Patents Assigned to TherapeuticsMD
  • Soluble estradiol capsule for vaginal insertion
    Patent number: 11065197
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: July 20, 2021
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani
  • Progesterone formulations having a desirable pk profile
    Patent number: 11033626
    Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: June 15, 2021
    Assignee: TherapeuticsMD, Inc.
    Inventors: Janice Cacace, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick, Neda Irani
  • Formulations for solubilizing hormones
    Patent number: 10912783
    Abstract: Compositions and methods for the solubilization of steroid hormones are disclosed.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: February 9, 2021
    Assignee: THERAPEUTICSMD, INC.
    Inventors: Thorsteinn Thorsteinsson, Frederick D. Sancilio, Brian A. Bernick, Julia M. Amadio
  • Soluble estradiol capsule for vaginal insertion
    Patent number: 10888516
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: January 12, 2021
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10835487
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: November 17, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner
  • SOLUBLE ESTRADIOL CAPSULE FOR VAGINAL INSERTION
    Publication number: 20200352961
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: April 1, 2020
    Publication date: November 12, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER, Thorsteinn THORSTEINSSON, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI
  • Natural combination hormone replacement formulations and therapies
    Patent number: 10806740
    Abstract: Pharmaceutical formulations for co-administering estradiol and progesterone are provided herein. In some embodiments, the formulation comprises solubilized estradiol, suspended progesterone, and a medium chain (C6-C12) oil.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: October 20, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Peter H. R. Persicaner, Brian A. Bernick, Julia M. Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10806697
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: October 20, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20200297735
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: March 27, 2020
    Publication date: September 24, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Thorsteinn THORSTEINSSON, Peter H.R. PERSICANER, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI, Julia AMADIO
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20200297736
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: March 27, 2020
    Publication date: September 24, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Thorsteinn THORSTEINSSON, Peter H.R. PERSICANER, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI, Julia AMADIO
  • SOLUBLE ESTRADIOL CAPSULE FOR VAGINAL INSERTION
    Publication number: 20200289529
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided.
    Type: Application
    Filed: March 27, 2020
    Publication date: September 17, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER, Thorsteinn THORSTEINSSON, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20200281849
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 10, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia AMADIO, Peter H.R. PERSICANER
  • SOLUBLE ESTRADIOL CAPSULE FOR VAGINAL INSERTION
    Publication number: 20200276210
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided.
    Type: Application
    Filed: May 15, 2020
    Publication date: September 3, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER, Thorsteinn THORSTEINSSON, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI
  • PROGESTERONE FORMULATIONS HAVING A DESIRABLE PK PROFILE
    Publication number: 20200268888
    Abstract: This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
    Type: Application
    Filed: September 20, 2019
    Publication date: August 27, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Janice Cacace, Peter H.R. Persicaner, Thorsteinn Thorsteinsson, Frederick Sancilio, Julia Amadio, Brian Bernick
  • SOLUBLE ESTRADIOL CAPSULE FOR VAGINAL INSERTION
    Publication number: 20200230153
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 23, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER, Thorsteinn THORSTEINSSON, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI
  • SOLUBLE ESTRADIOL CAPSULE FOR VAGINAL INSERTION
    Publication number: 20200230154
    Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 23, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER, Thorsteinn THORSTEINSSON, Janice Louise CACACE, Frederick D. SANCILIO, Neda IRANI
  • VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITIONS AND METHODS
    Publication number: 20200230050
    Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
    Type: Application
    Filed: March 30, 2020
    Publication date: July 23, 2020
    Applicant: TherapeuticsMD, Inc.
    Inventors: Brian A. BERNICK, Julia M. AMADIO, Peter H.R. PERSICANER
  • Natural combination hormone replacement formulations and therapies
    Patent number: 10675288
    Abstract: Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: June 9, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Brian A. Bernick, Janice Louise Cacace, Peter H. R. Persicaner, Neda Irani, Julia M. Amadio
  • Vaginal inserted estradiol pharmaceutical compositions and methods
    Patent number: 10668082
    Abstract: Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: June 2, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Sebastian Mirkin, Julia M. Amadio, Brian A. Bernick
  • Mold for a medical dosage form
    Patent number: RE48019
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: June 2, 2020
    Assignee: TherapeuticsMD, Inc.
    Inventors: Frederick D. Sancilio, Thorsteinn Thorsteinsson, Julia M. Amadio