Patents Assigned to Trustees of Dartmouth
  • Regulatory T cell mediator proteins and uses thereof
    Patent number: 8501915
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: August 6, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li Wang
  • Hydrothiolation of Unactivated Alkenes
    Publication number: 20130190505
    Abstract: The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
    Type: Application
    Filed: September 28, 2011
    Publication date: July 25, 2013
    Applicant: Trustees of Dartmouth Office
    Inventors: Jimmy Wu, Markku A. Savolainen
  • Systems and methods for noninvasively monitoring baroreflex response and nominal blood volume
    Patent number: 8485978
    Abstract: Systems and methods for noninvasively monitoring baroreflex response and nominal blood volume are disclosed herein. Software and methods for evaluating morphological features of a photoplethysmogram (PPG) obtained using a pulse oximeter allow for the affirmative detection and quantification of the baroreflex response from data obtained during orthostatic stress tests, lower body negative pressure chamber tests and treadmill stress tests.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: July 16, 2013
    Assignee: The Trustees of Dartmouth College
    Inventor: Stephen Paul Linder
  • System And Method For Automatically Remixing Digital Music
    Publication number: 20130170670
    Abstract: Systems and methods augment a target media with a plurality of source media. The target media and source media are processed to form time frequency distributions (TFDs). Target features are extracted from the associated TFD and source features are extracted from each of the associated source TFDs. The target features are segmented into temporal portions that are compared with each of the plurality of source features to determine one or more matched source features having nearest matches to the target feature segments. Portions of the source media associated with the matched source features are mixed with the target media to form an augmented target media, wherein the mixing is based upon a probabilistic mixing algorithm that uses a distance between the matched target feature and source features to define an amplitude of each portion of the source media.
    Type: Application
    Filed: February 18, 2011
    Publication date: July 4, 2013
    Applicant: The Trustees of Dartmouth College
    Inventor: Michael Casey
  • Apparatus and method for modulating neurochemical levels in the brain
    Patent number: 8473060
    Abstract: A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: June 25, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: James C. Leiter, Mykyta M. Chernov, David W. Roberts
  • Regulatory T cell mediator proteins and uses thereof
    Patent number: 8465740
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: June 18, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease
    Patent number: 8466121
    Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: June 18, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang
  • Synthetic triterpenoids and methods of use in the treatment of disease
    Patent number: 8455544
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 4, 2013
    Assignees: Reata Pharmaecuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Joining of parts via magnetic heating of metal aluminum powders
    Patent number: 8444045
    Abstract: A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase magnetic metal-aluminum powder at an interface between the at least two parts to be joined and applying an alternating magnetic field (AMF). The AMF has a magnetic field strength and frequency suitable for inducing magnetic hysteresis losses in the metal-aluminum powder and is applied for a period that raises temperature of the metal-aluminum powder to an exothermic transformation temperature. At the exothermic transformation temperature, the metal-aluminum powder melts and resolidifies as a metal aluminide solid having a non-magnetic configuration.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: May 21, 2013
    Assignee: The Trustees of Dartmouth College
    Inventor: Ian Baker
  • SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH
    Publication number: 20130122053
    Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
    Type: Application
    Filed: September 24, 2012
    Publication date: May 16, 2013
    Applicants: Trustees of Dartmouth College, Rutgers, The State University of New Jersey, The Regents of the University of California, Osteoscreen, Inc.
    Inventors: Trustees of Dartmouth College, Osteoscreen, Inc., The Regents of the University of California, Rutgers, The State University of new Jersey
  • Apparatus and method for modulating neurochemical levels in the brain
    Patent number: 8433415
    Abstract: A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: April 30, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: James C. Leiter, Mykyta M. Chemov, David W. Roberts
  • Refrigerant evaporators with pulse-electrothermal defrosting
    Patent number: 8424324
    Abstract: An pulse electro thermal defrost evaporator system has multiple refrigerant tubes formed from an electrically conductive metal and connected in parallel for refrigerant flow. These tubes are, however, connected electrically in series. A controller is capable of detecting ice accumulation and connecting the tubes to a source of electrical power for deicing when it is necessary to deice the tubes. Embodiments having a manifold having multiple conductive sections insulated from each other are disclosed for coupling tubes electrically in series. Alternative embodiments with a single, long, wide-bore, tube are disclosed, as are embodiments having an evaporating pan coupled in series or parallel with the tubes, and embodiments with thermal cutoff and electrical safety interlocks.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: April 23, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: Victor F. Petrenko, Fedor F. Petrenko
  • Compact helical heat exchanger with stretch to maintain airflow
    Patent number: 8418484
    Abstract: A heat exchanger for exchanging heat between gasses such as air and a liquid or gaseous coolant has narrow spacing between exchanger surfaces for high efficiency. To avoid undue obstruction of gas flow due to ice buildup on the exchanger surfaces, the heat exchanger is equipped with sensors to monitor the gas flow and an actuator that widens the spacing between exchanger surfaces such that gas flow remains unimpeded. Embodiments provide for defrosting of the exchanger surfaces when an limit on spacing of exchanger surfaces is reached, and for relaxing the spacing to the original narrow spacing when defrosting is completed.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: April 16, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: Victor Petrenko, Charles R. Sullivan
  • Methods for Using Synthetic Triterpenoids in the Treatment of Bone or Cartilage Diseases or Conditions
    Publication number: 20130089526
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Application
    Filed: May 8, 2012
    Publication date: April 11, 2013
    Applicants: Trustees of Dartmouth College, National Institute of Health, Beth Israel Deaconess Medical Center, Rutgers, The State University
    Inventors: Trustees of Dartmouth College, Beth Israel Deaconess Medical Center, National Institute of Health, Rutgers, The Sstate University
  • Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissue
    Patent number: 8417324
    Abstract: This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: April 9, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Mary-Ann Mycek, Ethan Dmitrovsky, Jonathan Pitts
  • Magnetic proximity sensor system and associated methods of sensing a magnetic field
    Patent number: 8416076
    Abstract: A magnetic proximity sensor is attached to a ferrous object such that the sensor alerts a practitioner if a threshold of magnetic strength has been exceeded by bringing the ferrous object within a certain proximity to the magnet of an MRI scanner. The magnetic proximity sensor includes at least one magnetic field sensor for sensing a magnetic field strength. An alarm in communication with the field sensor alerts a practitioner that a threshold of magnetic strength has been exceeded. A battery powers the field sensor and the alarm. The field sensor may produce an output voltage corresponding to the sensed magnetic field strength, and a potentiometer may provide a reference voltage corresponding to a threshold magnetic field strength. A comparator compares the reference voltage to the output voltage, and triggers an alarm if the output voltage exceeds the reference voltage.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: April 9, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: Alexander Mamourian, Michael Holland
  • Methods for diagnosing and treating neuroendocrine cancer
    Patent number: 8415109
    Abstract: The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: April 9, 2013
    Assignee: Trustees of Dartmouth College
    Inventor: William G. North
  • Compositions and methods for producing adaptive regulatory T cells
    Patent number: 8415154
    Abstract: The present invention relates to a method for producing adaptive regulatory T cells from effector T cells by contacting the effector T cells with retinoic acid. Adaptive regulatory T cells produced by this method are Foxp3+, home to the gut, and are refractory to reversion in vivo. As such, such cells find application in the treatment of autoimmune disease and facilitating transplantation tolerance.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: April 9, 2013
    Assignee: Trustees of Dartmouth College
    Inventor: Randolph J. Noelle
  • Compositions and methods for inhibiting the interaction between CFTR and CAL
    Patent number: 8415292
    Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: April 9, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Dean Madden, Patrick R. Cushing, Prisca Boinguérin, Rudolf Volkmer, Lars Vouilleme
  • Pulse electrothermal mold release icemaker with safety baffles for refrigerator
    Patent number: 8405002
    Abstract: An icemaker and a refrigerator having an icemaker are discussed. The icemaker has pulse-electrothermal ice release and includes an ice-making tray having several ice forming portions in which water is stored and ice is formed; and a housing surrounding the ice-making tray provided with at least one cold air inlet and/or ice ejection port through which cold air is supplied and ice released along a bent channel. The cold air inlet and/or ice ejection ports are baffled to prevent contact with a user's fingers and thereby reduce the possibility of electric shock.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: March 26, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: Victor F. Petrenko, Gabriel Martinez, Tae Hee Lee, Hong Hee Park, Joon Hwan Oh, Kwang Ha Suh