Patents Assigned to The University
  • Cationic lipids
    Patent number: 8759104
    Abstract: The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a cationic precursor; (ii) a linking moiety of formula (5): —(HNR5)2NC(O)R3C(O)—??(5), wherein: each R5 is independently an optionally substituted C1-4 alkylene moiety; and R3 is an optionally substituted alkylene or alkenylene moiety; and (iii) two lipophilic moieties, wherein the head group and each of the lipophilic moieties are connected to the linking moiety through amide linkages.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: June 24, 2014
    Assignee: The University Court of the University of Edinburgh
    Inventors: Asier Unciti-Broceta, Aleksandra Liberska, Mark Bradley
  • Tunable Nitric Oxide-Releasing Macromolecules Having Multiple Nitric Oxide Donor Structures
    Publication number: 20140171395
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Application
    Filed: February 19, 2014
    Publication date: June 19, 2014
    Applicants: The University of North Carolina at Chapel Hill, Novan, Inc.
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Cell-Matrix Microspheres, Methods for Preparation and Applications
    Publication number: 20140170745
    Abstract: A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 19, 2014
    Applicant: The University of Hong Kong
    Inventors: Barbara Pui Chan, Godfrey Chi-Fung Chan, Hoi Ling Wong, Pik To Cheung, Song-Eng Kathryn Cheah, Danny Chan
  • PEPTIDE-CROSSLINKED BIOACTIVE POLYMERIC MATERIALS
    Publication number: 20140171619
    Abstract: A method for creating a peptide crosslinked bioactive polymeric material includes reacting a hydroxy-functionalized small molecule with a amino acid to form an amino acid functionalized monomer, reacting the amino acid functionalized monomer with a urea bond former to form a amino acid-based poly(ester urea), and reacting the amino acid-based poly(ester urea) with a peptide based crosslinker to form the peptide crosslinked bioactive polymeric material.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 19, 2014
    Applicant: The University of Akron
    Inventors: Matthew Becker, Matthew Graham, Frank Harris, Fei Lin
  • METHODS AND KITS FOR DETECTING ADENOMAS, COLORECTAL CANCER, AND USES THEREOF
    Publication number: 20140171339
    Abstract: This invention is directed to a novel method to detect adenomas and colorectal cancer (CRC) using a bacterial signature. Included in the invention are methods of (a) determining an individual's risk developing adenomas or CRC; (b) determine whether or not a patient should have a colonoscopy; (c) differential diagnosis; (d) staging; (e) selecting therapies; (f) monitoring therapies; (g) patient surveillance; and (h) drug screening. Kits and reagents for detecting adenomas and CRC and/or drug screening are also part of the invention.
    Type: Application
    Filed: June 6, 2012
    Publication date: June 19, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Temitope Keku, Anthony Fodor, Nina Sanapareddy
  • PARP Substrates and Biomarkers
    Publication number: 20140170643
    Abstract: PARylated proteins are enriched by treating cell lysates comprising PARylated proteins and DNA/RNA with an endonuclease that cleaves the DNA/RNA but not the PAR; and separating the PARylated proteins from the cleaved DNA/RNA. PARylation sites are labeled by eluting PARylated proteins from a PAR-affinity substrate with a nucleophilic amine exchange reactant, wherein the reactant labels PARylation sites of the proteins. Specific binding agents are identified by screening compounds for specific binding to a PARylated protein disclosed herein; and identifying one of the compounds as a specific binder of the protein. Antibodies which specifically bind PARylation sites are also disclosed.
    Type: Application
    Filed: April 30, 2013
    Publication date: June 19, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventor: Yonghao Yu
  • Shape-Extraction Method and Shape-Extraction System
    Publication number: 20140169651
    Abstract: An unknown surface shape of a physical object can be extracted with good precision. Image data of a projective image that has been acquired by radiation projection to an object is acquired. Next, a predetermined mesh structure is used to acquire cross-sectional images of the subject from image data of the projective images by reconstruction using tomography. Lattice points constituting the mesh structure are then moved in conformity with the surface shape of the object, based on the cross-sectional image that has been acquired by reconstruction. Reconstruction is carried out again using the mesh whose lattice point positions have been corrected. Movement on the reconstruction of the lattice points is then repeated as many times as required.
    Type: Application
    Filed: February 28, 2012
    Publication date: June 19, 2014
    Applicant: The University of Tokyo
    Inventors: Yutaka Ohtake, Hiromasa Suzuki, Takuma Niizaka, Daiki Yamanaka
  • COMPOSITIONS AND METHODS RELATED TO ANTIBODIES TO STAPHYLOCOCCAL PROTEIN A
    Publication number: 20140170134
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).
    Type: Application
    Filed: August 15, 2012
    Publication date: June 19, 2014
    Applicant: The University of Chicago
    Inventors: Olaf Schneewind, Dominique M. Missiakas, Hwan Keun Kim, Carta Emolo, Andrea Dedent
  • MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY
    Publication number: 20140171807
    Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
    Type: Application
    Filed: December 19, 2012
    Publication date: June 19, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: Taner Akkin, Thomas E. Milner, Digant P. Dave, H. Grady Rylander, III
  • Methods and Compositions for Effecting Developmental Gene Expression in Plants
    Publication number: 20140173779
    Abstract: The invention provides nucleotide sequences that can be used in operable association with a promoter to express a polynucleotide sequence of interest in a plant, plant part or plant cell at particular stages of development and/or in specific tissues. and methods for directing developmental stage specific and/or tissue specific expression of a polynucleotide of interest.
    Type: Application
    Filed: April 5, 2013
    Publication date: June 19, 2014
    Applicants: The University of Guelph, Syngenta Participations AG
    Inventors: Christophe Liseron-Monfils, Manish N. Raizada, Joseph Colasanti, Gregory Downs, Yong-Mei Bi, Lewis N. Lukens, Steven J. Rothstein, Tong Zhu, Xi Chen
  • Activating extraction of demineralized bone matrix
    Patent number: 8753660
    Abstract: Demineralized bone matric (DBM) and native bone morphogenetic protein (nBMP) are complex mixtures of non-collagenous bone proteins. These mixtures contain many of the BMPs that are available as recombinant molecules. Information regarding the presence in these materials of molecules that may affect the availability and activity of the BMPs is very limited. A chemical extraction of DBM, such as using alkali-urea produces a water soluble extractate which inhibits the osteogenic activity of DBM. Noggin, an extracellular BMP ligand antagonist is found in the water soluble extractate from DBM. Differential chemical extraction is a useful means of removing non-osteogenic, or osteogenic inhibitory molecules from DBM and nBMP.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: June 17, 2014
    Assignees: The Regents of The University of California, The United States of America as Represented by The Department of Veterans Affairs
    Inventors: Keyvan Behnam, Elsa J. Brochmann-Murray, Samuel S. Murray
  • Methods and systems for spatially modulated ultrasound radiation force imaging
    Patent number: 8753277
    Abstract: Methods for determining the shear modulus of a tissue of an individual are disclosed. In one embodiment, an acoustic pulse is transmitted and a reference echo signal is received. A first push pulse is transmitted at a second location of the individual. A second push pulse is transmitted at a third location of the individual. A series of tracking pulses are transmitted at the first location and a tracking echo signal is received from each tracking pulse. The effect of the first and second push pulses on the tissue is determined through analysis of the tracking echo signals. The shear modulus of the tissue is calculated based on the effect of the push pulses on the tissue. A system for imaging a region of tissue is presented.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: June 17, 2014
    Assignee: The University of Rochester
    Inventor: Stephen A. McAleavey
  • Highly selective 5-HT(2C) receptor agonists that show anti-psychotic effects with antagonist activity at the 5-HT(2B) receptor
    Patent number: 8754132
    Abstract: Highly selective 5-HT(2C) receptor agonists receptors are disclosed. The 5-HT(2C) receptor agonists are used in the treatments of disease and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: June 17, 2014
    Assignees: The Board of Trustees of the University of Illinois, The University of North Carolina at Chapel Hill
    Inventors: Alan Kozikowski, Bryan Roth, Andreas Svennebring, Sung Jin Cho
  • Methods of detecting amyotrophic lateral sclerosis (ALS)
    Patent number: 8753818
    Abstract: In one aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising detecting one or more alterations in a profilin 1 (PFN1) sequence of an individual in need thereof compared to a wild type profilin sequence. In another aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising selectively sequencing a profilin 1 (PFN1) sequence of an individual in need thereof; and detecting one or more alterations in the PFN1 sequence of the individual. If the one or more alterations are detected then the individual has ALS.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 17, 2014
    Assignee: The University of Massachusetts
    Inventors: John E. Landers, Robert H. Brown
  • Thermally stable conducting polymers, methods of making, and methods of use thereof
    Patent number: 8753542
    Abstract: Disclosed herein are thermally stable conducting polymers prepared by template polymerization of a conducting monomer in the presence of a sulfonated poly(amic acid). The resulting conducting polymer-sulfonated poly(amic acid) complex can be thermally converted to a conducting polymer-sulfonated poly(imide) complex having high thermal stability and high conductivity. Also disclosed are articles prepared from the thermally stable conducting polymer.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: June 17, 2014
    Assignee: The University of Connecticut
    Inventor: Gregory A. Sotzing
  • Overproduction of ligninolytic enzymes
    Patent number: 8753844
    Abstract: Methods, compositions, and systems for overproducing ligninolytic enzymes from the basidiomycetous fungus are described herein. As described, the method can include incubating a fungal strain of Cerrena unicolor IBB 303 in a fermentation system having growth medium which includes lignocellulosic material and then cultivating the fungal strain in the fermentation system under conditions wherein the fungus expresses the ligninolytic enzymes. In some cases, the lignocellulosic material is mandarin peel, ethanol production residue, walnut pericarp, wheat bran, wheat straw, or banana peel.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: June 17, 2014
    Assignee: The Regents of The University of California
    Inventors: Vladimir Elisashvili, Eva Kachlishvili, Tamas Torok
  • Nanoporous substrates for the analytical methods
    Patent number: 8753897
    Abstract: Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 17, 2014
    Assignees: The Board of Regents of The University of Texas System, The Ohio State Research Foundation
    Inventors: Mauro Ferrari, Mark Ming-Cheng Cheng, Giovanni Cuda, Marco Gaspari, David Geho, Lance Liotta, Emmanuel Petricoin, Fredika Robertson, Rosa Terracciano
  • Semiconductor-nanocrystal/conjugated polymer thin films
    Patent number: 8753916
    Abstract: The invention described herein provides for thin films and methods of making comprising inorganic semiconductor-nanocrystals dispersed in semiconducting-polymers in high loading amounts. The invention also describes photovoltaic devices incorporating the thin films.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: June 17, 2014
    Assignee: The Regents of The University of California
    Inventors: A. Paul Alivisatos, Janke J. Dittmer, Wendy U. Huynh, Delia Milliron
  • Oligo-benzamide compounds and their use in treating cancers
    Patent number: 8754124
    Abstract: The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: June 17, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jung-Mo Ahn, Ganesh Raj
  • Solubilisation of membrane proteins
    Patent number: 8754168
    Abstract: A method is provided for solubilising a membrane protein. The method is applied to cellular material comprising the membrane protein and an associated membrane lipid. A copolymer of styrene and maleic acid, wherein the styrene:maleic acid ratio is between 1:2 and 10:1, is mixed with the cellular material to cause the copolymer, lipid and protein to form soluble macromolecular assemblies.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: June 17, 2014
    Assignee: The University of Birmingham
    Inventors: Timothy Dafforn, Michael Overduin, Timothy Knowles