Abstract: Provided is a method for adjusting the balance of TNF-R1 and TNF-R2 in cells present at a target organ, tissue or site. In the adjustment method provided, when increasing the relative presence of TNF-R2 compared to the presence of TNF-R1 in the cells, a synthetic peptide is supplied to the cells, with the peptide being essentially made of at a TNF-R1 signal peptide motif or a modified amino acid sequence thereof; and when decreasing the relative presence of TNF-R2 compared to the presence of TNF-R1 in the cells, a synthetic peptide is supplied to the cells, with the peptide being essentially made of a TNF-R2 signal peptide motif or a modified amino acid sequence thereof.

Abstract: Provided are a synthetic peptide having a multinucleation-inducing activity that can cause multinucleation in a target cell, a multinucleation-inducing agent containing this peptide, and a multinucleation induction method that uses this peptide. The synthetic peptide provided by the present invention is an artificially synthesized peptide that contains (A) a membrane-permeable peptide sequence and (B) a multinucleation-inducing peptide sequence, and that can cause multinucleation in at least one type of eukaryotic cell of human origin or non-human mammal origin. The multinucleation-inducing peptide sequence is constituted of an amino acid sequence given by SEQ ID NO: 1 or SEQ ID NO: 2 or a modified amino acid sequence therefrom.

Abstract: The deodorant composition of the present invention includes an amorphous aluminum silicate, a hydrazide compound, and a crystalline zinc oxide in which at least two peaks among three peaks detected within a diffraction angle (2?) range from 30 to 38 degrees when the crystalline zinc oxide is subjected to X-ray powder diffraction measurement have a half width of 0.4 to 1.2 degrees in an X-ray diffraction chart, wherein a content of the crystalline zinc oxide is in a range from 100 to 500 parts by mass based on 100 parts by mass of the hydrazide compound, and wherein a content of the amorphous aluminum silicate is in a range from 100 to 750 parts by mass based on 100 parts by mass of the hydrazide compound.

Abstract: A synthetic peptide having a stem cell differentiation-inducing activity to induce differentiation of pluripotent stem cells into endodermal cells, a stem cell differentiation inducer having this peptide as an active ingredient, and a method for inducing differentiation of pluripotent stem cells using these. The synthetic peptide provided by the present invention contains a stem cell differentiation-inducing peptide sequence, and this stem cell differentiation-inducing peptide sequence is selected from (1) an amino acid sequence constituting a signal peptide in any of amyloid precursor proteins (APP), amyloid precursor-like protein (APLP) 1 and APLP2, which are known as proteins belonging to the APP family, (2) a partial amino acid sequence constituting the signal peptide, or (3) a modified amino acid sequence formed by substitution, deletion and/or addition of 1, 2 or 3 amino acid residues in these amino acid sequences.

Abstract: It is an object of the present invention to provide a deodorant or a deodorant composition which has excellent deodorizing performance with respect to sulfurous stench from methyl mercaptan and hydrogen sulfide and the like. It is another object of the present invention to provide a deodorant or a deodorant composition which maintains a deodorizing effect with respect to sulfurous stench and which makes it possible to suppress resin deterioration in the case of being kneaded into a resin, and a deodorizing product containing the same. A deodorant of the present invention contains amorphous copper silicate represented by the following formula [1]: xNa2O.yCuO.SiO2.zH2O??[1] wherein, in formula [1], x is a positive number from 0.002 to 0.040, y is a positive number from 0.07 to 0.48, and z is a positive number from 0.02 to 0.30.

Abstract: The present invention provides a method that allows highly efficient and highly reliable evaluation of genomic stability of pluripotent stem cells, a method for removing pluripotent stem cells that have been identified as genomically unstable by the evaluation method from a culture of pluripotent stem cells to be evaluated, and a synthetic peptide that can be used for the methods. The methods provided by the present invention include preparing a culture of pluripotent stem cells of interest and analyzing an expression level of calreticulin for the pluripotent stem cells in the culture followed by identifying genomic stability or genomic instability of the stem cells on the basis of the expression level of calreticulin.

Abstract: A method for producing a (meth)acrylate comprises transesterification reaction of an alcohol and a monofunctional(meth) acrylate with catalysts in combination being cyclic tertiary amines having an azabicyclo structure and compounds containing zinc, separating a solid that contains the catalysts from a reaction product containing a (meth)acrylate, and producing a (meth)acrylate by transesterification reaction of an alcohol and a monofunctional (meth)acrylate, while using the recovered solid catalyst.

Abstract: A curable composition, which has low viscosity and is excellent in terms of appearance and hardness of a cured product, and preferably an active energy beam-curable composition are provided. The curable composition includes the following components (A) and (B), component (A): a (meth)acrylate mixture including glycerin tri(meth)acrylate as a main component, the mixture including a high-molecular-weight body, for which an area percent (%) is defined by a specific equation and is a value obtained in accordance with gel permeation chromatography measurement, is less than 30%; and component (B): an oligomer having two or more (meth)acryloyl groups, a reaction product of an organic polyisocyanate and a hydroxy group-containing (meth)acrylate, or a combination thereof.

Abstract: Provided are a synthetic peptide that increases the radiosensitivity of tumor cells and a pharmaceutical composition containing that synthetic peptide. The peptide provided by the present invention is a synthetic peptide having a radiosensitizing peptide sequence including the following amino acid sequence: CX2X3KX5X6X7X8C (wherein, X2 represents K or R, X3 represents S or A, X5 represents S or A, X6 represents R or G, X7 represents R or D and X8 represents S or P); or, a modified amino acid sequence in which one, two or three amino acid residues are substituted, deleted and/or added in that amino acid sequence. In addition, the pharmaceutical composition provided by the present invention is a composition used to increase the sensitivity of tumor cells to radiation in tumor radiation therapy, and contains the synthetic peptide described above.

Abstract: The deodorant composition of the present invention includes an amorphous aluminum silicate, a hydrazide compound, and a crystalline zinc oxide in which at least two peaks among three peaks detected within a diffraction angle (20) range from 30 to 38 degrees when the crystalline zinc oxide is subjected to X-ray powder diffraction measurement have a half width of 0.4 to 1.2 degrees is an X-ray diffraction chart, wherein a content of the crystalline zinc oxide is in a range from 100 to 500 parts by mass based on 100 parts by mass of the hydrazide compound, and wherein a content of the amorphous aluminum silicate is in a range from 100 to 750 parts by mass based on 100 parts by mass of the hydrazide compound.

Abstract: [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

Abstract: The present invention is a curable composition characterized by including a 2-cyanoacrylate and a particle containing titanium oxide and silicon oxide. The preferable content of the particle is in a range from 0.1 to 10.0 parts by mass based on 100 parts by mass of the 2-cyanoacrylate.

Abstract: A curable composition that has low viscosity and rapid curing ability in the form of thin film, further has excellent resistance to emulsification and preservation stability, and has high hardness in the form of cured film, thereby achieving excellent alkali developability, which is preferably an active energy beam-curable composition, is provided. The provided is a curable composition, which includes a mixture (A) of a compound having two or more (meth)acryloyl groups that is obtained by conducting a transesterification reaction of a polyalcohol and a compound having one (meth)acryloyl group under the presence of the following catalysts X and Y: catalyst X: a compound that is at least one selected from the group consisting of cyclic tertiary amine having an azabicyclo structure or a salt or complex thereof, amidine or a salt or complex thereof, and a compound having a pyridine ring or a salt or complex thereof; and catalyst Y: a compound including zinc.

Abstract: The ketone-based gas adsorbent of the present invention is characterized by containing a primary amine compound. The primary amine compound is preferably at least one selected from the group consisting of hydrazide compounds, aminoguanidine compounds, and polyamines.

Abstract: A curable composition that has low viscosity and rapid curing ability in the form of thin film, further has excellent resistance to emulsification and preservation stability, and has high hardness in the form of cured film, thereby achieving excellent alkali developability, which is preferably an active energy beam-curable composition, is provided. The provided is a curable composition, which includes a mixture (A) of a compound having two or more (meth)acryloyl groups that is obtained by conducting a transesterification reaction of diglycerin and/or glycerin and a compound having one (meth)acryloyl group under the presence of the following catalysts X and Y: catalyst X: a compound that is at least one member selected from the group consisting of cyclic tertiary amine having an azabicyclo structure or a salt or complex thereof, amidine or a salt or complex thereof, and a compound having a pyridine ring or a salt or complex thereof; and catalyst Y: a compound including zinc.

Abstract: The invention provides an ion-trapping agent for a lithium-ion rechargeable battery, which traps impurity metal ions generated from constituent parts of a lithium-ion rechargeable battery with high selectivity, has high adsorption capacity per unit mass, suppresses the occurrence of short circuit derived from impurities, and renders a liquid neutral such that the lithium-ion rechargeable battery is unlikely to influence an electrolyte solution, thereby imparting a long-life lithium-ion rechargeable battery.

Abstract: To provide a transparent aldehyde-gas-adsorbing liquid that has high adsorption performance for an aldehyde gas and excellent processability and storage stability. To also provide an aldehyde-gas-adsorbing processed product such as a paper or a nonwoven fabric or fiber exhibiting excellent adsorption performance using the gas-adsorbing liquid. An aldehyde-gas-adsorbing liquid that contains a dihydrazide compound and a metal oxide sol, the content of the dihydrazide compound being 1.3 to 6 mass % relative to the total amount of gas-adsorbing liquid, and the total content of the dihydrazide compound and the metal oxide sol solids content being 18 to 45 mass % relative to the total amount of gas-adsorbing liquid.

Abstract: The two-part curable composition has excellent curability, and exhibits flexibility and adhesion durability. The two-part curable composition includes a first reagent containing at least a 2-cyanoacrylic acid ester and a second reagent containing at least a polymer having a hydrolyzable silyl group, in which an elastomer and a curing catalyst for the above polymer are each contained in at least one of the first and second reagents in predetermined amounts. A preferable curing catalyst is a compound having a metal element and an organic group bonded to the metal element via oxygen, or an acid having a pKa of 4 or lower at 25° C. Preferably, a curing accelerator for 2-cyanoacrylic acid ester is contained in at least one of the first and second reagents.

Abstract: Provided is a method for producing myocardial cells from pluripotent stem cells. The myocardial cell production method provided by the present invention includes supplying an artificially produced synthetic peptide to a cell culture that contains pluripotent stem cells. The synthetic peptide is a peptide that contains a myocardial cell differentiation-inducing peptide sequence that induces pluripotent stem cells into myocardial cells. The myocardial cell differentiation-inducing peptide sequence is an amino acid sequence selected from the group consisting of (i) an amino acid sequence constituting the signal peptide of any protein belonging to the amyloid precursor protein (APP) family, (ii) a partial amino acid sequence of the amino acid sequence according to (i), and (iii) a modified amino acid sequence from the amino acid sequence according to (i) or (ii).

Abstract: The present invention provides a (meth)acrylate manufacturing method characterized in that when manufacturing a (meth) acrylate by an ester exchange reaction between an alcohol and a monofunctional (meth)acrylate using catalyst A and catalyst B together, contact treatment of the ester exchange reaction product with adsorbent C is performed. Catalyst A: One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure and salts or complexes thereof, amidine and salts or complexes thereof, compounds with a pyridine ring and salts or complexes thereof, phosphines and salts or complexes thereof, and compounds with a tertiary diamine structure and salts or complexes thereof. Catalyst B: One or more kinds of compounds selected from a group consisting of compounds comprising zinc. Adsorbent C: One or more kinds of compounds selected from a group consisting of oxides and hydroxides comprising at least one of magnesium, aluminum and silicon.