Abstract: An instrument for analyzing ions may include an ion source to generate ions, at least one ion processing instrument to process the generated ions by one or both of filtering the ions according to a molecular characteristic and dissociating the ions, and an electrostatic linear ion trap (ELIT) to receive and trap ions exiting the at least one ion processing instrument. The ELIT has first and second ion mirrors separated by a charge detection cylinder, and is configured such that trapped ions oscillate back and forth through the charge detection cylinder between the first and second ion mirrors with a duty cycle, corresponding to a ratio of time spent by the trapped ions traversing the charge detection cylinder and total time spent by the trapped ions traversing a combination of the first and second ion mirrors and the charge detection cylinder during one complete oscillation cycle, of approximately 50%.

Abstract: A terahertz modulator includes a substrate and an organic semiconductor layer. A material of the organic semiconductor layer is graphitic carbon nitride, and the organic semiconductor layer is coated on a surface of the substrate. The terahertz modulator has a high on-off contrast and is able to reach a high modulation speed. A terahertz spatial light modulator includes a terahertz modulator and an automatic pumped light spatial modulator. The automatic pumped light spatial modulator is optically connected with the terahertz modulator. The terahertz spatial light modulator generates a patterned terahertz light, and the terahertz spatial light modulator has a high on-off contrast and is able to reach a high modulation speed.

Abstract: The effervescent tablet for enhanced oil recovery is made of multi-walled carbon nanotubes (MWCNTs), sodium dodecyl sulfate (SDS), sodium phosphate monobasic (NaH2PO4), and sodium carbonate (Na2CO3). To perform enhanced oil recovery, a suspension is first prepared by adding the effervescent tablet to water. This preparation may be performed at room temperature. Steam is then injected into the oil well, followed by flooding the oil well with the suspension. One-third of the pore volume of an oil reservoir of the oil well may be injected with the steam, and two-thirds of the pore volume of the oil reservoir may be flooded with the suspension.

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

Abstract: In various embodiments, the present invention is directed to a facile one-pot reverse emulsion process to assemble core-shell nanoparticles (CS-SMNPs) into bright and noniridescent photonic supraballs. In one or more embodiments, the present invention is directed to core-shell nanoparticles having an inner high refractive index (RI) core and an outer low RI shell. In one or more embodiment, the present invention includes core-shell nanoparticles using high RI (˜1.74) melanin cores and low-RI (˜1.45) silica shells. In various embodiments, these nanoparticles may be self-assembled into bright and noniridescent supraballs using a scalable one-pot reverse emulsion process. According to various embodiments of the present invention, it is possible to generate a full spectrum of structural colors with the combination of only two ingredients, synthetic melanin and silica.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: A polymer three-dimensional (3D) printing methodology is disclosed for freeform fabrication of polymeric structures under ambient conditions without the use of printed support structures. The build material can be dissolved in a suitable solvent for 3D printing. The polymer solution can be printed in (e.g., continuously printed using a moving dispensing nozzle) a yield-stress support bath to form an intermediate article. The intermediate article may be liquid or only partially coagulated after being printed into the yield-stress support bath. The yield-stress support bath may be at least partially disposed within a container, and the container may be immersed in a post-treatment coagulation solution to remove some or all of the solvent, causing the build material to fully solidify to form a finished article from the intermediate article.

Abstract: In some embodiments, the systems and methods of the disclosure can efficiently and accurately classify neurodegenerative disorder(s) and/or movement disorder(s) of a subject (e.g., a patient) using at least quantitative features associated with one or more regions of interest determined from one or more sets of image data of the subject's brain. The method may include processing one or more sets of MRI image data of the subject's brain to extract one or more quantitative features for one or more regions. The one or more quantitative features may include a first quantitative and a second quantitative feature. The method may further include classifying at least the one or more quantitative features into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder and/or heathy control. The method may include generating a report including a classification of at least the one or more quantitative features.

Abstract: This present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for identifying optimized temporal patterns of spinal cord simulation (SCS) for minimizing variability in patient responses to SCS. The systems and methods of neuromodulation disclosed herein facilitate the treatment of neuropathic pain associated with various disease states and clinical indications.

Abstract: An apparatus for managing delegation consensus of a blockchain network, obtains state information including trust of each delegated node in the current epoch of the blockchain network, determines an action including a delegation rate by performing a neural network operation on the state information, creates, according to the determined action, a local trust opinion (hereinafter, LTO) matrix representing a mutual subjective evaluation of each delegated node, and selects, based on the trust calculated using the LTO matrix, K delegated nodes according to the determined delegation rate among N nodes.

Abstract: A stamping assembly includes an upper die, a lower die, first pins and second pins. Each of the upper and lower dies has columns of depressions and columns of guiding holes. Each column of the guiding holes is disposed between two adjacent columns of the depressions. The depressions of one of the upper and lower dies are registered with the guiding holes of another one of the upper and lower dies. The first pins and second pins are respectively positioned in the guiding holes of the upper and lower dies and extend outwardly. The first pins and the second pins are respectively arranged into first and second matrices.

Abstract: Provided is an otitis media treatment instrument and, more particularly, to an otitis media treatment instrument having a ventilation tube installed thereon, the otitis media treatment instrument including: a cutting sheath which is configured in a tube shape, and which has an inner diameter larger than the outer diameter of the ventilation tube; and a suction pipe formed to be able to move relative to the cutting sheath inside the cutting sheath along the longitudinal direction of the cutting sheath, the suction pipe having, on the front end portion thereof, an insertion portion having an outer diameter smaller than the inner diameter of the ventilation tube and having a fixing portion which extends toward the front end of the insertion portion, and which has an outer diameter larger than the inner diameter of the ventilation tube.

Abstract: Nanoscopic dispersion of trace enzymes and random heteropolymers in plastics provides to fully functional plastics with eco-friendly microplastic elimination and programmable degradation.

Abstract: The invention provides a complex comprising Zn2+ and a compound of formula (I): or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt thereof that is useful for treating cancer, as well as compositions and kits comprising such complexes.

Abstract: A cyber-physical integrated restoration method and system for distribution systems based on emergency mobile communications are provided. After extreme natural disasters which cause serious damage to distribution systems, damages of distribution systems are evaluated through system feedback data. When ground communication base stations are unavailable due to the damages, the method can make full use of existing wireless emergency communication resources to provide emergency communication services, and quickly restore the power supply through distribution automation functions with supports of the backup battery of automatic terminal devices, so as to effectively improve the resilience of distribution systems.

Abstract: The present disclosure provides a method for predicting a water invasion frontier for a complex well in a bottom-water gas reservoir. The technical solution is as follows: with consideration of forms of different well types and a gravitational pressure drop in production, a coupled permeability of a corresponding well type acting on a gas-water interface under the action of a baffle plate is expressed by using an equivalent percolation resistance method; a productivity of each infinitesimal section of the corresponding well type is calculated; a position of the gas-water interface is calculated with an equivalent permeability and a pseudo-productivity as characteristic parameters; water breakthrough is determined when there is a point over a water avoidance height, and a change in water invasion frontier form may be expressed with water quality point position data at this time.

Abstract: Methods and apparatus for electrochemical analysis of water include acid cleaning a quartz crystal microbalance (QCM), stabilizing a QCM in analyte solution, and analyzing the solution by chronoamperometry and measuring a frequency shift of the QCM. The method may further include cleaning the QCM in an acid solution prior to stabilizing the QCM in analyte solution. The apparatus may provide at least semi-automated electrochemical analysis of water including determining a concentration of an analyte in a water sample, and communicating the concentration of the analyte over a network. The analyte may be manganese.

Abstract: Disclosed herein are methods and compositions directed to a promising class of nanomaterials called organic nanoparticles, or carbon nanodots. The present disclosure provides a facile method for the conversion of biomolecule-based carbon nanodots into high surface area three-dimensional graphene networks with excellent electrochemical properties.

Abstract: The invention provides novel zwitterionic monomers and polymers (including copolymers) with pendent phosphonium-based zwitterionic moieties, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as surfactants, coatings, and interlayer materials, biomedical materials or agents.

Abstract: A new and distinct cultivar of Chamaecyparis plant named ‘RutCham1’, characterized by its good heat tolerance in USDA Hardiness Zone 8 relative to typical Chamaecyparis pisifera cultivars; foliage that turns golden in the winter and green in the summer for multi-seasonal interest; and a uniform, pyramidal shape.