Abstract: This invention relates to medical image registration. Specifically, the invention relates to a combined feature ensemble mutual information (COFEMI) for robust inter-modal, inter-protocol image registration.

Abstract: The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA.

Abstract: The present invention relates to novel diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes encoding proteins having diacylglycerol acetyltransferase activity, specifically for transferring an acetyl group to a diacylglycerol substrate to form acetyl-Triacylglycerols (ac-TAGS), for example, a 3-acetyl-1,2-diacyl-sn-glycerol. The present invention encompasses both native and recombinant wild-type forms of the transferase, as well as mutants and variant forms. The present invention also relates to methods of using novel diacylglycerol acyltransferase genes and proteins, including their expression in transgenic organisms at commercially viable levels, for increasing production of 3-acetyl-1,2-diacyl-sn-glycerols in plant oils and altering the composition of oils produced by microorganisms, such as yeast, by increasing ac-TAG production.

Abstract: The present invention provides methods embodied in a system that can be applied to genetic information comprising an individual genome to assess the regulatory impact of specific genetic variants and their possible impact on biological function or disease pathology.

Abstract: A controlled release substance containing organosilica sol-gels is provided. The organosilica sol-gels may be further functionalized with amino groups to control the rate of release of encapsulated molecules. The controlled release substance may be utilized as a controlled release fabric care substance, including at least one active fabric care substance in a host matrix comprising an organosilica gel. The fabric care substance may be at least one of a protein, enzyme, fragrance, anti-static agent, fabric softener, dye, or detergent, and may be in bead form, particle form or powder form.

Abstract: A method for organizing and displaying EEG data obtained from C EEG channels on a computer system in a user-friendly manner includes placing the C EEG channels into a schematic placement diagram dividing the C EEG channels, using a processor, into G channel groups for each of the G channel groups, combining any of the C EEG channels in such G channel group, using a processor, into a single trace, and for each of the G channel groups, displaying the single trace. A system for organizing and displaying EEG data is also provided.

Abstract: Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates.

Abstract: Asynchronous digital circuits are described, including arbitration and routing primitives for asynchronous and mixed-timing networks. An asynchronous arbitration primitive has two data inputs and one data output. A mutual exclusion element is used to select the first-arriving data request from one of the two inputs to the output. A asynchronous routing primitive has one data input and two data outputs. The incoming data is routed to one of the two outputs based on a routing bit accompanying the data. The primitives use handshaking with request and acknowledge signals to ensure that data is passed when neighboring circuits are ready to receive or send data.

Abstract: Measuring of the binding of a transcription factor (using, for example, chromatin immunoprecipitation) according to the present invention is provides an improved marker for a disease. These markers can be used in diagnostics for diseases where a transcription factor binding event plays a role. Additionally, they can be used to adjust disease risk profiles for healthy individuals as with typical genetic variants.

Abstract: An apparatus and method is provided for forming a flower pot cover with at least one indented portion to retain the flower pot cover on the flower pot.

Abstract: An optical sensor, a method of configuring an optical sensor, and a method of using an optical sensor are provided. The optical sensor includes an optical waveguide having a length and a laser source optically coupled to the waveguide. The laser source has a coherence length. Light from the source is transmitted to the waveguide as a first signal propagating along the waveguide in a first direction and a second signal propagating along the waveguide in a second direction opposite to the first direction. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after propagating through the waveguide to generate a third signal. The coherence length is greater than 1 meter or is in a range between 200 microns and 10 centimeters.

Abstract: The invention provides a method of creating an atrioventricular bypass tract for a heart comprising growing mesenchymal stem cells into a strip with two ends, and attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart. By this attachment, a tract is created that connects the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.

Abstract: A chemical composite useful for preparing a bioelectronic device includes a biologically active compound, such as an enzyme, that is bound directly or indirectly to a polyelectrolyte, which can be reversibly coupled to a chemically treated electrically conductive substrate by electrostatic forces to provide biomimetic sensors, catalyst systems, and other devices having an electrode that can be regenerated and reused. Required or desired cofactors, mediators or the like may be incorporated into the devices, typically by bonding them to the treated substrate and/or the polyelectrolyte.

Abstract: A method for forming a coating over a surface is disclosed. The method comprises depositing over a surface, a hybrid layer comprising a mixture of a polymeric material and a non-polymeric material. The hybrid layer may have a single phase or comprise multiple phases. The hybrid layer is formed by chemical vapor deposition using a single source of precursor material. The chemical vapor deposition process may be plasma-enhanced and may be performed using a reactant gas. The precursor material may be an organo-silicon compound, such as a siloxane. The hybrid layer may comprise various types of polymeric materials, such as silicone polymers, and various types of non-polymeric materials, such as silicon oxides. By varying the reaction conditions, the wt % ratio of polymeric material to non-polymeric material may be adjusted. The hybrid layer may have various characteristics suitable for use with organic light-emitting devices, such as optical transparency, impermeability, and/or flexibility.

Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C.

Abstract: A carbon dioxide permeable membrane is described. In some embodiments, the membrane includes a body having a first side and an opposite second side; a plurality of first regions formed from a molten carbonate having a temperature of about 400 degrees Celsius to about 1200 degrees Celsius, the plurality of first regions forming a portion of the body and the plurality of first regions extending from the first side of the body to the second side of the body; a plurality of second regions formed from an oxygen conductive solid oxide, the plurality of second regions combining with the plurality of first regions to form the body and the plurality of second regions extending from the first side of the body to the second side of the body; and the body is configured to allow carbon dioxide to pass from the first side to the second side.

Abstract: The present disclosure can provide apparatus, system, methods, and computer-accessible medium for generating particular information which is at least one of three-dimensional information or intensity information of a tissue portion which can include at least one of a tissue surface or a tissue volume. For example, the exemplary method can include determining a light intensity distribution of light provided on the tissue portion, using the light intensity distribution, determining one or more attenuation maps of the tissue portion, obtaining one or more multispectral measurements of the light intensity distribution on the tissue portion taken from one or more views, and generating the particular information using an image reconstruction procedure in conjunction with data from the one or more tissue attenuation maps and the multispectral measurements.

Abstract: This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.

Abstract: A peer to peer network includes multiple communication layers, each specifying a path through which network peers send data through the peer to peer network. A network peer in the peer to peer network may receive data from a parent network peer and send data to a child network peer. The network peer may identify communication interruption caused by the child network peer and a subsequent downstream network peer leaving the peer to peer network. The network peer may resolve the communication interruption by identifying a new child peer, for example, by accessing a descendant list of multiple levels. The peer to peer network may increase the streaming rate or streaming quality using the peers that have higher or better communication capacities. The peer to peer network may accommodate multiple channels for video/audio or other types of real-time data broadcasted by different or same network peers.

Abstract: The compounds herein disclosed are N-aminopyrrolylmethyltetrahydropyridine analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-aminopyrrolylmethyltetrahydropyridines have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.