Patents Assigned to Trustees of Princeton University
  • Publication number: 20230074229
    Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for providing programmable or pre-programmed in-memory computing (IMC) operations via an array of configurable IMC cores interconnected by a configurable on-chip network to support scalable execution and dataflow of an application mapped thereto.
    Type: Application
    Filed: February 5, 2021
    Publication date: March 9, 2023
    Applicant: The Trustees of Princeton University
    Inventors: Hongyang JIA, Murat OZATAY, Hossein VALAVI, Naveen VERMA
  • Publication number: 20230044467
    Abstract: Bacterial infections evading the current antibiotic arsenal warrant new treatment options. The mainstay treatment for Clostridium difficile infections involves administration of the broad-spectrum antibiotic vancomycin, which also depletes the gut microbiome and its natural defenses. This leads to recurrent C. difficile infections in 20-30% of patients. Alternative treatment options are limited, triggering a perpetual cycle of relapse and recovery that may eventually lead to death. Keratinicyclin B represents a glycopeptide antibiotic chemotype with a mechanism of action that is selective for Clostridia. When combined, vancomycin (or other glycopeptide antibiotic) and keratinicyclin B interact synergistically to inhibit the growth of C. difficile at concentrations far lower than their respective minimal inhibitory concentrations. Such a combination therapy could allow for targeted colonization clearance at low antibiotic doses, thereby minimizing toxicity and reducing the likelihood of relapse.
    Type: Application
    Filed: July 26, 2022
    Publication date: February 9, 2023
    Applicant: The Trustees of Princeton University
    Inventors: Mohammad R. Seyedsayamdost, Vasiliki T. Chioti, Katherine M. Davis, Kirklin L. McWhorter
  • Publication number: 20230028572
    Abstract: Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle.
    Type: Application
    Filed: November 19, 2020
    Publication date: January 26, 2023
    Applicant: The Trustees of Princeton University
    Inventors: Maksym MEZHERICHER, Howard A. STONE
  • Patent number: 11557034
    Abstract: Systems and methods are described for the fully automatic, template-free locating and extracting of a plurality of two-dimensional projections of particles in a micrograph image. A set of reference images is automatically assembled from a micrograph image by analyzing the image data in each of a plurality of partially overlapping windows and identifying a subset of windows with image data satisfying at least one statistic criterion compared to other windows. A normalized cross-correlation is then calculated between the image data in each reference image and the image data in each of a plurality of query image windows. Based on this cross-correlation analysis, a plurality of locations in the micrograph is automatically identified as containing a two-dimensional projection of a different instance of the particle of the first type. The two-dimensional projections identified in the micrograph are then used to determine the three-dimensional structure of the particle.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: January 17, 2023
    Assignee: The Trustees of Princeton University
    Inventors: Amit Singer, Ayelet Heimowitz, Joakim Anden, Yuehaw Khoo, Joseph Kileel
  • Patent number: 11549919
    Abstract: Systems and methods for prediction of state of charge (SOH), state of health (SOC) and other characteristics of batteries using acoustic signals, includes determining acoustic data at two or more states of charge and determining a reduced acoustic data set representative of the acoustic data at the two or more states of charge. The reduced acoustic data set includes time of flight (TOF) shift, total signal amplitude, or other data points related to the states of charge. Machine learning models use at least the reduced acoustic dataset in conjunction with non-acoustic data such as voltage and temperature for predicting the characteristics of any other independent battery.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: January 10, 2023
    Assignee: The Trustees of Princeton University
    Inventors: Daniel Artemis Steingart, Shoham Bhadra, Andrew Gaheem Hsieh, Benjamin Hertzberg, Peter James Gjeltema, Clarence Worth Rowley, III, Alexandre S. R. Goy, Jason Wolf Fleischer
  • Publication number: 20220409826
    Abstract: Systems and methods for automatic intravenous injection in accordance with embodiments of the invention are illustrated. One embodiment includes a method for automatically injecting a needle into a vein. The method includes steps for identifying an injection position using a first set of one or more sensors, positioning an injection mechanism at the identified injection position, and vertically inserting a needle until entry in a vein is detected using a second set of one or more sensors.
    Type: Application
    Filed: November 19, 2020
    Publication date: December 29, 2022
    Applicants: The Trustees of Princeton University, Invictis Labs, Inc.
    Inventors: Craig B. Arnold, Miles Cole
  • Publication number: 20220403364
    Abstract: Disclosed is a 3D porous medium and a method of manufacture. The 3D porous medium includes (i) a support structure of transparent hydrogel particles or emulsion droplets, (ii) bacterial nutrient in open volumes between the transparent hydrogel particles, as well as within micropores in the transparent hydrogel particles, and (iii) bacterial cells within the open volumes in the support structure.
    Type: Application
    Filed: April 28, 2020
    Publication date: December 22, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Sujit Datta, Tapomoy Bhattacharjee
  • Publication number: 20220403429
    Abstract: Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field.
    Type: Application
    Filed: June 21, 2022
    Publication date: December 22, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Jose L. Avalos, Makoto A. Lalwani, Mark P. Brynildsen
  • Publication number: 20220400375
    Abstract: According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a next generation core (NGC). The NGC includes an authentication server function (AUSF) configured to determine whether the computing device contains a valid subscriber identity module (SIM) card, and a user plane function (UPF) configured to allow a computing device to connect to the Internet. The architecture further includes a gateway connected to the UPF, the gateway configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access.
    Type: Application
    Filed: March 2, 2021
    Publication date: December 15, 2022
    Applicant: The Trustees of Princeton University
    Inventor: Paul Schmitt
  • Publication number: 20220400024
    Abstract: A system and method for chat-based studies utilizing a plurality of users may be provided, utilizing at least one chat room processor and a plurality of remote processors. The chat room processors may be configured to receive a chat room template, create a plurality of chat rooms based on the chat room template, assign participants to one chat rooms, provide instructions associated with the chat room when all participants are present, provide questions or prompts at times defined by the chat room template or when conditions defined by the chat room template are met, collect all messages received from each participant, and storing information that includes the message, a time stamp the message was sent and/or received, and at least one unique identification code associated with the participant sending the message.
    Type: Application
    Filed: June 14, 2022
    Publication date: December 15, 2022
    Applicant: The Trustees of Princeton University
    Inventor: Xiaoxiao Shen
  • Publication number: 20220383142
    Abstract: According to various embodiments, a machine learning based method, system, and non-transitory computer-readable medium for identifying content on social media related to one or more coordinated influence efforts are disclosed. The method includes generating one or more datasets of post-uniform resource locator (URL) pairs produced from one or more known coordinated influence efforts on one or more social media platforms. The method further includes generating one or more datasets of post-URL pairs produced from one or more random users on one or more social media platforms. The method additionally includes extracting a plurality of content-based features from the post-URL pairs from known coordinated influence efforts and random users.
    Type: Application
    Filed: August 28, 2020
    Publication date: December 1, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Meysam Alizadeh, Jacob Shapiro
  • Publication number: 20220370373
    Abstract: From diagnostic imaging to drug delivery, nanoparticles have found a tremendous variety of uses across fields. Often, when designing these nanoscale constructs, the two most important criteria are particle size and core loading. For example, small particles below 100 nm can have many advantages for drug delivery—including improved specificity to tumors through the enhanced permeability and retention (EPR) effect. Likewise, higher loading nanoparticles translate very well to more effective drug delivery and cancer imaging—allowing for lower dosage and reduced costs. Traditional formulations of nanoparticles using drug absorption or precipitation methods generally struggle to obtain >50% loading. Disclosed herein is a precipitation process allowing for production of stable particles at very high core loading by taking advantage of different time scales while maintaining biologically relevant sizes.
    Type: Application
    Filed: October 14, 2020
    Publication date: November 24, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Leon WANG, Kurt RISTROPH, Robert PRUD'HOMME
  • Publication number: 20220348966
    Abstract: A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 3, 2022
    Applicants: The Trustees of Princeton University, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Kyoto University
    Inventors: José L. AVALOS, Sarah K. HAMMER, Kouichi KURODA, Gerald R. FINK, Gregory STEPHANOPOULOS
  • Publication number: 20220339117
    Abstract: A precipitation route to form nanoparticles with a hydrophilic core containing water soluble materials and a hydrophobic shell is described. The process requires a stabilizing polymer composed of more polar and more non-polar regions. These regions can be arranged as a linear block copolymer, or as a comb polymer with a linear or branched polar backbone and non-polar side chains or substituents. Nucleic acids, including DNA and RNA, as well as proteins, peptides, and polysaccharides or combinations can be encapsulated in the nanoparticle core. The encapsulation of nucleic acids can require partially or fully neutralizing the acid with a base to enhance the solubility of the nucleic acid in the process solvent stream. The core or the shell of the resulting nanoparticles can be crosslinked. The nanoparticles may be coated with additional polymer to bring them into water, or processed into microparticles or larger monoliths.
    Type: Application
    Filed: September 2, 2020
    Publication date: October 27, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Robert F. Pagels, Chester E. Markwalter, Robert K. Prud'homme
  • Publication number: 20220337240
    Abstract: Disclosed is an electromagnetic-circuit co-design approach for massively reconfigurable, multifunctional, and high-speed programmable metasurfaces with integrated chip tiling. The ability to manipulate the incident electromagnetic fields in a dynamically programmable manner and at high speeds using integrated chip tiling approach is also disclosed. The scalable architecture uses electromagnetic-circuit co-design of metasurfaces where each individual subwavelength meta-element is uniquely addressable and programmable. The disclosed device comprises a large array of such meta-elements. The design relies on integrated high frequency switches designed in conjugation with meta-element for massive reconfigurability of incident amplitude and phase. The disclosed chip is multi-functional and can perform beamforming, high speed spatial light modulation, dynamic holographic projections, and wavefront manipulation.
    Type: Application
    Filed: April 5, 2022
    Publication date: October 20, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Suresh Venkatesh, Xuyang Lu, Hooman Saeidi, Kaushik Sengupta
  • Publication number: 20220319636
    Abstract: Disclosed is a method for calculating genetic score based on genotypic information that predicts plasticity in a phenotype. More particularly, disclosed is an algorithm to calculate a particular type of genetic score based on basic genotypic information that is provided by commercially available technologies ranging from “SNP-chips” to whole genome sequencing. Polygenic scores— attempts to summarize the genetic propensity for or risk of a given phenotype (i.e., disease or trait)—have been around for more than a decade. They aim to predict the level of a trait—i.e., how tall or short someone may be or what their blood pressure or BMI might be. The Variation Polygenic Score (“vPGS”) disclosed herein is different. Its purpose is not to predict whether someone who scores higher or lower on the vPGS will be, for instance, heavier or lighter or have a higher or lower IQ. Rather, it is formulated to predict variation. The disclosed vPGS does not predict the mean level but rather the dispersion around that mean.
    Type: Application
    Filed: March 16, 2022
    Publication date: October 6, 2022
    Applicant: The Trustees of Princeton University
    Inventor: Dalton Conley
  • Publication number: 20220305387
    Abstract: Disclosed is a method for experimentally optimizing information quality and engagement in crowd sourced evaluation systems. It allows estimating efficiencies of different strategies to provide the greatest opportunity for social learning. It can be used for continuous tuning of social feedback. Also disclosed is a system that allows experimentation with crowd sourced evaluations of virtual services. The experimental system supports large scale online recruitment of participants into web-browser 3D virtual world. The virtual world can be designed to approximate several types of real-world, distributed information systems. Social influences can be experimentally introduced into the feedback system in order to empirically optimize its utility.
    Type: Application
    Filed: March 15, 2022
    Publication date: September 29, 2022
    Applicants: The Trustees of Princeton University, The City University of New York
    Inventors: Dalton Conley, Ofer Tchernichovski
  • Publication number: 20220291119
    Abstract: Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.
    Type: Application
    Filed: March 8, 2022
    Publication date: September 15, 2022
    Applicant: The Trustees of Princeton University
    Inventors: Chu C. Teng, Gerard Wysocki
  • Publication number: 20220288021
    Abstract: A method and compositions of matter for treating or preventing an auto-immune disorder or immune response in a patient, that includes providing a therapeutic dose to the patient of a substituted indole compound having at least one substitution, wherein the substituted indole compound has only one thiol group, and wherein the ring the thiol group is attached to only contains one N or O atom.
    Type: Application
    Filed: July 10, 2020
    Publication date: September 15, 2022
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Micah T. Nelp
  • Publication number: 20220275390
    Abstract: Described herein are chimeric polypeptides that include one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Additional aspects of the present disclosure provide genetically altered plants having a chimeric polypeptide including one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Further aspects of the present disclosure relate to genetically altered plants having a stabilized polypeptide including two or more RBMs and one or both of an algal Rubisco-binding membrane protein (RBMP) and a Rubisco small subunit (SSU) protein. Other aspects of the present disclosure relate to methods of making such chimeric polypeptides and plants, as well as cultivating these genetically altered plants.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 1, 2022
    Applicants: The Trustees of Princeton University, The Board of Trustees of the Leland Stanford Junior University, University of York, Howard Hughes Medical Institute
    Inventors: Martin C. Jonikas, Moritz Meyer, Shan He, Alan Itakura, Vivian Chen Wong, Luke Colin Martin Mackinder, Zhiheng Yu, Doreen Matthies, Hui-Ting Chou