Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
Type:
Application
Filed:
November 22, 2023
Publication date:
October 31, 2024
Applicant:
TherapeuticsMD, Inc.
Inventors:
Janice Cacace, Peter H.R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick, Neda IRANI
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Application
Filed:
October 12, 2023
Publication date:
October 24, 2024
Applicant:
TherapeuticsMD, Inc.
Inventors:
Brian A. BERNICK, Thorsteinn THORSTEINSSON, Peter H.R. PERSICANER, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI, Julia AMADIO
Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
Type:
Application
Filed:
September 15, 2023
Publication date:
April 11, 2024
Applicant:
TherapeuticsMD, Inc..
Inventors:
Brian A. Bernick, Janice Louise Cacace, Peter H.R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
Type:
Grant
Filed:
June 15, 2021
Date of Patent:
January 9, 2024
Assignee:
TherapeuticsMD, Inc.
Inventors:
Janice Cacace, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick, Neda Irani
Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
Type:
Grant
Filed:
August 16, 2018
Date of Patent:
October 24, 2023
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Application
Filed:
October 12, 2022
Publication date:
July 6, 2023
Applicant:
TherapeuticsMD, Inc.
Inventors:
Brian A. BERNICK, Julia AMADIO, Peter H.R. PERSICANER
Abstract: This disclosure provides pharmaceutical compositions for delivering estradiol to a subject in need thereof, as well as methods of administering the compositions, and methods of using them.
Type:
Grant
Filed:
February 5, 2021
Date of Patent:
April 25, 2023
Assignee:
TherapeuticsMD, Inc.
Inventors:
Veeran Gowda Kadajji, Mafruhul Bari, Annette Shadiack, Thorsteinn Thorsteinsson, Peter H. R. Persicaner
Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
January 27, 2020
Date of Patent:
April 11, 2023
Assignee:
THERAPEUTICSMD, INC.
Inventors:
Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Application
Filed:
March 28, 2022
Publication date:
March 2, 2023
Applicant:
TherapeuticsMD, Inc.
Inventors:
Brian A. BERNICK, Thorsteinn THORSTEINSSON, Peter H.R. PERSICANER, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI, Julia AMADIO
Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
Type:
Grant
Filed:
July 23, 2019
Date of Patent:
December 20, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
March 30, 2020
Date of Patent:
November 15, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Julia Amadio, Peter H.R. Persicaner
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
March 27, 2020
Date of Patent:
June 7, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Thorsteinn Thorsteinsson, Peter H. R. Persicaner, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani, Julia Amadio
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
January 17, 2020
Date of Patent:
April 19, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Thorsteinn Thorsteinsson, Peter H. R. Persicaner, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani, Julia Amadio
Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
Type:
Grant
Filed:
December 7, 2016
Date of Patent:
March 8, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Sebastian Mirkin, Julia M. Amadio, Brian Bernick
Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
February 15, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Julia M. Amadio, Sebastian Mirkin
Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
Type:
Application
Filed:
June 15, 2021
Publication date:
February 10, 2022
Applicant:
TherapeuticsMD, Inc.
Inventors:
Janice Cacace, Peter H.R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick, Neda IRANI
Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
March 27, 2020
Date of Patent:
February 8, 2022
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Thorsteinn Thorsteinsson, Peter H. R. Persicaner, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani, Julia Amadio
Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
Type:
Grant
Filed:
August 16, 2018
Date of Patent:
November 9, 2021
Assignee:
THERAPEUTICSMD, INC.
Inventors:
Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio, Frederick D. Sancilio
Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
April 1, 2020
Date of Patent:
September 21, 2021
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani
Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
April 1, 2020
Date of Patent:
September 14, 2021
Assignee:
TherapeuticsMD, Inc.
Inventors:
Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani