Abstract: The present invention embraces a recombinant prokaryotic host cell containing nucleic acids encoding an eukaryotic UDP-GaINAc:UDP-GaINAc polypeptide transferase and expressing an UDP-GIcNAc C-4 epimerase and methods for using the same to produce an O-glycosylated protein.

Abstract: The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.

Abstract: Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. The incoming beam is split into two beams of substantially equal intensity, one of which is delayed for a delay period t. The two split beams are recombined to shine onto a thick SHG crystal at rotation angle ? and light emitted from the thick SHG crystal is detected as data and stored with reference to the delay period t and the angle ?. The thick SHG crystal is rotated by an angle ??, and light is detected as data and stored until the thick SHG crystal has completed 360° of rotation. This is repeated for ?t increases in the delay period until a selected beam delay period range has been completed. The stored data is processed to determine amplitude and phase versus frequency of the incoming beam of pulsed laser light.

Abstract: The present invention is a nanotechnology-based personal sensor device composed of molecularly imprinted polymers that are interrogated using radio frequency identification (RFID) technology for use in simultaneously monitoring airborne contaminants, e.g., of second-hand cigarette smoke.

Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.

Abstract: Micromagnetic elements, logic devices and methods of fabricating and using them to store data and perform logic operations are disclosed. Micromagnetic elements for data storage, as well as those providing output from a logic device, are at least partially covered with an optical coating that facilitates determination of the magnetic state. The disclosed logic devices perform one or more of AND, OR, NAND and NOR operations.

Abstract: The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer germ cells. The present invention provides for a kit and method for determining response to treatment with decitabine at low doses.

Abstract: The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA molecules are capable of attenuating tumor growth and interfering with tumor angiogenesis.

Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.

Abstract: A thermal treatment system with acoustic monitoring applies substantially constant electromagnetic energy superposed with pulsed electromagnetic energy to targeted tissue. The pulsed electromagnetic energy reacts with tissue to create an acoustic pressure wave within the tissue. The acoustic pressure wave is sensed by an acoustic sensor, and a sensor signal indicative of the acoustic pressure wave is generated and processed to determine changes in tissue composition.

Abstract: The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of determining the ras status of the cancer, wherein a determination that the subject has mutant ras status is indicative that the subject is suitable for treatment with a purine-based roscovitine-like inhibitor.

Abstract: One aspect of the present invention is a method of playing multi-media content through a personal computer. The personal computer includes a processor and memory, with the memory having software instructions stored therein. The processor executes the instructions to carry-out the method. The method includes: receiving data representing multi-media content at the personal computer; receiving at the personal computer an initial set of data representing a base set of usage rights that is associated with the multi-media content, wherein the initial set of data defines a first set of rights that is permissible without upgrading or renewing the base set of usage rights; and upon receiving a request to perform an action involving the multi-media content, checking the initial set of data representing the base set of usage rights to determine whether the action is permissible, and providing an option to a user through the personal computer to contact a remote computer to negotiate for an upgraded set of usage rights.

Abstract: The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen.

Abstract: The present invention embraces a bi-specific fusion protein composed of an effector cell-specific antibody-variable region fragment operably linked to at least a portion of a natural killer cell receptor. Methods for using the fusion protein in the treatment of cancer and pathogenic infections are also provided.

Abstract: A multi-mode to single mode optical interface device includes an optically pumped edge emitting semiconductor laser device and a lens. The optically pumped edge emitting semiconductor laser device includes (1) a gain area, and (2) an edge located single mode output. The lens focuses a multi-mode optical fiber output beam into a substantially line shaped output beam focused onto the gain area of the optically pumped edge emitting semiconductor laser device. A method for converting a multi-mode optical signal into a single mode optical signal includes (1) focusing the multi-mode optical signal onto a gain area of an optically pumped edge emitting semiconductor laser using at least a line focusing lens, and (2) converting the multi-mode optical signal into the single mode optical signal using the semiconductor laser.

Abstract: The present invention features methods for decreasing fat mass, increasing energy expenditure, increasing resistance to obesity, and lowering blood glucose levels in a subject with an agent that inhibits the expression or activity of type III deiodinase. In this regard, agents of the invention are useful in treating diabetes and obesity.

Abstract: The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing glial tumor cell proliferation and treating glioma.

Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

Abstract: Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous antigens, and methods of protecting an animal against a T. gondii and non-T. gondii disease.

Abstract: The present invention provides attenuated Toxoplasma gondii knockout mutants of the de novo pyrimidine synthesis pathway and use of the same in vaccines and methods of providing an immune response and protecting a subject against infection by T. gondii and a non-T. gondii disease.