Abstract: A method for sampling and/or introducing a matter to an environment comprises introducing a first array of plugs through a first microchannel of a device into an exchange region of the device in which mass transport between the environment and the plug fluid of at least one plug in the first array of plugs occurs and a second array of plugs is formed. The exchange region is in fluid communication with the first microchannel. The method further comprises directing the second array of plugs into a second microchannel downstream of and in fluid communication with the exchange region.

Abstract: A computer-readable recording medium stores a visualization program that renders an internal organ and causes a computer to execute a process that includes generating along an input normal vector, a given stereoscopic shape; calculating an overlapping portion that overlaps the given stereoscopic shape and the shape of the internal organ; changing a degree of transparency of the overlapping portion; and rendering the shape of the internal organ to include the overlapping portion for which the degree of transparency has been changed.

Abstract: A method of preparing a DNA copy of a target polynucleotide using template switching is described. The method includes mixing a double stranded template/primer substrate made up of a DNA primer oligonucleotide associated with a complementary oligonucleotide template strand with a target polynucleotide in a reaction medium and adding a suitable amount of a non-retroviral reverse transcriptase to the reaction medium to extend the DNA primer oligonucleotide from its 3? end to provide a DNA copy polynucleotide. The DNA copy polynucleotide includes a complementary target DNA polynucleotide that is synthesized using the target polynucleotide as a template. Methods of adding nucleotides to the double stranded template/primer substrate are also described. The method can be used to facilitate detection, PCR amplification, cloning, and determination of RNA and DNA sequences.

Abstract: The present invention relates to a therapeutic agent for malignant mesothelioma comprising a substance which inhibits binding of CD26 to extracellular matrix such as an siRNA targeting CD26 cDNA or an anti-CD26 antibody. The present invention also relates to a method of treating malignant mesothelioma, which comprises administering the substance to a patient in need thereof.

Abstract: A dinuclear zinc complex PPi sensor is provided, that may be represented by the formula where X is hydrogen, —COOEt, —CH?CH2, —OR, or —NR2, wherein X is a monovalent organic group having from 1 to about 20 carbon atoms. A method of preparing the dinuclear zinc complex PPi sensor is also provided. Methods for detecting PPi in an aqueous solution and methods for pyrosequencing by using the dinuclear zinc complex are described.

Abstract: A method, system, or computer program product to enhance the performance of multi-hop cellular networks or other wireless networks is provided. A wireless device (e.g., cellular telephone) is able to communicate with a base-station in a cell of the cellular network over a non-cellular interface via another wireless device in the cell through the use of multi-hopping. By enabling wireless devices to communicate with a base station in such a manner, the effective coverage area of the cellular network is expanded and the effective capacity of the cellular network is improved. Distributed routing, device management, adaptive scheduling, and distributed algorithms can be used to enhance the overall performance of multi-hop cellular networks.

Abstract: The present invention generally relates to alcohol-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes, to polyurethane compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to primary alcohol-terminated polyisobutylene compounds having two or more primary alcohol termini and to a process for making such compounds. In yet another embodiment, the present invention relates to primary terminated polyisobutylene compounds having two or more primary termini selected from amine groups or methacrylate groups.

Abstract: The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including for the treatment of demyelinating diseases and/or in vivo imaging of the central nervous system to diagnose and/or assess the progression of MS or other diseases.

Abstract: Compositions and methods for targeted delivery to and detection of sites of neovascular growth, including tumor vasculature, are provided. Compositions include polypeptides conjugated to or complexed with a bioactive compound, wherein the polypeptide is capable of binding to an OEC or a circulating progenitor thereof. Methods for identifying additional polypeptides with the same binding characteristics are further provided. Methods for targeted delivery of a bioactive compound to a site of neovascular growth are provided in which polypeptides capable of binding OECs or progenitors thereof are conjugated to or complexed with the bioactive compound and administered to a subject in need thereof. Methods for detecting neovascular growth are also provided, wherein the polypeptides conjugated to or complexed with a detectable label are administered to a subject and the label is detected.

Abstract: A method of purifying a nanodiamond powder includes preparing the nanodiamond powder, heating the nanodiamond powder at between 450° C. and 470° C. in an atmosphere including oxygen, performing a hydrochloric acid treatment on the heated nanodiamond powder, and performing a hydrofluoric acid treatment on the nanodiamond powder obtained after performing the hydrochloric acid treatment.

Abstract: A photovoltaic (PV) system includes a fiber optical waveguide comprising an active core that hosts material configured to absorb and emit light, a cladding layer surrounding the active core, the cladding layer being configured to allow ambient light to pass through the cladding layer, and an exit port located proximate an end of the waveguide. The PV system further comprises one or more solar cells disposed at the exit port of the waveguide. The waveguide is configured to guide light to the one or more solar cells. Another photovoltaic (PV) system includes a waveguide comprising an active cladding layer hosting material configured to absorb and emit light, and a core layer configured to confine light emitted by the active cladding layer. The PV system further includes one or more solar cells disposed proximate the waveguide. The core layer is configured to guide light to the one or more solar cells.

Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

Abstract: Embodiments of apparatuses, systems, and methods for label-free detection of biomolecules. In one embodiment, a system includes a light source configured to emit broadband Gaussian light. The system may also include an optical fiber coupled to the light source. Additionally, the system may include an optical sensor. The optical sensor may include a fiber-interface surface configured to be coupled to the optical fiber and to receive broadband Gaussian light from the optical fiber. The optical sensor may also include a sensor body coupled to the fiber-interface surface, the sensor body having a refractive index different from a refractive index of the optical fiber, such that at least a portion of light received by the fiber-interface surface is reflected back to the optical fiber during use; and a binder-interface surface coupled to the sensor body, the binder-interface surface configurable to receive a chemical binder layer.

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.

Abstract: A system is provided for detecting, analyzing and quarantining unwanted files in a network environment. A host agent residing on a computing device in the network environment detects a new file introduced to the computing device and sends the new file to a network service for analysis. The network service is accessible to computing devices in the network environment. An architecture for the network service may include: a request dispatcher configured to receive a candidate file for inspection from a given computing device in the network environment and distribute the candidate file to one or more of a plurality of detection engines, where the detection engines operate in parallel to analyze the candidate file and output a report regarding the candidate file; and a result aggregator configured to receive reports from each of the detection engines regarding the candidate file and aggregates the reports in accordance with an aggregation algorithm.

Abstract: The present invention provides for methods of treating cognitive deficits resulting from interruption of blood supply and/or oxygen deficit by administering a therapeutically effective dose of a sulfonyl fluoride, such as methanesulfonyl fluoride and ethanesulfonyl fluoride. The underlying cause of the or oxygen deficit can be from stroke, trauma, carbon monoxide poisoning, and other poisonings. This method also includes co-administering with sulfonyl fluoride with a therapeutically effective dose of a second agent.

Abstract: A rapid and sensitive analyte detection assay is based on whispering gallery modes of fluorescently labelled microspheroidal particles. Ligands for the analyte, such as nucleic acids, are anchored to the particles. The fluorescent labels may comprise fluorophores or quantum dots. In the latter case, the particles may comprise melamine formaldehyde. The assay may be used to detect analytes in aqueous samples.

Abstract: A surface with a low work function is formed from a starting material of diamond or diamond-like carbon. An oxygenation treatment is performed, so that the surface of the diamond or diamond-like carbon is oxygenated. Lithium is then deposited onto the oxygenated surface by means of a physical vapour deposition process. Excess lithium is then removed to form a lithium monolayer.

Abstract: An optical noise monitoring method and monitor, the monitor comprising an optical transmitter for receiving at least a portion of an optical signal, a device arranged to extract a reflected optical signal comprising a portion of the optical signal back-reflected by stimulated Brillouin scattering in the optical transmitter, and a photodetector for receiving the reflected optical signal. The optical transmitter can scatter the optical signal by stimulated Brillouin scattering.

Abstract: The present application relates to systems and methods for altering temperature in a mammalian body. Optionally, the systems and methods can be used to lower or raise core body temperature of a mammalian subject. Optionally, the systems and methods can be used to lower or raise the temperature of glabrous skin of a mammalian subject.