Patents Assigned to Umwelt (GmbH)
-
Patent number: 8217009Abstract: The present invention is directed to a T cell receptor (TCR) recognizing antigenic peptides derived from tumor-associated antigen FMNL1/KW13 and being capable of inducing peptide specific killing of a target cell. The present invention is further directed to one antigenic peptides derived from tumor-associated antigen FMNL1/KW13, to an antigen specific T cell, comprising said TCR, to a nucleic acid coding for said TCR and to the use of the antigen specific T cells for the manufacture of a medicament for the treatment of malignancies characterized by overexpression of FMNL1/KW13.Type: GrantFiled: June 18, 2007Date of Patent: July 10, 2012Assignee: Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Gesundheit und UmweltInventors: Angela Krackhardt, Ingrid Schuster, Dirk Busch
-
Patent number: 8210738Abstract: The invention relates to a horizontal agitator for producing a flow in a clearing basin, wherein a propeller (2) having a plurality of blades (4) is connected to a submersible motor (1) axially disposed thereto. In order to increase the efficiency of the horizontal agitator, according to the invention the propeller (2) and the submersible motor (1) are configured such that during operation of the submersible motor (1) a flow (P2) that is directed from the propeller (2) to the submersible motor (1) is produced.Type: GrantFiled: February 14, 2008Date of Patent: July 3, 2012Assignee: Invent Umwelt-und Verfahrenstechnik AGInventor: Marcus Hoefken
-
Patent number: 8206701Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.Type: GrantFiled: September 16, 2003Date of Patent: June 26, 2012Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Dolores Schendel, Rudolf Wank
-
Patent number: 8197825Abstract: The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the site of a naturally occurring deletion in the MVA genome, and the use of such recombinant MVA viruses for the production of polypeptides, e.g. antigens or therapeutic agents, or viral vectors for gene therapy, and the use of such recombinant MVA viruses encoding antigens as vaccines.Type: GrantFiled: June 14, 2010Date of Patent: June 12, 2012Assignee: GSF-Forschungszentrum fur Umwelt und Gesundheit GmbHInventors: Gerd Sutter, Marion Ohlmann, Volker Erfle
-
Publication number: 20120128704Abstract: The present invention is directed to a kit-of-parts or composition containing nucleic acid sequences coding for high-avidity, allo-restricted TCR, wherein the TCR are independently directed against the tyrosinase antigen, the melan-A antigen and the survivin antigen. The invention is further directed to a kit-of-parts or composition containing at least three groups of transgenic lymphocytes transformed with vectors coding for TCR against said antigens. Furthermore, the present invention provides a pharmaceutical composition and its use in the treatment of diseases involving malignant cells expressing said tumor-associated antigens. The invention further relates to a nucleic acid molecule coding for a TCR that recognizes the survivin antigen, a TCR encoded thereby and a T cell expressing said TCR. Further, the invention discloses a vector, a cell and a pharmaceutical composition encoding/containing same and their use in the treatment of diseases involving malignant cells expressing survivin.Type: ApplicationFiled: February 9, 2010Publication date: May 24, 2012Applicants: Max-Delbrueck-Centrum fuer Molekulare Medizin, HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZEN TRUM FUER GESUNDHEIT UND UMWELT (GMBH)Inventors: Dolores J. Schendel, Susanne Wilde, Bernhard Frankenberger, Wolfgang Uckert
-
Publication number: 20120123256Abstract: A method of thermoacoustic imaging of an object includes providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component.Type: ApplicationFiled: June 29, 2009Publication date: May 17, 2012Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Daniel Razansky, Vasilis Ntziachristos, Amir Rosenthal
-
Publication number: 20120085517Abstract: A device with a heat exchanger with a feed pipe for a medium leading from a medium inlet to the heat exchanger entrance and with a discharge pipe leading away from the heat exchanger exit is characterized in that it has a first bypass from the medium inlet to the discharge pipe and a second bypass from the feed pipe to the medium outlet and valves, so that the medium can also flow from the heat exchanger exit to the heat exchanger entrance.Type: ApplicationFiled: August 15, 2011Publication date: April 12, 2012Applicant: Martin GmbH fuer Umwelt-und EnergietechnikInventors: Johannes Martin, Robert Von Raven, Alexander Seitz
-
Patent number: 8153138Abstract: The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the site of a naturally occurring deletion in the MVA genome, and the use of such recombinant MVA viruses for the production of polypeptides, e.g. antigens or therapeutic agents, or viral vectors for gene therapy, and the use of such recombinant MVA viruses encoding antigens as vaccines.Type: GrantFiled: September 19, 2006Date of Patent: April 10, 2012Assignee: GSF-Forschungszentrum fur Umwelt und Gesundheit GmbHInventors: Gerd Sutter, Marion Ohlmann, Volker Erfle
-
Patent number: 8142772Abstract: This invention is directed to therapeutic compositions containing non-MHC-restricted Tcells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which comprise LAK cells. Furthermore, the present invention is directed to the use of the above combination in the treatment of tumors in humans, which tumors show a missing, low or aberrant expression of MHC class Ia or Ib molecules. By using the aforementioned compositions/combinations it is possible to provide a balanced selective pressure against emergence of tumor cell variants that would otherwise escape immune detection.Type: GrantFiled: April 22, 2010Date of Patent: March 27, 2012Assignee: Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH)Inventors: Elfriede Noessner, Elisabeth Weiss, Dolores Schendel, Christine Falk
-
Patent number: 8119135Abstract: The present invention provides anti-thrombotic agents, methods for screening for said anti-thrombotics agents and methods of treating thrombotic and other cardiovascular disorders.Type: GrantFiled: January 16, 2009Date of Patent: February 21, 2012Assignees: Helmhotz Zentrum Munchen, Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH), Corimmun GmbHInventors: Götz Münch, Meinrad Gawaz, Andreas Bültmann, Elisabeth Kremmer
-
Publication number: 20120035072Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: ApplicationFiled: August 26, 2011Publication date: February 9, 2012Applicants: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH, Mayo Foundation for Medical Education and Research, Eberhard Karls Universitaet TuebingenInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra (Leitner) Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
-
Publication number: 20120020940Abstract: The present invention relates to a peptide comprising or consisting of the following amino acid sequence: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12 (formula II), wherein A0 is a hydrophobic amino acid residue or is absent; A1, A4, A7, A8, A12 each are a hydrophobic amino acid residue; and A2, A6, A9, A10 each are a basic amino acid residue; A5 is an alanine or a basic amino acid residue; A3, A11 each are a basic amino acid residue, or a hydrophobic amino acid residue; or a peptidomimetic thereof; wherein the basic amino acid residues are selected from the group consisting of arginine, lysine and histidine; wherein the hydrophobic amino acid residues are selected from the group consisting of leucine, alanine, isoleucine, valine, methionine and phenylalanine; and wherein said peptide or peptidomimetic has antimicrobial and/or antiviral activity.Type: ApplicationFiled: September 24, 2009Publication date: January 26, 2012Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)Inventors: Jörg Durner, Christian Lindermayr, Ruth Brack-Werner
-
Patent number: 8094910Abstract: A method of reconstructing an image function on the basis of a plurality of projection profiles corresponding to a plurality of projection directions through a region of investigation, each projection profile including a series of value positions, wherein measured projection values corresponding to projection lines parallel to the respective projection direction are assigned to respective value positions and a plurality of remaining value positions are empty, comprises the steps of (a) assigning first interpolation values to the empty value positions for constructing a plurality of interpolation profiles on the basis of the projection profiles, wherein the first interpolation values are obtained from a first interpolation within a group of measured projection values having the same value position in different projection profiles, and (b) determining the image function by applying a predetermined reconstruction algorithm on the interpolation profiles.Type: GrantFiled: March 14, 2007Date of Patent: January 10, 2012Assignees: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Yuan Xu, Oleg Tischenko, Christoph Hoeschen
-
Patent number: 8090089Abstract: An imaging method for imaging a region of investigation of an object comprises the steps of generating an energy input beam with an energy beam source, irradiating the region of investigation with energy input beam components of the energy input beam along a plurality of projection directions, the energy input beam components being formed with a frame mask being arranged between the energy input beam and the object and including frame mask windows, measuring first integrated attenuation values of the energy input beam components with an outer detector device arranged outside the frame mask, measuring second integrated attenuation values of the energy input beam components with a frame mask detector device being arranged on an inner surface of the frame mask, and reconstructing an image of the region of investigation based on the first and second integrated attenuation values. Furthermore, an imaging device for imaging a region of investigation of an object is described.Type: GrantFiled: October 25, 2006Date of Patent: January 3, 2012Assignees: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Oleg Tischenko, Christoph Hoeschen, Yuan Xu
-
Patent number: 8081807Abstract: A method of reconstructing an (n+1)-dimensional image function ƒ representing a region of investigation comprises determining the image function ƒ from n-dimensional or less dimensional Radon data comprising a plurality of projection functions p?(t) measured corresponding to a plurality of predetermined projection directions (?), wherein the image function ƒ is determined as a sum of polynomials multiplied with values of the projection functions p?(t). Imaging methods, imaging devices, and computer tomography devices using this reconstruction method are described.Type: GrantFiled: December 21, 2005Date of Patent: December 20, 2011Assignees: State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Yuan Xu, Oleg Tischenko, Christoph Hoeschen
-
Publication number: 20110306857Abstract: A method of multi-spectral opto-acoustic tomography (MSOT) imaging of a target tissue including a target tissue biomarker includes illuminating the target tissue with an illumination device emitting at least one pulsed illumination pattern at several illumination wavelengths, detecting pressure signals from the target tissue biomarker with a detector device, wherein the pressure signals being produced in the target tissue are in response to the illumination, and reconstructing a quantitative tomographic image of a distribution of the target tissue biomarker in the target tissue, wherein the pressure signals are analyzed using a photon propagation model which depends on an illuminating light fluence in the target tissue and on the illumination wavelengths, at least one spectral processing scheme, and an inversion scheme providing the tomographic image.Type: ApplicationFiled: July 25, 2008Publication date: December 15, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Daniel Razansky, Vasilis Ntziachristos
-
Publication number: 20110294721Abstract: The present invention relates to a peptide comprising or consisting of a sequence of formula I A-B-C-D-E-F-G-H-I (formula I), wherein A is a peptide consisting of three or four basic amino acid residues; B is a peptide consisting of two to four hydrophobic amino acid residues; C is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; D is a peptide consisting of two hydrophobic amino acid residues; E is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; F is a peptide consisting of three amino acid residues selected from the group consisting of glycine and hydrophobic amino acid residues; G is an amino acid residue selected from the group consisting of hydrophobic and basic amino acid residues; H is a peptide consisting of two or three amino acid residues selected from the group consisting of serine and hydrophobic amino acid residues; I is a peptide consisting of two to four basic amino acid residues; or a pType: ApplicationFiled: September 24, 2009Publication date: December 1, 2011Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH)Inventors: Jörg Durner, Christian Lindermayr, Ruth Brack-Werner
-
Publication number: 20110262902Abstract: The invention relates to identification of a cis-acting diversification activator (DIVAC) that is necessary and sufficient for the activation of diversification in transcription units linked thereto. The invention provides a method for diversification of a target nucleic acid comprising introducing a genetic construct comprising the diversification activator into a recipient cell, wherein the diversification activator is linked to the target nucleic acid.Type: ApplicationFiled: April 9, 2009Publication date: October 27, 2011Applicant: Heimholz Zentrum Munchen Deutsches Forschungszen- trum fur Gesundheit und Umwelt (GmbHInventors: Randolph B Caldwell, Jean-Marie Buerstedde, Ulrike Schötz
-
Patent number: 8029986Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.Type: GrantFiled: September 27, 2005Date of Patent: October 4, 2011Assignees: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Eberhard Karls Universitaet Tuebingen, Mayo Foundation for Medical Education and ResearchInventors: Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
-
Patent number: D665047Type: GrantFiled: August 4, 2010Date of Patent: August 7, 2012Assignee: Invent Umwelt-und Verfahrenstechnik AGInventor: Marcus Höfken