Patents Assigned to The University of Tokyo
  • NOVEL ADSORBENT
    Publication number: 20230071223
    Abstract: The present invention is to provide a novel adsorbent which is low in cost, has versatility and high adsorption ability. Specifically, the present invention is to provide an adsorbent of a specific metal element containing a metal salt of a cyanometallic acid, a method for producing the same, and a method for removing the ion of the element that is the target of adsorption using such an adsorbent.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 9, 2023
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Kazuyuki ISHII, Kyoko ENOMOTO
  • System and method for cell evaluation, and cell evaluation program
    Patent number: 11598712
    Abstract: A cell evaluation system includes physical measurement unit, a database, and evaluation unit. The evaluation unit refers to a relevance stored in the database, searches reference measurement information based on measurement information of a cell newly measured via the physical measurement unit, and evaluates the cell with biological measurement information associated with the searched reference measurement information.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: March 7, 2023
    Assignees: THINKCYTE, INC., THE UNIVERSITY OF TOKYO
    Inventors: Masashi Ugawa, Yoko Kawamura, Sadao Ota
  • Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems
    Patent number: 11597919
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 7, 2023
    Assignees: THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Silvana Konermann, Alexandro Trevino, Mark Brigham, Fei Ran, Patrick Hsu, Chie-yu Lin, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, Feng Zhang
  • Crown identification device, identification method, program, and recording medium
    Patent number: 11594020
    Abstract: The present invention provides a system for identifying individual crowns of individual fruit trees using aerial images. A crown identification device 40 of the present invention includes an identification criterion determination unit 41 and a crown identification unit 42.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: February 28, 2023
    Assignees: NEC Solution Innovators, Ltd., THE UNIVERSITY OF TOKYO
    Inventors: Kazuki Sekiya, Hiroaki Ochiai, Yurika Nagoshi, Wei Guo, Yue Mu, Masayuki Hirafuji, Seishi Ninomiya, Daisuke Takata
  • Enzyme-specific intracellularly-retained red fluorescent probe
    Patent number: 11591359
    Abstract: It is an object of the present invention to provide a fluorescence imaging probe capable of selectively visualizing target cells such as cells expressing ?-galactosidase (lacZ expressing cells) at a single-cell level in a red fluorescence region, and of performing co-staining together with GFP.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 28, 2023
    Assignee: The University of Tokyo
    Inventors: Yasuteru Urano, Mako Kamiya, Hiroki Ito, Yu Kawamata
  • LIGHT MODULATOR AND LIGHT MODULATOR ARRAY
    Publication number: 20230054271
    Abstract: A light modulator includes a base layer, a metal reflective layer formed on the base layer, a modulation layer of a nonlinear optical crystal formed on the reflective layer, and a conductive pattern layer including a plurality of pattern portions arranged periodically in a first direction and each extending in a second direction, and formed on the modulation layer. The modulation layer changes a reflectance for object light by changing a refractive index when a voltage is applied between the reflective layer and the conductive pattern layer. The light modulator outputs the object light being incident from an upper surface side of the modulation layer, transmitted through the modulation layer, and reflected by the reflective layer to the outside as modulated light with an intensity modulated by the reflectance change.
    Type: Application
    Filed: August 10, 2022
    Publication date: February 23, 2023
    Applicants: The University of Tokyo, HAMAMATSU PHOTONICS K.K.
    Inventors: Hiroki MIYANO, Go SOMA, Taichiro FUKUI, Takuo TANEMURA, Yoshiro NOMOTO
  • REGRESSION ANALYSIS DEVICE, REGRESSION ANALYSIS METHOD, AND PROGRAM
    Publication number: 20230059056
    Abstract: A regression model having a correspondence relationship with variation of an explanatory variable and variation of a target variable is constructed. A regression analysis device includes a data acquisition unit that reads out, from a storage device storing training data used as a target variable and an explanatory variable of a regression model and a constraint condition defining in advance whether the explanatory variable should be varied positively or negatively to vary the target variable in a positive direction or a negative direction, the training data and the constraint condition, and a coefficient update unit that repeatedly updates, using the training data, coefficients of the explanatory variable in the regression model to minimize a cost function including a regularization term that increases a cost in a case where the constraint condition is contravened.
    Type: Application
    Filed: February 4, 2021
    Publication date: February 23, 2023
    Applicants: THE UNIVERSITY OF TOKYO, DAICEL CORPORATION
    Inventors: Hiroshi OKAMOTO, Marina TAKAHASHI, Shuji SHINOHARA, Shunji MITSUYOSHI, Hidetoshi KOZONO, Masahiro HAITSUKA, Fumihiro MIYOSHI
  • Method for integrally detecting nondestructive measurement information and genome-related information of one cell
    Patent number: 11584951
    Abstract: The present invention provides a method for integrally detecting nondestructive measurement information and genome-related information of single cells. More specifically, the present invention uses a method including: preparing a plurality of compartments containing single cell or a derivative thereof, a first bead(s), and a second bead(s) per compartment; detecting both nondestructive measurement information of single cell and imaging information of the first bead(s) and associating the nondestructive measurement information of single cell with the imaging information of the first bead(s) before preparation of each compartment or in each compartment; obtaining a hybridized complex; producing an amplified product derived from the hybridized complex; and integrally detecting nondestructive measurement information and genome-related information in single cell.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: February 21, 2023
    Assignee: The University of Tokyo
    Inventors: Nozomu Yachie, Sadao Ota
  • Optical property evaluation apparatus and optical property evaluation method
    Patent number: 11585696
    Abstract: An optical property evaluation apparatus evaluates an optical property of an evaluation object, and includes a light source, a polarization beam splitter, a polarization adjuster, a first detector, a second detector, and an analyzer. The analyzer obtains a reflectance when linearly polarized light in a specific direction is incident on the evaluation object based on the detection result by the first detector when the light with which the evaluation object is irradiated is set to be the linearly polarized light in the specific direction. The analyzer obtains a phase property at the reflection of the evaluation object based on the detection result by the first detector or the second detector when the light with which the evaluation object is irradiated is set to have a polarization state different from the linearly polarized light in the specific direction, and a Jones matrix.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: February 21, 2023
    Assignees: HAMAMATSU PHOTONICS K.K., The University of Tokyo
    Inventors: Yoshiro Nomoto, Takuo Tanemura
  • FLUORESCENT PROBE FOR DETECTION OF ENPP ACTIVITY
    Publication number: 20230052551
    Abstract: Provided is a novel fluorescent probe. A compound of the following general formula (I) or a salt thereof.
    Type: Application
    Filed: June 8, 2020
    Publication date: February 16, 2023
    Applicants: THE UNIVERSITY OF TOKYO, PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, RIKEN
    Inventors: Yasuteru URANO, Toru KOMATSU, Shingo SAKAMOTO, Hiroyuki NOJI, Hidehiko NAKAGAWA, Mitsuyasu KAWAGUCHI, Rikiya WATANABE
  • Dynamic high-speed high-sensitivity imaging device and imaging method
    Patent number: 11579075
    Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: February 14, 2023
    Assignees: The University of Tokyo, Osaka University
    Inventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
  • Engineering and optimization of systems, methods, enzymes and guide scaffolds of CAS9 orthologs and variants for sequence manipulation
    Patent number: 11578312
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 14, 2023
    Assignees: THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, UNIVERSITY OF TOKYO
    Inventors: Feng Zhang, Winston Yan, Osamu Nureki, Kaijie Zheng, Le Cong, Hiroshi Nishimasu, Fei Ran, Yinqing Li
  • Anti-human TLR7 antibody
    Patent number: 11578138
    Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: February 14, 2023
    Assignees: Daiichi Sankyo Company, Limited, The University of Tokyo
    Inventors: Kensuke Miyake, Yusuke Murakami, Yuji Motoi, Atsuo Kanno, Toshiyuki Shimizu, Umeharu Ohto, Takaichi Shimozato, Atsushi Manno, Takashi Kagari, Jun Ishiguro, Kensuke Nakamura, Takashi Isobe
  • Recording device and recording method
    Patent number: 11574652
    Abstract: Provided is a recording device. The recording device includes: an external magnetic field application unit that is configured to apply an external magnetic field to a magnetic recording medium; a light irradiation unit that is configured to irradiate light; and a light focusing unit that is configured to focus the light from the light irradiation unit by resonating the light to generate an enhanced magnetic field in which a magnetic field of the light is enhanced, in which magnetization of the magnetic recording medium is inverted by applying the external magnetic field and the enhanced magnetic field to the magnetic recording medium.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: February 7, 2023
    Assignees: THE UNIVERSITY OF TOKYO, OSAKA UNIVERSITY, FUJIFILM Corporation
    Inventors: Shin-ichi Ohkoshi, Marie Yoshikiyo, Kenta Imoto, Kosuke Nakagawa, Asuka Namai, Hiroko Tokoro, Makoto Nakajima, Masashi Shirata, Kenji Naoi
  • HMGN partial peptide and cancer therapy using the same
    Patent number: 11572393
    Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: February 7, 2023
    Assignees: THE UNIVERSITY OF TOKYO, ONO PHARMACEUTICAL CO., LTD., TOKYO UNIVERSITY OF SCIENCE FOUNDATION
    Inventors: Kouji Matsushima, Satoshi Ueha, Shungo Deshimaru, Chang-Yu Chen, Shoji Yokochi, Yoshiro Ishiwata, Shiro Shibayama
  • Driving assistance control device
    Patent number: 11572062
    Abstract: A driving assistance control device includes an active pedal configured to control a driving and braking force of a vehicle, an electronic control unit configured to detect a potential risk area in which an obstacle entering a scheduled traveling route of the vehicle is likely to be present, and determine a reference speed at which contact between the vehicle and the obstacle can be avoided even when the obstacle enters the scheduled traveling route of the vehicle from the detected potential risk area based on a positional relationship between the vehicle and the potential risk area, and a force feedback unit configured to apply an assistance reaction force in a direction in which the amount of manipulation is reduced, to the active pedal when a current speed of the vehicle exceeds the reference speed.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: February 7, 2023
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Tokyo University of Agriculture and Technology, THE UNIVERSITY OF TOKYO, SCHOOL JUDICIAL PERSON IKUTOKU GAKUEN
    Inventors: Shintaro Inoue, Pongsathorn Raksincharoensak, Yuichi Saito, Takuma Ito, Tsukasa Shimizu, Hideo Inoue
  • SMART TREADMILL
    Publication number: 20230031291
    Abstract: A treadmill according to the present invention includes: a frame; an endless belt; an endless-belt drive unit; a plurality of cameras provided on the frame such that the orientations and/or locations thereof can be adjusted; a motion-data acquisition unit that markerlessly acquires motion data of a subject by using image information obtained with camera images; a motion analysis unit that analyzes the motion of the subject by using the motion data; and a control unit that controls the endless-belt drive unit based on the motion data.
    Type: Application
    Filed: December 24, 2020
    Publication date: February 2, 2023
    Applicants: THE UNIVERSITY OF TOKYO, OHTAKE ROOT KOGYO CO., LTD.
    Inventors: Yoshihiko NAKAMURA, Yosuke IKEGAMI, Yoshitake OTA, Yuji KANZAKI, Hirotaka KOGA
  • Intranasal vaccine that induces cellular immunity
    Patent number: 11564993
    Abstract: The present invention provides a nanogel nasal vaccine that induces cell-mediated immunity. The present invention relates to a vaccine preparation comprising a complex of a nanogel, a vaccine antigen, and an adjuvant, wherein the vaccine preparation can efficiently induce the cell-mediated immunity, and can also induce a systemic and mucosal immune response.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: January 31, 2023
    Assignees: THE UNIVERSITY OF TOKYO, HANAVAX INC.
    Inventors: Yoshikazu Yuki, Rika Nakahashi, Hiroshi Kiyono
  • Cell culture substrate, cell culture vessel, and method for cell culture
    Patent number: 11566232
    Abstract: The purpose of the invention is to provide novel cell culture substrates, cell culture vessels, and methods for cell culture. A cell culture substrate having a planar mesh structure, the substrate being coated with a polymer, is provided. Cells are cultured in a cell culture vessel having this substrate.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 31, 2023
    Assignees: HITACHI, LTD., THE UNIVERSITY OF TOKYO
    Inventors: Maiko Tanabe, Shizu Takeda, Masahiro Okanojo, Hiroko Hanzawa, Masao Washizu, Kennedy Omondi Okeyo
  • Position information processing system and position information processing apparatus
    Patent number: 11567215
    Abstract: The present invention sequentially and repeatedly accepts a plurality of types of information that can change with time, including position information obtained using a satellite signal, and correlates and records the accepted plurality of types of information with time information.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: January 31, 2023
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Ryosuke Shibasaki, Dinesh Manandhar, Mamoru Miyawaki