucleotide that specifically binds a complementary sequence of the Interleukin-7 receptor (IL7R) pre-mRNA that influences splicing of exon 6, wherein the SM-ASO increases or decreases inclusion of exon 6 in IL7R pre-mRNAs and respectively decreases or increases expression of the soluble isoform of IL7R (sIL7R). In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO), or a splice-modulating antisense oligonucleotide (SM-ASO).

Abstract: Methods and systems for assisting tonally-challenged singers. A microphone can be integrated with a sound reinforcement system used in a live performance. The microphone, which can transduce the performer's voice, can serve multiple purposes such as, for example, to feed input to the natural ear and to the sound reinforcement system. The processed sound of the performer's voice (with fundamental frequencies emphasized) can be mixed into the signal fed to a stage “monitor” speaker facing the performer or a headset worn by the performer.

Abstract: Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.

Abstract: The present disclosure comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. In other embodiments, the method provides for directed to a method of determining the level of circulating tumor cells (CTCs) in a sample having blood cells from a patient by contacting a sample having blood cells from a patient.