Patents Assigned to The University of Tokyo
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Patent number: 11539141Abstract: A radio wave absorber includes a base member, and a radio wave absorption film formed on the base member. The radio wave absorption film includes at least MTC-substituted ?-Fe2O3 and black titanium oxide. The MTC-substituted ?-Fe2O3 is a crystal belonging to the same space group as an ?-Fe2O3 crystal and expressed by ?-MxTiyCoyFe2?2y?xO3 where M is at least one element selected from the group consisting of Ga, In, Al, and Rh, 0<x<1, and 0<y<1.Type: GrantFiled: June 25, 2018Date of Patent: December 27, 2022Assignees: PANASONIC HOLDINGS CORPORATION, THE UNIVERSITY OF TOKYOInventors: Shin-ichi Ohkoshi, Asuka Namai, Seiji Nishitani, Tomohiro Kuzuu
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Publication number: 20220403642Abstract: A fracture caused by fatigue of a connecting portion positioned at a corner of a reinforcing frame directly secured to a frame is avoided regardless of a relative displacement that occurs in the frame upon disposing the reinforcing frame made of steel, which has an elevational shape surrounding the frame along an inner circumferential surface of the frame and a cross-sectional shape with a flange on a side of the frame, in a structure plane of the frame of a column and a beam of reinforced concrete structure, and joining the reinforcing frame to the inner circumferential surface of the frame. A reinforcing frame is constituted of a column portion along a column of a frame, a beam portion along a beam, and a connecting portion that is joined to the column portion and the beam portion, and connects the column portion to the beam portion.Type: ApplicationFiled: August 4, 2021Publication date: December 22, 2022Applicants: THE UNIVERSITY OF TOKYO, SANKO TECHONO CO., LTD., KSE network Co., Ltd., OHMOTO GUMI CO., LTD., ssd CorporationInventors: Hitoshi SHIOHARA, Masaomi TESHIGAWARA, Yoshio INOUE, Takashi SATO, Yasue YAGISAWA, Kenji YOKOTA, Syunichiro SHISHIDO, Koji OKA
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Patent number: 11530396Abstract: A mutant SaCas9 protein such as a protein having an amino acid sequence resulting from mutations of glutamic acid at the 782-position to lysine (E782K), leucine at the 800-position to arginine (L800R), asparagine at the 968-position to arginine (N968R), asparagine at the 985-position to alanine (N985A), arginine at the 991-position to alanine (R991A), alanine at the 1021-position to serine (A1021S), threonine at the 927-position to lysine (T927K), lysine at the 929-position to asparagine (K929N), and isoleucine at the 1017-position to phenylalanine (I1017F) in SEQ ID NO: 2 has relaxed restriction on target sequence while maintaining binding ability to guide RNA, and is useful as a tool for gene editing.Type: GrantFiled: September 5, 2018Date of Patent: December 20, 2022Assignees: THE UNIVERSITY OF TOKYO, MODALIS THERAPEUTICS CORPORATIONInventors: Osamu Nureki, Hiroshi Nishimasu, Hisato Hirano, Shohei Kajimoto, Tetsuya Yamagata, Yuanbo Qin, Keith M. Connolly, Iain Thompson
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Patent number: 11530254Abstract: An antibody is provided that inhibits infection of cells with a norovirus. The antibody is a nanoantibody comprising a polypeptide described in (a), (b), or (c), and inhibiting infection of intestinal cells with HuNoV GII.4: (a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13; (b) a polypeptide consisting of an amino acid sequence comprising a substitution, deletion, insertion and/or addition of one or several amino acids with respect to the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13; and (c) a polypeptide consisting of an amino acid sequence having a sequence identity of 80% or more to the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13.Type: GrantFiled: March 30, 2018Date of Patent: December 20, 2022Assignee: THE UNIVERSITY OF TOKYOInventors: Yoshikazu Yuki, Hiroshi Kiyono, Shiho Kurokawa
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Publication number: 20220391761Abstract: A machine learning device includes: an input unit that acquires input data; an intermediate calculation unit that performs calculation on the input data a plurality of times; a weighting unit that performs weighting on an output of the intermediate calculation means for each of the plurality of times; an output unit that outputs output data based on a result of the weighting by the weighting means; and a learning unit that performs learning of a weight obtained by the weighting by the weighting means.Type: ApplicationFiled: October 27, 2020Publication date: December 8, 2022Applicants: NEC CORPORATION, THE UNIVERSITY OF TOKYOInventors: Yusuke SAKEMI, Kai MORINO, Kazuyuki AIHARA
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Publication number: 20220387674Abstract: In a medical instrument that is inserted into an affected area or tissue to perform treatment, a technique of delivering various drugs to a target site is desired. Provided is a medical instrument that is inserted into an affected area or tissue to perform treatment, wherein a drug-loaded nanostructure is covalently bound to the medical instrument via a photosensitive linker immobilized on the surface of at least a portion of the medical instrument.Type: ApplicationFiled: July 9, 2020Publication date: December 8, 2022Applicant: THE UNIVERSITY OF TOKYOInventors: Yuki AKAGI, Yasutaka ANRAKU, Ichiro SAKUMA, Hayato Laurence MIZUNO
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Patent number: 11519901Abstract: The invention aims to provide a method of screening for a therapeutic drug for cancer as a molecular-targeted drug targeting some protein from a number of candidate target proteins, without identifying the true target protein. In particular, the invention provides a method of screening for a therapeutic drug for cancer, including (i) a step of expressing an exogenous cell regulatory factor in a target cancer cell under contact or no contact with a test substance, (ii) a step of confirming change in the cancer cell, and (iii) a step of selecting the test substance as a therapeutic drug for cancer when the change of cancer cell increased under contact with the test substance as compared to no contact therewith.Type: GrantFiled: April 1, 2016Date of Patent: December 6, 2022Assignee: THE UNIVERSITY OF TOKYOInventors: Yasuhiro Yamada, Katsunori Semi, Knut Woltjen, Yutaka Matsuda
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Patent number: 11517287Abstract: There is provided a tissue elasticity measurement device 100 and a measurement method that allow for quantitative evaluation of biological changes related to tissue elasticity such as liver fibrosis. The tissue elasticity measurement device 100 has a supersonic wave measuring instrument 100a that measures a pulse waveform corresponding to a blood flow velocity by a pulse wave Doppler method, and an information processor 100b that calculates a deviation index value corresponding to a coefficient of variation from a pulse waveform obtained by the supersonic wave measuring instrument 100a.Type: GrantFiled: March 7, 2018Date of Patent: December 6, 2022Assignee: THE UNIVERSITY OF TOKYOInventors: Yoko Soroida, Takuma Nakatsuka, Masaya Sato, Hayato Nakagawa, Hitoshi Ikeda, Kazuhiko Koike, Yutaka Yatomi
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Publication number: 20220383855Abstract: An information processing apparatus and a non-transitory computer readable media storing a program are provided to learn classification of utterances by a person or confirm a classification result. According to an aspect of the present invention, provided is an information processing apparatus comprising a processor configured to execute a program so as to: in a display information generation step, generate first display information for displaying a plurality of objects associated with each of options, wherein the option corresponds to type of utterance defined according to conversation information; and in a selection information generation step, generate selection information associated with option corresponding to the selected object and time of the selection each time any of the objects is selected.Type: ApplicationFiled: May 25, 2022Publication date: December 1, 2022Applicant: THE UNIVERSITY OF TOKYOInventor: Hiromasa YOSHIMOTO
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Publication number: 20220381737Abstract: Provided are a standard sample film for use in laser ablation inductively coupled plasma mass spectrometry, the standard sample film containing an organic substance and having a small variation in signal intensity of an ion of a metal element depending on a measurement position; a standard sample; a method for producing a standard sample film; a sample set; a quantitative analysis method; and a transfer film. The standard sample film of the present invention is a standard sample film for use in laser ablation inductively coupled plasma mass spectrometry, the standard sample film containing a polymer and a metal element, and having a maximum height difference in film thickness of the standard sample film of 0.50 ?m or less.Type: ApplicationFiled: August 3, 2022Publication date: December 1, 2022Applicants: FUJIFILM Corporation, THE UNIVERSITY OF TOKYOInventors: Takuro SUGIYAMA, Yuko TERAO, Yasuhiko HIRANA, Tetsuro OTSUKA, Akinori SUGISHIMA, Yasuharu SHIRAISHI, Takafumi HIRATA, Yoshiki MAKINO
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Publication number: 20220380255Abstract: Provided is a novel cured article that enables to expand the use of debris and the like as well as the use of plant biomass. The cured article contains an inorganic material and at least one selected from lignin and cellulose.Type: ApplicationFiled: July 8, 2020Publication date: December 1, 2022Applicants: BIOAPATITE, INC., THE UNIVERSITY OF TOKYOInventors: Yuya SAKAI, Koichi NAKAMURA, Yuki SAKAI, Masahiro KAWAMOTO
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Patent number: 11513102Abstract: According to one embodiment, a sensor includes a first structure body, a second structure body, and a detector. The first structure body includes a supporter, a deformable part supported by a first portion of the supporter, and a membrane part. At least a portion of the membrane part is connected to the deformable part and a second portion of the supporter. The second structure body is connected to the first structure body. A liquid is provided between the first structure body and the second structure body. The detector outputs a signal corresponding to a deformation of the deformable part.Type: GrantFiled: September 11, 2020Date of Patent: November 29, 2022Assignees: University of Tokyo, Kabushiki Kaisha ToshibaInventors: Isao Shimoyama, Thanh-Vinh Nguyen, Minh Dung Nguyen, Takahiro Omori, Kazuo Watabe
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Publication number: 20220373270Abstract: Provided is a heat exchange promotion member and a heat exchanger that can improve heat transfer performance while holding down an increase in pressure drag of a fluid that exchanges heat with the heat exchange promotion member. A heat dissipation fin 14 of the present invention is a heat exchange promotion member that exchanges heat with a flowing fluid. The heat dissipation fin 14 includes a planar part 12 which is a surface substantially parallel to the fluid flowing direction and a raised part 13 that protrudes from the planar part 12 toward the fluid. The raised part 13 has a portion slanted relative to the direction in which the fluid flows, and there are a plurality of the raised parts 13 formed spaced apart from one another in the fluid flowing direction.Type: ApplicationFiled: September 23, 2020Publication date: November 24, 2022Applicants: Atago Manufacturing Co., Ltd., The University of Tokyo, DENSO CORPORATIONInventors: Noboru Otomo, Ken Yamamoto, Kenichi Morimoto, Yuji Suzuki
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Publication number: 20220371233Abstract: According to an embodiment, there is provided a method of manufacturing a molded body from a waste material including at least one of food waste and seaweed, the method comprising: preparing dry powder made from at least the waste material; and forming a molded body by pressurizing the dry powder in a state in which the dry powder is heated to a predetermined temperature.Type: ApplicationFiled: May 18, 2022Publication date: November 24, 2022Applicant: The University of TokyoInventors: Yuya Sakai, Kota Machida
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Patent number: 11504379Abstract: The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.Type: GrantFiled: August 6, 2018Date of Patent: November 22, 2022Assignees: Hiroshima University, Tokyo University of Pharmacy & Life Sciences, The University of TokyoInventors: Tomoichiro Asano, Yusuke Nakatsu, Hisanaka Ito, Takayoshi Okabe
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Publication number: 20220360067Abstract: A current interrupting device includes: a current limiting element provided on a power supply path from a predetermined power supply to a load device, the current limiting element being configured to exhibit a current limiting action when current flowing the power supply path exceeds a first current threshold value; a current diversion path switch capable of switching on and off of an electric conduction of a current diversion path, the current diversion path switch being connected in parallel with the power supply path; and a controller configured to control on and off of the current diversion path switch, wherein, the controller is configured to: switch the current diversion path switch on from an off state when it is detected that current flowing the current limiting element is limited to a second current threshold value after the current flowing the current limiting element has exceeded the first current threshold value; and switch the current diversion path switch off again after a predetermined switchedType: ApplicationFiled: September 15, 2020Publication date: November 10, 2022Applicants: National University Corporation Saitama University, TOKYO INSTITUTE OF TECHNOLOGY, The University of TokyoInventors: Yuki INADA, Yasushi YAMANO, Mitsuaki MAEYAMA, Shungo ZEN, Wataru OHNISHI
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Patent number: 11491507Abstract: An object is to suppress a variation in amount of a sealant that is applied on an object to be sealed. There is provided a sealant discharge nozzle configured such that a sealant from a cartridge is discharged from a discharge hole of the sealant discharge nozzle. The sealant discharge nozzle has a leading end portion comprising a pair of side wall portions; and a connecting wall portion configured to connect the pair of side wall portions with each other and provided in cooperation with the pair of side wall portions to form a first recess that is open on one side in a first direction perpendicular to an axial direction of the sealant discharge nozzle, and on a leading end side. The discharge hole has an opening formed on a first recess side of the connecting wall portion.Type: GrantFiled: June 19, 2020Date of Patent: November 8, 2022Assignee: THE UNIVERSITY OF TOKYOInventors: Masayoshi Okamoto, Tadamichi Mawatari, Kensuke Tsuchiya, Masayoshi Zaitsu, Naohiro Otsuki, Junji Tsuchiya, Youhei Matsumoto
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Patent number: 11494383Abstract: When a DBMS receives a suspend instruction in which a suspend completion time of query processing is a future time and between receipt of the suspend instruction and the suspend completion time, if there is a target object (at least a processing object whose execution is in progress upon receipt of the suspend instruction) whose predicted completion time is at or precedes the suspend completion time, the DBMS changes the state of the target object to a state signifying a snapshot suspend. If there is a processing object whose state signifies a snapshot suspend, the DBMS executes the processing object at or before the suspend completion time.Type: GrantFiled: September 20, 2019Date of Patent: November 8, 2022Assignees: HITACHI, LTD., THE UNIVERSITY OF TOKYOInventors: Akira Shimizu, Kouji Kimura, Kazuhiko Mogi, Masaru Kitsuregawa, Kazuo Goda, Yuto Hayamizu
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Patent number: 11491666Abstract: A control system according to an embodiment includes a motor configured to drive a link, a first sensor configured to detect information about the driving by the motor or information about a relation between the driving means and the load member as first sensor information, a second sensor configured to detect information about a displacement of the link as second sensor information, and a control unit configured to perform feedback control of the driving means so as to follow a command value in a two-inertial system model including an inertial system on a load side and an inertial system on a driving side. The control unit includes a disturbance observer configured to estimate a disturbance, and a filter configured to convert an estimated value of the disturbance into a driving force of the motor.Type: GrantFiled: October 17, 2019Date of Patent: November 8, 2022Assignees: THE UNIVERSITY OF TOKYO, TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Hiroshi Fujimoto, Akiyuki Hasegawa, Taro Takahashi
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Patent number: 11491343Abstract: A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.Type: GrantFiled: April 7, 2020Date of Patent: November 8, 2022Assignees: THE UNIVERSITY OF TOKYO, OSAKA UNIVERSITYInventors: Youichi Saitoh, Masaki Sekino, Keita Yamamoto