Abstract: This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenated acetoacetate and a biocatalyst solution in the micro-reaction system composed of a micro-mixer, a micro-channel reactor, and a pH regulator to obtain the (R)-4-halo-3-hydroxy-butyrate. Compared to the prior art, the reaction time of the method is only a few minutes, the yield of the product (R)-4-halo-3-hydroxy-butyrate is greater than 95%, the reaction process is continuous, the degree of automation is high, the efficiency is high, and the process is simple to operate and easy to be used in industrialized production.

Abstract: The present disclosure to an electrolyte membrane containing a polyfluorene-based ionomer, and more particularly, to an electrolyte membrane containing a polyfluorene-based ionomer which has a fluorene main chain composed of only a carbon-carbon bond and a side chain composed of a perfluorosulfonic acid group. The electrolyte membrane containing the polyfluorene-based ionomer has high proton conductivity, excellent chemical durability, excellent mechanical property, and excellent volume stability.

Abstract: An RF catheter for treating hypertrophic cardiomyopathy includes: a body part constituting a catheter body made of a flexible and soft material; and an intraseptal insertion part provided at a distal part of the body part and having one or more electrodes, a tapered tip gradually becoming thinner toward an end thereof, and a guidewire lumen therein, into which a guidewire is inserted, so that during hypertrophic cardiomyopathy treatment, the intraseptal insertion part is inserted into the interventricular septum along the guidewire. A method of treating hypertrophic cardiomyopathy by using an RF ablation catheter includes: i) positioning the guidewire to a hypertrophied septum through a coronary sinus and a septal vein; ii) transferring the RF ablation catheter to the hypertrophied septum; and iii) performing RF ablation by applying RF energy to the electrodes provided at an end part of the RF ablation catheter by using an RF generator.

Abstract: Provided herein are novel polypeptides, methods for their production and uses thereof.

Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin through equilibrium or enforced adsorption technique. Methods for dual delivery of SPIONs and curcumin to a target for diagnosis or therapy, for example, for SPION-based magnetic resonance imaging or for targeted delivery of curcumin to a cell or tissue. The technique can be extend to co-precipitation of mixed metal oxide involving Ni, Mn, Co and Cu oxide. The calcination temperature can be varied from 500-900° C. The nanocombination is functionalized with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility in vivo.

Abstract: A receiver system and a method for receiving a transmitted signal via a long-range link. The system comprises a plurality of interconnected devices in a short-range network, the plurality of devices including at least one main device and one or more assisting devices, the at least one main device and the one or more assisting devices each configured to receive the transmitted signal via the long-range link; wherein the one or more assisting devices are configured to transmit a relayed signal representing the received transmitted signal at the assisting device to the at least one main device via the short-range network; and wherein the at least one main device is configured to generate output data representing the content of the transmitted signal based on the transmitted signal received at the at least one main device and the one or more relayed signals received from the one or more assisting devices.

Abstract: The subject pertains to systems, methods, and devices to provide improved teamwork guidelines for collaborators in geographic simulation experiments, whereby the collaborators can be led to participate in the geographic simulation tasks according to the teamwork guideline and be instructed to implement the simulation tasks to achieve their goals. The invention can automatically recommend appropriate geographic simulation schemes for specific geographic problems and communicate simulation task information and dependencies. Novel guide cards can instruct teamwork in geographic simulation experiments. Thus, the cards can advantageously instruct, promote, or guide teamwork in geographic simulation experiments and enhance the efficiency of geographic problem-solving.

Abstract: An auxin-degron system kit controlling degradation of a target protein in a non-plant-derived eukaryotic cell, in which the auxin-degron system kit includes a first nucleic acid encoding a mutant TIR1 family protein that has a mutation at an auxin-binding site; an auxin analog having an affinity for the mutant TIR1 family protein; and a second nucleic acid encoding a degradation tag that includes at least a partial Aux/IAA family protein and has an affinity for a complex of the mutant TIR1 family protein and the auxin analog.

Abstract: The disclosure relates to a vertical field effect transistor, and a manufacturing method thereof. The vertical field effect transistor according to an embodiment may include: a substrate; a source region, an insulating layer, and a drain region stacked vertically on the substrate; and a tunnel barrier, an active region, a gate barrier, and a gate region are stacked to surround a top surface of the substrate, and the source region, the insulating layer, and the drain region vertically stacked.

Abstract: The present disclosure provides a method for evaluating a geological storage amount of carbon dioxide (CO2) in a fractured-vuggy carbonate reservoir, including: performing image identification on a three-dimensional scanned image of a rock sample to obtain identified rock information; inputting the identified rock information to a computational fluid dynamics-based numerical simulator for constructing a fractured-vuggy rock structure model, and obtaining geometric topological information of the rock sample based on the fractured-vuggy rock structure model; inputting relevant parameters of the rock sample and the geometric topological information to a multi-scale multi-phase flow numerical model for numerical simulation of multi-phase flow migration of CO2 in models of different scales and obtaining a multi-scale numerical simulation result; and calculating a multi-scale CO2 storage efficiency based on the multi-scale numerical simulation result.

Abstract: The present invention provides a comprehensive assay capable of comprehensively measuring interactive factors for a variety of different types of proteins. In the present invention, provided is a system for detecting activation of a protein by integrating, with mediation of a plurality of factors, changes in the transcriptional regulatory region of a gene whose expression is changed by activation of the protein. The stimulation response ratio of transcription activity before and after stimulation by ligands possessed by individual transcriptional regulatory regions is synergistically integrated, so that a highly sensitive reporter assay system can be constructed.

Abstract: According to one embodiment, an organo-ionic hydrogel foam, includes: a MXene foam comprising MXene and having a three-dimensional framework structure; and an organo-ionic hydrogel coating a portion of the MXene foam. A dry-state region not coated by the organo-ionic hydrogel is positioned over a wet-state region coated by the organo-ionic hydrogel.

Abstract: The present disclosure relates to a stretchable display and a method of manufacturing the same. The stretchable display according to one embodiment includes a stretchable substrate; a plurality of pixel islands formed on the stretchable substrate, wherein each of the pixel islands includes at least one thin-film transistor and one micro-LED; a plurality of pixel wires formed based on a liquid metal and connecting adjacent pixel islands among the pixel islands to each other; and a plurality of bus wires formed based on the liquid metal and connected to at least one pixel island among the pixel islands.

Abstract: The present disclosure discloses a computing-aware traffic steering method, apparatus and system in a mobile network. According to the present disclosure, there is provided a computing-aware traffic steering method of mobile network control plane, the method including in a case where it is confirmed that there is no target data network access identifier (DNAI) mapped to a service ID when a PDU session establishment request including the service ID of a user equipment (UE) is made, transmitting the service ID and user plane path information to a CATS controller in a computing-aware traffic steering (CATS) network environment using segment routing, and reconfiguring a user plane path for accessing an optimal service contact instance IP address determined as one of a plurality of service contact instances based on a base station connected by the UE and computing and networking metrics in conjunction with the CATS controller.

Abstract: A system for conditionally tracing an anonymous transaction is provided, and cryptography technology is used to add tags to transaction-related information, and relies on implicit tags to achieve transaction traceability. In addition, based on the secret sharing idea, the information of reconstructed users' real transactions is divided, and differentiated information reconstruction methods are used to reduce the probability of collusion attacks, prevent the full scope of supervision without restriction, and reduce the traceability cost.

Abstract: A system of underwater swarm of robotic fish for monitoring and telepresence. The system comprising a floating platform communicatively coupled to a controller, a submersible sinker communicatively coupled to the floating platform, and a plurality of underwater drones communicatively coupled to the submersible sinker. The controller is configured to receive instructions from an operator for remotely exploring an underwater environment using the submersible sinker and the plurality of underwater drones, transmit the instructions to the plurality of underwater drones via the floating platform and the submersible sinker, the instructions directing the plurality of underwater drones to navigate the underwater environment and collect data, receive the collected data from the plurality of underwater drones via the floating platform and the submersible sinker, and display the collected data to the operator via a virtual display.

Abstract: A method of generating hydrogen including applying a potential of greater than 0 to 2.0 V to an electrochemical cell that is partially submerged in an aqueous solution. On applying the potential, water in the aqueous solution is reduced, and thereby forms hydrogen. The electrochemical cell includes an electrocatalyst and a counter electrode. The electrocatalyst includes a substrate, WO3?x nanosheets, and CdS1?y nanospheres, in which, x is from greater than 0 to less than 3 and y is from greater than 0 to less than 1. The CdS1?y nanospheres are dispersed on the WO3?x nanosheets to form a nanocomposite, which is dispersed on a surface of the substrate. The WO3?x nanosheets have an average length of 600-800 nanometers (nm) and an average width of 300-500 nm, and the CdS1?y nanospheres have an average diameter of 10-50 nm.

Abstract: A new and distinct Corylus avellana plant is disclosed, distinguished by its low vigor, globose growth habit, production of nuts with round kernels that fall free of the husk at maturity, resistance to eastern filbert blight and big bud mite, S-alleles, nut size, kernel percentage, frequency of nut defects, time of pollen shed, and length of the husk or involucre.

Abstract: A method of producing a charred sludge material includes combining automotive paint sludge (APS) with a lignin to form an APS-lignin mixture and turning the APS-lignin mixture into char.