Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

Abstract: A high-throughput, low cost, patterning platform is provided that is an alternative to conventional photolithography and direct laser ablation patterning techniques. The processing methods are useful for making patterns of microsized and/or nanosized structures having accurately selected physical dimensions and spatial orientation that comprise active and passive components of a range of microelectronic devices. Processing provided by the methods is compatible with large area substrates, such as device substrates for semiconductor integrated circuits, displays, and microelectronic device arrays and systems, and is useful for fabrication applications requiring patterning of layered materials, such as patterning thin film layers in thin film electronic devices.

Abstract: The subject invention provides a unidirectional site-specific integration system for integrating a nucleic acid into the genome of a target cell. The provided systems include a (1) a mutant, unidirectional site specific integrase, which can be provided by an integrase vector encoding the mutant integrase and (2) a targeting vector that includes: (a) a nucleic acid to be integrated; and (b) a vector attachment site, where the targeting vector attachment site serves as a substrate for the mutant, unidirectional site-specific integrase. In using the subject systems for site-specific integration, the targeting vector and integrase are introduced into the target cell and the cell is maintained under conditions sufficient to provide for site-specific integration of the nucleic acid into the target cell genome via a recombination event mediated by the site-specific integrase. Also provided are kits that include the subject systems.

Abstract: A method for distributing a quantum key is provided, including sending a first photon to a first receiver; sending a second photon to a second receiver, the first and second photons being a pair of time-energy entangled photons; and providing a coding scheme comprising a plurality of time bins and a plurality of frequency bins, wherein a combination of a time bin and a frequency bin corresponds to a character.

Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.

Abstract: A decorative cover positionable about a flower pot is formed of a polymeric material or a laminated polymeric material. The decorative cover has a texture and/or appearance simulating the texture and/or appearance of paper on at least a portion of one surface thereof while exhibiting improved durability and decreased sensitivity to water, humidity and pressure when compared to a decorative cover formed of paper.

Abstract: Circuits that operate with power supplies of less than 1 Volt are presented. More particularly, circuits that operate with supply voltages near or lower than the threshold voltage of the transistors in those circuits are presented. Various circuits and embodiments such as operational transconductance amplifiers, biasing circuits, integrators, continuous-time sigma delta modulators, track-and-bold circuits, and others are presented. The techniques and circuits can be used in a wide range of applications and various transistors from metal-oxide-semiconductor to bipolar junction transistors may implement the techniques presented herein.

Abstract: With the advent of low cost, high-throughput whole genome sequencing (“next generation sequencing”), tools are available to assay human genetic variation contributing to inherited disease syndromes. A method is disclosed for prioritization of genetic variants, and identification of disease genes, using network modeling of gene associations.

Abstract: The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.

Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.

Abstract: Embodiments of the present invention provide methods and systems that perform comprehensive assessment of genetic variation presenting in a personal genome and provide quantitative diagnosis of the impact of each variant on physiological function and patient health.

Abstract: Methods, systems, and media for identifying similar songs using jumpcodes are provided. In some embodiments, methods for a cover song from a query song are provided, the methods comprising: identifying a query song jumpcode for the query song, wherein the query song jumpcode is indicative of changes in prominent pitch over a portion of the query song; identifying a plurality of reference song jumpcodes for a reference song, wherein each of the reference song jumpcodes is indicative of changes in prominent pitch over a portion of the reference song; determining if the query song jumpcode matches any of the plurality of reference song jumpcodes; and upon determining that the query song jumpcode matches at least one of the plurality of reference song jumpcodes, generating an indication that the reference song is a cover song of the query song.

Abstract: A microfabricated optical gyroscope that utilizes a linear array of micron scale optical ring resonators closely spaced to allow evanescent coupling of electromagnetic fields in adjacent resonators. Within each resonator, the optical Sagnac effect produces a phase difference between clockwise and counterclockwise propagating light that is proportional to the inertial rotation rate perpendicular to the plane of the resonator. The disclosure enhances the overall sensitivity to rotations by varying the strengths of the evanescent coupling between resonators and/or the circumferences of the resonators. The size and coupling strengths control the optical interference between resonators.

Abstract: This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.

Abstract: An amphiphilic substance includes a hydrophobic group, and a polynucleotide group attached to the hydrophobic group. The polynucleotide group includes a first polynucleotide segment and a second polynucleotide segment. The first and second polynucleotide segments are at least partially complementary and are bound together by interactions including base pairing. At least one of the first and second segments includes at least one of an aptamer and a nucleic acid-based enzyme. A lipid vesicle may include the amphiphilic substance, a first polar lipid that is an unstable vesicle former, and a polar liquid. Upon exposure to a rupture agent, the vesicle may rupture, releasing the contents of the vesicle. Substances that may be released from the vesicle include bioactive agents, such as drug agents.

Abstract: The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.

Abstract: Analysis of samples is facilitated. According to an example embodiment, an electrophoresis approach involves electrophoretically stacking and/or separating a sample or samples. An electrolyte and a mixture of one or more samples with another electrolyte are added to a microchannel or capillary. An electric field is applied to stack (and, in some applications, further separate) the one or more samples. Generally, the electric field and electrolyte are used to facilitate isotachophoretic (ITP) stacking. In some embodiments, a further electric field is applied and used with the electrolyte to facilitate subsequent capillary electrophoresis (CE).

Abstract: A magnetic proximity sensor is attached to a ferrous object such that the sensor alerts a practitioner if a threshold of magnetic strength has been exceeded by bringing the ferrous object within a certain proximity to the magnet of an MRI scanner. The magnetic proximity sensor includes at least one magnetic field sensor for sensing a magnetic field strength. An alarm in communication with the field sensor alerts a practitioner that a threshold of magnetic strength has been exceeded. A battery powers the field sensor and the alarm. The field sensor may produce an output voltage corresponding to the sensed magnetic field strength, and a potentiometer may provide a reference voltage corresponding to a threshold magnetic field strength. A comparator compares the reference voltage to the output voltage, and triggers an alarm if the output voltage exceeds the reference voltage.

Abstract: The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.

Abstract: Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a pressure sensor and an integrated circuit. The body portion includes a first end for receiving a fluid, a second end mateable with a feeding nipple, and a conduit in fluid communication with the first and second ends. The pressure sensor is disposed in the body portion, is in contact with the fluid in the conduit, and generates a signal representing a pressure of the fluid passing through the conduit during a feeding session. The integrated circuit is disposed in the body portion and is electrically connected to the pressure sensor. The integrated circuit receives the pressure signal and determines a feeding factor over the feeding session indicative of the infant feeding performance.