Patents Assigned to Umwelt (GmbH)
  • Patent number: 10696001
    Abstract: A portable roller compactor for compacting waste located in a container, which is open on the top, has a frame-like basic structure and an articulated arm, one end of which is supported by the basic structure, and the other, free end of which supports a roller compactor that essentially can be rotated about a horizontal axis of rotation. The articulated arm of the roller compactor is pivotably attached to a sliding carriage, which is mounted on the frame-like base structure and can be moved in a longitudinal direction.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: June 30, 2020
    Assignee: HUSMANN UMWELT-TECHNIK GmbH
    Inventors: Heinz Hermann Husmann, Wolfgang Muchall
  • Patent number: 10669278
    Abstract: The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: June 2, 2020
    Assignee: HELMHOLTZ ZENTRUM MUENCHEN—DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Kamyar Hadian, Jara Kerstin Brenke, Oliver Plettenburg, Gerrit Juerjens
  • Patent number: 10647687
    Abstract: The present invention relates to spiropyrazine compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 12, 2020
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Marcus Conrad, Joel Schick, Bettina Proneth, Peter Sennhenn
  • Patent number: 10626159
    Abstract: The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding the same, a T cell expressing the TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing the tumor-associated antigen.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: April 21, 2020
    Assignees: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Dolores Jean Schendel, Susanne Wilde, Bernhard Frankenberger, Wolfgang Uckert
  • Patent number: 10588516
    Abstract: A device and an according method for multispectral optoacoustic imaging of an object is provided comprising: an irradiation unit configured to irradiate the object with electromagnetic radiation at two or more different irradiation wavelengths the electromagnetic radiation having a time-varying intensity; a detection unit configured to detect acoustic waves generated in the object upon irradiating the object with the electromagnetic radiation at the different irradiation wavelengths; and a processing unit configured to reconstruct images of the object based on the detected acoustic waves generated in the object at each of the irradiation wavelengths and to determine a spatial distribution of at least one first concentration value, which relates to a concentration of at least one electromagnetic radiation absorber in the object.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 17, 2020
    Assignee: HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Stratis Tzoumas, Ivan Olefir, Amir Rozental, Vasilis Ntziachristos
  • Patent number: 10568852
    Abstract: The present invention relates to compositions comprising at least two different active compounds and the use of such combination compositions in medicine, in particular in methods for treating obesity and obesity-related disorders and/or in methods for inhibiting weight gain.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: February 25, 2020
    Assignee: HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Timo Dirk Mueller, Matthias Tschoep, Christoffer Clemmensen, Brian Finan
  • Patent number: 10520494
    Abstract: The present invention relates to the use of the biomarker Flattop (Fltp) for distinguishing mature ? cells from immature progenitor ? cells. The present invention further relates to a method for distinguishing a mature ? cell from an immature progenitor ? cell, the method comprising: determining the presence or absence of the biomarker Flattop (Fltp) in a ? cell; wherein the presence of Fltp in the cell indicates that the cell is a mature ? cell and wherein the absence of Fltp in the cell indicates that the cell is an immature progenitor ? cell. Furthermore, the present invention relates to a method of identifying a compound suitable for differentiating immature progenitor ? cells into mature ? cells as well as to a method of identifying a compound suitable for preventing the de-differentiating of mature ? cells.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: December 31, 2019
    Assignee: Helmholtz Zentrum München-Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)
    Inventors: Heiko Lickert, Adriana Migliorini, Moritz Gegg, Erik Bader
  • Patent number: 10520266
    Abstract: In a method for protecting heat exchanger pipe in boiler systems having at least one heat exchanger pipe, which is surrounded by a ceramic component, into which flue gas is directed from at least two opposite sides, gas is introduced between the heat exchanger pipe and the ceramic component.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: December 31, 2019
    Assignee: Martin GmbH fuer Umwelt- und Energietechnik
    Inventors: Toralf Weber, Johannes Martin
  • Patent number: 10421749
    Abstract: The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: September 24, 2019
    Assignees: HELMHOLTZ ZENTRUM MÜNCHEN-DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH), LEIBNIZINSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E. V. -HANS-KNÖLL-INSTITUT
    Inventors: Ruth Brack-Werner, Markus Helfer, Manfred Rösner, Martha Schneider, Ulrike Protzer, Christian Hertweck, Martina Werneburg
  • Patent number: 10412927
    Abstract: The present invention concerns a device for improved hygienic monitoring of individually ventilated caging (IVC) rack systems for laboratory animals and method for contamination-free removal of biological samples from unwanted organisms from the IVC-rack system. The device allows the performance of sampling operations on a ventilated shelving system in a safe and effective manner, without interfering with the ventilation air flow. The method of the invention allows the removal and transfer of the biological sample from inside the IVC-rack in a contamination-free manner by enabling a safe transfer of the sample from inside the IVC-rack system to any further processing procedure for analysis of the biological sample outside the IVC-rack system. It is also an object of the present invention to provide a device which is adapted to be used also on existing ventilated shelving systems, allowing the refitting of existing IVC-rack systems.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: September 17, 2019
    Assignees: TECNIPLAST S.P.A., HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Markus Brielmeier, Wolfgang Nagel, Julia Zorn, Alfredo Campiotti, II, Gianpaolo Milite, Carmelo Di Martino
  • Publication number: 20190211025
    Abstract: The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 11, 2019
    Applicant: HELMHOLTZ ZENTRUM MUENCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Kamyar Hadian, Jara Kerstin Brenke, Oliver Plettenburg, Gerrit Juerjens
  • Patent number: 10314490
    Abstract: An imaging device includes (a) a light source device arranged to illuminate a sample under investigation with illumination light, (b) a detector device arranged to collect a plurality of images including at least one sample light image backscattered by the sample, and at least one marker light image originating from at least one marker substance in the sample, and (c) a processor device adapted to process the at least one sample light image.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: June 11, 2019
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Vasilis Ntziachristos, George Themelis
  • Patent number: 10300129
    Abstract: The present invention relates to a vaccine comprising a particle, said particle comprising (i) at least one Epstein-Barr virus (EBV) structural polypeptide, (ii) at least one EBV lytic polypeptide, (iii) membrane lipids, said particle being devoid of EBV DNA, wherein (a) the B-cell transformation capacity of one or more EBV polypeptides required for B-cell transformation as comprised in said particle is disabled while their immunogenicity is maintained; and or (b) said particle is devoid of one or more EBV polypeptides required for B-cell transformation. Furthermore, the invention relates to a method for generating a particle, to a cell obtained in the method of the invention, a kit comprising the vaccine or the particle generated according in the method of the invention. Also, the invention relates to the use of the vaccine or the particle generated according to the method of the invention for generating CD8+ cells specific for an EBV antigen.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: May 28, 2019
    Assignee: HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMB)
    Inventors: Romana Ruiss, Gilbert Reisbach, Wolfgang Hammerschmidt, Reinhard Zeidler
  • Patent number: 10292593
    Abstract: An imaging device configured for optoacoustic imaging of an object, including an illumination device including optical components arranged to illuminate the object, a detector device comprising an array of detector elements arranged in a tank and arranged to detect acoustic signals created in the object, and a container device including a tank arranged to accommodate the detector device, the object and a matching transmission medium, a holding device adapted to position and move the object relative to the illumination device and the detector device, wherein the optical components are arranged in the tank to illuminate the object from different directions.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: May 21, 2019
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Daniel Razansky, Vasilis Ntziachristos
  • Patent number: 10280179
    Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterized by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: May 7, 2019
    Assignee: HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Marcus Conrad, Joel Schick, Bettina Proneth, Peter Sennhenn
  • Patent number: 10238735
    Abstract: The invention relates to a pharmaceutical composition made of one or more preparation and comprising a therapeutically effective dose of at least one recombinant human C3-derivative and at least one antigen für vaccination.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: March 26, 2019
    Assignees: PLS-DESIGN GMBH, KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN, HELMHOLTZ ZENTRUM MUNCHEN FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT GMBH
    Inventors: Reinhard Bredehorst, Thomas Grunwald, Markus Ollert, Carsten Schmidt-Weber, Edzard Spillner
  • Patent number: 10233418
    Abstract: A device for wetting at least one sample by means of an aerosol, the device has: side walls, a base region which is bounded by the side walls, the base region adapted for receiving or interacting with a positioning device for positioning the sample, a cover region, which sits vertically opposite the base region and is bounded by the side walls. The device forms an exposure chamber and an aerosolizing device for producing an aerosol, which is arranged in the vicinity of the cover region. The aerosolizing device is arranged above the base region in such a way that the aerosolizing device at least partially covers the base region in a vertical plan view. A method for wetting at least one sample by an aerosol is also provided that includes the steps of: providing at least one sample, producing a cloud above the at least one sample in a position which at least partially covers the base region in a vertical plan view, and allowing the cloud to descend in the direction of the sample.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: March 19, 2019
    Assignee: Helmholtz Zentrum Muenchen Deutsche Forschungszentrum fuer Gesundheit und Umwelt GmbH
    Inventors: Otmar Schmid, Anke-G Lenz, Bernd Lentner, Oliver Eickelberg
  • Publication number: 20190063745
    Abstract: A special distribution of nozzles in the flue gas outlet and their alignment make it possible to guide the flue gas along a wavy line. The addition of combustion air for primary air and secondary air can be variably distributed during operation of the combustion plant, for example so as to also keep the burnout per unit of time constant while maintaining a constant combustion air ratio.
    Type: Application
    Filed: August 22, 2018
    Publication date: February 28, 2019
    Applicant: Martin GmbH fuer Umwelt- und Energietechnik
    Inventors: Ulrich MARTIN, Robert VON RAVEN, Martin MURER
  • Patent number: 10214723
    Abstract: The present invention relates to a method of producing a non-human, mammalian oocyte carrying a modified target sequence in its genome, the method comprising the steps of introducing into a non-human, mammalian oocyte: (a) a clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated protein 9 (Cas9 protein) or a nucleic acid molecule encoding said Cas9 protein; and (b-i) a target sequence specific CRISPR RNA (crRNA) and a trans-activating crRNA (tracr RNA) or a nucleic acid molecule encoding said RNAs; or (b-ii) a chimaeric RNA sequence comprising a target sequence specific crRNA and tracrRNA or a nucleic acid molecule encoding said RNA; wherein the Cas9 protein introduced in (a) and the RNA sequence(s) introduced in (b-i) or (b-ii) form a protein/RNA complex that specifically binds to the target sequence and introduces a single or double strand break within the target sequence.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: February 26, 2019
    Assignee: HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT
    Inventors: Ralf Kühn, Wolfgang Wurst, Oskar Ortiz Sanchez
  • Publication number: 20190049111
    Abstract: A power-generation system having a combined heat and power plant and a fermentation plant has an electrolysis plant, which is connected by lines to both the combined heat and power plant and to the fermentation plant. This arrangement enables a method in which heat from a combined heat and power plant can be used for a fermentation plant and additionally heat from an electrolysis plant can be used for the fermentation plant, whilst the oxygen from the electrolysis plant is used for the combined heat and power plant.
    Type: Application
    Filed: August 6, 2018
    Publication date: February 14, 2019
    Applicant: Martin GmbH fuer Umwelt- und Energietechnik
    Inventors: Robert VON RAVEN, Ulrich MARTIN, Max Josef SCHOENSTEINER