Patents Assigned to The University
  • Methods for treating ovarian cancer by inhibiting fatty acid binding proteins
    Patent number: 8748470
    Abstract: The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: June 10, 2014
    Assignee: The University of Chicago
    Inventors: Ernst Lengyel, Kristin Nieman, Hilary Kenny
  • 4-phenylpiperazine derivatives with functionalized linkers as dopamine Dreceptor selective ligands and methods of use
    Patent number: 8748608
    Abstract: Dopamine D3 receptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylpiperazine class of ligands, improved D3 receptor affinity and selectivity, as well as water solubility, is achieved. A series of linking-chain derivatives are disclosed wherein functionality such as OH or OAc groups have been introduced into the linking chain. In general, these modifications are well tolerated at D3 receptors and achieve high selectivity over D2 and D4 receptors.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: June 10, 2014
    Assignees: The United States of America as Represented by the Secretary of the Department of Health and Human Services, The University of North Texas Health Science Center at Fort Worth
    Inventors: Amy Hauck Newman, Peter Grundt, George C. Cyriac, Robert Luedtke, Jianjing Cao
  • Methods of treating post-traumatic stress disorder using pro-neurogenic compounds
    Patent number: 8748473
    Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: June 10, 2014
    Assignee: Board of the Regents of The University of Texas System
    Inventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
  • Repairing method, repairing structure and connecting structure of embedded optical fiber of composite material structure
    Patent number: 8746991
    Abstract: A method of repairing an embedded optical fiber of a composite material structure including an embedded optical fiber embedded in a composite material, includes removing a portion of the composite material including a damaged portion of the embedded optical fiber to form an opening portion; polishing an end surface of the embedded optical fiber exposed in the opening portion and an end surface of the composite material exposed in the opening portion; and performing position adjustment such that a core of the polished embedded optical fiber and a core of a replacement optical fiber are aligned with each other, butting the end surface of the embedded optical fiber and an end surface of the replacement optical fiber with each other, and connecting the end surface of the embedded optical fiber and the end surface of the replacement optical fiber together.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: June 10, 2014
    Assignees: The University of Tokyo, Kawasaki Jukogyo Kabushiki Kaisha
    Inventors: Nobuo Takeda, Shu Minakuchi, Tadahito Mizutani, Junichi Kimoto, Noriyoshi Hirano, Hiroaki Tsutsui
  • Asphaltene based photovoltaic devices
    Patent number: 8748740
    Abstract: Photovoltaic devices and methods of making the same are disclosed herein. The cell comprises: a first electrically conductive layer; at least one photoelectrochemical layer comprising metal-oxide particles, an electrolyte solution, an asphaltene dye, and a second electrically conductive layer.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: June 10, 2014
    Assignees: Board of Regents, The University of Texas System, Sandia Corporation
    Inventors: Russell R. Chianelli, Karina Castillo, Vipin Gupta, Ali M. Qudah, Brenda Torres, Rajib E. Abujnah
  • Reversible fuel cell
    Patent number: 8748052
    Abstract: An electricity storage system comprising a reversible fuel cell having a first electrode and a second electrode separated by an ionically conducting electrolyte, and at least two chambers adapted to hold fuel and/or a reaction product, wherein the system is substantially closed and at least one reactant for discharge is hydrogen or oxygen.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: June 10, 2014
    Assignee: The University Court of the University of St. Andrews
    Inventors: John Thomas Sirr Irvine, Julie Margaret Nairn, Paul Alexander Conner, James Rennie, Alan Feighery, Frances Gwyneth Elaine Jones, Kelcey Lynn Eccleston, Pierrot Sassou Attidekou
  • Methods, systems, and computer readable media for automatically generating customizable user interfaces using programming patterns
    Patent number: 8752011
    Abstract: Methods, systems and computer readable media for automatically generating customizable user interfaces using programming patterns are disclosed. According to one method, application objects of an application computer program are analyzed to identify programming patterns. Each programming pattern is a relationship among signatures of application methods in one of the application objects. The signatures of the application methods include public interfaces of the application methods. A user interface is automatically generated for the computer program. Automatically generating a user interface includes providing for at least one of a user and a programmer of the computer program to customize mappings between the application objects and user interface elements, where the user interface elements include at least one of user interface widgets and speech grammar rules.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: June 10, 2014
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Prasun Dewan, Olufisayo Omojokun
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20140155587
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Application
    Filed: February 11, 2014
    Publication date: June 5, 2014
    Applicant: The University of Western Australia
    Inventors: Stephen Donald WILTON, Sue Fletcher, Graham McClorey
  • ANTIFUNGAL COMPOUND AND USES THEREOF
    Publication number: 20140155478
    Abstract: Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.
    Type: Application
    Filed: December 3, 2013
    Publication date: June 5, 2014
    Applicant: The University of Hong Kong
    Inventors: Chaminda Jayampath SENEVIRATNE, Yi Tsun Richard KAO, Lakshman Perera SAMARANAYAKE, Kwok Yung YUEN, Dan YANG, Yu WANG, Sze Wah Sarah WONG
  • Adaptive automatic exposure apparatus and method for digital images
    Patent number: 8743235
    Abstract: An apparatus and method for automatically adjusting an exposure for a digital imaging device by (a) receiving a current image frame using an exposure value (EV), (b) computing a current image spatial entropy (ISE) for the current image frame, and (c) whenever the current ISE is greater than a previous ISE, setting the previous ISE equal to the current ISE, increasing the EV, and repeating steps (a) and (b), and (d) whenever the current ISE is less than or equal to the previous ISE, decreasing the EV, receiving the current image frame using the EV, and displaying the current image frame.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: June 3, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nasser Kehtarnavaz, Mohammad T. Rahman
  • Rapid method to measure cyanide in biological samples
    Patent number: 8741658
    Abstract: A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: June 3, 2014
    Assignees: The Regents of the University of California, Board of Regents, The University of Texas System
    Inventors: Gerry Boss, Vijay Sharma, Matthew Brenner, Purnendu K. Dasgupta, William Curt Blackledge
  • Portable ultrafine particle sizer (PUPS) apparatus
    Patent number: 8739602
    Abstract: The Portable Ultrafine Particle Sizer (PUPS) invention is provided. The PUPS is an instrument which can measure particle number concentration for particle sizes under 200 nanometers in-situ. The PUPS is a compact design for quick mounting on vehicles. Size discrimination is accomplished using a compact reverse Differential Mobility Analyzer (rDMA). Particle charging is accomplished using corona ionization. Concentration measurements are completed using a unique flexible printed circuit board electrode which can be removed for cleaning, disposal or chemical analysis of collected particles at the end of its in situ measurement life.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: June 3, 2014
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Andrew Vize, Matthew Casari, Britt Holmen, Jeff Frolik
  • CMOS linear differential distributed amplifier and distributed active balun
    Patent number: 8742851
    Abstract: A CMOS distributed amplifier with distributed active input balun is disclosed. Each gm cell within the distributed amplifier employs dual-output two-stage topology that improves gain and linearity without adversely affecting bandwidth and power.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: June 3, 2014
    Assignee: The Regents of The University of California
    Inventors: Amin Jahanian, Payam Heydari
  • Visualization processing method and apparatus with mask surface
    Patent number: 8743123
    Abstract: This method includes: generating data of a mask surface with respect to visualization data arranged in a virtual three-dimensional space, for calculation values at respective calculation points; identifying, from a first data storage storing, as time-series data, positions of the calculation points and calculation values at the calculation points, a first point whose position is closest to a predetermined point on the mask surface; reading out, from the first data storage, a position of the identified first point in each time; arranging the mask surface in each time based on a direction of a user's sight line and the read position in each time so as to make the mask surface perpendicular to the direction of the user's sight line and have the predetermined point on the mask surface arranged at the read position; and drawing polygon data of the visualization data and the mask surface in time series.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: June 3, 2014
    Assignees: Fuhitsu Limited, The University of Tokyo
    Inventors: Masahiro Watanabe, Toshiaki Hisada, Seiryo Sugiura, Takumi Washio, Jun-ichi Okada, Yoshimasa Kadooka
  • Moisture sensors on conductive substrates
    Patent number: 8739623
    Abstract: A moisture sensor includes a first electrode (a conductive substrate) having a first sensor portion and a first terminal portion as well as a second electrode having a second sensor portion and a second terminal portion. The moisture sensor also includes a layer of porous dielectric material sandwiched between the first sensor portion and the second sensor portion. Further the moisture sensor includes a layer of dense insulating material sandwiched between the first terminal portion and the second terminal portion. Leads are then connected to the two terminal portions.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: June 3, 2014
    Assignee: The University of Kentucky Research Foundation
    Inventors: Zhi David Chen, Ibrahim Yucedag
  • Reproducing apparatus, reproducing method, and storage medium
    Patent number: 8744244
    Abstract: Disclosed is a reproducing apparatus which reproduces a sound based on audio data, including: an audio data storage unit; an analyzing unit to analyze the audio data; an imaging unit to convert the analysis result into corresponding image data; a generating unit to generate an audio image arrangement diagram in which an audio image is arranged to a relative time axis originating on a current time; and a display control unit to display the audio image arrangement diagram when a sound based on the audio data is output, wherein in the audio image arrangement diagram, an audio image output at a current time point can be recognized, and the audio image arrangement diagram includes an audio image of any one time zones of one from the current time to a past, from the current time to a future, and from a past to a future.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: June 3, 2014
    Assignees: The University of Electro-Communications, Funai Electric Co., Ltd.
    Inventors: Kota Takahashi, Yasuo Masaki
  • Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
    Patent number: 8741838
    Abstract: A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: June 3, 2014
    Assignee: The University of Chicago
    Inventors: F. Gary Toback, Terence E. Martin, Margaret M. Walsh-Reitz
  • Three-dimensional wafer stacking with vertical interconnects
    Patent number: 8741737
    Abstract: Described are three-dimensional stacked semiconductor structures having one or more vertical interconnects. Vertical stacking relies on vertical interconnects and wafer bonding using a patternable polymer. The polymer is preferably lithographically patternable and photosensitive. Curing of the polymer is preselected from about 35% to up to about 100%, depending on a desired outcome. When fabricated, such vertically stacked structures include electrical interconnects provided by solder reflow. Solder reflow temperature is bounded by a curing and glass transition temperatures of a polymer used for bonding.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: June 3, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Dan O. Popa, Rachita Dewan, Praveen Pandojirao-Sunkojirao, Jung-Chih Chiao
  • No-carrier-added nucleophilic [F-18] fluorination of aromatic compounds
    Patent number: 8742139
    Abstract: Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No-carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F-18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F-18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F-18]fluoro-L-dopa.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: June 3, 2014
    Assignee: The Regents of The University of California
    Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio
  • Chimeric isoprenoid synthases and uses thereof
    Patent number: 8741651
    Abstract: Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: June 3, 2014
    Assignee: The Board of Trustees of The University of Kentucky
    Inventors: Joseph Chappell, Kyoungwhan Back