Patents Assigned to The University of Toledo
  • Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
    Patent number: 10829441
    Abstract: Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: November 10, 2020
    Assignee: The University of Toledo
    Inventors: Kevin M. Nash, Isaac Schiefer, Zahoor Shah
  • Expandable inter-vertebral cage and method of installing same
    Patent number: 10828171
    Abstract: An intervertebral cage includes a plurality of segments that are connected together by one or more members formed from a shape memory alloy material such that the segments are automatically moved from an initial orientation before implantation/insertion in an intervertebral space to an expanded orientation after implantation/insertion in the intervertebral space. Each of the plurality of segments may have a plurality of passageways or recesses formed therethrough, and wherein a wire formed from a shape memory alloy material extends through each of the plurality of passageways or recesses. The member may be formed from a shape memory alloy material that demonstrates shape memory effects and superelasticity properties, such as nitinol.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: November 10, 2020
    Assignee: The University of Toledo
    Inventors: Anand K. Agarwal, Vijay K. Goel, Aakash Agarwal, David Dick
  • Enzymatic Digestion of Microalgal Biomass for Lipid, Sugar, and Protein Recovery
    Publication number: 20200347414
    Abstract: Methods for the recovery of lipids, sugars, and proteins from microbial biomass by enzymatic digestion are disclosed. The methods involve treating microalgae with a fungal acid protease, or with a mixture of at least one protease and at least one amylase.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Applicant: The University of Toledo
    Inventors: Agasteswar Vadlamani, Patricia A. Relue, Sridhar Viamajala, Heng Shao, Sasidhar Varanasi
  • PERC-like Contact to CdTe Solar Cells
    Publication number: 20200343403
    Abstract: Methods for forming electrical contacts with CdTe layers, methods for forming photovoltaic devices, methods for passivating a CdTe surface, and photovoltaic devices are described.
    Type: Application
    Filed: April 29, 2020
    Publication date: October 29, 2020
    Applicant: The University of Toledo
    Inventors: Michael J. Heben, Adam B. Phillips, Fadhil K. Alfadhili, Randall J. Ellingson, Ebin Bastola, Dipendra Pokhrel, Kamala Khanal Subedi
  • Protocol for preconcentration and quantification of microcystins using LC-MS
    Patent number: 10809259
    Abstract: Methods for detecting and quantifying one or more microcystin compounds in a sample are described. The methods may include a preconcentration step, and generally utilize an LC-MS or LC-MS/MS analysis with an Orbitrap Fusion mass spectrometer or a QqQ mass spectrometer. The methods provide excellent recoveries and limits of quantification of microcystins.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: October 20, 2020
    Assignee: The University of Toledo
    Inventors: Dragan Isailovic, Dilrukshika Palagama, David Baliu-Rodriguez, Bruce S. Levison, David J. Kennedy, Steven T. Haller, Kenneth Hensley
  • Assembly of Charge Mosaic Membranes from Ionic Polymers
    Publication number: 20200324250
    Abstract: Charge mosaic membranes useful for desalination applications, and methods of making and using the same, are described.
    Type: Application
    Filed: April 14, 2020
    Publication date: October 15, 2020
    Applicant: The University of Toledo
    Inventors: Glenn Lipscomb, Ghazaleh Vaseghi
  • Therapeutic polysaccharide midi-GAGR and related materials and methods
    Patent number: 10792301
    Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders as well as bone disorders in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum. Also describe herein are pharmaceutical compositions comprising one or more of such materials, and methods for their preparation and use.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: October 6, 2020
    Assignee: The University of Toledo
    Inventors: Joshua J. Park, Dong-Shik Kim, Kenneth Hensley, Kevin Christopher, Vishruti Makani
  • MATERIALS AND METHODS USEFUL TO INDUCE CANCER CELL DEATH VIA METHUOSIS OR AUTOPHAGY OR A COMBINATION THEREOF
    Publication number: 20200297709
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Application
    Filed: September 26, 2018
    Publication date: September 24, 2020
    Applicant: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul W. Erhardt, Piyush Trivedi
  • Use of Formin Agonists in Overcoming Brain Tumor Radio- and Chemo-resistance by Targeting Tumor Microtubes
    Publication number: 20200289440
    Abstract: Compositions and methods for inhibiting brain tumor proliferation, or for inhibiting or halting TM formation, invasion, and/or proliferation, or for rendering brain tumor cells sensitive to chemotherapy or radiation, or for treating a brain tumor, or for inducing cell death, involving mDia agonists such as IMM01 and IMM02, are described.
    Type: Application
    Filed: March 10, 2020
    Publication date: September 17, 2020
    Applicant: The University of Toledo
    Inventors: Kathryn Eisenmann, Krista M. Pettee, Kathryn Becker
  • Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
    Patent number: 10776461
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: September 15, 2020
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • MICROCELLULAR MATERIALS WITH STRESS-ACTIVATED PORES EXHIBITING OPTO-MECHANICAL PROPERTIES AND THEIR USE AS SENSORS
    Publication number: 20200276739
    Abstract: Materials that exhibit stress-induced porosity, and methods of making and using the same, are described.
    Type: Application
    Filed: February 20, 2020
    Publication date: September 3, 2020
    Applicant: The University of Toledo
    Inventors: Syed Reza Rizvi, Sheikh Rasel, Md Emran Hossain Bhuiyan, Navid Namdari, Bilal Nizar Abdul Halim
  • POTENT INHIBITORS OF ASPARTATE N-ACETYL-TRANSFERASE FOR THE TREATMENT OF CANAVAN DISEASE
    Publication number: 20200270202
    Abstract: Compounds, compositions, and methods for the treatment of Canavan disease are described.
    Type: Application
    Filed: March 23, 2017
    Publication date: August 27, 2020
    Applicant: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang
  • SENSOR FOR DETECTION AND MEASUREMENT OF ICE, SNOW AND LIQUID WATER CONTENT (LWC) AND METHODS OF USING SAME
    Publication number: 20200271603
    Abstract: A sensor for detecting the presence and wetness of at least one medium, including ice, snow and water, on a surface of an object, is described.
    Type: Application
    Filed: February 20, 2020
    Publication date: August 27, 2020
    Applicant: The University of Toledo
    Inventors: Ahmed Abdelaal, Mehdi Sarayloo, Douglas K. Nims, Hossein Sojoudi
  • Enzymatic digestion of microalgal biomass for lipid, sugar, and protein recovery
    Patent number: 10752924
    Abstract: Methods for the recovery of lipids, sugars, and proteins from microbial biomass by enzymatic digestion are disclosed. The methods involve treating microalgae with a fungal acid protease, or with a mixture of at least one protease and at least one amylase.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: August 25, 2020
    Assignee: The University of Toledo
    Inventors: Agasteswar K. Vadlamani, Patricia Relue, Sridhar Viamajala, Heng Shao, Sasidhar Varanasi
  • Magnetic ionic liquids, methods of making and uses thereof as solvents in the extraction and preservation of nucleic acids
    Patent number: 10752648
    Abstract: Described herein are methods for making and using magnetic ionic liquid that have at least one cationic component and at least one anionic component, where at least one of the cationic components or the anionic components is a paramagnetic component. The magnetic ionic liquids are capable of manipulation by an external magnetic field.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: August 25, 2020
    Assignee: The University of Toledo
    Inventors: Jared L. Anderson, Omprakash Nacham, Kevin D. Clark
  • PPARG modulators for the treatment of osteoporosis
    Patent number: 10744117
    Abstract: The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 18, 2020
    Assignees: The Scripps Research Institute, The University of Toledo
    Inventors: Patrick R. Griffin, Theodore Kamenecka, Beata Lecka-Czernik
  • Telestroke Eye Examination Accessory
    Publication number: 20200253532
    Abstract: A telestroke eye examination accessory device, a system incorporating the same, and methods of using the same, are described. The telestroke eye examination accessory device includes eyewear having a first eye well and a second eye well, a first camera positioned within the first eye well, a second camera positioned within the second eye well, a first light array having lights in each of four different quardrants in the first eye well, and a second light array having lights in each of four different quadrants in the second eye well. The system further includes a graphical user interface useful for a practitioner using the telestroke eye examination accessory device to assess the field of vision of a patient wearing the eyewear.
    Type: Application
    Filed: February 6, 2020
    Publication date: August 13, 2020
    Applicant: The University of Toledo
    Inventors: Mouhammad A. Jumaa, Syed F. Zaidi, Hisham Salahuddin
  • Enhancement of lignocellulose saccharification via a low temperature ionic liquid pre-treatment scheme
    Patent number: 10724060
    Abstract: A method for pretreating lignocellulosic biomass having a lignin component, a hemicellulose component, and a cellulose component, for conversion to sugar is disclosed. Also disclosed is the pretreated lignocellulosic biomass resulting from the method.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: July 28, 2020
    Assignee: The University of Toledo
    Inventors: Constance A. Schall, Samira Vasheghani Farahani
  • Use of acyl-homoserine lactone derivatives as anti-thrombotic agents
    Patent number: 10702497
    Abstract: Uses of acyl-homoserine lactone compounds are described. In particular, uses of acyl-homoserine lactone compounds as anti-thrombotic agents, to inhibit platelets from becoming hypersensitive, and/or to prevent thrombosis, are described.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: July 7, 2020
    Assignee: The University of Toledo
    Inventors: Randall G. Worth, Glenn R. Westphal, Brenton R. Keeley, Leah M. Wuescher
  • Dual-branched shape memory alloy organ positioner to prevent damage to healthy tissue during radiation oncology treatments
    Patent number: 10688317
    Abstract: Devices, systems, and methods for repositioning organs, such as the rectum, during radiation therapy treatments, are described.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: June 23, 2020
    Assignee: The University of Toledo
    Inventors: E. Ishmael Parsai, Mohammad Elahinia