Abstract: An object of the present invention is to provide a method for measuring tryptase activity in a blood sample accurately and rapidly by a convenient operation in order to accurately evaluate the state of a disease whose state involves mast cells. The present invention enables tryptase activity in a blood sample to be directly measured without the pretreatment, such as purification or concentration, of the blood sample, using a substrate for measuring tryptase activity, comprising a tripeptide C-terminally linked through a peptide bond to a dye label, selected from the following formulas (1) to (3): (1) Lys-Ala-Arg-X, (2) Ala-Ala-Arg-X, and (3) Abu-Ala-Arg-X (wherein X represents a dye label whose fluorescence characteristics or color development characteristics change upon the cleavage of the peptide bond with Arg, and Abu represents 2-aminobutyric acid).
Type:
Application
Filed:
September 4, 2020
Publication date:
November 17, 2022
Applicants:
National University Corporation Tokyo University of Agriculture and Technology, Peptide Support Co., Ltd.
Abstract: A radial-gap type superconducting synchronous machine 1 is prepared which includes a rotor 20 having, on its peripheral side, a convex magnetic pole 21 which includes, at its distal end part, bulk superconductors 30. When viewed in the direction of the rotational axis C1 of the rotor 20, the magnetic pole center side of the bulk superconductors 30 is disposed nearer to a stator 10 than the magnetic pole end side of the bulk superconductors 30. A ferromagnet 28 is disposed on the rotational axis C1 side of the bulk superconductors 30. A magnetizing apparatus 100 is disposed outside the bulk superconductors 30 in the radial direction of the rotor 20. Magnetization of the bulk superconductors 30 is performed by directing magnetic flux lines from the magnetizing apparatus 100 toward the bulk superconductors 30.
Type:
Grant
Filed:
February 10, 2020
Date of Patent:
November 15, 2022
Assignee:
National University Corporation Tokyo University Of Marine Science And Technology
Abstract: This disclosure provides a vapor-liquid reaction device including a vapor-liquid reaction chamber and a projecting member. The vapor-liquid reaction chamber holds a molten metal in a lower portion of an internal space of the vapor-liquid reaction chamber.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
November 15, 2022
Assignees:
National University Corporation Tokyo University of Agriculture and Technology, Taiyo Nippon Sanso Corporation, Taiyo Nippon Sanso CSE Corporation
Abstract: The present invention provides a method for quantitatively detecting ?-1,3-1,6-glucan separately from ?-1,3-glucan and ?-1,3-1,4-glucan. The present invention is a method for measuring ?-1,3-1,6-glucan, the method including: a step for mixing ?-glucan in a test sample, a molecule that specifically binds to a ?-(1?3) bond, and a molecule that specifically binds to a ?-(1?6) bond to form a complex containing the molecule that specifically binds to a ?-(1?3) bond and the molecule that specifically binds to a ?-(1?6) bond; a step for detecting the complex; and a step for measuring the amount of ?-1,3-1,6-glucan in the test sample, on the basis of the results of the detection.
Type:
Application
Filed:
May 18, 2022
Publication date:
September 1, 2022
Applicants:
OLYMPUS CORPORATION, Tokyo University of Pharmacy & Life Sciences
Abstract: An encrypted data processing system is provided including an encryption device and a server. The encryption device includes an encrypting section that encrypts first information based on a first encryption key and transmits the encrypted information for registration to the server, and encrypts second information based on a second encryption key and transmits the encrypted information to be compared to the server. The server includes a comparison section that employs a cipher comparison function for comparing encrypted information to compare the encrypted information for registration against the encrypted information to be compared, and transmits a comparison result to the encryption device. The encryption device further includes a comparison result decrypting section that employs a decryption function for decrypting the comparison result with the first encryption key and the second encryption key to find a degree of matching between the first information and the second information.
Abstract: There is provided technology for promoting permeation of a substance into a cell layer. Provided is a cell layer permeation promoter comprising a compound represented by general formula (1). Also provided is a composition for facilitating drug absorption that contains the cell layer permeation promoter, said composition being for facilitating absorption of a drug into a living body. Also provided is a pharmaceutical composition that contains the cell layer permeation promoter and furthermore contains a drug to be absorbed into a living body.
Type:
Application
Filed:
March 19, 2020
Publication date:
July 21, 2022
Applicants:
University of Tsukuba, Tokyo University of Pharmacy and Life Sciences
Abstract: Provided are: a pharmaceutical composition for curing, treating, or preventing a disease involving a biological mechanism controlled by a dendritic cell immunoreceptor, in which the pharmaceutical composition contains a carbohydrate modifying enzyme as an active ingredient; and a method of curing, treating, or preventing a disease involving a biological mechanism controlled by a dendritic cell immunoreceptor.
Abstract: A map information provision system includes: a road map information database configured to store road map information; a vehicle position determination unit configured to detect and determine a position of a vehicle on a road; a road map information extraction unit configured to extract the road map information around the vehicle from the road map information database, based on the position of the vehicle; and a waypoint map constructor unit configured to determine positions of waypoints and configure a waypoint map that is made up of the plurality of the waypoints, wherein the waypoint map is supplied to a driving support device for the vehicle or a driving control device for the vehicle and is utilized as map information on the planned driving route.
Type:
Grant
Filed:
October 5, 2018
Date of Patent:
April 19, 2022
Assignees:
TOYOTA JIDOSHA KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, National University Corporation Tokyo University of Agriculture and Technology, SCHOOL JUDICIAL PERSON IKUTOKU GAKUEN
Abstract: Provided are stereoscopic eyeglasses capable of reducing visual fatigue in binocular stereoscopic display by a simple configuration. In stereoscopic eyeglasses, in order to expand a tolerance of match between vergence and accommodation enabling comfortable stereovision in eyeglasses-using stereoscopic display, wide-focus lenses ranging in focal length are incorporated so as to overlap optical filters in light transmission directions, and accordingly, visual fatigue to be caused by vergence-accommodation conflict during stereoscopic image observation is reduced.
Type:
Grant
Filed:
June 7, 2019
Date of Patent:
April 12, 2022
Assignees:
National University Corporation Tokyo University of Agriculture and Technology, Itoh Optical Industrial Co., Ltd.
Abstract: The transplant fish production method includes selecting a donor fish species, selecting first and second fish species which are a combination that could be sterile, producing a hybrid fish species of the selected first fish species and second fish species, and transplanting reproductive cells of the donor fish species into the produced hybrid fish species.
Type:
Application
Filed:
March 1, 2021
Publication date:
January 27, 2022
Applicants:
National University Corporation Tokyo University of Marine Science and Technology, Nippon Suisan Kaisha, Ltd.
Abstract: An electrolyte solution for a potassium ion battery or a potassium ion capacitor, the electrolyte solution comprising at least one potassium salt compound selected from the group consisting of potassium bis(trifluoromethanesulfonyl)amide and potassium bis(fluorosulfonyl)amide and at least one solvent selected from the group consisting of ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, tetraethylene glycol dimethyl ether, pentaethylene glycol dimethyl ether, ethylene carbonate, and propylene carbonate, in which a concentration of the potassium salt compound in the electrolyte solution is from 1.5 mol/kg to 12.0 mol/kg.
Abstract: An object of the present invention is to develop a therapeutic agent for an inflammatory disease such as an inflammatory bowel disease or NASH, which therapeutic agent shows less side effects and high effectiveness. The present invention provides a compound represented by Formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic agent or a prophylactic agent for an inflammatory disease, and a therapeutic agent or a prophylactic agent for colon cancer, containing the compound.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
December 21, 2021
Assignees:
Hiroshima University, Tokyo University of Pharmacy & Life Sciences, The University of Tokyo
Abstract: A driving assistance system includes a driving readiness degree estimation unit configured to estimate a driving readiness degree relating to a driving consciousness of the driver based on the travel state of the vehicle or the driving operation of the vehicle by the driver and the traveling environment of the vehicle, a proportional gain calculation unit configured to calculate a proportional gain based on the driving readiness degree and the speed of the vehicle, and an assistance torque calculation unit configured to calculate the assistance torque according to a value obtained by multiplying a difference between the target steering angle and the actual steering angle by the proportional gain. If the speed is constant, the proportional gain calculation unit is configured to calculate the proportional gain as a smaller value as the driving readiness degree becomes lower.
Type:
Grant
Filed:
June 17, 2019
Date of Patent:
December 7, 2021
Assignees:
TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Tokyo University of Agriculture and Technology
Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
Type:
Grant
Filed:
November 15, 2017
Date of Patent:
December 7, 2021
Assignees:
Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
Abstract: Polycrystalline magnesium silicide containing only carbon as a dopant and having carbon distributed at the crystal grain boundaries and within the crystal grains, a thermoelectric conversion material obtained using the polycrystalline magnesium silicide, a sintered compact, a thermoelectric conversion element, and a thermoelectric conversion module, and methods for producing polycrystalline magnesium silicide and a sintered compact.
Abstract: An energy-sensitive composition including at least one of a silane compound monomer capable of forming a polysilane compound, a silane compound oligomer and the polysilane compound, and a base generator (B) represented by the following formula (1): in which R1 to R11 each independently represents a hydrogen atom, a halogen atom, a nitro group, an alkyl group, an aryl group, an arylalkyl group or an alkoxy group, R5 and R6 may be connected to each other via a single bond or a divalent linking group, Zq+ represents a q-valent counter cation composed of a base having a pKa of 24 or more, and q represents an integer of 1 or more.
Type:
Grant
Filed:
April 22, 2019
Date of Patent:
August 31, 2021
Assignees:
Tokyo Ohka Kogyo Co., Ltd., Tokyo University of Science Foundation
Inventors:
Kunihiro Noda, Dai Shiota, Koji Arimitsu
Abstract: A three-dimensional printing system (1) includes: a head (2) to which a first continuous material (FL) including a resin and a second continuous material (FB) including fibers are fed; a platform (3) on which a printing material based on the first and second continuous materials from the head is stacked; a cutting device (10) which is capable of cutting at least fibers; and a controller (5) which controls an operation device including at least one of the head, the platform, and the cutting device.
Type:
Grant
Filed:
May 27, 2015
Date of Patent:
August 31, 2021
Assignees:
Nihon University, Tokyo University of Science Foundation
Abstract: An object of the present invention is to provide a novel composition for use in suppressing fat accumulation, a novel composition for use in suppressing body weight gain, and a composition for use in promoting the production of a ketone body. According to the present invention, there is provided a composition for use in suppressing fat accumulation, suppressing body weight gain and/or promoting the production of a ketone body, comprising, as an active ingredient, a medium chain fatty acid glyceride comprising a saturated fatty acid having 8 carbon atoms as a constituent fatty acid. The ratio of the amount of the saturated fatty acid having 8 carbon atoms to the total amount of medium chain fatty acids of the medium chain fatty acid glyceride can be set to 0.6 or more. The medium chain fatty acid glyceride may further comprise, as a constituent fatty acid, a saturated fatty acid having 10 carbon atoms and/or a saturated fatty acid having 12 carbon atoms.
Type:
Application
Filed:
July 2, 2019
Publication date:
August 26, 2021
Applicants:
National University Corporation Tokyo University of Agriculture and Technology, THE FOOD SCIENCE INSTITUTE FOUNDATION, MEIJI CO., LTD.
Abstract: To provide a moth-eye transfer mold and a method of manufacturing a moth-eye transfer mold that provide a simple and inexpensive manufacturing process. A moth-eye transfer mold 1 is characterized by including a base 10, an underlayer 20 formed on the base 10, and a glassy carbon layer 30 formed on the underlayer 20, the glassy carbon layer 30 has an inverted moth-eye structure RM over a surface 30a, and the inverted moth-eye structure RM is randomly arranged cone-shaped pores.
Type:
Grant
Filed:
June 12, 2019
Date of Patent:
August 17, 2021
Assignees:
Tokyo University of Science Foundation, GEOMATEC CO., LTD.