Patents Assigned to The University of Toledo
  • Dual-branched shape memory alloy organ positioner to prevent damage to healthy tissue during radiation oncology treatments
    Patent number: 10688317
    Abstract: Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: June 23, 2020
    Assignee: The University of Toledo
    Inventors: E. Ishmael Parsai, Mohammad Elahinia
  • BILEVEL EQUALIZER FOR BATTERY CELL CHARGE MANAGEMENT
    Publication number: 20200185931
    Abstract: An equalizer circuit provides both passive and active cell voltage equalization in a battery pack to improve charge and discharge capacity at a low cost. The equalizer circuit is a bilevel circuit that uses both passive equalizers and active equalizers to balance cell voltage. The cells may be grouped into size limited sections which are balanced by passive equalizers. The sections are balanced by active equalizers to promote increased pack charge and discharge capacity. The equalizer circuit can use a current detector or a voltage controlled oscillator to assist in closed loop current control to reduce switching losses and permit use of smaller transistors. The equalizer circuit can use open line protection with capacitors to store excess charge and prevent voltage overload of the switching devices.
    Type: Application
    Filed: October 31, 2019
    Publication date: June 11, 2020
    Applicant: The University of Toledo
    Inventor: Thomas A. Stuart
  • FUROXANS AS THERAPIES FOR NEURODEGENERATIVE DISORDERS
    Publication number: 20200172526
    Abstract: Furoxan compounds, compositions comprising the same, and methods of making and using the same, are described.
    Type: Application
    Filed: January 28, 2020
    Publication date: June 4, 2020
    Applicant: The University of Toledo
    Inventors: Isaac Schiefer, Zahoor Shah
  • Thin molecules for the treatment of obesity and type II diabetes
    Patent number: 10662153
    Abstract: Thin molecules, compounds producible by cleaving bilirubin at its methylene site in the center of the molecule, methods of making the same, and methods of using the same, are described.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: May 26, 2020
    Assignee: The University of Toledo
    Inventors: Terry D. Hinds, Jr., David E. Stec, Christopher J. Trabbic
  • Anti-infective 2-aminothiophenes
    Patent number: 10647725
    Abstract: 2-Aminothiophene derivatives, uses of the same, and methods of making the same, are described.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: May 12, 2020
    Assignees: The University of Toledo, Colorado State University Research Foundation
    Inventors: Steven Sucheck, Sandeep Thanna, Richard Slayden
  • Crosslinked Membrane for Anion Exchange Applications
    Publication number: 20200119379
    Abstract: Crosslinked membranes for anion exchange applications, and methods of making and using the same, are described.
    Type: Application
    Filed: October 8, 2019
    Publication date: April 16, 2020
    Applicant: The University of Toledo
    Inventors: Matthew Liberatore, George Amobi Ozioko, Karl Schoeps
  • Pyrrole-Based Polymers for Metal Extraction, Analysis, and Removal
    Publication number: 20200102410
    Abstract: Materials and methods for extracting metals from solutions, involving a polymer of Formula A are described: where each X is independently either S or O, and n is an integer greater than 1.
    Type: Application
    Filed: September 26, 2019
    Publication date: April 2, 2020
    Applicant: The University of Toledo
    Inventors: Jon R. Kirchhoff, Ahmad Rohanifar, Govind Sharma Shyam Sunder
  • Furoxans as therapies for neurodegenerative disorders
    Patent number: 10590119
    Abstract: Furoxan compounds, compositions comprising the same, and methods of making and using the same, are described.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 17, 2020
    Assignee: The University of Toledo
    Inventors: Isaac Schiefer, Zahoor Shah
  • MATERIALS AND METHODS FOR JOINING METAL SHEETS
    Publication number: 20200072264
    Abstract: Embodiments of connectors for joining metal sheets, and methods of using the same, are described.
    Type: Application
    Filed: August 27, 2019
    Publication date: March 5, 2020
    Applicant: The University of Toledo
    Inventor: Hongyan Zhang
  • Macroporous Granules of Alkaline Earth Phosphates Using Cement Technology and Gas Evolving Porogen
    Publication number: 20200061235
    Abstract: Macroporous cement compositions, methods of making the same, and methods of using the same, are described.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Applicant: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou, Anand K. Agarwal, Vijay K. Goel, Sameh Saleh
  • Spontaneous Autoimmune Diabetes in Humanized Mice Carrying Human Type 1 Diabetes Susceptibility and Uses Therefor
    Publication number: 20200037586
    Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: The University of Toledo
    Inventors: Shahnawaz Imam, Maria Alfonso-Jaume, Juan Carlos Jaume
  • Nitinol Organ Positioner to Prevent Damage to Healthy Tissue During Radiation Oncology Treatments
    Publication number: 20200016433
    Abstract: Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described.
    Type: Application
    Filed: September 27, 2019
    Publication date: January 16, 2020
    Applicant: The University of Toledo
    Inventors: E. Ishmael Parsai, Mohammad Elahinia
  • High Yield Algal Biomass Production Without Concentrated CO2 Supply Under Open Pond Conditions
    Publication number: 20200017820
    Abstract: Methods and systems for efficient culturing of algae in open ponds are described.
    Type: Application
    Filed: September 24, 2019
    Publication date: January 16, 2020
    Applicant: The University of Toledo
    Inventors: Brahmaiah Pendyala, Agasteswar Vadlamani, Sridhar Viamajala, Sasidhar Varanasi, Mohammadmatin Hanifzadeh
  • COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20200010435
    Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, and methods of making and using the same, are described.
    Type: Application
    Filed: February 16, 2018
    Publication date: January 9, 2020
    Applicants: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20200000789
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 2, 2020
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Methods, Assays and Kits for Detecting Exposure to Cyanotoxins
    Publication number: 20200003775
    Abstract: Methods and kits for the detection of toxic cyanobacteria in a sample by analyzing the sample for the presence antibodies raised in a host, where the presence of antibodies is indicative of toxic cyanobacteria, are described.
    Type: Application
    Filed: June 27, 2019
    Publication date: January 2, 2020
    Applicant: The University of Toledo
    Inventors: David Kennedy, Steven Haller, R. Mark Wooten, Deepa Mukundan, Apurva Lad, John Presloid, Jason Huntley, Bruce Levison
  • Altering Shear Thickening in Fumed Silica Suspensions Using Nanoparticles
    Publication number: 20190359855
    Abstract: Slurry compositions useable in chemical mechanical polishing processes, as well as methods of making and methods of using the same, are described.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 28, 2019
    Applicant: The University of Toledo
    Inventors: Matthew Liberatore, Ehsan Akbari Fakhrabadi
  • Apparatus and method for injecting bone graft substitute and other materials
    Patent number: 10478315
    Abstract: A metering delivery apparatus for injecting bone graft cement includes a body portion, a material containment vessel, an actuator, and a control unit. The body portion includes a drive housing that supports an actuator drivetrain and receiver end that supports the material containment vessel. The actuator has a first end connected to the actuator drivetrain and a second end that supports a moveable portion of the vessel to dispense material in the vessel and a retracting movement that relieves pressure applied to the material. The control unit receives actuator parameter inputs and includes a sensor to detect a signal of at least one of a pressure level and a time period. The sensor provides the detected signal to the control unit such that the control unit operates the actuator between the dispensing and retracting movements based on the detected signal and the actuator parameter inputs.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 19, 2019
    Assignee: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Joel M. Gerber, Aakash Agarwal
  • MONOCLONAL IGM ANTIBODIES FROM ENTIRELY CARBOHYDRATE CONSTRUCTS
    Publication number: 20190345255
    Abstract: Entirely carbohydrate immunogens, monoclonal antibodies generated from immune responses to entirely carbohydrate immunogens, vaccine compositions, pharmaceutical compositions, and methods of making and using the same, are described.
    Type: Application
    Filed: September 19, 2017
    Publication date: November 14, 2019
    Applicant: The University of Toledo
    Inventors: Peter Andreana, Kevin Trabbic, Mengchao Shi, Jean Paul Bourgault
  • ELISA Assay for Measuring Function of Properdin
    Publication number: 20190346451
    Abstract: Methods measuring properdin function and uses thereof are described.
    Type: Application
    Filed: May 10, 2019
    Publication date: November 14, 2019
    Applicant: The University of Toledo
    Inventor: Viviana P. Ferreira