Abstract: Prodrugs of glutamine analogs, such as prodrugs of acivicin, are disclosed.

Abstract: Various embodiments of the present disclosure are to provide a tumor microenvironment-responsive nanocomplex capable of presenting a novel paradigm for tumor therapy by reprogramming tumor microenvironments and an anticancer composition containing the same.

Abstract: A state-estimator for the estimation or initialization of the state of a discrete-time state-space dynamical model based on sensor measurements of the model output, comprising fitting a continuous-time function to acquired sensor measurement data-points of each model output, and subsequently sampling the continuous time function at exactly the sample-period of the state-space dynamic model for which the state is being estimated or initialized, in order to construct a model state via a synthesized output trajectory.

Abstract: Described are novel female fertility therapies. A first aspect of the invention is directed to therapies that include FSH lowering methodologies to prevent and/or treat egg infertility. A second aspect of the invention is directed to agents that bind to activin, bind to receptors that bind activin, or that otherwise disrupt activin signaling (collectively referred to herein as “activin pathway modifier agents” or “APM agents”) and methods of utilizing these agents to prevent and/or treat egg infertility. A third aspect of the invention is directed to methods of administering an effective amount of an APM agent to a subject to increase oocyte yield and/or ovarian reserve. All three aspects of the invention may be used in humans and in animals. Additional aspects of the invention include therapeutic drug kits for treatment of humans and animals based on the methodologies described above.

Abstract: The disclosure is directed to polyelectrolyte complex nanoparticles that can be used to deliver agents deep into hydrocarbon reservoirs. Methods of making and using said polyelectrolyte complex nanoparticles are also provided.

Abstract: The present disclosure provides a build plate for physically adhering or holding a three-dimensional (3D) object to a build surface and methods for mechanically anchoring the 3D object to the build surface using printing or building materials. In one embodiment, a build plate comprises a plurality of anchor holes spaced throughout a top surface of the first build plate, in which an individual anchor hole comprises a top hole portion and a bottom chamfer hole portion that is larger in size than the top portion.

Abstract: A device and method for reinforcing recycled aggregate based on in-situ C—S—H production including a first, second, third chamber, and a blast drier. A spray structure arranged on the top of the third chamber; the first and second chamber connected to the spray structure through pumps. A hollowed container arranged at the bottom of the spray structure. A certain gap reserved between the bottom of the container and the bottom of the third chamber, the bottom of the third chamber is provided with at least one drain outlet; the blast drier connected to the bottom of the third chamber, and a cover is arranged on the top of the third chamber. The first chamber contains calcium hydroxide solution. The second chamber contains a mixed solution of TEOS, water and anhydrous ethanol. The container is arranged in the third chamber, and the container is used to contain to-be-treated recycled aggregate.

Abstract: A photocurrent scanning system comprises a laser generating device, a focusing device, a displacement adjustment device, a bias supply device, and a measuring device. The laser generating device is used to emit a laser. The focusing device is used to focus the laser to a surface of a sample. The displacement adjustment device is used to place the sample and adjust a position of the sample, to make the laser focused onto different parts of the surface of the sample. The bias supply device is used to supply a voltage to the sample. The measuring device is used to measure a photocurrent signal flowing through the sample.

Abstract: A diesel engine employs a turbulent jet ignition system and method. In another aspect, diesel fuel and air are premixed prior to introduction of the mixture into a main engine combustion chamber. A further aspect employs a turbocharger compressor to boost air pressure into a main piston combustion chamber and/or an ignition pre-chamber for missing with a heavy fuel, such as diesel.

Abstract: Systems, techniques, and devices for detecting plant biometrics, for example, plants in a crop field. An imaging device of an unmanned vehicle may be used to generate a plurality of images of the plants, and the plurality of images may be used to generate a 3D model of the plants. The 3D model may define locations and orientations of leaves and stems of plants. The 3D model may be used to determine at least one biometric parameter of at least one plant in the crop. Such detection of plant biometrics may facilitate the automation of crop monitoring and treatment.

Abstract: The present invention discloses a system and control method of all-DC power supply and storage for a building. The system includes a renewable energy power generation apparatus, a mains grid system, a first DC/DC conversion apparatus, an AC/DC conversion apparatus, a first voltage DC bus, a first energy storage apparatus, and a first charge-discharge conversion apparatus. The first DC/DC conversion apparatus is configured to convert DC voltage generated by the renewable energy power generation apparatus to voltage of the first voltage DC bus. The AC/DC conversion apparatus is configured to convert AC power from the mains grid system to DC power. The first charge-discharge conversion apparatus is configured to control charge/discharge of the first energy storage apparatus. The first voltage DC bus is connected to a first electrical device and configured to power the first electrical device.

Abstract: A subsurface flow constructed wetland (SFCW) includes a sand layer having a ventilation property of 90 mL/(cm·s) and a permeation rate of less than 0.3 kg/m2/h under a two-meter-high pressure head, a filter layer disposed on the sand layer, and a gabion module disposed on the filter layer. The filter layer includes fine sand with a particle size of 0.25-0.35 cm. The gabion module includes a gabion box including a plant layer and a filler layer, and the filler layer is disposed on the plant layer.

Abstract: The present invention relates to diagnostic methods, reagents, and kits for detecting and diagnosing Early Stage Parkinson's disease.

Abstract: There are proposed an attention memory method and system for locating an object through visual dialogue. The attention memory system for identifying an object on an image includes: a control unit which generates a question for identifying a preset object on the image, derives an answer to the generated question, and identifies the preset object on the image based on the question and the answer; and memory which stores the image. The control unit generates the question by incorporating information about objects included in the image into the question, and updates the information about the objects based on the answer.

Abstract: Provided are a polymer containing S,S-dioxide-dibenzothiophene in backbone chain with content-adjustable triarylamine end groups, and a preparation method and an application thereof. Triarylamines hole-transport small molecules are introduced into the polymer end group, and a content of the triarylamine end groups can be adjusted by controlling a polymer molecular weight, so that the polymer has better electron-transport and hole-transport capabilities, and charge carrier transport can be balanced, so that more exciton recombination takes place effectively, thus improving the luminous efficiency and stability of the polymer. The polymer is prepared by a Suzuki polymerization reaction and does not require synthesis of new monomers. The polymer material is used for preparing highly effective and stable monolayer devices, and is dissolved directly in an organic solvent, then spin-coated, ink-jet printed, or printed to form a film.

Abstract: A steep-slope (SS) field effect transistor (FET) including a FET having a source region and a drain region, and a threshold switching device in direct contact with the source region or the drain region of the FET. Fabricating the steep-slope (SS) field effect transistor (FET) includes fabricating an AlGaN/GaN metal-insulator-semiconductor high electron mobility transistor (MIS-HEMT) having a source region and a drain region, depositing a first electrode layer directly on the source region or the drain region, depositing a threshold switching layer directly on the first electrode layer, and depositing a second electrode layer directly on the threshold switching layer.

Abstract: A device and a method for simultaneously inspecting defects of a surface and a subsurface of an optical element are provided. Combined with laser-induced ultrasound and laser scattering inspection technologies, through generating acoustic sound waves on the surface and the subsurface of the optical element to be tested by lasers, a static light scattering effect of subsurface defects under modulation of the acoustic sound wave is observed and analyzed; through analyzing amplitude and phase changes of scattered light intensity and reflected light intensity, inspection for the defects of the surface and the subsurface of the optical element is realized. The present invention can be applied in quality inspection of precise optical elements, especially in finished product inspection of ultra-precise optical elements having strict requirements on the subsurface defects.

Abstract: A high-concentration anaerobic fermentation apparatus includes a liquid accumulation tank, a fermentation vessel, a feeding assembly, and a biogas residue collecting bin. The feeding assembly includes a hopper and a return conveyor belt including a first portion extending downward from the hopper till below a liquid level, a second portion extending upward from a bottom end of the first portion till above the liquid level, a third portion extending downward from a top end of the second portion till the liquid level, and a fourth portion extending upward from a bottom end of the third portion till out of the liquid level and above the biogas residue collecting bin. A pressure-feed flange is disposed at an outer side of the fermentation vessel, a feed channel is formed between the pressure-feed flange and the first portion, and a discharge channel is formed between the pressure-feed flange and the fourth portion.

Abstract: The purpose of the present invention is to provide a peptide that is capable of efficiently delivering an antigen to dendritic cells and improving the vaccine effects of the antigen. A peptide that has at least one motif sequence comprising the amino acid sequence of sequence listing 1, or an amino acid sequence comprising the aforementioned amino acid sequence, but in which a mutation has been induced in the amino acid residue at the first and/or second position of the amino acid sequence, is bound to an antigen protein or an antigen peptide to efficiently deliver the antigen protein or antigen peptide to dendritic cells, allowing for significantly superior vaccine effects to be exhibited.

Abstract: When a predetermined image is displayed for a user such that the user is able to visually recognize the image, the user sight line direction is detected, a part assumed to be present in the detected user sight line direction is set to a first image, an image complementary to the first image for the predetermined image is set to a second image, the positions of the retinas of the eyes of the user are scanned with laser light from a retinal scanning display unit fitted to the head of the user and the first image is focused on a position away from the position of the eyes of the user by a first distance and is displayed. The second image is displayed on the surface of the panel of a panel display unit in a position away from the user by a second distance shorter than the first.