Patents Assigned to Third Wave Technologies, Inc.
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Publication number: 20030165954Abstract: The present invention relates to genetic profiles and markers of cancers and provides systems and methods for screening drugs that are effective for specific patients and types of cancers. In particular, the present invention provides personalized treatment customized to an individual's cancer.Type: ApplicationFiled: January 9, 2003Publication date: September 4, 2003Applicant: Third Wave Technologies, Inc.Inventors: Toyomasa Katagiri, Yasuyuki Ohnishi, Yusuke Nakamura
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Publication number: 20030143535Abstract: The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure.Type: ApplicationFiled: June 15, 2001Publication date: July 31, 2003Applicant: Third Wave Technologies, Inc.Inventors: Victor Lyamichev, Hatim Allawi, Fang Dong, Bruce P. Neri, Tatiani I. Vener
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Publication number: 20030134349Abstract: The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that cleave the nucleic acid cleavage structure in a site-specific manner to produce non-target cleavage products. The present invention provides enzymes having an improved ability to specifically cleave a DNA member of a complex comprising DNA and RNA nucleic acid strands.Type: ApplicationFiled: January 11, 2001Publication date: July 17, 2003Applicant: Third Wave Technologies, Inc.Inventors: Wu-Po Ma, Victor I. Lyamichev, Michael W. Kaiser, Natalie E. Lyamicheva, Hatim Taysir Allawi, James J. Schaefer, Bruce P. Neri
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Publication number: 20030124526Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.Type: ApplicationFiled: August 15, 2001Publication date: July 3, 2003Applicant: Third Wave Technologies, Inc.Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
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Publication number: 20030113237Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.Type: ApplicationFiled: August 15, 2001Publication date: June 19, 2003Applicant: Third Wave Technologies, Inc.Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
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Publication number: 20030113236Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.Type: ApplicationFiled: August 15, 2001Publication date: June 19, 2003Applicant: Third Wave Technologies, Inc.Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
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Publication number: 20030104470Abstract: The present invention relates to electronic medical records having polymorphisms data, an electronic library of these electronic medical records, and systems and methods for managing genetic information. For example, the present invention provides system and methods for collecting, storing, and retrieving patient-specific genetic information from one or more electronic databases.Type: ApplicationFiled: August 14, 2001Publication date: June 5, 2003Applicant: Third Wave Technologies, Inc.Inventors: Lance Fors, Rocky Ganske, Amy M. Brower, Witold Ziarno
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Publication number: 20030104378Abstract: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.Type: ApplicationFiled: May 24, 2001Publication date: June 5, 2003Applicant: Third Wave Technologies, Inc.Inventors: Hatim Allawi, Christian Tor Bartholomay, LuAnne Chehak, Michelle L. Curtis, Peggy S. Eis, Jeff G. Hall, Hon S. Ip, Michael Kaiser, Robert W. Kwiatkowski, Andrew A. Lukowiak, Victor Lyamichev, WuPo Ma, Marilyn C. Olson-Munoz, Sarah M. Olson, James J. Schaefer, Zbigniew Skrzypczynski, Tsetska Y. Takova, Kevin L. Vedvik, Natalie Lyamichev, Burce P. Neri
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Publication number: 20030092039Abstract: The present invention relates to screening assays for testing nutraceuticals. In particular, the present invention relations to methods for detecting RNA is cells exposed to various types, concentrations, and combinations of nutraceuticals employing the INVADER detection assay. In preferred embodiments, the screening assays of the present invention are configured for high throughput screening.Type: ApplicationFiled: August 1, 2002Publication date: May 15, 2003Applicant: Third Wave Technologies, Inc.Inventors: Marilyn C. Olson-Munoz, Glen Donald
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Publication number: 20030082544Abstract: The present invention provides systems and methods for acquiring and analyzing biological information. For example, the present invention provides systems and methods for the use of genetic information in the generation of assays for detecting the genetic identity of samples, the production of assays, the use of assays for gathering genetic information of individuals and populations, and the storage, analysis, and use of the obtained information.Type: ApplicationFiled: July 25, 2001Publication date: May 1, 2003Applicant: Third Wave Technologies, Inc.Inventors: Lance Fors, Rocky Ganske
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Patent number: 6555357Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. Structure-specific nucleases derived from a variety of thermostable organisms are provided. These structure-specific nucleases are used to cleave target-dependent cleavage structures, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.Type: GrantFiled: October 6, 2000Date of Patent: April 29, 2003Assignee: Third Wave Technologies, Inc.Inventors: Michael W. Kaiser, Victor I. Lyamichev, Natasha Lyamicheva
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Publication number: 20030072689Abstract: The present invention relates to polymer synthesizers and methods of using polymer synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis. The present invention also relates to synthesizer arrays for efficient, safe, and automated processes for the production of large quantities of polymers.Type: ApplicationFiled: August 15, 2001Publication date: April 17, 2003Applicant: Third Wave Technologies, Inc.Inventors: Raymond F. Cracauer, Zbigniev Skrzypczynski, Ned D. Reimer
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Publication number: 20020156255Abstract: The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis, as well as methods of modifying pre-existing synthesizers to improve efficiency, reliability, and safety.Type: ApplicationFiled: October 26, 2001Publication date: October 24, 2002Applicant: Third Wave Technologies, Inc.Inventor: Raymond F. Cracauer
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Publication number: 20020142454Abstract: The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid synthesis, as well as methods of modifying pre-existing synthesizers to improve efficiency, reliability, and safety.Type: ApplicationFiled: November 13, 2001Publication date: October 3, 2002Applicant: Third Wave Technologies, Inc.Inventors: Raymond F. Cracauer, Witold A. Ziarno
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Patent number: 6458535Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of human cytomegalovirus nucleic acid in a sample.Type: GrantFiled: July 9, 1999Date of Patent: October 1, 2002Assignee: Third Wave Technologies, IncInventors: Jeff G. Hall, Victor I. Lyamichev, Andrea L. Mast, Mary Ann D. Brow
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Publication number: 20020128465Abstract: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.Type: ApplicationFiled: February 6, 2001Publication date: September 12, 2002Applicant: Third Wave Technologies, Inc.Inventors: Victor Lyamichev, Zbigniew Skrzpczynski, Hatim T. Allawi, Sarah R. Wayland, Tsetska Takova, Bruce P. Neri
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Patent number: 6372424Abstract: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.Type: GrantFiled: August 30, 1995Date of Patent: April 16, 2002Assignee: Third Wave Technologies, INCInventors: Mary Ann D. Brow, Victor I. Lyamichev, David Michael Olive
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Patent number: 6358691Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).Type: GrantFiled: October 2, 2000Date of Patent: March 19, 2002Assignee: Third Wave Technologies, Inc.Inventors: Bruce Neri, Fang Dong, Victor Lyamichev, Mary Ann D. Brow, Lance Fors
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Patent number: 6355437Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).Type: GrantFiled: October 2, 2000Date of Patent: March 12, 2002Assignee: Third Wave Technologies, Inc.Inventors: Bruce Neri, Fang Dong, Victor Lyamichev, Mary Ann D. Brow, Lance Fors
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Patent number: 6348314Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.Type: GrantFiled: July 9, 1999Date of Patent: February 19, 2002Assignee: Third Wave Technologies, Inc.Inventors: James R. Prudent, Jeff G. Hall, Victor I. Lyamichev, Mary Ann D. Brow, James E. Dahlberg