Patents Assigned to Trustee
  • Strains of which inhibit
    Patent number: 11786565
    Abstract: Disclosed herein are compositions and methods for treating periodontal disease.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: October 17, 2023
    Assignee: Trustees of Tufts College
    Inventors: Linden Hu, Louis Cornacchione
  • Magnetic separation filters and microfluidic devices using magnetic separation filters
    Patent number: 11786914
    Abstract: A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: October 17, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Issadore, Venkata Yelleswarapu, Jina Ko
  • CRISPR/Cas system and method for genome editing and modulating transcription
    Patent number: 11788088
    Abstract: A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 17, 2023
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Ryan E. Clarke, Bradley J. Merrill, Matthew S. MacDougall, Hannah M. Pennington, Brian R. Shy
  • System and method for scaphoid fixation
    Patent number: 11786283
    Abstract: A system and method for installation of a k-wire through a scaphoid or other fractured bone can include a guide block for accurate trajectory of a k-wire. A support frame for a guide block can be casted and/or secured into place, and a CT scan is obtained, so the fractured bone and the location of the window can be known in the same three-dimensional space. An ideal k-wire trajectory can be plotted through the fractured bone, and a guide block with a lumen can be designed and printed using a three-dimensional printer. The guide block can be inserted into the frame so the lumen aligns with the ideal k-wire trajectory, and a k-wire can be inserted through the lumen into the fractured bone. The net effect would be ideal placement of the k-wire that would facilitate the ultimate insertion of a percutaneous screw to provide fixation of the fractured bone.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: October 17, 2023
    Assignees: Dartmouth-Hitchcock Clinic, The Trustees of Dartmouth College
    Inventors: Matthew C. DeWolf, Alexander Hartov, Lance G. Warhold
  • Mapping and localization system for autonomous vehicles
    Patent number: 11790542
    Abstract: Accurate vehicle localization is arguably the most critical and fundamental task for autonomous vehicle navigation. While dense 3D point-cloud-based maps enable precise localization, they impose significant storage and transmission burdens when used in city-scale environments. A highly compressed representation for LiDAR maps, along with an efficient and robust real-time alignment algorithm for on-vehicle LiDAR scans, is proposed here. The proposed mapping framework, requires less than 0.1% of the storage space of the original 3D point cloud map. In essence, mapping framework emulates an original map through feature likelihood functions. In particular, the mapping framework models planar, pole and curb features. These three feature classes are long-term stable, distinct and common among vehicular roadways. Multiclass feature points are extracted from LiDAR scans through feature detection.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: October 17, 2023
    Assignee: Board of Trustees of Michigan State University
    Inventors: Hayder Radha, Daniel Morris, Su Pang
  • Distributed sensor networks deployed using soft growing robots
    Patent number: 11788916
    Abstract: A distributed sensor network for soft growing robots is provided. Sensor bands are distributed at discrete intervals along the length of the flexible tube, and the sensor bands each are wrapped circumferentially around the diameter of the flexible tube. Each sensor band has one or more sensors and one or more semi-rigid islands containing a self-contained microcontroller, and one or more communication lines to an aggregator microcontroller located at the base of the soft growing robot communicatively connecting signals from the sensor bands. A casing laminates the distributed sensor network. In one example the encasing has cavities or a tooth geometry to allow bending. The casing is flexible to not hinder the growth of the soft growing robot, yet protecting the distributed sensor network.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: October 17, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Alexander M. Gruebele, Andrew C. Zerbe, Margaret M. Coad, Mark R. Cutkosky
  • Compositions comprising riboregulators and methods of use thereof
    Patent number: 11788156
    Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: October 17, 2023
    Assignees: President and Fellows of Harvard College, Trustees of Boston University
    Inventors: Alexander A. Green, Peng Yin, James J. Collins, Jongmin Kim
  • C19 scaffolds and steroids and methods of use and manufacture thereof
    Patent number: 11787835
    Abstract: The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: October 17, 2023
    Assignee: Trustees of Dartmouth College
    Inventor: Glenn C. Micalizio
  • Three dimensional multiphasic structures via vaporization induced phase separation (VIPS)
    Patent number: 11786879
    Abstract: This disclosure demonstrates a new method to produce three dimensional multiphasic structures, including bijels, via vapor-induced phase separation (VIPS). In VIPS, the evaporation of the co-solvent from a ternary mixture of oil, water and ethanol, induces phase separation. Particles present in the mixture attach to the interface and arrest the phase separation between water and oil. VIPS enables, inter alia, the fabrication of films and coatings via spreading or spraying particle-laden suspension onto a surface without the need for an outer aqueous phase.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: October 17, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Kathleen J Stebe, Tiancheng Wang
  • Circuits for intermediate-frequency-filterless, double-conversion receivers
    Patent number: 11791854
    Abstract: Circuits for receivers including: N first mixers that each receive an input signal, are each clocked by a different phase of a first common clock frequency, and each provide an output; and for each N first mixer: a set of M second mixers, wherein each second mixer receives as an input the output of a same one of the N first mixers unique to the set, wherein each of M second mixer is clocked by a different phase of a second common clock frequency, and wherein each second mixer has an output; a set of M resistors having a first side and a second side, wherein the first side is connected to the output of a corresponding one of the set of M second mixers; and a set of M trans-impedance amplifiers that each having an input connected to the second side of a corresponding one of the resistors.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: October 17, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Guoxiang Han, Peter R. Kinget, Tanbir Haque
  • RNA printing and sequencing devices, methods, and systems
    Patent number: 11788120
    Abstract: Described herein are devices, systems, and methods for trapping single-cell lysates in sealed, microwells capable of printing RNA on glass or capturing RNA on beads. These provide efficient, inexpensive manipulation of RNA from individual cells suitable for single-cell transcriptomics on a large scale. Also described are dual barcode capture beads and merged barcode capture beads.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 17, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Peter A. Sims, Sayantan Bose, Jinzhou Yuan
  • System and method to maintain health using personal digital phenotypes
    Patent number: 11786174
    Abstract: A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: October 17, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjiv M. Narayan, Mahmood Alhusseini
  • Small gap device system and method of fabrication
    Patent number: 11791142
    Abstract: A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: October 17, 2023
    Assignees: Spark Thermionics, Inc., The Trustees of the University of Pennsylvania
    Inventors: Matthew Campbell, Mohsen Azadi, Kyana Van Houten, Jared William Schwede, Samuel M. Nicaise, Igor Bargatin
  • Modular medical mobility device
    Patent number: 11786418
    Abstract: A modular ride-on is provided that is adjustable based on the needs of the operator. The modular ride-on offers children and young adults with disabilities a higher degree of freedom and comfort over traditional mobility devices—such as wheelchairs. The modular ride-on includes a chassis configured to removably couple a plurality of adjustable modules. The independently adjustable modules include a front-end module, first and second drive modules, a seating module, a harness module, an armrest module, a footrest module, a leg support, module, a body module, and a control module.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: October 17, 2023
    Assignee: University of North Florida Board of Trustees
    Inventors: Juan Aceros, Matthew Cantwell, John Prisco
  • SYNTHETIC PEPTIDES FOR DISSOLVING TAU INCLUSIONS
    Publication number: 20230322861
    Abstract: A synthetic peptide may be provided for use in dissolving tau inclusions. The peptide may include a first sequence consisting of M serine residues, where M is at least 30, and may be, e.g., 36-48. The synthetic peptide may include a second sequence fused to the C— or N-terminus of the first sequence. The second sequence may include 4-7 amino acids, the 4-7 amino acids including a kinase docking site. The kinase docking site may be configured such that the kinase phosphorylates an adjacent serine residue and starts a cascade such that all serine residues in the first sequence become phosphorylated. In some embodiments, the 4-7 amino acids may include a glutamic acid residue and/or an aspartic acid residue. In some embodiments, the glutamic acid residue and/or an aspartic acid residue is adjacent to a serine residue. Introduction of these peptides to cells allows for the dissolution of tau aggregates.
    Type: Application
    Filed: March 21, 2023
    Publication date: October 12, 2023
    Applicant: The Trustees of Princeton University
    Inventors: Clifford P. Brangwynne, David W. Sanders
  • SYSTEM AND METHOD FOR GRAPHICAL RETICULATED ATTACK VECTORS FOR INTERNET OF THINGS AGGREGATE SECURITY (GRAVITAS)
    Publication number: 20230328094
    Abstract: According to various embodiments, a system for detecting security vulnerabilities in at least one of cyber-physical systems (CPSs) and Internet of Things (IoT) devices is disclosed. The system includes one or more processors configured to construct an attack directed acyclic graph (DAG) unique to each CPS or IoT device of the devices. The processors are further configured to generate an aggregate attack DAG from a classification of each device and a location of each device in network topology specified by a system administrator. The processors are also configured to calculate a vulnerability score and exploit risk score for each node in the aggregate attack DAG. The processors are further configured to optimize placement of defenses to reduce an adversary score of the aggregate attack DAG.
    Type: Application
    Filed: September 20, 2021
    Publication date: October 12, 2023
    Applicant: The Trustees of Princeton University
    Inventors: Jacob BROWN, Tanujay SAHA, Niraj K. JHA
  • GENETIC TOOLS FOR RECOMBINING TRANSGENES AT THE SAME LOCUS
    Publication number: 20230323342
    Abstract: Provided herein are materials and methods useful for facilitating transgene recombination. The present disclosure relates to, for example, techniques for manipulating recombination frequencies and generating organisms that contain multiple transgenic elements docking at the same locus on a single chromosome. The time consumed by the entire recombination process is proportional to the logarithm of the number of transgenes to be recombined.
    Type: Application
    Filed: October 15, 2021
    Publication date: October 12, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Junjie LUO, Mark J. SCHNITZER, Cheng HUANG
  • SURGICAL NAVIGATION WITH STEREOVISION AND ASSOCIATED METHODS
    Publication number: 20230320649
    Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon’s perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
    Type: Application
    Filed: May 31, 2023
    Publication date: October 12, 2023
    Applicant: The Trustees of Dartmouth College
    Inventors: David W. ROBERTS, Keith D. PAULSEN, Alexander HARTOV, Songbai JI, Xiaoyao FAN
  • DEBRIS MITIGATION IN LASER PRODUCED PLASMAS USING THREE-DIMENSIONAL MAGNETIC NULLS
    Publication number: 20230324816
    Abstract: Disclosed is a method of debris mitigation in laser produced plasma EUV light sources. The method describes a class of magnetic field configurations which exhausts debris away from sensitive components of the EUV device. This class contains a large range of configurations that may be suited and tuned to specific application requirements with a high degree of flexibility and can be generated by coils that are located away from the light collection cone.
    Type: Application
    Filed: April 6, 2023
    Publication date: October 12, 2023
    Applicant: The Trustees of Princeton University
    Inventors: Ahmed Diallo, Christopher Berg Smiet, Ben Israeli, Marien Simeni Simeni
  • SCALABLE PURIFICATION METHOD FOR AAV1
    Publication number: 20230323312
    Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.
    Type: Application
    Filed: June 13, 2023
    Publication date: October 12, 2023
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Martin Lock, Mauricio Alvira