Patents Assigned to Tokyo University
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Publication number: 20230032859Abstract: Provided is a head-mounted display capable of expanding the range in which a user can clearly view images. A head-mounted display 1 includes a display device 3 to display images 3a and 3b for the left eye and the right eye on a screen 3c, and virtual image forming optical systems 4a and 4b for the left eye and the right eye respectively disposed with respect to the images 3a and 3b for the left eye and the right eye on the screen 3c, wherein the virtual image forming optical systems 4a and 4b have positive power set in respective regions that visual lines of a user pass through, and include, at outer sides of optical centers in directions orthogonal to optical axes, power adjusting regions 55 having power set closer to the negative side than power at the optical centers.Type: ApplicationFiled: January 18, 2021Publication date: February 2, 2023Applicants: National University Corporation Tokyo University of Agriculture and Technology, Itoh Optical Industrial Co., Ltd.Inventors: Yasushi Miyajima, Yasuhiro Takaki
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Patent number: 11566047Abstract: Provided is a peptide having a short chain length, for example, having the number of amino acid residues of 20 or less and having a high myostatin inhibitory activity. The present invention is a peptide comprising an amino acid sequence represented by Formula (1) in the specification and having the number of amino acid residues of 20 or less.Type: GrantFiled: August 8, 2017Date of Patent: January 31, 2023Assignee: TOKYO UNIVERSITY OF PHARMACY & LIFE SCIENCESInventors: Yoshio Hayashi, Kentaro Takayama, Yoichi Negishi
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Publication number: 20230026894Abstract: Provided is a light detection device having a laser light source, a splitting unit, a first modulation unit, a second modulation unit, a first detection unit and a second detection unit that detect light, and a control unit.Type: ApplicationFiled: December 24, 2020Publication date: January 26, 2023Applicant: National University Corporation Tokyo University of Agriculture and TechnologyInventors: Kazuhiko Misawa, Terumasa Ito
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Patent number: 11558694Abstract: An electret includes a composite oxide having an ABO3 type perovskite structure containing two different metal elements A and B. The composite oxide is in a polarized state, at least a part of one of the metal elements A and B is substituted with a dopant element having a lower valence than the one of the metal elements A and B, and the composite oxide has a bandgap energy of 4 eV or more.Type: GrantFiled: December 9, 2020Date of Patent: January 17, 2023Assignees: DENSO CORPORATION, TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Yoshihiro Kozawa, Noriyuki Matsushita, Kazuhiko Kanoh, Yumi Tanaka, Tomoya Maruyama, Hiroshi Okamoto, Naoya Morioka, Katsuyoshi Saiki
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Publication number: 20230003813Abstract: Proposed is a phase shift introduction method, a structure, and a circuit device for eliminating or minimizing a risk associated with dissimilar materials, solving in principle a problem of mixing of a signal current and a control current that occurs due to DC connection of a phase shifter to a signal line, and stably and reliably providing a phase shift that is desired to be introduced without being adversely effected by noise generated by an ambient magnetic field, which is generated due to use of an external power supply. A structure according to the present invention includes a phase shifter 101 and a closed-loop circuit 103 that is directly used for computation or storage, and a quantum phase shift is generated in the closed-loop circuit 103 by using a fractional flux quantum captured by the phase shifter 101 that is DC-separated from the closed-loop circuit 103.Type: ApplicationFiled: November 26, 2020Publication date: January 5, 2023Applicants: National Institute of Advanced Industrial Science and Technology, NATIONAL INSTITUTE FOR MATERIALS SCIENCE, Tokyo University of Science FoundationInventors: Yasumoto TANAKA, Hirotake YAMAMORI, Takashi YANAGISAWA, Shunichi ARISAWA, Taichiro NISHIO
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Patent number: 11542292Abstract: Provided a polymerizable compound represented by the following Formula A-1 or Formula A-2: In Formula A-1 or Formula A-2, R1 represents an electron-donating group; n represents an integer from 1 to 5; R2 represents a hydrogen atom, a halogen atom, or —ORO, wherein RO represents a hydrogen atom, an alkyl group, or a protecting group of a hydroxy group; R3 represents a hydrogen atom or a protecting group of a hydroxy group; and X represents a structure represented by any one of Formula B-1 to Formula B-5.Type: GrantFiled: November 9, 2017Date of Patent: January 3, 2023Assignee: TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Takeshi Wada, Tatsuya Saito, Yuka Ishii, Yohei Nukaga
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Publication number: 20220380763Abstract: A novel anti-tumor agent capable of delivering siRNA or shRNA specifically to pancreatic cancer cells and suppressing tumor growth, invasion, and metastasis of pancreatic cancer is provided. The present invention provides a nucleic acid delivery enhancer for delivering siRNA or shRNA into cells, which consists of a folic acid-cationic oligopeptide complex. The present invention also provides an anti-tumor agent having siRNA or shRNA capable of binding to mRNA or snoRNA expressed in pancreatic cancer cells to inhibit its expression and a folic acid-cationic oligopeptide complex. The siRNA is capable of binding to RNA selected from the group consisting of, for example, SNORA18 snoRNA, NUP85 mRNA, WASF2 mRNA, and SNORA22 snoRNA.Type: ApplicationFiled: October 26, 2020Publication date: December 1, 2022Applicants: NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY, TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Keisuke TANIUCHI, Takeshi WADA, Rintaro HARA, Kazuki SATO, Kazunori TAKAGI
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Patent number: 11504379Abstract: The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.Type: GrantFiled: August 6, 2018Date of Patent: November 22, 2022Assignees: Hiroshima University, Tokyo University of Pharmacy & Life Sciences, The University of TokyoInventors: Tomoichiro Asano, Yusuke Nakatsu, Hisanaka Ito, Takayoshi Okabe
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Publication number: 20220364141Abstract: An object of the present invention is to provide a method for measuring tryptase activity in a blood sample accurately and rapidly by a convenient operation in order to accurately evaluate the state of a disease whose state involves mast cells. The present invention enables tryptase activity in a blood sample to be directly measured without the pretreatment, such as purification or concentration, of the blood sample, using a substrate for measuring tryptase activity, comprising a tripeptide C-terminally linked through a peptide bond to a dye label, selected from the following formulas (1) to (3): (1) Lys-Ala-Arg-X, (2) Ala-Ala-Arg-X, and (3) Abu-Ala-Arg-X (wherein X represents a dye label whose fluorescence characteristics or color development characteristics change upon the cleavage of the peptide bond with Arg, and Abu represents 2-aminobutyric acid).Type: ApplicationFiled: September 4, 2020Publication date: November 17, 2022Applicants: National University Corporation Tokyo University of Agriculture and Technology, Peptide Support Co., Ltd.Inventors: Hiroshi Matsuda, Norikazu Nishino
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Patent number: 11502590Abstract: A radial-gap type superconducting synchronous machine 1 is prepared which includes a rotor 20 having, on its peripheral side, a convex magnetic pole 21 which includes, at its distal end part, bulk superconductors 30. When viewed in the direction of the rotational axis C1 of the rotor 20, the magnetic pole center side of the bulk superconductors 30 is disposed nearer to a stator 10 than the magnetic pole end side of the bulk superconductors 30. A ferromagnet 28 is disposed on the rotational axis C1 side of the bulk superconductors 30. A magnetizing apparatus 100 is disposed outside the bulk superconductors 30 in the radial direction of the rotor 20. Magnetization of the bulk superconductors 30 is performed by directing magnetic flux lines from the magnetizing apparatus 100 toward the bulk superconductors 30.Type: GrantFiled: February 10, 2020Date of Patent: November 15, 2022Assignee: National University Corporation Tokyo University Of Marine Science And TechnologyInventors: Mitsuru Izumi, Motohiro Miki
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Patent number: 11499247Abstract: This disclosure provides a vapor-liquid reaction device including a vapor-liquid reaction chamber and a projecting member. The vapor-liquid reaction chamber holds a molten metal in a lower portion of an internal space of the vapor-liquid reaction chamber.Type: GrantFiled: May 17, 2018Date of Patent: November 15, 2022Assignees: National University Corporation Tokyo University of Agriculture and Technology, Taiyo Nippon Sanso Corporation, Taiyo Nippon Sanso CSE CorporationInventors: Akinori Koukitu, Hisashi Murakami, Akira Yamaguchi, Kazushige Shiina, Hayato Shimamura
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Publication number: 20220356462Abstract: A nucleic acid amplification method using a solid-phase carrier according to the present invention comprises: capturing a target nucleic acid comprising mRNA on a solid-phase carrier; carrying out complementary-strand synthesis on the solid phase; carrying out exonuclease treatment to degrade and remove unreacted target- capturing nucleic acid on the solid phase; and then carrying out mRNA degradation and homopolymer addition by TdT reaction in the presence of a chain-terminating nucleotide triphosphate. According to the method of the present invention, cDNA can be stably and highly efficiently amplified even from a small amount of sample even in cases where the ratio of the amount of enzyme to the DNA substrate on the solid phase is excessive, where the reaction time is excessive, and/or where reagents show lot-to-lot variation.Type: ApplicationFiled: July 10, 2020Publication date: November 10, 2022Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Kouji MATSUSHIMA, Satoshi UEHA, Shigeyuki SHICHINO, Satoru ITO, Hiroyasu AOKI
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Patent number: 11472109Abstract: A three-dimensional printing apparatus (1) allowing a linear filament (F) in which a fiber bundle (C) is impregnated with resin (P) to be continuously ejected includes twisting means (6) for allowing a total amount of twisting of the filament (F) or an amount of twisting of the fiber bundle (C) to be changed.Type: GrantFiled: February 13, 2018Date of Patent: October 18, 2022Assignees: NIHON UNIVERSITY, TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Masahito Ueda, Ryosuke Matsuzaki, Yoshiyasu Hirano
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Publication number: 20220313647Abstract: Disclosed is a novel measure that is effective in therapy etc. of psychiatric or neurological disorders or symptoms, such as anxiety or depressive disorders, and is unlikely to cause problems such as dependence and adverse effects and is highly safe. The present invention provides an agent for treating, preventing, or ameliorating psychiatric or neurological disorders or symptoms, wherein the agent contains any of the followings as an active ingredient: (1) disulfiram, (2) a metal complex of diethyldithiocarbamate, (3) a disulfide capable of generating diethyldithiocarbamate in the body, (4) a pharmaceutically acceptable salt of (1), (2), or (3), and (5) a solvate of (1), (2), (3), or (4).Type: ApplicationFiled: September 25, 2020Publication date: October 6, 2022Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Akiyoshi SAITOH, Yuya TERASHIMA, Kouji MATSUSHIMA, Yoshitake SANO
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Patent number: 11450445Abstract: A method for manufacturing an electroconductive pattern 40, provided with: a lamination step for laminating an acid generation film 10 containing an acid proliferation agent and a photoacid generator on a polymer film 20 containing an electroconductive polymer formed on a substrate 21; a masking step for masking the top of the acid generation film 10; a light irradiation step for irradiating the laminate from the acid-generation-film 10 side; a doping step for doping the electroconductive polymer with an acid generated and proliferated in the acid generation film 10 by the light irradiation; and a releasing step for releasing the acid generation film 10 from the polymer film 20. This method makes it possible to provide an electroconductive film and a method for manufacturing an electroconductive pattern in which photoacid generation and acid proliferation effects are utilized.Type: GrantFiled: June 8, 2020Date of Patent: September 20, 2022Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Koji Arimitsu, Makoto Wakabayashi
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Publication number: 20220281746Abstract: An embodiment of the present invention provides a noble gas hydride having the following formula 1: NgnHm. In formula 1, Ng represents a noble gas atom, n represents an integer from 1-8, and m represents an integer from 1-46.Type: ApplicationFiled: July 6, 2020Publication date: September 8, 2022Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventor: Kazuo WATANABE
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Publication number: 20220276231Abstract: The present invention provides a method for quantitatively detecting ?-1,3-1,6-glucan separately from ?-1,3-glucan and ?-1,3-1,4-glucan. The present invention is a method for measuring ?-1,3-1,6-glucan, the method including: a step for mixing ?-glucan in a test sample, a molecule that specifically binds to a ?-(1?3) bond, and a molecule that specifically binds to a ?-(1?6) bond to form a complex containing the molecule that specifically binds to a ?-(1?3) bond and the molecule that specifically binds to a ?-(1?6) bond; a step for detecting the complex; and a step for measuring the amount of ?-1,3-1,6-glucan in the test sample, on the basis of the results of the detection.Type: ApplicationFiled: May 18, 2022Publication date: September 1, 2022Applicants: OLYMPUS CORPORATION, Tokyo University of Pharmacy & Life SciencesInventors: Hidetaka NAKATA, Yoshiyuki ADACHI, Kenichi ISHIBASHI, Daisuke YAMANAKA, Naohito OHNO
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Patent number: 11427776Abstract: The present invention provides a method for producing a biofuel that allows an animal/vegetable fat/oil raw material containing a free fatty acid to react with a lower alcohol in the presence of a solid acid catalyst, in which the consumption of the lower alcohol is reduced and the free fatty acid and the lower alcohol are selectively esterified to reform the animal/vegetable fat/oil. In this method, as a solid acid catalyst is used a catalyst selected from an SiO2/Al2O3 solid acid catalyst, an SiO2/Al2O3 solid acid catalyst with aluminum being partially introduced into mesoporous silica, an Al2O3/B2O3 solid acid catalyst, and a sulfated zirconia solid acid catalyst, with a molar ratio of the free fatty acid and the lower alcohol of 1 to 6.Type: GrantFiled: July 17, 2019Date of Patent: August 30, 2022Assignees: FUJITUSYO CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE & TECHNOLOGYInventors: Eika W. Qian, Toshitaka Watanabe, Masaaki Katou
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Patent number: 11431686Abstract: An encrypted data processing system is provided including an encryption device and a server. The encryption device includes an encrypting section that encrypts first information based on a first encryption key and transmits the encrypted information for registration to the server, and encrypts second information based on a second encryption key and transmits the encrypted information to be compared to the server. The server includes a comparison section that employs a cipher comparison function for comparing encrypted information to compare the encrypted information for registration against the encrypted information to be compared, and transmits a comparison result to the encryption device. The encryption device further includes a comparison result decrypting section that employs a decryption function for decrypting the comparison result with the first encryption key and the second encryption key to find a degree of matching between the first information and the second information.Type: GrantFiled: December 11, 2018Date of Patent: August 30, 2022Assignee: Tokyo University of Science FoundationInventors: Satoshi Iriyama, Maki Kihara
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Patent number: 11405072Abstract: A communication method includes generating at a first node, a message of a predetermined message temporal length that indicates an input value to be encoded and transmitting, at the first node, a signal including a pulse train corresponding to the generated message. The signal including the pulse train includes two pulses that define start and end of the message, respectively, and further two pulses that define within the message, a first time interval calculated from the input value in accordance with a first function and a second time interval calculated from the input value in accordance with a second function, respectively.Type: GrantFiled: July 16, 2019Date of Patent: August 2, 2022Assignees: NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY, TOKYO UNIVERSITY OF SCIENCE FOUNDATIONInventors: Ferdinand Peper, Kenji Leibnitz, Tetsuya Shimokawa, Mikio Hasegawa, Kaori Kuroda