Abstract: A device for generating pressure waves of high amplitude, in particular for boiler cleaning, has a pressure-resistant container (21, 40) with a combustion chamber (121) inserted therein, which can be filled with a flowable burn-off material via supply lines. The pressure-resistant container has a discharge opening (306) for the directional discharge of gas pressure generated by ignition of the combustible material. A piston (70) closes the discharge opening, can release it for directional discharge and can be pushed back into the initial position by a spring device.

Abstract: The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.

Abstract: The present invention relates to the field of immunotherapy, in particular, to adoptive T cell therapy, T cell receptor (TCR) gene therapy and vaccination. The invention provides a method for preparing a nucleic acid encoding the TCR alpha chain construct (TRA) and TCR beta chain construct (TRB) of a TCR construct specific for an epitope from an antigen presented on major histocompatibility complex (MHC), comprising contacting T cells isolated from a donor with a library of artificial antigen presenting cells (APC) comprising cells expressing all MHC I or MHC II alleles present in the donor, preferably, in K562 cells. The TCR construct can be expressed in a T cell, which is useful for adoptive T cell therapy, e.g., of cancer, viral infections or autoimmune diseases. The invention further provides a method for identifying the epitope recognized by said TCR. Immunogenic epitopes recognized by said TCRs can be used to develop vaccine formulations to induce antigen-specific T cell immunity in patients.

Abstract: The present invention refers to novel UV-light cleavable drug conjugates comprising a diazirine linker.

Abstract: A grate bar has a grate bar head, two side walls, a running surface behind the head and between the side walls and an underside disposed below the surface and between the side walls. A recess in one side wall forms an air slot between the surface and underside and is arranged only on one side wall, not in its opposite side wall. In a grate bar arrangement including multiple grate bars, each including a running surface and a grate bar head, in which an upper grate bar with grate bar head is moveably arranged relative to a lower grate bar so that the head may slide over front and rear grate bar running surface areas, the running surface has air slots in the front and rear areas and the head is displaceable relative to these slots so that the opening cross section of all slots remains constant.

Abstract: The present invention relates to new cinnamic add amides which may be used for treatment of fibrosis and neoplasia and to cinnamic acid amides for use in the treatment of fibrosis, neoplasia, arthrolithiasis, familiar mediterranean fever and pericarditis. Further, the invention relates to a pharmaceutical composition comprising said cinnamic acid amides and to a screening essay for identifying compounds suitable for the treatment of fibrosis.

Abstract: The invention relates to a device and a method for optoacoustic sensing, wherein an irradiation unit is configured to generate at least one train of periodic pulses of electromagnetic energy, the pulses of the at least one train of periodic pulses exhibiting a pulse duration and repetition rate, and to irradiate a target with the generated train of periodic pulses. A detection unit is configured to detect acoustic waves generated in the target and to generate an according detection signal, the detection signal comprising, for each train of the at least one train of periodic pulses, detection signal components at a plurality of discrete frequencies in the frequency domain, the discrete frequencies being spaced from each other by a frequency spacing corresponding to the repetition rate of the pulses of the at least one train of periodic pulses.

Abstract: An isolated chimeric antigen receptor (CAR) polypeptide, wherein the CAR includes an extracellular antigen-binding domain, including an antibody or antibody fragment that binds to a protein encoded by a herpes virus, or to a protein complex including the protein (herpes virus antigen), wherein the herpes virus antigen is present on the surface of a human cell that is latently infected with said herpes virus and supports the lytic phase of viral replication. The invention further relates to a nucleic acid molecule encoding the CAR of the invention, a genetically modified immune cell, preferably a T cell, expressing the CAR of the invention and the use of the cell in the treatment of a medical disorder associated with human herpesvirus, such as herpes virus-associated cancers, chronic active herpes virus infections or primary herpes virus infections.

Abstract: The present invention relates to a method of diagnosing eczema and/or psoriasis, wherein said method differentiates between eczema and psoriasis, and comprises determining the expression of at least two markers in a sample taken from an individual, wherein said at least two markers are selected from CCL27, NOS2, IL36G, KLK13, SOST, NPTX1, PLA2G4D, GDA, IL36A, TGM1, CLEC4G, IL13, TCN1, TMPRSS11D and RHCG, provided that said at least two markers consist of or comprise (a) CCL27 and NOS2; (b) CCL27 and KLK13; (c) IL36G and KLK13; (d) CCL27 and IL36G; (e) NOS2 and IL36G; (f) NOS2 and KLK13; (g) SOST; or (h) NPTX1; and assessing on the basis of the expression of said at least two markers whether the individual is afflicted with eczema and/or psoriasis.

Abstract: A propeller fastened to a shaft in a clamping manner, the shaft having a driver profile extending in the axial direction, wherein: the propeller is formed from multiple elements, each element (having a hub portion with a counter profile corresponding to the driver profile; a first connection portion and a propeller blade extending from the first connection portion are formed on one side of the hub portion, and a second connection portion is formed on the opposite other side of the hub portion; the first connection portion is designed to bear interlockingly against a further second connection portion of an adjacent further element; and, when the elements are connected such that their connection portions bear against one another, the hub portions of all the elements complement one another to form a hub surrounding the shaft in an interlocking manner.

Abstract: The present invention provides a novel IGFR-like receptor 2 and antagonists and agonists for targeting said receptor. Said antagonists and agonists are envisaged for use as a medicament, and in particular for treatment of cancer or diabetes.

Abstract: A method operates a furnace unit with a feed chute and a camera for capturing an image of the surface of the chute. The chute includes a slide on which material flows to a grate, and the coverage of the chute and in particular of the slide with material, the burning bed thickness and the burnout zone are determined by an image evaluation.

Abstract: Described herein is a genetically modified plant or non-human animal having reduced expression of an endogenous target gene.

Abstract: Devices and methods for mass spectroscopic analysis of particles are disclosed herein. An example device includes: a first irradiation unit configured to irradiate a particle with electromagnetic radiation to cause components of the particle to detach from the particle. The example device further includes a second irradiation unit configured to irradiate substantially simultaneously i) at least a part of the detached components, and optionally a residual core of the particle, with a first beam of electromagnetic radiation the first beam of electromagnetic radiation exhibiting a first intensity, and ii) at least a part of the residual core, of the particle with a second beam of electromagnetic radiation. The second beam of electromagnetic radiation exhibiting a second intensity, which is preferably larger than the first intensity. The example device further includes a mass spectrometer comprising an ion source region, a first detection channel, and optionally a second detection channel.

Abstract: The invention relates to a device (1) for endoscopic optoacoustic imaging comprising an imaging unit (2) configured to be at least partially inserted into an object (5), said imaging unit (2) comprising an irradiation unit (6) configured to irradiate a region of interest (7) inside the object (5) with electromagnetic radiation and a detection unit (8) comprising at least one ultrasound transducer configured to detect ultrasound waves generated in the region of interest (7) in response to irradiating the region of interest (7) with the electromagnetic radiation and to generate according detection signals, wherein the at least one ultrasound transducer exhibits a field of view (8b) being at least partially located in the irradiated region of interest (7).

Abstract: An apparatus for photo-acoustic measurement of a measurement target in a fluid flow comprises:—an ellipsoidal measurement chamber (3) having a first focal point and a second focal point; —a duct (6, 7, 8) configured to guide a fluid flow through the measurement chamber (3) along a first axis (X) through the first focal point; —light source means for generating an excitation light beam of modulated intensity; —means configured to pass the excitation light beam through the measurement chamber (3) along a second axis (Y), which is different from the first axis (X), such that the excitation light beam crosses the fluid flow at the first focal point and that the crossing of the fluid flow and the excitation light beam defines an excitation volume (4) within which the fluid flow is excited by the excitation light beam to generate acoustic waves; and —detecting means (5) arranged at the second focal point and configured to detect said acoustic waves, wherein the detecting means has no direct contact with the fluid f

Abstract: A grate bar has a grate bar head, two side walls, a running surface behind the head and between the side walls and an underside disposed below the surface and between the side walls. A recess in one side wall forms an air slot between the surface and underside and is arranged only on one side wall, not in its opposite side wall. In a grate bar arrangement including multiple grate bars, each including a running surface and a grate bar head, in which an upper grate bar with grate bar head is moveably arranged relative to a lower grate bar so that the head may slide over front and rear grate bar running surface areas, the running surface has air slots in the front and rear areas and the head is displaceable relative to these slots so that the opening cross section of all slots remains constant.

Abstract: A method includes producing an arrangement of grate bars for supporting fuel that is burned in an incinerator or other furnace device. The method includes positioning a pair of grate bars in adjacent side by side relation and with the respective upper sides that are configured to support the fuel, in generally aligned relation. The method further includes after positioning the grate bars, manipulating a fastener through respective recesses that extend in the grate bars, so that the grate bars are held in operative connection and in pressed together relation by the fastener. The method further includes subsequent to the fastener manipulation step, covering the recesses with at least one cover, such that the fastener is rendered inaccessible through the upper sides of the grate bars.

Abstract: The present invention relates to a method for the quantification of radionuclides in liquid media comprising measuring a gamma-ray spectrum, a device for the quantification of radionuclides in liquid media and the use for the quantification of radionuclide concentrations in hydrometallurgical processing media, especially the quantification of uranium and/or radioactive uranium decay product concentrations in uranium mining solutions or in uranium recovery solutions or the quantification of thorium and/or radioactive 232Th decay products in rare-earth element processing solutions.

Abstract: The present invention relates to a kit-of-parts comprising at least one mitochondrial uncoupler and at least one cationic amphiphilic drug and its use in medicine. The invention further relates to a pharmaceutical composition comprising at least one mitochondrial uncoupler and at least one cationic amphiphilic drug for use in medicine. Moreover, the invention is directed to the kit-of-parts and the pharmaceutical composition for use in the treatment of cancer, in particular glioma, pancreatic cancer, small cell lung cancer, metastatic prostate cancer, liver cancer and triple-negative breast cancer.