Patents Assigned to Trustees of Dartmouth
  • Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG15 and/or UBP43
    Patent number: 8283113
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 9, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret A. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • Nicotinamide Riboside Kinase Compositions and Methods for Using the Same
    Publication number: 20120251463
    Abstract: The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
    Type: Application
    Filed: April 12, 2012
    Publication date: October 4, 2012
    Applicant: Trustees of Dartmouth College
    Inventor: Charles M. Brenner
  • Compositions and methods for regulating RNA translation via CD154 CA-dinucleotide repeat
    Patent number: 8278107
    Abstract: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3?-untranslated region of CD154.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: October 2, 2012
    Assignee: Trustees of Dartmouth College
    Inventor: William F. C. Rigby
  • Method for diagnosing non-small cell lung carcinoma
    Patent number: 8273701
    Abstract: The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: September 25, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: David J. Robbins, Ziqiang Yuan, John A. Goetz
  • Method for Detecting Cardiac Ischemia via Changes in B-Natriuretic Peptide Levels
    Publication number: 20120220055
    Abstract: The present invention relates to a method of detecting cardiac ischemia by measuring the levels of BNP or NTproBNP. Increases in BNP or NTproBNP levels in an individual are indicative of cardiac ischemia.
    Type: Application
    Filed: May 3, 2012
    Publication date: August 30, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Robert S. Foote, Kiang-Tech Jërry Yeo
  • Chimeric NK receptor and methods for treating cancer
    Patent number: 8252914
    Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: August 28, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Tong Zhang, Charles L. Sentman
  • Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof
    Publication number: 20120214732
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 23, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate CD4+ and CD8+ T cell immunity
    Patent number: 8236304
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: August 7, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Regulatory T cell mediator proteins and uses thereof
    Patent number: 8231872
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: July 31, 2012
    Assignee: The Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li Wang
  • Free electron laser, and associated components and methods
    Patent number: 8228959
    Abstract: A system generates FIR laser radiation. An electron source generates an electron beam. A grating horn interacts with the electron beam to produce the FIR laser radiation. The grating horn may comprise a flat base and a pair of grating elements attached to the base, each of the grating elements being ruled with a grating period, the grating elements oriented in phase and in substantial symmetry about a normal to the flat base.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 24, 2012
    Assignee: The Trustees of Dartmouth College
    Inventor: James Hayden Brownell
  • Compositions and Methods for Treating Cancer
    Publication number: 20120165365
    Abstract: The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial cell proliferation and preventing or treating colon cancers and gliomas.
    Type: Application
    Filed: July 13, 2010
    Publication date: June 28, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Dmitry A. Androsov
  • Imaging by magnetic resonance adsorption, elastography and tomography
    Patent number: 8207733
    Abstract: A microwave imaging system provides superior breast imaging resolution by combining MR microwave absorption and MR-compatible microwave tomography calculations. These techniques may also be supplemented with magnetic resonance elastography techniques, for example, to facilitate quick multispectral imaging.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: June 26, 2012
    Assignee: The Trustees of Dartmouth College
    Inventors: Paul M. Meaney, Keith D. Paulsen, John B. Weaver
  • MicroRNA biomarkers for human breast and lung cancer
    Patent number: 8207325
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: June 26, 2012
    Assignees: Univ. of Copenhagen, Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Method for Identifying an Agent that Inhibits Candida albicans-Mediated Host Cell Differentiation
    Publication number: 20120156697
    Abstract: The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention find application in the prevention and treatment of candidiasis.
    Type: Application
    Filed: August 13, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventor: Paula Sundstrom
  • Composition and Method for Prevention, Mitigation or Treatment of an Enteropathogenic Bacterial Infection
    Publication number: 20120157529
    Abstract: The present invention embraces the use of palmitoleic acid, or a derivative, mimetic, or extract containing the same, to decrease the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection.
    Type: Application
    Filed: July 21, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: F. Jon Kull, Ronald K. Taylor, Michael Lowden, Karen Skorupski, Jessica Day, Gabriela Kovacikova
  • Compositions for Inhibiting Growth of Cancer Stem Cells
    Publication number: 20120156312
    Abstract: The present invention is a biomarker of chemotherapeutic drug-resistant cancer stem cells and a method of inhibiting the growth of drug-resistant cancer stem cells. In one embodiment the cancer stem cells are testicular cancer germ cells. In another embodiment the present invention is a method of overcoming drug resistance in cancer treatment where the combination of low dose decitabine and administration of a chemotherapeutic drug to which cancer cells were resistant results in successful cancer treatment.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy
  • Nicotinamide riboside kinase compositions and methods for using the same
    Patent number: 8197807
    Abstract: The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: June 12, 2012
    Assignee: Trustees of Dartmouth College
    Inventor: Charles M. Brenner
  • Method for enantioselective synthesis of phosphorus-stereogenic phosphines
    Patent number: 8193392
    Abstract: The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: June 5, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Corina Scriban, David S. Glueck
  • Methods for Screening for Antibiotic Compounds
    Publication number: 20120115157
    Abstract: The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
    Type: Application
    Filed: July 1, 2010
    Publication date: May 10, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Ambrose Cheung, Zhibiao Fu
  • Joining of parts via magnetic heating of metal-aluminum powders
    Patent number: 8172126
    Abstract: A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least two parts to be joined and applying an alternating magnetic field (AMF). The AMF has a magnetic field strength and frequency suitable for inducing magnetic hysteresis losses in the metal-aluminum powder and is applied for a period that raises temperature of the metal-aluminum powder to an exothermic transformation temperature. At the exothermic transformation temperature, the metal-aluminum powder melts and resolidifies as a metal aluminide solid having a non-magnetic configuration.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: May 8, 2012
    Assignee: The Trustees of Dartmouth College
    Inventor: Ian Baker