Patents Assigned to Umwelt (GmbH)
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Patent number: 10696001Abstract: A portable roller compactor for compacting waste located in a container, which is open on the top, has a frame-like basic structure and an articulated arm, one end of which is supported by the basic structure, and the other, free end of which supports a roller compactor that essentially can be rotated about a horizontal axis of rotation. The articulated arm of the roller compactor is pivotably attached to a sliding carriage, which is mounted on the frame-like base structure and can be moved in a longitudinal direction.Type: GrantFiled: November 25, 2015Date of Patent: June 30, 2020Assignee: HUSMANN UMWELT-TECHNIK GmbHInventors: Heinz Hermann Husmann, Wolfgang Muchall
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Patent number: 10669278Abstract: The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.Type: GrantFiled: September 18, 2017Date of Patent: June 2, 2020Assignee: HELMHOLTZ ZENTRUM MUENCHEN—DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)Inventors: Kamyar Hadian, Jara Kerstin Brenke, Oliver Plettenburg, Gerrit Juerjens
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Patent number: 10647687Abstract: The present invention relates to spiropyrazine compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.Type: GrantFiled: November 10, 2015Date of Patent: May 12, 2020Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Marcus Conrad, Joel Schick, Bettina Proneth, Peter Sennhenn
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Patent number: 10626159Abstract: The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding the same, a T cell expressing the TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing the tumor-associated antigen.Type: GrantFiled: November 27, 2017Date of Patent: April 21, 2020Assignees: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Dolores Jean Schendel, Susanne Wilde, Bernhard Frankenberger, Wolfgang Uckert
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Patent number: 10588516Abstract: A device and an according method for multispectral optoacoustic imaging of an object is provided comprising: an irradiation unit configured to irradiate the object with electromagnetic radiation at two or more different irradiation wavelengths the electromagnetic radiation having a time-varying intensity; a detection unit configured to detect acoustic waves generated in the object upon irradiating the object with the electromagnetic radiation at the different irradiation wavelengths; and a processing unit configured to reconstruct images of the object based on the detected acoustic waves generated in the object at each of the irradiation wavelengths and to determine a spatial distribution of at least one first concentration value, which relates to a concentration of at least one electromagnetic radiation absorber in the object.Type: GrantFiled: February 12, 2016Date of Patent: March 17, 2020Assignee: HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH)Inventors: Stratis Tzoumas, Ivan Olefir, Amir Rozental, Vasilis Ntziachristos
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Combination compositions and their use in methods for treating obesity and obesity-related disorders
Patent number: 10568852Abstract: The present invention relates to compositions comprising at least two different active compounds and the use of such combination compositions in medicine, in particular in methods for treating obesity and obesity-related disorders and/or in methods for inhibiting weight gain.Type: GrantFiled: May 23, 2016Date of Patent: February 25, 2020Assignee: HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)Inventors: Timo Dirk Mueller, Matthias Tschoep, Christoffer Clemmensen, Brian Finan -
Patent number: 10520494Abstract: The present invention relates to the use of the biomarker Flattop (Fltp) for distinguishing mature ? cells from immature progenitor ? cells. The present invention further relates to a method for distinguishing a mature ? cell from an immature progenitor ? cell, the method comprising: determining the presence or absence of the biomarker Flattop (Fltp) in a ? cell; wherein the presence of Fltp in the cell indicates that the cell is a mature ? cell and wherein the absence of Fltp in the cell indicates that the cell is an immature progenitor ? cell. Furthermore, the present invention relates to a method of identifying a compound suitable for differentiating immature progenitor ? cells into mature ? cells as well as to a method of identifying a compound suitable for preventing the de-differentiating of mature ? cells.Type: GrantFiled: March 26, 2015Date of Patent: December 31, 2019Assignee: Helmholtz Zentrum München-Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)Inventors: Heiko Lickert, Adriana Migliorini, Moritz Gegg, Erik Bader
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Patent number: 10520266Abstract: In a method for protecting heat exchanger pipe in boiler systems having at least one heat exchanger pipe, which is surrounded by a ceramic component, into which flue gas is directed from at least two opposite sides, gas is introduced between the heat exchanger pipe and the ceramic component.Type: GrantFiled: January 13, 2014Date of Patent: December 31, 2019Assignee: Martin GmbH fuer Umwelt- und EnergietechnikInventors: Toralf Weber, Johannes Martin
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Patent number: 10421749Abstract: The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.Type: GrantFiled: April 7, 2016Date of Patent: September 24, 2019Assignees: HELMHOLTZ ZENTRUM MÜNCHEN-DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH), LEIBNIZINSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E. V. -HANS-KNÖLL-INSTITUTInventors: Ruth Brack-Werner, Markus Helfer, Manfred Rösner, Martha Schneider, Ulrike Protzer, Christian Hertweck, Martina Werneburg
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Patent number: 10412927Abstract: The present invention concerns a device for improved hygienic monitoring of individually ventilated caging (IVC) rack systems for laboratory animals and method for contamination-free removal of biological samples from unwanted organisms from the IVC-rack system. The device allows the performance of sampling operations on a ventilated shelving system in a safe and effective manner, without interfering with the ventilation air flow. The method of the invention allows the removal and transfer of the biological sample from inside the IVC-rack in a contamination-free manner by enabling a safe transfer of the sample from inside the IVC-rack system to any further processing procedure for analysis of the biological sample outside the IVC-rack system. It is also an object of the present invention to provide a device which is adapted to be used also on existing ventilated shelving systems, allowing the refitting of existing IVC-rack systems.Type: GrantFiled: October 28, 2016Date of Patent: September 17, 2019Assignees: TECNIPLAST S.P.A., HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)Inventors: Markus Brielmeier, Wolfgang Nagel, Julia Zorn, Alfredo Campiotti, II, Gianpaolo Milite, Carmelo Di Martino
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Publication number: 20190211025Abstract: The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.Type: ApplicationFiled: September 18, 2017Publication date: July 11, 2019Applicant: HELMHOLTZ ZENTRUM MUENCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)Inventors: Kamyar Hadian, Jara Kerstin Brenke, Oliver Plettenburg, Gerrit Juerjens
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Patent number: 10314490Abstract: An imaging device includes (a) a light source device arranged to illuminate a sample under investigation with illumination light, (b) a detector device arranged to collect a plurality of images including at least one sample light image backscattered by the sample, and at least one marker light image originating from at least one marker substance in the sample, and (c) a processor device adapted to process the at least one sample light image.Type: GrantFiled: February 8, 2018Date of Patent: June 11, 2019Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Vasilis Ntziachristos, George Themelis
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Patent number: 10300129Abstract: The present invention relates to a vaccine comprising a particle, said particle comprising (i) at least one Epstein-Barr virus (EBV) structural polypeptide, (ii) at least one EBV lytic polypeptide, (iii) membrane lipids, said particle being devoid of EBV DNA, wherein (a) the B-cell transformation capacity of one or more EBV polypeptides required for B-cell transformation as comprised in said particle is disabled while their immunogenicity is maintained; and or (b) said particle is devoid of one or more EBV polypeptides required for B-cell transformation. Furthermore, the invention relates to a method for generating a particle, to a cell obtained in the method of the invention, a kit comprising the vaccine or the particle generated according in the method of the invention. Also, the invention relates to the use of the vaccine or the particle generated according to the method of the invention for generating CD8+ cells specific for an EBV antigen.Type: GrantFiled: March 22, 2016Date of Patent: May 28, 2019Assignee: HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMB)Inventors: Romana Ruiss, Gilbert Reisbach, Wolfgang Hammerschmidt, Reinhard Zeidler
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Patent number: 10292593Abstract: An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.Type: GrantFiled: July 23, 2010Date of Patent: May 21, 2019Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Daniel Razansky, Vasilis Ntziachristos
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Patent number: 10280179Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterized by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.Type: GrantFiled: September 18, 2017Date of Patent: May 7, 2019Assignee: HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)Inventors: Marcus Conrad, Joel Schick, Bettina Proneth, Peter Sennhenn
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Patent number: 10238735Abstract: The invention relates to a pharmaceutical composition made of one or more preparation and comprising a therapeutically effective dose of at least one recombinant human C3-derivative and at least one antigen für vaccination.Type: GrantFiled: June 14, 2013Date of Patent: March 26, 2019Assignees: PLS-DESIGN GMBH, KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN, HELMHOLTZ ZENTRUM MUNCHEN FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT GMBHInventors: Reinhard Bredehorst, Thomas Grunwald, Markus Ollert, Carsten Schmidt-Weber, Edzard Spillner
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Patent number: 10233418Abstract: A device for wetting at least one sample by means of an aerosol, the device has: side walls, a base region which is bounded by the side walls, the base region adapted for receiving or interacting with a positioning device for positioning the sample, a cover region, which sits vertically opposite the base region and is bounded by the side walls. The device forms an exposure chamber and an aerosolizing device for producing an aerosol, which is arranged in the vicinity of the cover region. The aerosolizing device is arranged above the base region in such a way that the aerosolizing device at least partially covers the base region in a vertical plan view. A method for wetting at least one sample by an aerosol is also provided that includes the steps of: providing at least one sample, producing a cloud above the at least one sample in a position which at least partially covers the base region in a vertical plan view, and allowing the cloud to descend in the direction of the sample.Type: GrantFiled: September 22, 2015Date of Patent: March 19, 2019Assignee: Helmholtz Zentrum Muenchen Deutsche Forschungszentrum fuer Gesundheit und Umwelt GmbHInventors: Otmar Schmid, Anke-G Lenz, Bernd Lentner, Oliver Eickelberg
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Publication number: 20190063745Abstract: A special distribution of nozzles in the flue gas outlet and their alignment make it possible to guide the flue gas along a wavy line. The addition of combustion air for primary air and secondary air can be variably distributed during operation of the combustion plant, for example so as to also keep the burnout per unit of time constant while maintaining a constant combustion air ratio.Type: ApplicationFiled: August 22, 2018Publication date: February 28, 2019Applicant: Martin GmbH fuer Umwelt- und EnergietechnikInventors: Ulrich MARTIN, Robert VON RAVEN, Martin MURER
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Patent number: 10214723Abstract: The present invention relates to a method of producing a non-human, mammalian oocyte carrying a modified target sequence in its genome, the method comprising the steps of introducing into a non-human, mammalian oocyte: (a) a clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated protein 9 (Cas9 protein) or a nucleic acid molecule encoding said Cas9 protein; and (b-i) a target sequence specific CRISPR RNA (crRNA) and a trans-activating crRNA (tracr RNA) or a nucleic acid molecule encoding said RNAs; or (b-ii) a chimaeric RNA sequence comprising a target sequence specific crRNA and tracrRNA or a nucleic acid molecule encoding said RNA; wherein the Cas9 protein introduced in (a) and the RNA sequence(s) introduced in (b-i) or (b-ii) form a protein/RNA complex that specifically binds to the target sequence and introduces a single or double strand break within the target sequence.Type: GrantFiled: July 13, 2016Date of Patent: February 26, 2019Assignee: HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELTInventors: Ralf Kühn, Wolfgang Wurst, Oskar Ortiz Sanchez
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Publication number: 20190049111Abstract: A power-generation system having a combined heat and power plant and a fermentation plant has an electrolysis plant, which is connected by lines to both the combined heat and power plant and to the fermentation plant. This arrangement enables a method in which heat from a combined heat and power plant can be used for a fermentation plant and additionally heat from an electrolysis plant can be used for the fermentation plant, whilst the oxygen from the electrolysis plant is used for the combined heat and power plant.Type: ApplicationFiled: August 6, 2018Publication date: February 14, 2019Applicant: Martin GmbH fuer Umwelt- und EnergietechnikInventors: Robert VON RAVEN, Ulrich MARTIN, Max Josef SCHOENSTEINER