Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.

Abstract: In accordance with one embodiment of the present invention an apparatus for a low numerical aperture exclusion imaging apparatus is provided. The apparatus may include an electromagnetic illumination source for illuminating a portion of a specimen; and for collecting an image created by the electromagnetic radiation an objective lens optically coupled to the electromagnetic illuminated portion of the specimen. The apparatus also includes an optical blocking plate disposed between the objective lens and a focusing lens. The optical blocking plate is positioned to substantially block undesired electromagnetic radiation from image sources distally aligned in the same optical axis as the specimen. This invention is enhances narrow depth of field characteristics in imaging. It also enhances discreet imaging in a narrow focus field by eliminating some or most of the light which contributes to wide depth of field focus. This is useful for optical sectioning ranging from microscopy to photography.

Abstract: The invention, in part, includes methods and compounds useful to prepare and functional class XIV myosin. Functional class XIV myosin prepared using methods of the invention may be useful to screen for and identify compounds that inhibit and treat parasitic infections and contamination.

Abstract: The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.

Abstract: The present invention has to do with a method and system for a high precision electronic psychrometer operable at low temperatures and high humidity environments. The electronic psychrometer includes thermistors for measuring wet and dry bulb temperatures and a wicked cage surrounding one of the thermistors. The wicking action of the wicked cage is controlled by an evaporation controller in conjunction with the wick's physical parameters. The electronic psychrometer determines relative humidity and provides a readout display and/or a control signal.

Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.

Abstract: The present invention generally relates to inhibitors of DUOX1. In some aspects, an inhibitor may be applied to a subject having or being at risk for asthma or other conditions. The inhibitor may be applied by various techniques, such as pulmonary or topical delivery. In some embodiments, the inhibitor may include a peptide or other moiety having a reactive electrophile. The reactive electrophile can target cysteine or other residues within DUOX1 to inhibit its activity, e.g., by covalently binding to the residue. Other non-limiting examples of suitable inhibitors include hydroxynonenal, curcumin, sulforaphane, cinnamaldehyde, dimethyl fumarate, or phenyl vinyl sulfonate. Other aspects of the invention are generally directed to methods of making or using such inhibitors, kits involving such inhibitors, devices or formulations containing such inhibitors, or the like.

Abstract: Methods for diagnosing and treating conditions associated with life-threatening neurological complications are provided. The methods involve in some aspects the identification of oxLDL and LOX-1 as critical players in pregnant subjects and in some cases subjects having severe preeclampsia (early onset preeclampsia). Related products and kits are also provided.

Abstract: A system for processing signals to enhance patient audibility of a plurality of signals in an MRI environment is provided. The system includes an acoustic measuring device for measuring sound power levels generated by the M RI and a principal frequency component identifier for identifying principal frequencies measured by the acoustic measuring device. The system also includes an audio equalizer for controlling the amplitude and frequency of each of the plurality of signals in accordance with the principal frequencies. Further provided by the system is an attenuator for attenuating an overall sound level of the signals being processed and a dynamic range compression processor.

Abstract: The invention described herein provides an energy transfer system via a tire based inductor system. By using the tire, the area inside the tire, the tire rim, or the wheel as the inductive pick-up for a powered roadway system the prior art problems are solved. Namely, since the tire/wheel is always in contact, or near contact with the road, the air gap is reduced to a minimum, and substantially fixed, distance. By mounting the secondary on the perimeter of a wheel, relative motion between the road and inductor is minimized. In addition, the pick-up can be encased in the tire, eliminating the problem of road debris, snow and ice entirely. Also, some heating of the tire due to electrical losses may enhance traction and tread performance on snowy or wet roads. In all configurations, the vehicle's wheel suspension adjusts vertically adjusting for road imperfections and obstacles.

Abstract: The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.

Abstract: The invention relates to methods for modulating PPAR-? activity using relaxin or agonists thereof. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including small vessel disorders of the brain and those associated with increased blood-brain barrier permeability, cognitive disorders such as Alzheimer's disease, vascular dementia, epilepsy, stroke, CADASIL and migraine.

Abstract: The invention disclosed herein provides for high particle removal rate and/or heat transfer from surfaces. The device removes particulate matter from a surface using a bounded vortex generated over the surface, with suction in the vortex center and jets for blowing air along the periphery. The jets are tilted in the tangential direction to induce vortex motion within the suction region. The vortex is said to be bounded because streamlines originating in the downward jets are entrained back into the central vortex.

Abstract: The invention, in part, includes methods and compounds useful to prepare and functional class XIV myosin. Functional class XIV myosin prepared using methods of the invention may be useful to screen for and identify compounds that inhibit and treat parasitic infections and contamination.

Abstract: Systems and methods of digitally recording and reproducing tactile drawings are disclosed. The method includes moving a stylus over a path on the first tactile drawing medium to form a tactile feature thereon, and digitally recording the path of the moving stylus to generate digital path data. The method also include reproducing the tactile feature on a second tactile drawing medium operably disposed in a tactile printer based on the digital path data. The systems and methods include forming tactile drawings based on a digital graphics file, including filtering the digital graphics file to form a .RLD file suitable for forming a tactile drawing having features capable of being tactilely sensed.

Abstract: A method for forming a crystalline film of a material is provided, including depositing a solution, having a base critical speed separating deposition regimes, on a substrate such that a crystalline film is formed. The solution is deposited at a speed greater than the base critical speed and the crystalline film has a crystal structure characteristic of a crystalline film formed from the solution at a speed less than the base critical speed. In another aspect, a crystalline film is formed on a base film by depositing a solution on the base film. The solution has a critical speed between deposition regimes, and the solution is deposited at a speed greater than or equal to the critical speed, such that a crystalline film is formed on the base film. A device is disclosed, the device having a film made from any of the disclosed methods and an electrical lead.

Abstract: Cardiac output is measured using a non-invasive method comprised of administering hyperbaric or hypobaric gas to the subject then after a time measuring the resultant changes in central or peripheral oxygen saturation times using a pulse oximeter located at a peripheral body site. Preferably the device is portable and is comprised of a gas cartridge, with one or more doses, and a mouth-piece, a microprocessor for performing the analysis, a pulse oximeter probe and a display for reporting the cardiac output.

Abstract: The Portable Ultrafine Particle Sizer (PUPS) invention is provided. The PUPS is an instrument which can measure particle number concentration for particle sizes under 200 nanometers in-situ. The PUPS is a compact design for quick mounting on vehicles. Size discrimination is accomplished using a compact reverse Differential Mobility Analyzer (rDMA). Particle charging is accomplished using corona ionization. Concentration measurements are completed using a unique flexible printed circuit board electrode which can be removed for cleaning, disposal or chemical analysis of collected particles at the end of its in situ measurement life.

Abstract: The invention, in part, includes methods and compounds useful to prepare and functional class XIV myosin. Functional class XIV myosin prepared using methods of the invention may be useful to screen for and identify compounds that inhibit and treat parasitic infections and contamination.

Abstract: A thermal eraser for erasing tactile drawing features from a tactile drawing medium, along with methods of erasing tactile drawing features formed on a tactile drawing medium, are disclosed. The thermal eraser has a heated tip that can be heated to a temperature sufficient to cause the tactile drawing feature to flow back into the surface of the tactile drawing medium. The heated tip has a tip temperature that can be controlled by a temperature-regulating circuit. A set-point temperature can be used to set the tip temperature and maintain the tip temperature. The thermal eraser can be controlled by hand or by an electro-mechanical device such as a tactile printer.