Abstract: There is a continuing need for methods and compositions relating to hormone-receptor-dependent cancers, including pharmaceutical compositions including one or more compounds having activity against steroid hormone-receptor-dependent cancer and methods of treatment of a steroid hormone-receptor-dependent cancer in a subject using said pharmaceutical compositions. ELK1 is a steroid hormone receptor tethering, protein that is implicated in hormone receptor dependent cancers. Compositions and methods according to aspects of the present invention inhibit the association of steroid hormone receptors with ELK1 providing activity against steroid hormone-receptor-dependent cancer.

Abstract: Methods of decellularization of tissue, such as mammalian tissue, are provided, along with methods of making an extracellular matrix (ECM) preparation. Systems and apparatus useful in performing the methods are also provided.

Abstract: The invention describes a two-phase steel comprising 8-12 wt. % Mn, 0.3-0.6 wt. % C, 1-4 wt. % Al, 0.4-1 wt. % V, and a balance of Fe. The steel has martensite and retained austenite phases, and may include vanadium carbide precipitations. A method for making the two-phase steel involves the steps of (a) hot rolling the ingots of the composition to produce a plurality of thick steel sheets, (b) treating the steel sheets by an air cooling process, (c) warm rolling the steel sheets at a temperature in the range of 300-800° C. with a thicknesses reduction of 30-50%, (d) annealing the steel sheets a first time at a temperature in the range of 620-660° C. for 10-300 min, (e) cold rolling the steel sheets at room temperature with a thickness reduction of 10-30% to generate hard martensite, and (f) annealing the steel sheets a second time at a temperature in the range of 300-700° C. for 3-60 min to facilitate the partitioning of carbon and release the residual stress n martensite.

Abstract: A connector system is provided with a first connector including a first transmission line, and a second connector including a second transmission line. The second connector includes a processing unit configured to perform an information transmission process of creating information regarding verification, and transmitting the information to the first connector. The first connector includes: a switch configured to, in a state where the first connector and the second connector are connected to each other, select whether or not to electrically connect the first transmission line and the second transmission line to each other; a verification unit configured to perform a verification process of verifying the second connector, based on the information received from the second connector; and a control unit configured to control the switch, based on a result of the verification process.

Abstract: An MRI contrast composition includes a liposome and a europium metal complex disposed within the liposome. The europium metal complex includes a europium metal ion and a multi-dentate ligand selected from the group consisting of cryptands and thiacryptands and one or more counter-ions that balances a charge of the europium metal ion and the multi-dentate ligand, the europium metal ion being switchable between a 2÷ and 3÷ oxidation state. The contrast composition advantageously provides an oxidation-responsive dual-mode contrast agent because it would enhance either T1-weighted images or CEST images depending on the oxidation state of Eu.

Abstract: Techniques for fingertip design are disclosed that leverage how most grasp contacts can share a few classes of local geometries. In order to maximize the contact areas for achieving more robust grasps, contact primitives, which represent a set of contacts of similar local geometries, are identified. A uniform cost algorithm, which can be formulated as a decision making process in a tree structure, can be utilized to cluster a set of example grasp contacts into a finite set of one or more contact primitives. Fingertips can be designed by optimization to match the local geometry of each contact primitive, and then fingertips can be 3D printed using soft materials to compensate for optimization residuals. For novel objects, an approach to generate grasp contacts that match the fingertip geometries while together forming stable grasps can be utilized.

Abstract: Described here are methods and compositions for treating tumors and metastases that improve anti-angiogenesis therapy. By inhibiting these mechanisms in a biological system with an anti-beta one integrin composition in combination with an antiangiogenic composition, tumors and metastases may be deprived of an adequate blood supply, thereby resulting in tumor cell growth arrest and possibly regression, including tumor cell death. The present compositions comprise an anti-beta one integrin agent in combination with an anti-VEGF agent, in a pharmaceutical composition or compositions. Methods of treatment and of imaging are also described.

Abstract: Disclosed herein are precursor compounds, composite electrodes comprising the same, and methods of making and use thereof.

Abstract: An apparatus for manufacturing a hologram includes a holographic optical element on which a first interference pattern of a first signal beam and a first reference beam is recorded and a second interference pattern of a second signal beam modulated by a Fourier lens and a second reference beam is recorded. Also, an apparatus for reconstructing a hologram by using the holographic optical element is provided.

Abstract: Disclosed are differential temperature push bending method and device for tube with small bending radius, the device comprising: a push bending die, core, fillers and pushers, wherein the core and the fillers are both arranged in a bending chamber of the push bending die, an inlet and an outlet end of the push bending die are respectively provided with a front guiding sleeve and a rear guiding sleeve, the pusher in the front guiding sleeve abuts against a plurality of fillers, and the pusher in the rear guide sleeve abuts against the core. A heat rod is provided at an outer end of the bending chamber. The present disclosure adopts differential temperature type push bending, flow performance of the tube blank at the outer corner of the die can be improved, and the material can be timely fed to prevent excessive stretching and thinning of the outer material.

Abstract: A slurry composition is disclosed which includes: a corrosion inhibitor including a material selected from carbon allotropes and derivatives thereof; and an oxidant. A method of manufacturing an integrated circuit device is disclosed which includes: forming a first metal film and a second metal film on a substrate, the first metal film and the second metal film respectively including different metals; and polishing, by using the slurry composition, a polishing target surface at which the first metal film and the second metal film are exposed.

Abstract: A sequence signal generator and a sequence signal generation method are provided. In the sequence signal generation method, a waveform output instruction sent by a host computer is received to acquire waveform data. The waveform data includes original square wave sequence data and target square wave sequence data, and the target square wave sequence data includes a preliminary delay parameter and a secondary delay parameter. An original square wave sequence signal is acquired according to the original square wave sequence data. According to the preliminary delay parameter, preliminary delay processing is performed on the original square wave sequence signal to acquire an intermediate square wave sequence signal, and according to the secondary delay parameter, secondary delay processing is performed on the intermediate square wave sequence signal to acquire a target square wave sequence signal.

Abstract: An optical imaging system to image a target object includes a light source configured to emit one or more light rays to illuminate the target object and an image detector configured to capture a three-dimensional topography image of the target object when emitted light is emitted from the target object in response to being illuminated by the light rays emitted by the light source. A fluorescence image detector captures a fluorescence image of the target object when fluorescence is emitted from the target object in response illumination by light rays emitted by the light source. A controller instructs the image detector to capture the 3D topography image and the fluorescence image detector to detect the fluorescence image of the target object intraoperatively and to co-register and simultaneously display intraoperatively the co-registered topography and fluorescence information to the user via a display.

Abstract: The invention relates to a multi-objective optimization method for power system peak-shaving based on index linkage analysis. The invention comprehensively considers five peak shaving indexes, and introduces a linkage analysis theory in economics to test stationarity and causality of data series of peak-shaving indexes. The purpose is to effectively clarify linkage relationship between indexes. A regression analysis method is used to quantify the mutual influence relationship. A multi-index coupling peak shaving optimization model for generation scheduling is developed and finally solved by using genetic algorithm. The invention can objectively describe comprehensive peak shaving requirements of a provincial power grid, and is helpful for generation dispatcher to reduce subjective assumptions in the decision-making.

Abstract: A particle deposition system can have a particle source providing a nanomaterial at a controlled rate and a gas distribution system coupled with the particle source and operable to receive the nanomaterial aerosol. A high pressure chamber can be coupled with the gas distribution system, and a nozzle can be disposed between the high pressure chamber and a low pressure chamber. The nozzle can have a nozzle opening allowing fluidic communication of a nanomaterial aerosol between the high pressure chamber and the low pressure chamber and the opening can have a length exceeding a width.

Abstract: An immunogenic fusion protein for use as a mucosal vaccine is provided, which includes: i) one or more FcyR1-binding domains; ii) one or more antigens from one or more infectious disease organisms; and iii) one or more FcRn-binding domains.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: Embodiments of the present invention provide compositions and methods for recombinantly generating tagless constructs of proteins or peptides. In certain embodiments, recombinant proteins or peptides disclosed herein concern human papilloma virus (HPV). Other embodiments concern using these constructs in compositions to elicit immune responses in a subject to one or more HPV types. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infections are also disclosed. Nucleic acids and expression vectors coding for constructs contemplated herein are provided. In certain embodiments, an HPV capsid protein generated is devoid of any fusion tags. In addition, truncated forms of HPV L1 are contemplated.

Abstract: A method for determining a specific surface area of a given material includes preparing plural samples of a dye and the given material; imagining the plural samples to generate digital images; calculating from the digital images, a saturation S for each of the plural samples; selecting a single saturation S value that corresponds to an excess dye condition; and calculating the specific surface area Ss based on the single saturation S value, for the given material.

Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.