Abstract: A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors.

Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.

Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.

Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.

Abstract: Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage high enough to deice a windshield in less than thirty seconds at ambient temperatures above ?10 C. Some of the disclosed systems include sensors for deicing element and ambient temperatures, and in some embodiments windspeed. All embodiments have a controller for limiting deicing time to that sufficient to melt a boundary layer of ice. The controller of embodiments with sensors computes deicing time as a function of ambient temperature. Embodiments interact with wiper systems to enable wipers to clear ice once the boundary layer is melted.

Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

Abstract: Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as temperatures below the melting point of glass. Semiconductors produced are suitable for semiconductor devices such as photovoltaics or displays.

Abstract: The present invention is method for non-covalently immobilizing an infectious prion protein using a magnetic substrate.

Abstract: A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical impedance imaging overlay 330 is adapted to be positioned on a transducer window 304 of an ultrasound probe 320, and may be integrally formed as part of the ultrasound probe 320 or as a modular adapter for coupling with, and optionally uncoupling from, an ultrasound probe 320 to form the dual imaging probe 300. A method (FIG. 6) of reconstructing composite images using both ultrasound and electrical impedance data is described. Applications for medical diagnosis are described. A particular use for prostate imaging is described.

Abstract: Optical devices for use with a magnetic resonance imaging breast compression system include light wands and optical adapters that can releasably mate with grids. These devices, and their associated methods, may reduce or eliminate the need for biopsy by allowing for the differentiation of cancerous tumors, non-cancerous tumors, calcifications and cysts.

Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.

Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.

Abstract: The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival and select treatment modalities for breast cancer. The present invention is also a method for inducing apoptosis in breast cancer cells by inhibiting the expression or activity of Spot 14. Compositions and methods for treating breast cancer are also provided.

Abstract: Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.

Abstract: Alloys including iron, nickel, manganese, aluminum and chromium are disclosed. The alloys have high strength and ductility. The alloys are prepared from readily available transition metals, and can be used in applications where properties similar to steel are necessary or advantageous.

Abstract: A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a displacement to tissue at a particular frequency selected from a range of frequencies, and the force monitor adapted to monitor a mechanical response of tissue. The system also has a processor coupled to drive the actuator and to read the mechanical response, the processor coupled to execute from memory a poroelastic model of mechanical properties of the material, and a convergence procedure for determining parameters for the poroelastic model such that the model predicts mechanical response of the tissue to within limits.

Abstract: A beamforming sensor node has an array of pressure wave sensors and beamforming circuitry. Each pressure wave sensor is configured within a unique processing channel including a time delay circuit for producing a signal, with a phase offset, representative of received pressure waves at said pressure wave sensor. The beamforming circuitry includes the time delay circuits for all processing channels and (a) sets the phase offset of each processing channel and (b) parallel processes all signals from the array of pressure wave sensors through respective time delay circuits to form a first coherent beam-formed signal from the node. A secondary beamforming node combines coherent beam-formed signals from the plurality of sensor nodes to produce a combined acoustic signal representative of received pressure waves at all sensor nodes.

Abstract: The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.

Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.

Abstract: A biodegradable iron oxide nanoparticle gel for hyperthermia treatment of cancer includes a polysaccharide-based carrier matrix and starch-coated iron oxide nanoparticles. The gel has sufficient deformability to integrate into a diffuse tumor site, adheres to tissue and has sufficient mechanical properties to remain in place during hyperthermia treatment. The gel releases iron oxide nanoparticles for uptake by cancerous cells at the tumor margin.