Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.
Type:
Application
Filed:
June 13, 2023
Publication date:
October 12, 2023
Applicant:
The Trustees of the University of Pennsylvania
Abstract: A biopolymer composition can be formed based, at least in part, on a recombinantly expressed protein, expressed from a DNA coding sequence of a source protein, and the recombinantly expressed protein can optionally comprise one or more tags that enhance the crosslinking capacity of the protein. It was determined that such biopolymer composition can be suitable for use to obtain, for example, a biodegradable textile that exhibits a functional characteristic associated with the recombinantly expressed protein.
Type:
Application
Filed:
March 24, 2021
Publication date:
October 12, 2023
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Theanne Schiros, Chui Lian Lee, Valentina Gomez, Morgana Katterm, Helen H. Lu, Alie Obermeyer, Philip Brudnicki, Sebastian S. Cocioba, Christopher Z. Mosher, Romare M. Antrobus, Yuncan Zuh, Aditi Sharma
Abstract: A stacked three-dimensional (3D) metasurface includes a first layer with a first kernel configured to apply a first convolution on a first frequency of an incident polarized light, and a second layer with a second kernel different than the first kernel. The second kernel is configured to apply a second convolution different than the first convolution on a second frequency of the incident polarized light and the second frequency is different than the first frequency such that the stack 3D metasurface provides at least two independent convolutions on the incident polarized light.
Type:
Application
Filed:
April 8, 2022
Publication date:
October 12, 2023
Applicants:
Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Shanhui Fan, Ercan Mehmet Dede, Sean P. Rodrigues, Haiwen Wang
Abstract: A method and apparatus for estimating depth information of an image are disclosed. The depth information estimation method of the image includes providing a confidence map for a ground truth depth map; and learning a depth information estimation model for estimating depth information of an image based on the ground truth depth map and the confidence map.
Type:
Application
Filed:
April 7, 2023
Publication date:
October 12, 2023
Applicants:
Electronics and Telecommunications Research Institute, The Trustees of Indiana University
Inventors:
Soon-Heung JUNG, David Crandall, Vibhas Kumar Vats, Shaurya Shubham, Md Alimoor Reza, Chuhua Wang
Abstract: A method of fabricating a power semiconductor device includes forming a bi layer mask on a semiconductor substrate, where the bilayer mask comprises a first dielectric layer on the semiconductor substrate and a second dielectric layer on the first dielectric layer. The first and second dielectric layers are through-etched to define an exposed portion of the semiconductor substrate. The first dielectric layer is selectively etched to form an undercut region of the bi layer mask. A crystalline semiconductor material is epitaxially grown on the exposed portion of the semiconductor substrate, and a polycrystalline semiconductor material is deposited on the second dielectric layer of the bilayer mask. After the epitaxial growth, the bilayer mask and the polycrystalline semiconductor material are removed from the semiconductor substrate, leaving behind a mesa comprising the crystalline semiconductor material on the semiconductor substrate.
Type:
Application
Filed:
July 30, 2021
Publication date:
October 12, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Kyekyoon Kim, Palash Sarker, Frank P. Kelly
Abstract: Current oscillometric devices for monitoring central blood pressure (BP) maintain the cuff pressure at a constant level to acquire a pulse volume plethysmography (PVP) waveform and calibrate it to brachial BP levels estimated with population average methods. A physiologic method was developed to further advance central BP measurement. A patient-specific method was applied to estimate brachial BP levels from a cuff pressure waveform obtained during conventional deflation via a nonlinear arterial compliance model. A physiologically-inspired method was then employed to extract the PVP waveform from the same waveform via ensemble averaging and calibrate it to the brachial BP levels. A method based on a wave reflection model was thereafter employed to define a variable transfer function, which was applied to the calibrated waveform to derive central BP.
Type:
Grant
Filed:
July 12, 2018
Date of Patent:
October 10, 2023
Assignee:
Board of Trustees of Michigan State University
Abstract: A system for providing intraoperative feedback to a user during the course of surgery. A core imaging unit provides low-coherence optical radiation coupled to a sampling device and generates optical coherence tomography (OCT) data based on combining scattered light received from the sampling device together with a reference signal. The sampling device is adapted to receive the low-coherence optical radiation from the core imaging unit and to illuminate the tissue, and to collect light scattered by the tissue and to return said light to the core imaging unit. A core software unit receives the OCT data from the core imaging unit provides real-time feedback, such as an image, to the user via an indicator.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
October 10, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk
Abstract: In some embodiments, an in-memory-computing SRAM macro based on capacitive-coupling computing (C3) (which is referred to herein as “C3SRAM”) is provided. In some embodiments, a C3SRAM macro can support array-level fully parallel computation, multi-bit outputs, and configurable multi-bit inputs. The macro can include circuits embedded in bitcells and peripherals to perform hardware acceleration for neural networks with binarized weights and activations in some embodiments. In some embodiments, the macro utilizes analog-mixed-signal capacitive-coupling computing to evaluate the main computations of binary neural networks, binary-multiply-and-accumulate operations. Without needing to access the stored weights by individual row, the macro can assert all of its rows simultaneously and form an analog voltage at the read bitline node through capacitive voltage division, in some embodiments.
Type:
Grant
Filed:
May 31, 2022
Date of Patent:
October 10, 2023
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Mingoo Seok, Zhewei Jiang, Jae-sun Seo, Shihui Yin
Abstract: Compositions and regimens useful in treating hemophilia A are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human Factor VIII.
Type:
Grant
Filed:
April 13, 2017
Date of Patent:
October 10, 2023
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Lili Wang, James M. Wilson, Jenny Agnes Sidrane
Abstract: An exemplary system, method, and computer-accessible medium for determining a position or a characteristic of a target(s) for a transcranial magnetic stimulation (TMS) treatment of a patient(s) can be provided, which can include, for example, receiving imaging information of a portion(s) of a head of the patient(s), and determining the position or the characteristic of the target(s) for the TMS treatment of the patient(s) based on the imaging information. The imaging information can be magnetic resonance imaging information. The imaging information can include information regarding a brain and a skull of the patient(s). The position or the characteristic of the target(s) can be determined by identifying (i) the skull, and (ii) a parcel in a section(s) of a brain of the patient(s). The parcel can a dorsolateral prefrontal cortex (DLPFC) parcel. The DLPFC parcel can be identified using a parcellation procedure, which can be a human connectome pipeline procedure.
Type:
Grant
Filed:
April 25, 2022
Date of Patent:
October 10, 2023
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Daniel Javitt, Joan Prudic, Stefan Rowny, Marta Moreno
Abstract: Materials and methods for enhancing the effectiveness of proton radiation therapy (e.g., high linear energy transfer (LET) proton radiation therapy) against tumor cells are provided herein.
Type:
Grant
Filed:
September 27, 2021
Date of Patent:
October 10, 2023
Assignees:
Humanetics Corporation, Trustees of the University of Pennsylvania
Inventors:
Adam J. Harvey, Michael D. Kaytor, Keith Cengel, Eric Stanton Diffenderfer
Abstract: Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets.
Type:
Grant
Filed:
May 4, 2022
Date of Patent:
October 10, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ravindra Majeti, Irving L. Weissman, Siddhartha Jaiswal, Mark P. Chao
Abstract: Engineered proteins, polynucleotides encoding such proteins, and methods of use thereof are provided, which engineered proteins enhance the sensitivity of a cell to IL-2.
Type:
Grant
Filed:
December 5, 2018
Date of Patent:
October 10, 2023
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Parker Institute for Cancer Immunotherapy
Inventors:
Kenan Christopher Garcia, Sean Parker, Jonathan Sockolosky, Michael Hollander
Abstract: A medication bottle includes an outer container wall, an inner container wall and a fluid, such as an aversive liquid, located between the walls. In another aspect, the fluid is located within separate compartments or channels located between the walls where the walls contact or are secured to each other. A further aspect provides a removeable cap including multiple sensors, at least one of which is a biometric sensor.
Type:
Grant
Filed:
September 21, 2021
Date of Patent:
October 10, 2023
Assignees:
Board of Trustees of Michigan State University, Board of Regents of the University of Nebraska
Inventors:
Bahar Aliakbarian, Muhammad Rabnawaz, Susan E. Selke, Krystal Cheng, Arun Ross, Austin Cozzo, Anurag Chowdhury, Ali Tamayol, Carina Russell, Prem Chahal
Abstract: Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRP? on a host phagocytic cell, in an effective dose for increasing the phagocytosis of infected cells.
Type:
Grant
Filed:
December 14, 2021
Date of Patent:
October 10, 2023
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The United States of America, as represented by the Secretary, Department of Health and Human Services, The Regents of the University of California
Inventors:
Kipp Andrew Weiskopf, Kim J. Hasenkrug, Cheryl A. Stoddart, Joseph McCrary McCune, Irving L. Weissman
Abstract: A flexible photovoltaic device is provided. The flexible photovoltaic device includes a flexible inorganic halide perovskite. The flexible inorganic halide perovskite is free of organic components, has a thickness of greater than or equal to about 1 ?m to less than or equal to about 1 nm, and has an average grain size of less than or equal to about 500 nm.
Type:
Grant
Filed:
May 1, 2019
Date of Patent:
October 10, 2023
Assignee:
Board of Trustees of Michigan State University
Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
Type:
Grant
Filed:
September 22, 2017
Date of Patent:
October 10, 2023
Assignees:
University of Rhode Island Board of Trustees, Yale University
Inventors:
Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
Type:
Grant
Filed:
June 28, 2019
Date of Patent:
October 10, 2023
Assignee:
Trustees of Boston University
Inventors:
Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
Abstract: Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, nucleic acid molecules, such as cell-free nucleic acids, can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.
Type:
Grant
Filed:
April 27, 2022
Date of Patent:
October 10, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Jacob J. Chabon, David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
Abstract: Embodiments of the invention are generally directed to lignin-modifying enzymes and systems and methods of their manufacture. In many embodiments, yeast strains, including S. cerevisiae, are used to produce and secrete lignin-modifying enzymes Further embodiments are directed to methods to screening peroxidase-producing yeast strains, including S. cerevisiae. Additional embodiments are directed to an expression vector or cassette encoding for a protein of interest and one or more proteins to allow for surface to display of the protein of interest.
Type:
Application
Filed:
June 7, 2021
Publication date:
October 5, 2023
Applicant:
The Board of Trustees of the Leland Stanford Junior University