Abstract: In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess iron from the body, for example in the treatment of iron overload. The NGAL mutants of the invention also have antibacterial activity and can be used in the treatment of bacterial infections, such as those of the urinary tract.

Abstract: The present disclosure discusses systems and methods for imaging tissue. The system can reduce the amount of vibrations that are transmitted from a magnetic resonance imaging device to a tissue sample. The system can include a stabilization platform with at least one vibration dampener coupled towards either end of the stabilization platform. A fluid reservoir is coupled to the stabilization platform and a resonator is coupled to the exterior of the fluid reservoir.

Abstract: A mechanochromic system comprising a first inorganic/polymer composite layer; and a first elastomer layer bonded to the composite layer to form a composite/elastomer assembly, methods of making, and methods of use thereof are provided.

Abstract: Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

Abstract: An electret element includes: an Si layer, an SiO2 layer formed at a surface of the Si layer; and an electret formed at the SiO2 layer near an interface of the SiO2 layer and the Si layer.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Abstract: Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed herein are methods for analyzing these images to infer cellular and molecular structure in each of these habitats. The methods can involve spatially superimposing two or more radiological images of the tumor sufficient to define regional habitat variations in two or more ecological dynamics in the tumor, and comparing the habitat variations to one or more controls to predict the severity of the tumor.

Abstract: A single-stage multi-input forward DC-DC chopper type high-frequency link's inverter with series simultaneous power supply includes a multi-input single-output combined isolated bidirectional forward DC-DC chopper, a plurality of input filters connected to non-common ground and a common output filter circuit. The plurality of input filters and the output filter circuit are connected by the multi-input single-output combined isolated bidirectional forward DC-DC chopper. Each input end of the multi-input single-output combined isolated bidirectional forward DC-DC chopper is connected to output ends of each input filter in a one-to-one correspondence. The output ends of the multi-input single-output combined isolated bidirectional forward DC-DC chopper are connected to the output filter circuit. The inverter has multiple input sources connected to non-common ground, the power is supplied in a time-sharing or simultaneous manner, a high-frequency electrical isolation is performed between the output and the input.

Abstract: A rotary motor capable of reducing repulsive force is disclosed. The rotary motor comprises a housing, a stator located in the housing and configured to have a shape of a cylinder on which a central part is penetrated, and a rotator configured to rotate in the stator. Here, the stator rotates clockwise or counterclockwise.

Abstract: The present invention discloses a synchronization method for multi-station data of dynamic coordinate measurement by a workshop measuring and positioning network. The method comprises the following steps of: determining a measuring and positioning space according to the in-situ measurement dimension, selecting locations for placing several transmitters, calibrating external parameters of the transmitters by a reference ruler, and establishing a measurement field; in a communication data packet of a signal processor, attaching local clock information into the angle information of each transmitter; and setting fixed time nodes on a time axis, and synchronizing data of different transmitters to corresponding time nodes so as to realize data synchronization.

Abstract: An additive manufacturing system, method of manufacturing, and fabricated part. The system uses a material joining laser system to join together foil sheets to form a metal part. The material joining laser system can be configured to join adjacent foil sheets together in a substantially uniform manner. The manufacturing system also includes a material removal system that removes material from selected locations of the foil sheets to shape the foil sheets to correspond with selective slices of the part. The material removal system can be a laser system, such as a laser system configured to remove material from a foil sheet without removing material from an underlying layer. One embodiment involves the manufacture of amorphous alloy components.

Abstract: A motor includes a rotor used in conjunction with a stator to produce a magnetic field in the air gap having p pole pairs, wherein a single cross section of the rotor taken orthogonal to an axis of rotation comprises iron having a structure forming p teeth. The stator has at least one stator winding configured to form p pole pairs to produce a first magnetic field to rotate the rotor about the axis of rotation and configured to produce a second magnetic field of either one pole pair or p±1 pole pairs to create forces radial to the axis of rotation. The at least one stator winding has two sets of terminals, a first set of terminals for carrying current that produces the first magnetic field in the air gap having p pole pairs to rotate the rotor about the axis of rotation and a second set of terminals for carrying current that produces the second magnetic field in the air gap having either one pole pair or p±1 pole pairs to create the forces radial to the axis of rotation.

Abstract: In an aspect, a sensor includes a combining portion 240 that combines with a second substance 220 having a molecular weight larger than a molecular weight of a first substance 210. Further, in an aspect, the sensor includes a substrate 10 including a surface on which the combining portion 240 is disposed, the combining portion 240 detecting whether or not the first substance 210 is included in an analyte that has come into contact with both an aptamer 230 including a first combining part 231 for the first substance 210 and a second combining part 232 for the second substance 220 and being combined with either of the first substance 210 and the second substance 220 and the second substance 220.

Abstract: The present invention is directed to methods comprising a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The nanotubes have a passage extending between an input end proximate to the bioreactor chamber and an output end distal to the bioreactor chamber, and comprises one or more nanopores within the passage with each nanopore having a reduced diameter relative to the passage.

Abstract: A device for calculating construction assistance information includes: an acquisition unit that acquires, from a vibratory hammer construction machine, information that contains at least values indicating a eccentricity force of a vibratory hammer which the vibratory hammer construction machine imparts to a construction object, the number of impacts, and a depth of penetration of the construction object; and a calculation unit that calculates a accumulated impact force indicating a work load of construction on the basis of the information acquired by the acquisition unit.

Abstract: The present disclosure discloses a production method of Danshensu, belonging to the technical field of bioengineering. The present disclosure constructs a novel genetic engineering strain co-expressed by three enzymes, which can be applied to the production of optically pure 3-(3,4-dihydroxyphenyl)-2-hydroxypropionic acid. All of the (D/L)-?-hydroxycarboxylic acid dehydrogenase selected by the present disclosure have the characteristics of poor substrate specificity and strong optical specificity, and can produce optically pure D-danshensu and L-danshensu. Further, the production efficiency of the recombinant strain is improved by knocking out or enhancing the expression of a related gene on the E. coli genome to promote substrate transport and reduce product decomposition.

Abstract: A streakline visualization apparatus sets a partial region including a discrete point at a first position on a first streakline in an analysis space as an analysis target region of the discrete point. Based on a velocity of fluid in the analysis target region indicated by fluid information, the apparatus calculates a second position indicating a destination of a particle on the discrete point at a second analysis time point. Next, based on information about a structure in the analysis target region indicated by structure information, the apparatus determines a region occupied by the structure in the analysis target region at the second analysis time point. Next, based on the first and second positions, the apparatus determines whether a second streakline has entered the occupied region. If the second streakline has not entered the occupied region, the apparatus displays the second streakline passing through the second position.

Abstract: The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b E, and = are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.

Abstract: A beam alignment method for an antenna array is provided. In the method, a base station uses multi-modal beam patterns for transmitting several synchronization signals. User equipment scans the synchronization signals, determines a synchronization signal with the strongest received power and a receive beam direction corresponding thereto, and transmits an initial access message including index information indicating the strongest synchronization signal.

Abstract: The invention provides novel antibacterial diamide compounds, pharmaceutical compositions comprising the compounds and methods for treating or preventing an infection in a subject using the compounds.