Patents Assigned to The University of Toledo
  • Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same
    Patent number: 10941125
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 9, 2021
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
  • Altering shear thickening in fumed silica suspensions using nanoparticles
    Patent number: 10934457
    Abstract: Slurry compositions useable in chemical mechanical polishing processes, as well as methods of making and methods of using the same, are described.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: March 2, 2021
    Assignee: The University of Toledo
    Inventors: Matthew Liberatore, Ehsan Akbari Fakhrabadi
  • Compositions and methods for reverse automated nucleic acid synthesis
    Patent number: 10927140
    Abstract: Methods for reverse automated nucleic acid synthesis, and 5?-H-phosphonates suitable for use in the same, as well as methods for making 5?-H-phosphonates, are described.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: February 23, 2021
    Assignee: The University of Toledo
    Inventors: Matthew Ellis, Amanda Bryant-Friedrich
  • Composite micro-sensor for detecting free radicals
    Patent number: 10928342
    Abstract: A sensor and method for detecting free radicals in a sample includes providing an electrode at least partially coated with: an inner coating of a first material capable of catalyzing rapid electron transfer; and, an outer coating at least partially coating the inner coating. The outer coating can be a second material comprised of a cerium oxide/graphene composite.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: February 23, 2021
    Assignee: The University of Toledo
    Inventors: Dong-Shik Kim, Surachet Duanghathaipornsuk
  • Analogs of Proxisome Proliferator Activated Receptor (PPAR) Agonists and Methods of Using the Same
    Publication number: 20210038571
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: September 14, 2020
    Publication date: February 11, 2021
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20210038586
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: October 20, 2020
    Publication date: February 11, 2021
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Furoxans as therapies for neurodegenerative disorders
    Patent number: 10913732
    Abstract: Furoxan compounds, compositions comprising the same, and methods of making and using the same, are described.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: February 9, 2021
    Assignee: The University of Toledo
    Inventors: Isaac Schiefer, Zahoor Shah
  • Thermoresponsive Injectable Microparticles-Gel Composites with Low Dose of Recombinant BMP-9 and VEGF for Bone Repair
    Publication number: 20210023240
    Abstract: Compositions for delivering one or more active substances, or for repairing a bone, and methods of making and using the same, are described.
    Type: Application
    Filed: July 21, 2020
    Publication date: January 28, 2021
    Applicant: The University of Toledo
    Inventors: Ambalangodage C. Jayasuriya, Bipin Gaihre
  • High-yield production of fuels and petro- and oleo-chemical precursors from vegetable oils and other liquid feedstocks in a continuous-flow pyrolysis reactor with or without catalysts
    Patent number: 10894920
    Abstract: Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: January 19, 2021
    Assignee: The University of Toledo
    Inventors: Yaser Shirazi, Sridhar Viamajala, Sasidhar Varanasi
  • MICROPATTERNED SILICONE OXYGENATING DRESSING FOR CHRONIC WOUNDS
    Publication number: 20210001001
    Abstract: A wound dressing system having an oxygen-permeable membrane having a first surface and a second surface with oxygen-permeable pillars extending from the second surface is described.
    Type: Application
    Filed: March 21, 2019
    Publication date: January 7, 2021
    Applicant: The University of Toledo
    Inventors: Chandan Das, Munier Nazzal, F. Charles Brunicardi
  • Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same
    Patent number: 10882831
    Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, and methods of making and using the same, are described.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: January 5, 2021
    Assignees: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • SYNDESMOSIS FIXATION AND RECONSTRUCTION SYSTEM AND METHOD OF USING THE SAME
    Publication number: 20200405329
    Abstract: A fixation/reconstruction system for treating syndesmotic ankle fractures includes a screw guide assembly configured to align the cannulated screw for insertion into, and securing within, the patients bone; and, a tension band alignment assembly configured to insert at least one tension band through a transverse opening in the patient s leg, and to secure the tension band.
    Type: Application
    Filed: February 26, 2019
    Publication date: December 31, 2020
    Applicant: The University of Toledo
    Inventors: Jiayong Liu, David Dick, Vijay K. Goel, Nabil A. Ebraheim
  • EXTERNAL LOCKING FIXATION DEVICE FOR EXTRA-ARTICULAR FRACTURES
    Publication number: 20200397482
    Abstract: A locking fixation device for treating extra-articular fractures includes a connector assembly connected to two end plates. Rotation of the connector assembly about an axis extending therethrough converts rotational motion to linear motion, and advances the end plates in a linear direction away from (lengthening) or toward (compression) each other.
    Type: Application
    Filed: February 26, 2019
    Publication date: December 24, 2020
    Applicant: The University of Toledo
    Inventors: Jiayong Liu, Stephen J. Snider, David Dick, Vijay K. Goel, Nabil A. Ebraheim
  • Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
    Patent number: 10865163
    Abstract: Methods of synthesizing compounds using CO2 as a directing group for C—H functionalization, and compounds made thereby, are described.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: December 15, 2020
    Assignee: The University of Toledo
    Inventors: Michael C. Young, Mohit Kapoor
  • IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME
    Publication number: 20200385374
    Abstract: Imidazole-based anticancer agents and derivatives thereof, as well as methods of making and methods of using the same, are described. The imidazole-based anticancer agents are HDAC inhibitor compounds having a 1-(1H-imidazol-2-yl)ethan-1-one or 1-(1H-imidazol-2-yl)ethane-1-thione moiety.
    Type: Application
    Filed: August 17, 2018
    Publication date: December 10, 2020
    Applicant: The University of Toledo
    Inventors: Viranga Tillekeratne, Ayad Al-Hamashi, Samkeliso Dlamini, Abdulateef Saeed S. Alqahtani, Endri Karaj
  • Bilevel equalizer for battery cell charge management
    Patent number: 10862318
    Abstract: An equalizer circuit provides both passive and active charge transfer between cells in a battery pack to improve charge and discharge efficiency. The equalizer circuit is a bilevel circuit that uses both resistive equalizers and switching equalizers to balance cell charge. The cells may be grouped into size limited sections which are balanced by resistive equalizers. The sections are balanced by switching equalizers to promote increased pack discharge capacity.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: December 8, 2020
    Assignee: The University of Toledo
    Inventor: Thomas A. Stuart
  • Biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same
    Patent number: 10849540
    Abstract: A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The transducer component includes the electrode and microprocessor configured to screen noise and to pick up impedance change at a very low frequency range.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: December 1, 2020
    Assignee: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Dong-Shik Kim, Do Young Yoon, Boren Lin, Hamid Feyzizarnagh
  • SURGICAL INSTRUMENT SLEEVE SYSTEM
    Publication number: 20200367884
    Abstract: A surgical instrument sleeve system and method of using the same are described.
    Type: Application
    Filed: May 20, 2020
    Publication date: November 26, 2020
    Applicant: The University of Toledo
    Inventors: Mohammad Mahbub Jamil, Israt Nisa
  • ONE STEP LIQUID-TO-METAL HIGH SURFACE AREA CATALYSTS VIA LOW TEMPERATURE REDUCTION
    Publication number: 20200368726
    Abstract: High surface area metal catalysts, and methods of making and using the same, are described.
    Type: Application
    Filed: December 4, 2018
    Publication date: November 26, 2020
    Applicant: The University of Toledo
    Inventor: John A. Setlock
  • Development of a Cofilin Inhibitor for the Treatment of Hemorrhagic Brain Injury-Induced Neuroinflammation
    Publication number: 20200369603
    Abstract: Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-?, reducing NF-?B, and improving motor deficits in a subject are described.
    Type: Application
    Filed: May 5, 2020
    Publication date: November 26, 2020
    Applicant: The University of Toledo
    Inventors: Saleh Alaqel, Viranga Tillekeratne, Zahoor A. Shah