Patents Assigned to Trustees of Princeton University
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Publication number: 20230074229Abstract: Various embodiments comprise systems, methods, architectures, mechanisms and apparatus for providing programmable or pre-programmed in-memory computing (IMC) operations via an array of configurable IMC cores interconnected by a configurable on-chip network to support scalable execution and dataflow of an application mapped thereto.Type: ApplicationFiled: February 5, 2021Publication date: March 9, 2023Applicant: The Trustees of Princeton UniversityInventors: Hongyang JIA, Murat OZATAY, Hossein VALAVI, Naveen VERMA
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Publication number: 20230044467Abstract: Bacterial infections evading the current antibiotic arsenal warrant new treatment options. The mainstay treatment for Clostridium difficile infections involves administration of the broad-spectrum antibiotic vancomycin, which also depletes the gut microbiome and its natural defenses. This leads to recurrent C. difficile infections in 20-30% of patients. Alternative treatment options are limited, triggering a perpetual cycle of relapse and recovery that may eventually lead to death. Keratinicyclin B represents a glycopeptide antibiotic chemotype with a mechanism of action that is selective for Clostridia. When combined, vancomycin (or other glycopeptide antibiotic) and keratinicyclin B interact synergistically to inhibit the growth of C. difficile at concentrations far lower than their respective minimal inhibitory concentrations. Such a combination therapy could allow for targeted colonization clearance at low antibiotic doses, thereby minimizing toxicity and reducing the likelihood of relapse.Type: ApplicationFiled: July 26, 2022Publication date: February 9, 2023Applicant: The Trustees of Princeton UniversityInventors: Mohammad R. Seyedsayamdost, Vasiliki T. Chioti, Katherine M. Davis, Kirklin L. McWhorter
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Publication number: 20230028572Abstract: Disclosed herein is a simple method for generation of high-throughput aerosols of monodisperse micro-shell particles. To create the aerosol, small nozzles are employed blowing slightly compressed air on a thin liquid film. This allows one to generate bubble aerosols consisting of particles having a thin liquid shell surrounding a gas core, which are suspended in a carrier gas flow or environment. The diameter of the created liquid shells is uniform and scales with the inner diameter of the blowing nozzle, enabling control on the size of the produced monodispersed aerosol and formation of particles between few microns to several hundred of microns in outer diameter. The process throughput is very high, reaching several thousands of particles with liquid micro-shells per second for one blowing nozzle.Type: ApplicationFiled: November 19, 2020Publication date: January 26, 2023Applicant: The Trustees of Princeton UniversityInventors: Maksym MEZHERICHER, Howard A. STONE
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Patent number: 11557034Abstract: Systems and methods are described for the fully automatic, template-free locating and extracting of a plurality of two-dimensional projections of particles in a micrograph image. A set of reference images is automatically assembled from a micrograph image by analyzing the image data in each of a plurality of partially overlapping windows and identifying a subset of windows with image data satisfying at least one statistic criterion compared to other windows. A normalized cross-correlation is then calculated between the image data in each reference image and the image data in each of a plurality of query image windows. Based on this cross-correlation analysis, a plurality of locations in the micrograph is automatically identified as containing a two-dimensional projection of a different instance of the particle of the first type. The two-dimensional projections identified in the micrograph are then used to determine the three-dimensional structure of the particle.Type: GrantFiled: June 13, 2018Date of Patent: January 17, 2023Assignee: The Trustees of Princeton UniversityInventors: Amit Singer, Ayelet Heimowitz, Joakim Anden, Yuehaw Khoo, Joseph Kileel
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Patent number: 11549919Abstract: Systems and methods for prediction of state of charge (SOH), state of health (SOC) and other characteristics of batteries using acoustic signals, includes determining acoustic data at two or more states of charge and determining a reduced acoustic data set representative of the acoustic data at the two or more states of charge. The reduced acoustic data set includes time of flight (TOF) shift, total signal amplitude, or other data points related to the states of charge. Machine learning models use at least the reduced acoustic dataset in conjunction with non-acoustic data such as voltage and temperature for predicting the characteristics of any other independent battery.Type: GrantFiled: March 8, 2019Date of Patent: January 10, 2023Assignee: The Trustees of Princeton UniversityInventors: Daniel Artemis Steingart, Shoham Bhadra, Andrew Gaheem Hsieh, Benjamin Hertzberg, Peter James Gjeltema, Clarence Worth Rowley, III, Alexandre S. R. Goy, Jason Wolf Fleischer
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Publication number: 20220409826Abstract: Systems and methods for automatic intravenous injection in accordance with embodiments of the invention are illustrated. One embodiment includes a method for automatically injecting a needle into a vein. The method includes steps for identifying an injection position using a first set of one or more sensors, positioning an injection mechanism at the identified injection position, and vertically inserting a needle until entry in a vein is detected using a second set of one or more sensors.Type: ApplicationFiled: November 19, 2020Publication date: December 29, 2022Applicants: The Trustees of Princeton University, Invictis Labs, Inc.Inventors: Craig B. Arnold, Miles Cole
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Publication number: 20220403364Abstract: Disclosed is a 3D porous medium and a method of manufacture. The 3D porous medium includes (i) a support structure of transparent hydrogel particles or emulsion droplets, (ii) bacterial nutrient in open volumes between the transparent hydrogel particles, as well as within micropores in the transparent hydrogel particles, and (iii) bacterial cells within the open volumes in the support structure.Type: ApplicationFiled: April 28, 2020Publication date: December 22, 2022Applicant: The Trustees of Princeton UniversityInventors: Sujit Datta, Tapomoy Bhattacharjee
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Publication number: 20220403429Abstract: Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field.Type: ApplicationFiled: June 21, 2022Publication date: December 22, 2022Applicant: The Trustees of Princeton UniversityInventors: Jose L. Avalos, Makoto A. Lalwani, Mark P. Brynildsen
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Publication number: 20220400375Abstract: According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a next generation core (NGC). The NGC includes an authentication server function (AUSF) configured to determine whether the computing device contains a valid subscriber identity module (SIM) card, and a user plane function (UPF) configured to allow a computing device to connect to the Internet. The architecture further includes a gateway connected to the UPF, the gateway configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access.Type: ApplicationFiled: March 2, 2021Publication date: December 15, 2022Applicant: The Trustees of Princeton UniversityInventor: Paul Schmitt
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Publication number: 20220400024Abstract: A system and method for chat-based studies utilizing a plurality of users may be provided, utilizing at least one chat room processor and a plurality of remote processors. The chat room processors may be configured to receive a chat room template, create a plurality of chat rooms based on the chat room template, assign participants to one chat rooms, provide instructions associated with the chat room when all participants are present, provide questions or prompts at times defined by the chat room template or when conditions defined by the chat room template are met, collect all messages received from each participant, and storing information that includes the message, a time stamp the message was sent and/or received, and at least one unique identification code associated with the participant sending the message.Type: ApplicationFiled: June 14, 2022Publication date: December 15, 2022Applicant: The Trustees of Princeton UniversityInventor: Xiaoxiao Shen
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Publication number: 20220383142Abstract: According to various embodiments, a machine learning based method, system, and non-transitory computer-readable medium for identifying content on social media related to one or more coordinated influence efforts are disclosed. The method includes generating one or more datasets of post-uniform resource locator (URL) pairs produced from one or more known coordinated influence efforts on one or more social media platforms. The method further includes generating one or more datasets of post-URL pairs produced from one or more random users on one or more social media platforms. The method additionally includes extracting a plurality of content-based features from the post-URL pairs from known coordinated influence efforts and random users.Type: ApplicationFiled: August 28, 2020Publication date: December 1, 2022Applicant: The Trustees of Princeton UniversityInventors: Meysam Alizadeh, Jacob Shapiro
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Publication number: 20220370373Abstract: From diagnostic imaging to drug delivery, nanoparticles have found a tremendous variety of uses across fields. Often, when designing these nanoscale constructs, the two most important criteria are particle size and core loading. For example, small particles below 100 nm can have many advantages for drug delivery—including improved specificity to tumors through the enhanced permeability and retention (EPR) effect. Likewise, higher loading nanoparticles translate very well to more effective drug delivery and cancer imaging—allowing for lower dosage and reduced costs. Traditional formulations of nanoparticles using drug absorption or precipitation methods generally struggle to obtain >50% loading. Disclosed herein is a precipitation process allowing for production of stable particles at very high core loading by taking advantage of different time scales while maintaining biologically relevant sizes.Type: ApplicationFiled: October 14, 2020Publication date: November 24, 2022Applicant: The Trustees of Princeton UniversityInventors: Leon WANG, Kurt RISTROPH, Robert PRUD'HOMME
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Publication number: 20220348966Abstract: A method for producing metabolites that are heavy alcohols, and particularly branched-chain alcohols is provided, involving contacting a suitable substrate with recombinant microorganisms. The microorganisms contain at least one deletion, disruptions, or mutations from the GLN gene family, VPS gene family, GNP gene family, AVT gene family, GCN gene family, or YDR391C, and combinations thereof, and overproduce the heavy alcohol as compared to a wild-type yeast strain.Type: ApplicationFiled: September 25, 2020Publication date: November 3, 2022Applicants: The Trustees of Princeton University, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Kyoto UniversityInventors: José L. AVALOS, Sarah K. HAMMER, Kouichi KURODA, Gerald R. FINK, Gregory STEPHANOPOULOS
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Publication number: 20220339117Abstract: A precipitation route to form nanoparticles with a hydrophilic core containing water soluble materials and a hydrophobic shell is described. The process requires a stabilizing polymer composed of more polar and more non-polar regions. These regions can be arranged as a linear block copolymer, or as a comb polymer with a linear or branched polar backbone and non-polar side chains or substituents. Nucleic acids, including DNA and RNA, as well as proteins, peptides, and polysaccharides or combinations can be encapsulated in the nanoparticle core. The encapsulation of nucleic acids can require partially or fully neutralizing the acid with a base to enhance the solubility of the nucleic acid in the process solvent stream. The core or the shell of the resulting nanoparticles can be crosslinked. The nanoparticles may be coated with additional polymer to bring them into water, or processed into microparticles or larger monoliths.Type: ApplicationFiled: September 2, 2020Publication date: October 27, 2022Applicant: The Trustees of Princeton UniversityInventors: Robert F. Pagels, Chester E. Markwalter, Robert K. Prud'homme
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Publication number: 20220337240Abstract: Disclosed is an electromagnetic-circuit co-design approach for massively reconfigurable, multifunctional, and high-speed programmable metasurfaces with integrated chip tiling. The ability to manipulate the incident electromagnetic fields in a dynamically programmable manner and at high speeds using integrated chip tiling approach is also disclosed. The scalable architecture uses electromagnetic-circuit co-design of metasurfaces where each individual subwavelength meta-element is uniquely addressable and programmable. The disclosed device comprises a large array of such meta-elements. The design relies on integrated high frequency switches designed in conjugation with meta-element for massive reconfigurability of incident amplitude and phase. The disclosed chip is multi-functional and can perform beamforming, high speed spatial light modulation, dynamic holographic projections, and wavefront manipulation.Type: ApplicationFiled: April 5, 2022Publication date: October 20, 2022Applicant: The Trustees of Princeton UniversityInventors: Suresh Venkatesh, Xuyang Lu, Hooman Saeidi, Kaushik Sengupta
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Publication number: 20220319636Abstract: Disclosed is a method for calculating genetic score based on genotypic information that predicts plasticity in a phenotype. More particularly, disclosed is an algorithm to calculate a particular type of genetic score based on basic genotypic information that is provided by commercially available technologies ranging from “SNP-chips” to whole genome sequencing. Polygenic scores— attempts to summarize the genetic propensity for or risk of a given phenotype (i.e., disease or trait)—have been around for more than a decade. They aim to predict the level of a trait—i.e., how tall or short someone may be or what their blood pressure or BMI might be. The Variation Polygenic Score (“vPGS”) disclosed herein is different. Its purpose is not to predict whether someone who scores higher or lower on the vPGS will be, for instance, heavier or lighter or have a higher or lower IQ. Rather, it is formulated to predict variation. The disclosed vPGS does not predict the mean level but rather the dispersion around that mean.Type: ApplicationFiled: March 16, 2022Publication date: October 6, 2022Applicant: The Trustees of Princeton UniversityInventor: Dalton Conley
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Publication number: 20220305387Abstract: Disclosed is a method for experimentally optimizing information quality and engagement in crowd sourced evaluation systems. It allows estimating efficiencies of different strategies to provide the greatest opportunity for social learning. It can be used for continuous tuning of social feedback. Also disclosed is a system that allows experimentation with crowd sourced evaluations of virtual services. The experimental system supports large scale online recruitment of participants into web-browser 3D virtual world. The virtual world can be designed to approximate several types of real-world, distributed information systems. Social influences can be experimentally introduced into the feedback system in order to empirically optimize its utility.Type: ApplicationFiled: March 15, 2022Publication date: September 29, 2022Applicants: The Trustees of Princeton University, The City University of New YorkInventors: Dalton Conley, Ofer Tchernichovski
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Publication number: 20220291119Abstract: Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.Type: ApplicationFiled: March 8, 2022Publication date: September 15, 2022Applicant: The Trustees of Princeton UniversityInventors: Chu C. Teng, Gerard Wysocki
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Publication number: 20220288021Abstract: A method and compositions of matter for treating or preventing an auto-immune disorder or immune response in a patient, that includes providing a therapeutic dose to the patient of a substituted indole compound having at least one substitution, wherein the substituted indole compound has only one thiol group, and wherein the ring the thiol group is attached to only contains one N or O atom.Type: ApplicationFiled: July 10, 2020Publication date: September 15, 2022Applicant: The Trustees of Princeton UniversityInventors: John T. Groves, Micah T. Nelp
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Publication number: 20220275390Abstract: Described herein are chimeric polypeptides that include one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Additional aspects of the present disclosure provide genetically altered plants having a chimeric polypeptide including one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Further aspects of the present disclosure relate to genetically altered plants having a stabilized polypeptide including two or more RBMs and one or both of an algal Rubisco-binding membrane protein (RBMP) and a Rubisco small subunit (SSU) protein. Other aspects of the present disclosure relate to methods of making such chimeric polypeptides and plants, as well as cultivating these genetically altered plants.Type: ApplicationFiled: July 30, 2020Publication date: September 1, 2022Applicants: The Trustees of Princeton University, The Board of Trustees of the Leland Stanford Junior University, University of York, Howard Hughes Medical InstituteInventors: Martin C. Jonikas, Moritz Meyer, Shan He, Alan Itakura, Vivian Chen Wong, Luke Colin Martin Mackinder, Zhiheng Yu, Doreen Matthies, Hui-Ting Chou