Patents Assigned to Umwelt (GmbH)
  • Patent number: 9359446
    Abstract: The present invention relates to an antibody binding to a carbonic anhydrase, wherein the antibody comprises (a) the amino acid sequences SEQ ID NOS. 1 (CDR 1), 2 (CDR 2) and 3 (CDR 3) determining the CDRs of the VH region, and the amino acid sequences SEQ ID NOS. 4 (CDR 1), 5 (CDR 2) and 6 (CDR 3) determining the CDRs of the VL region; or (b) the amino acids sequences of (a), wherein at least one amino acid is conservatively substituted in any one of the amino acid sequences SEQ ID NOS. 1 to 6.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: June 7, 2016
    Assignee: Hemholtz Zentrum Munchen—Deutches Forschungszentrum Fur Gesundheit Und Umwelt (GmbH)
    Inventors: Reinhard Zeidler, Christina Battke, Elisabeth Kremmer, Andrew Flatley, Claudiu Supuran
  • Patent number: 9354143
    Abstract: A device for the automated isolation and transfer of at least one microscopic sample from a sample carrier to a collecting system for subsequent automatic analysis is provided. The device comprises a selection unit for selecting at least one sample located on the sample carrier, a controllable isolation unit for the automated isolation of the at least one selected sample, a controllable transfer unit, which has carrier means for the defined receiving and deposition of the at least one selected isolated sample, for an automated and defined transfer of the at least one selected isolated sample from the sample carrier to the collecting system, and a control unit, which has a data link to the selection unit, the isolation unit and the transfer unit, for an automated isolation and transfer operation.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: May 31, 2016
    Assignee: HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)
    Inventor: Stefan Thalhammer
  • Patent number: 9354330
    Abstract: A method for detecting radiation during the examination of a sample (1) comprises the steps of generating the radiation, more particularly X-ray radiation or proton radiation, by means of a source device (10), passing the radiation through the sample (1), and detecting the radiation by means of at least one photoelectric solid-state detector (20) containing a photoconduction section having a predetermined response threshold and a potential well section for taking up free charge carriers. The solid-state detector (20) is a GaN- or GaAs-based semiconductor detector and the potential well section contains a two-dimensional electron gas (2DEG). A setting of the radiation is provided in such a way that the solid-state detector (20) is operated separately from the response threshold of the photoconduction section and in a sensitivity range of the potential well section.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: May 31, 2016
    Assignees: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Technische Universitaet Muenchen
    Inventors: Stefan Thalhammer, Markus Hofstetter, John Howgate, Martin Stutzmann
  • Patent number: 9354329
    Abstract: The invention relates to an X-ray camera (100) for the high-resolution detection of X-rays (1), comprising a plurality of radiation detectors (10), each of which has a carrier substrate (11), a detector layer (12), and contact electrodes (13). The detector layer (12) contains GaN, lies on the carrier substrate (11), and has a thickness of less than 50 ?m. The contact electrodes (13) form ohmic contacts with the detector layer (12). The X-ray camera also comprises a retaining device (20) on which the radiation detectors (10) are arranged along a specified reference line or reference surface (21). The invention also relates to a method for capturing an image of an object (2, 3) being examined using X-rays (1), said X-ray camera (100) being used in the method.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: May 31, 2016
    Assignee: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (Gmbh)
    Inventors: Stefan Thalhammer, Markus Hofstetter, John Howgate, Martin Stutzmann
  • Patent number: 9341617
    Abstract: The present invention is directed to a method of identifying CD4+ T cell antigens as well as to antigens which were identified by such a method. The present invention further is directed to the application of those identified antigens in medicine.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: May 17, 2016
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Josef Mautner, Uta Behrends, Slavoljub Milosevic
  • Patent number: 9271654
    Abstract: A method of thermoacoustic imaging of an object includes providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: March 1, 2016
    Assignee: Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH)
    Inventors: Daniel Razansky, Vasilis Ntziachristos, Amir Rosenthal
  • Patent number: 9238063
    Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: January 19, 2016
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundlheit und Umwelt (GmbH)
    Inventors: Dolores Schendel, Rudolf Wank
  • Publication number: 20160010047
    Abstract: A device for wetting at least one sample by means of an aerosol, the device has: side walls, a base region which is bounded by the side walls, the base region adapted for receiving or interacting with a positioning device for positioning the sample, a cover region, which sits vertically opposite the base region and is bounded by the side walls. The device forms an exposure chamber and an aerosolizing device for producing an aerosol, which is arranged in the vicinity of the cover region. The aerosolizing device is arranged above the base region in such a way that the aerosolizing device at least partially covers the base region in a vertical plan view. A method for wetting at least one sample by an aerosol is also provided that includes the steps of: providing at least one sample, producing a cloud above the at least one sample in a position which at least partially covers the base region in a vertical plan view, and allowing the cloud to descend in the direction of the sample.
    Type: Application
    Filed: September 22, 2015
    Publication date: January 14, 2016
    Applicant: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
    Inventors: Otmar SCHMID, Anke-G LENZ, Bernd LENTNER, Oliver EICKELBERG
  • Publication number: 20150366458
    Abstract: An imaging apparatus (100), configured for thermoacoustic tomographic imaging a region of interest (2) in an object (1), comprises a source device (10) being arranged for emitting an electromagnetic energy input into the region of interest (2), a detector device (20) being arranged for detecting mechanical wave response signals generated in the region of interest (2) along multiple angular projection directions in response to the electromagnetic energy input, and an image data acquisition and processing device (30) being arranged for providing tomographic image data representing the image of the region of interest (2) on the basis of the mechanical wave response signals, wherein the source device (10) is adapted for continuously emitting the electromagnetic energy input with a predetermined input modulation, and the image data acquisition and processing device (30) is adapted for converting the mechanical wave response signals into the frequency domain and for performing data processing and image reconstructi
    Type: Application
    Filed: May 7, 2012
    Publication date: December 24, 2015
    Applicant: Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (GmbH)
    Inventors: Stephan Kellnberger, Vasilis Ntziachristos, George Sergiadis, Nikolaos Deliolanis, Murad Omar
  • Patent number: 9063338
    Abstract: An autostereoscopic display includes a background illumination with a multiplicity of parallel light strip groups with in each case at least two parallel light strips, wherein the individual light strip groups are arranged next to one another with a first grid dimension, and a lens grid arranged before the background illumination and has a multiplicity of parallel lens strips, wherein the lens strips are arranged next to one another with a second grid dimension, as well as a light modulator arranged before the lens grid and displays image information.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: June 23, 2015
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Christoph Hoeschen, Oleg Tischenko, Matthias Klaften, Lars Kroker, Michael Scholles, Jens Knobbe
  • Patent number: 9028840
    Abstract: The present invention discloses an ex vivo method for producing a preparation containing CD4+ T cells specific for EBV structural antigens for use in the prophylaxis and treatment of patients with a reduced T cell activity in order to prevent or treat growth of EBV infected B cells.
    Type: Grant
    Filed: November 27, 2008
    Date of Patent: May 12, 2015
    Assignees: Helmholtz Zentrum Munchen Deutsches Forschungzentrum fur Gesundheit und Umwelt (GmbH), Deutsches Krebsforschungzentrum (DKFZ)
    Inventors: Dinesh Adhikary, Uta Behrends, Josef Mautner, Henri-Jacques Delecluse, Regina Feederle
  • Publication number: 20150072729
    Abstract: The invention relates to a method for operating an electronic terminal (1.1-1.4) comprising an integrated image sensor (2.1-2.4) that has a large number of pixels, in particular for a mobile telephone. According to the invention, a dosage value of ionising radiation striking the image sensor is determined by means of the image sensor (2.1-2.4). The invention further relates to a terminal that operates accordingly (e.g. a smart phone having a corresponding application program).
    Type: Application
    Filed: October 24, 2011
    Publication date: March 12, 2015
    Applicants: Umwelt (GmbH)
    Inventors: Christoph Hoeschen, Rolf-Dieter Klein, Mathias Reichl
  • Publication number: 20150069219
    Abstract: The invention relates to a monitoring device (6) for monitoring the environment, in particular for monitoring the environment for radioactive radiation, comprising at least one receiver for receiving measured values of an environmental variable that potentially poses a health hazard and comprising a computing unit (10) for computing a hazard warning (4.1-4.4) dependent on the measured values. The receiver is designed to receive the measured values from a plurality of spatially distributed electronic terminals (2.1-2.4), in particular from mobile telephones with an image sensor for measuring the radioactive radiation. The invention further relates to a corresponding terminal (2.1-2.4) and to a complete monitoring system with a monitoring device and numerous terminals (2.1-2.4) for measuring the environmental variable.
    Type: Application
    Filed: November 17, 2011
    Publication date: March 12, 2015
    Applicants: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH
    Inventors: Rolf-Dieter Klein, Mathias Reichl, Christoph Hoeschen
  • Patent number: 8971481
    Abstract: A tomography apparatus that generates images of an object includes a radiation source emitting a radiation beam, wherein the radiation beam rotates around the object and penetrates the object; a radiation detector rotating around the object opposite the radiation source so that the radiation detector detects the radiation beam after penetration of the object; a radiation mask surrounding the object that masks the radiation beam, wherein the radiation mask is arranged in a path of the radiation beam between the radiation source and the radiation detector and the radiation beam passes the radiation mask only once between the radiation source and the radiation detector.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: March 3, 2015
    Assignee: Helmholtz Zentrum Munchen Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventors: Oleg Tischenko, Hugo De Las Heras, Christoph Hoeschen
  • Publication number: 20150053864
    Abstract: The invention relates to an electronic device, in particular a mobile telephone (1), comprising an image sensor (4) with multiple pixels for capturing an image. The image sensor (4) is also sensitive to ionizing radiation, in particular pulsed high-energy radiation. The invention additionally relates to a radiation sensor (5) for measuring the ionizing radiation.
    Type: Application
    Filed: November 25, 2011
    Publication date: February 26, 2015
    Applicants: Umwelt (GmbH)
    Inventors: Rolf-Dieter Klein, Mathias Reichl, Christoph Hoeschen
  • Publication number: 20140363066
    Abstract: A system for creating an object image of an object under investigation, comprises a computing device being configured for creating the object image by using first tomography data of the object provided by a first tomography system and second tomography data of the object provided by a second tomography system, wherein the computing device is configured for calculating a first forward model describing the first tomography data using the second tomography data, performing a first inversion of the first forward model, calculating a parameter set using the first inversion, and performing a second inversion using the parameter set to obtain the object image to be created. Furthermore, a method of imaging an object under investigation is described, wherein the system for creating an object image is used.
    Type: Application
    Filed: November 18, 2011
    Publication date: December 11, 2014
    Applicant: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH)
    Inventors: Vasilis Ntziachristos, Angelica Ale
  • Patent number: 8863675
    Abstract: A steam generator for producing superheated steam in a waste incineration plant, includes a boiler housing having a combustion chamber with walls having an evaporator. The evaporator has tubes carrying water and being acted upon by heat energy released during incineration of waste, for producing superheated steam. A wall superheater for increasing temperature of the superheated steam includes a plurality of tubes in a wall of the boiler housing for carrying superheated steam being protected against flue gas from an incineration process by plate-like elements formed of a corrosion-proof material. The boiler housing includes an evaporator housing section having the water-carrying tubes and a wall-superheater housing section spatially separated from the evaporator housing section and having the superheated steam-carrying tubes. The wall-superheater housing section is movable relative to and disposed downstream of the evaporator housing section in flue gas flow direction.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: October 21, 2014
    Assignee: MVV Umwelt GmbH
    Inventors: Johannes Günther, Hansjörg Roll, Peter Knapp, Uwe Zickert
  • Publication number: 20140302096
    Abstract: The invention relates to a method for in vitro maturation of at least one immate dendritic cell, comprising stimulating said immature dendritic cell with TNF?, IL-1?, IFN?, a TLR7/8 agonist and prostaglandin E2(PG). Furthermore, the invention elates to a composition comprising these factors as well as to mature dendritic cells produced by a method of the invention.
    Type: Application
    Filed: February 6, 2014
    Publication date: October 9, 2014
    Applicant: Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH)
    Inventors: Dolores J. SCHENDEL, Anke ZOBYWALSKI, Iris BIGALKE
  • Publication number: 20140288060
    Abstract: The invention relates to a compound for use in treating a cancer, wherein the cancer depends on the proteolytic activity of the MALT1 protease, and wherein the compound has the general formula (I) wherein X is N or C; Y is S, O, SO2, SO, NH, CO, CH2, CH?CH, CH2?CH2; ( )z is a C1-C5 linear or branched alkyl chain; A is NR3R4, or OR5, or HET; R1 and R2 in each occurrence are independently selected from —H, —CH3, —OH, —OCH3, —SCH3, —F, —Cl, —CF3, —NH2, and —COOH; R3, R4, and R5 are H, or C1-C5 linear or branched alkyl groups, and HET is a heterocyclic ring of 5, 6, or 7 members, wherein the ring atoms can be C, O, N, or S, the ring can be saturated or aromatic, and the ring can be substituted with H or C1-C5 linear or branched alkyl groups; or a pharmaceutically acceptable salt, prodrug, enantiomer, diastereomer, racemic mixture, crystalline form, amorphous form, unsolvated form or solvate of said compound. The compound of the invention may further be used in the treatment of MALT1-dependent immune diseases.
    Type: Application
    Filed: August 1, 2012
    Publication date: September 25, 2014
    Applicant: Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit and Umwelt GmbH)
    Inventors: Daniel Krappmann, Daniel Nagel, Dolores Schendel, Stefani Spranger
  • Publication number: 20140261248
    Abstract: A steam generator for producing superheated steam in a waste incineration plant, includes a boiler housing having a combustion chamber with walls having an evaporator. The evaporator has tubes carrying water and being acted upon by heat energy released during incineration of waste, for producing superheated steam. A wall superheater for increasing temperature of the superheated steam includes a plurality of tubes in a wall of the boiler housing for carrying superheated steam being protected against flue gas from an incineration process by plate-like elements formed of a corrosion-proof material. The boiler housing includes an evaporator housing section having the water-carrying tubes and a wall-superheater housing section spatially separated from the evaporator housing section and having the superheated steam-carrying tubes. The wall-superheater housing section is movable relative to and disposed downstream of the evaporator housing section in flue gas flow direction.
    Type: Application
    Filed: May 29, 2014
    Publication date: September 18, 2014
    Applicant: MVV UMWELT GMBH
    Inventors: JOHANNES GUENTHER, HANSJOERG ROLL, PETER KNAPP, UWE ZICKERT