Patents Assigned to The University
  • G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
    Patent number: 11613547
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: March 28, 2023
    Assignees: University of Health Sciences & Pharmacy in St. Louis, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
    Inventors: Susruta Majumdar, Vsevolod Katritch, Bryan Roth, Jay McLaughlin, Saheem Zaidi, Gavril W. Pasternak, Rajendra Uprety
  • Combined administration of cysteine-aspartic protease inhibitors with P2Y12 receptor antagonists protects the heart against myocardial infarction
    Patent number: 11612615
    Abstract: The present disclosure generally pertains to methods of treating myocardial infarct involving administering a platelet anti-aggregate, a cysteine-aspartic protease inhibitor, and reperfusion therapy. In certain embodiments, the platelet anti-aggregate is at least one P2Y12 receptor antagonist or Glycoprotein IIb/IIIa inhibitor, the cysteine-aspartic protease inhibitor is selected from the group consisting of Caspase-1, 4, 5, 11 and 12 inhibitors, and reperfusion therapy is percutaneous coronary intervention. In certain embodiments, the at least one P2Y12 receptor antagonist is selected from the group consisting of cangrelor, ticagrelor, clopidogrel and prasugrel. The disclosed methods provide an improved cardioprotective effect against infarction when compared with the current standard of care.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 28, 2023
    Assignee: The University of South Alabama
    Inventors: Jonathon P. Audia, James M. Downey, Diego Alvarez, Michael V. Cohen
  • MEDICAL IMAGE PROCESSING APPARATUS, MEDICAL IMAGE PROCESSING METHOD, AND STORAGE MEDIUM
    Publication number: 20230086533
    Abstract: A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain a medical image. The processing circuitry is configured to calculate a first blood flow direction on the basis of a structure of a region of interest rendered in the medical image. The processing circuitry is configured to calculate a second blood flow direction on the basis of a structure in the surroundings of the region of interest. The processing circuitry is configured to identify a condition of the region of interest, on the basis of the first blood flow direction and the second blood flow direction.
    Type: Application
    Filed: September 19, 2022
    Publication date: March 23, 2023
    Applicants: The University of Tokyo, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Gakuto AOYAMA, Ichiro SAKUMA, Minoru ONO, Shu TAKAGI, Asuka HATANO, Haruo YAMAUCHI, Eriko MAEDA (Deceased), Naoki TOMII, Hiroyuki TSUKIHARA
  • SUBSTANCE DELIVERY CARRIER AND COMPOSITION
    Publication number: 20230092306
    Abstract: According to one embodiment, a substance delivery carrier and a composition are used for delivering an intended substance to a myeloid tumor cell. The substance delivery carrier has a lipid particle, and an intended substance encapsulated in the lipid particle. The lipid particle contains, as a constituent thereof, at least a first lipid represented by formula (I).
    Type: Application
    Filed: April 1, 2022
    Publication date: March 23, 2023
    Applicants: KABUSHIKI KAISHA TOSHIBA, The University of Tokyo
    Inventors: Mitsuko ISHIHARA, Shigehisa KAWATA, Susumu GOYAMA
  • Methods and Devices for Analyzing Particles
    Publication number: 20230091562
    Abstract: Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.
    Type: Application
    Filed: May 27, 2022
    Publication date: March 23, 2023
    Applicant: The University of British Columbia
    Inventors: Carl Lars Genghis Hansen, Hans Zahn, Jens Huft, Marinus Theodorus Johannes VAN LOENHOUT, Kaston Leung, Bill Kengli Lin, Anders Klaus, Samuel Alves Jana Rodrigues APARICIO, Sohrab Prakash Shah, Adi Steif
  • IONIC LIQUID TO ENHANCE PERFORMANCE AND DURABILITY OF MEMBRANE ASSEMBLY ELECTRODE (MEA)
    Publication number: 20230092991
    Abstract: A dimeric ionic liquid that enhances and improves the performance and durability of a fuel cell catalyst. The dimeric ionic liquid comprises 1,1-(butane-1,4-diyl)bis(9-methyl-3,4,6,7,8,9-hexahydro-2H-pyrimido[1,2-a]pyrimidin-1-ium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (D-[MTBD][C4F9SO3]). Membrane electrode assemblies (MEAs) and polymer electrolyte membrane fuel cells (PEMFCs) employing the dimeric ionic liquid are also disclosed.
    Type: Application
    Filed: September 3, 2021
    Publication date: March 23, 2023
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The University of Texas at Austin
    Inventors: Liang Wang, Hongfei Jia, Joan F. Brennecke, Oscar Morales Collazo, Hisao Kato
  • CONJUGATE POLYPEPTIDES AND VACCINES FOR INDUCING IMMUNE RESPONSES
    Publication number: 20230087396
    Abstract: Methods and compositions are disclosed for inducing immune responses against one or more antigens in a mammal.
    Type: Application
    Filed: November 15, 2022
    Publication date: March 23, 2023
    Applicant: The Regents of The University of California
    Inventor: Dennis J. Hartigan-O'Connor
  • METHODS AND COMPOSITIONS COMPRISING TRANS-ACTING TRANSLATIONAL ACTIVATORS
    Publication number: 20230090706
    Abstract: The current disclosure relates to nucleic acid therapeutics that target mRNA molecules and recruit translation machinery to increase the translation from the mRNA, thus increasing the protein product in a subject or cell. Accordingly, aspects of the disclosure relate to a chimeric nucleic acid comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA.
    Type: Application
    Filed: February 26, 2021
    Publication date: March 23, 2023
    Applicant: The University of Chicago
    Inventors: Bryan DICKINSON, Yang CAO
  • NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20230085899
    Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
    Type: Application
    Filed: July 1, 2022
    Publication date: March 23, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Jinming GAO, David BOOTHMAN, Kejin ZHOU, Xiaonan HUANG, Yiguang WANG
  • HUMAN 4-1BB AGONIST ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20230092390
    Abstract: Isolated or recombinant monoclonal antibodies that bind to 4-1BB are provided. In son cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.
    Type: Application
    Filed: February 17, 2021
    Publication date: March 23, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael A. CURRAN, Renee CHIN, Marie-Andrée FORGET, Chantale BERNATCHEZ
  • Data processing apparatus and method
    Patent number: 11610303
    Abstract: A medical image data processing apparatus is provided and includes processing circuitry to receive medical image data in respect of at least one subject; receive non-image data; generate a filter based on the non-image data; and apply the filter to the medical image data, wherein the filter limits a region of the medical image data.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: March 21, 2023
    Assignees: The University Court of the University of Edinburgh, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Grzegorz Jacenków, Sotirios Tsaftaris, Brian Mohr, Alison O'Neil, Aneta Lisowska
  • Generation of high-power spatially-restructurable spectrally-tunable beams in a multi-arm-cavity VECSEL-based laser system
    Patent number: 11611194
    Abstract: A collinear T-cavity VECSEL system generating intracavity Hermite-Gaussian modes at multiple wavelengths, configured to vary each of these wavelengths individually and independently. A mode converter element and/or an astigmatic mode converter is/are aligned intracavity to reversibly convert the Gaussian modes to HG modes to Laguerre-Gaussian modes, the latter forming the system output having any of the wavelengths provided by the spectrum resulting from nonlinear frequency-mixing intracavity (including generation of UV, visible, mid-IR light). The laser system delivers Watt-level output power in tunable high-order transverse mode distribution.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: March 21, 2023
    Assignee: Arizona Board of Regents on behalf of The University of Arizona
    Inventors: Mahmoud Fallahi, Ewan Wright, Chris Hessenius
  • Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
    Patent number: 11608308
    Abstract: Aspects of the present disclosure include fatty acid ?-hydroxyester compounds (e.g., fatty acid esters of ?-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid ?-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: March 21, 2023
    Assignees: The J. David Gladstone Institutes, The Regents of The University Of California, Ithaca College
    Inventors: Eric Verdin, Scott Michael Ulrich, John C. Newman
  • Comprehensive framework for protecting intellectual property in the semiconductor industry
    Patent number: 11611429
    Abstract: Methods and integrated circuit architectures for assuring the protection of intellectual property between third party IP providers, system designers (e.g., SoC designers), fabrication entities, and assembly entities are provided. Novel design flows for the prevention of IP overuse, IP piracy, and IC overproduction are also provided. A comprehensive framework for forward trust between 3PIP vendors, SoC design houses, fabrication entities, and assembly entities can be achieved, and the unwanted modification of IP can be prevented.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 21, 2023
    Assignees: University of Florida Research Foundation, Incorporated, The University of Connecticut
    Inventors: Mark M. Tehranipoor, Domenic J. Forte, Ujjwal Guin
  • Paper products subjected to a surface treatment comprising enzyme-treated surface enhanced pulp fibers and methods of making the same
    Patent number: 11608596
    Abstract: Methods of making a paper product can comprise forming a substrate from a first furnish that comprises a plurality of pulp fibers, at least partially dewatering the substrate, treating a second furnish that comprises a plurality of surface enhanced pulp fibers (SEPF) at least by adding one or more enzymes to the second furnish, and sizing the dewatered substrate at least by depositing the treated second furnish onto at least one of opposing first and second surfaces of the dewatered substrate. The SEPF can have a length weighted average fiber length that is greater than or equal to 0.20 millimeters (mm) and an average hydrodynamic specific surface area that is greater than or equal to 10 square meters per gram (m2/g).
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: March 21, 2023
    Assignees: Domtar Paper Company, LLC, The University of British Columbia
    Inventors: Harshad Pande, Alexander Timothy Beam, Mark Martinez, Jingqian Chen, Miaoran Li, Heather Trajano
  • METHODS FOR RAPID CLONING AND EXPRESSION OF HLA CLASS I CELLS
    Publication number: 20230079539
    Abstract: The present disclosure provides methods of generating HLA class-I null cells that can be used for expression of exogenous HLA genes and presentation of antigens, such tumor neoantigens. Method for using HLA class-I null cells from selecting, stimulating and propagating immune effector cells are also provided.
    Type: Application
    Filed: February 10, 2021
    Publication date: March 16, 2023
    Applicant: Board of Regents, The University of Texas System
    Inventors: Hiroki TORIKAI, Shan ZONG
  • Vacuole-inducing compounds, methods of making and using the same
    Patent number: 11602531
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: March 14, 2023
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • TOLL-LIKE RECEPTOR AGONIST FORMULATIONS AND METHODS OF USE
    Publication number: 20230073245
    Abstract: Aspects of the disclosure relate to nanoparticle formulations and methods for generating nanoparticles. Embodiments include nanoparticles comprising an amphiphile and a polymer co-assembly agent. In some cases, polymers for use in therapeutic delivery are described. In some embodiments, the disclosed methods and compositions involve TLR agonists and formulations thereof capable of activating an immune response. Certain aspects relate to nanoparticles comprising linked TLR agonists for use in immunotherapy.
    Type: Application
    Filed: January 13, 2021
    Publication date: March 9, 2023
    Applicants: The University of Chicago, Central Michigan University
    Inventors: Aaron ESSER-KAHN, Saikat MANNA, WenJun DU, Sampa MAITI
  • METHODS FOR THE ASSESSMENT OF RISK AND TREATMENTS FOR LIVER CANCERS AND LETHAL LIVER DISEASE COMPLICATIONS
    Publication number: 20230073981
    Abstract: Disclosures herein are directed to methods and compositions for predicting high- and low-risk liver disease in patients. Based on the results achieved from the methods and compositions disclosed herein, liver disease patients can be classified into a prognostic risk group, which enables early diagnosis and prevention of HCC and other lethal complications. Methods and compositions disclosed herein substantially improve the poor prognosis of subjects having or at risk for one or more liver diseases.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 9, 2023
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Yujin Hoshida, Naoto Fujiwara, Amit G. Singal, Thomas F. Baumert
  • Adjustable locking surgical retractor
    Patent number: 11596394
    Abstract: A surgical retractor assembly for providing surgical exposure. The surgical retractor assembly consists of two frame segments connected by adjustable ratchet mechanisms to form a retractor frame. The ratchet mechanisms can be attached to tissue retractor blades that provide exposure of the wound when expanded, without the requirement of a direct connection/attachment to an operating table or bed frame. The tissue retractor blades are attached in a manner that is adjustable and facilitates the ability of the overall surgical retractor assembly to be raised or lowered with respect to the patient. The retractor frame also allows attachments of additional retractor blades or other surgical retractor accessories for additional surgical exposure.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: March 7, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ramon Francisco Cestero, Justin Alexander Long, Clarence Lamar Long, Jeffrey Adam Long