Abstract: Methods that include inhibition of ROCK1/2 and other protein kinases to treat Friedreich Ataxia.

Abstract: The disclosure discloses a strain of Lactobacillus crispatus capable of preventing and/or treating Helicobacter pylori infection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus crispatus CCFM1118. The Lactobacillus crispatus CCFM1118 can inhibit Helicobacter pylori, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of the Lactobacillus crispatus CCFM1118 on Helicobacter pylori can reach 13.14 mm; and (2) the Lactobacillus crispatus CCFM1118 can significantly reduce the adhesion of Helicobacter pylori to AGS cells. Therefore, the Lactobacillus crispatus CCFM1118 has great application prospects in inhibiting Helicobacter pylori (not for the purposes of disease diagnosis and treatment) and preparing Helicobacter pylori inhibitors.

Abstract: Provided herein are screening methods to select catalysts having a desired set of target properties from a reference catalyst, and catalysts so obtained, as well as related catalysts material, composition, methods and systems.

Abstract: Provided herein are methods and systems for targeted gene disruption (knock-out, missense mutation) and targeted gene knock-in in mammalian cells using base editors and guide RNAs (gRNAs) designed to target splice acceptor-splice donor sites. Also provided herein are universally acceptable genetically engineered cells comprising targeted disruptions in immunotherapy-related genes and comprising a CAR/TCR for therapeutic applications.

Abstract: Disclosed herein is a photo-polymerizable coating with broad-spectrum antimicrobial properties designed for personal protective equipment (PPE), such as face masks.

Abstract: A composition which conditions a surface for electroless deposition of a metal is disclosed. The composition comprises a polymer surfactant comprising repeating units of a monomer, wherein each of the repeating units comprises a functional group; a metal ion; and water, wherein the functional group in each of the repeating units forms a complex with the metal ion. In a preferred embodiment, the functional group is amine, and the surfactant comprises polyethyleneimine and/or polyallylamine. The metal ion comprises cobalt, rhodium, palladium or silver. A method of forming the composition as well as a method of electroless deposition using the composition are also disclosed.

Abstract: An everting vine robot intubation device capable of automatically and autonomously intubating the trachea and producing a lumen through which artificial ventilation may be conducted. The device includes an everting primary vine robot attached to a mouthpiece and a smaller diameter everting intubation vine robot associated with the primary everting vine robot. The primary vine robot is shaped and sized to extend to the back of a patient's laryngopharynx when fully actuated and the intubation everting vine robot is shaped and sized to extend from the primary vine robot into the patient's trachea when fully actuated.

Abstract: An automatic pressure regulating valve for an electro-pneumatic braking system of a commercial vehicle comprises an upper valve body and a lower valve body. The upper valve body includes a normally open switching valve, a quick-acting intake valve, a normally open quick-acting intake valve, a quick-acting exhaust valve, and a control chamber A. A lower valve body includes a relay valve and a working chamber B. The normally open switching valve has a manually controlled air inlet a and an electronically controlled air inlet b, and an air outlet c connected to an air inlet d of the normally open quick-acting intake valve. An air outlet e of the normally open quick-acting intake valve, an air inlet f of the quick-acting exhaust valve and an air outlet i of the quick-acting air intake valve are connected together to the control chamber A.

Abstract: Embodiments described herein relate to a vertical take-off and landing aircraft, specifically an electric or hybrid electric aircraft having a plurality of ducted fans. The aircraft includes a plurality of axially oriented fans, laterally oriented fans, forward air intakes, side exit ports, rear exhaust ports, plenum air chamber and annular inlet. The aircraft achieves flight by capturing air in the intakes and diverting the air through the axially oriented fans or the laterally oriented fans through the channels selectively.

Abstract: This invention relates to a truncated dysferlin nucleic acid and protein, vectors (e.g., adeno-associated virus vectors) comprising the nucleic acid and methods of using the same for delivery of dysferlin to a cell or a subject and treating dysferlinopathy.

Abstract: A reconfigurable intelligent surface includes a radiant layer, a sensing feeding circuit layer, a processing layer and a controlling circuit layer. The radiant layer includes at least two antennas and a plurality of reflecting units. Each of the at least two antennas is configured for sensing a polarization, a frequency or a direction angle of an incident electromagnetic wave. The reflecting units are arranged to form a reflecting surface. The sensing feeding circuit layer is signally connected to the antennas. The processing layer is signally connected to the sensing feeding circuit layer, and the processing layer is configured to produce a controlling signal corresponding thereto. The controlling circuit layer is signally connected to the radiant layer and the processing layer, wherein the controlling circuit layer receives the controlling signal and controls the reflecting units according to the controlling signal to adjust and form a reflecting electromagnetic wave.

Abstract: Protein-based nanoparticles for treating cancer, such as those characterized by intracranial tumors, and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ?about 8 kDa and ?about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ?about 1 nm to ?about 4 nm. The nanoparticle may have a transcription factor such as a therapeutic nucleic acid in the mesh structure. Methods of making such nanoparticles may include jetting a liquid comprising the water-soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.

Abstract: A dental apparatus includes a central component. The central component includes an elongated member having a first end, a second end, and a body extending between the first and second ends thereof. The dental apparatus also includes a first holding assembly movably coupled to the body of the elongated member and a second holding assembly movably coupled to the body of the elongated member. Each one of the first and second holding assemblies is configured to releasably hold dental articulating paper. The dental apparatus, loaded with two pieces of articulating paper that are separated from one another by a certain distance, can be moved via one hand to position the two pieces of articulating paper between two adjacent teeth to assist the dentist in determining the fit of a prosthetic crown that will be cemented over a prepared natural tooth or over an implant.

Abstract: The gas measurement device includes a gas sensor disposed in a gas chamber, a filter configured to control passing gas molecules to the gas chamber, and a driving unit configured to move at least a part of a member defining the gas chamber.

Abstract: Disclosed is a memory system using a heterogeneous data format, which provides a personalized recommendation algorithm function to an internet service user based on a plurality of items, which includes a user preference analyzer for each item that calculates a user preference value corresponding to each item of a analysis target service; and a memory that stores data related to the each item in a first data format or stores data related to the each item in a second data format with required bits less than the first data format, based on the user preference value of the each item.

Abstract: The present invention relates to a near-field acoustic platform capable of synthesizing high resolution, arbitrarily shaped energy potential wells. A thin and viscoelastic membrane is utilized to modulate acoustic wavefront on a deep, sub-wavelength scale by suppressing the structural vibration selectively on the platform. This new acoustic wavefront modulation mechanism is powerful for manufacturing complex biologic products.

Abstract: An electrocatalyst, a method of producing hydrogen gas by a hydrogen evolution reaction, and a method of producing oxygen gas by an oxygen evolution reaction. The electrocatalyst includes manganese oxide nanoparticles, and silver containing nanoparticles disposed on the manganese oxide nanoparticles, the silver-containing nanoparticles include a shell of silver tungstate disposed on a core of Ag. The electrocatalyst has an electrical resistivity of 0.50×107 ohm (?) to 6.0×107?, a charge transfer resistance of 325? to 450?, a Tafel slope of 55 mV/dec to 125 mV/dec, and an overpotential at 10 mA/cm2 of 0.05 mV to 200 mV.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.

Abstract: An integrated power conversion apparatus for an electric vehicle according to the present disclosure includes a first H-bridge converter with one side connected to a high voltage battery; a three-winding transformer in which a primary winding is connected to the other side of the first H-bridge converter; a second H-bridge converter with one side which is connected to a secondary winding of the three-winding transformer; an AC-DC converter in which one side is connected to the other side of the second H-bridge converter and the other side is selectively connected to a motor or a power system; and a low voltage stage converter in which one side is selectively connected to a tertiary winding of the three-winding transformer through a selective switch and the other side is connected to a low voltage battery.

Abstract: Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted quinoline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.