Abstract: The invention relates to a horizontal agitator for producing a substantially horizontal flow in a wastewater treatment tank, a propeller being installed on a polygonal shaft driven by means of a submersible motor, wherein the propeller is produced form a first material, which is formed from a polymer reinforced with first fibers, and as hub has a sleeve which corresponds to the outer shape of the polygonal shaft and which is produced from a second material which is different from the first material.

Abstract: A system for creating an object image of an object under investigation, comprises a computing device being configured for creating the object image by using first tomography data of the object provided by a first tomography system and second tomography data of the object provided by a second tomography system, wherein the computing device is configured for calculating a first forward model describing the first tomography data using the second tomography data, performing a first inversion of the first forward model, calculating a parameter set using the first inversion, and performing a second inversion using the parameter set to obtain the object image to be created. Furthermore, a method of imaging an object under investigation is described, wherein the system for creating an object image is used.

Abstract: The present invention relates to an antibody binding to a carbonic anhydrase, wherein the antibody comprises (a) the amino acid sequences SEQ ID NOS. 1 (CDR 1), 2 (CDR 2) and 3 (CDR 3) determining the CDRs of the VH region, and the amino acid sequences SEQ ID NOS. 4 (CDR 1), 5 (CDR 2) and 6 (CDR 3) determining the CDRs of the VL region; or (b) the amino acids sequences of (a), wherein at least one amino acid is conservatively substituted in any one of the amino acid sequences SEQ ID NOS. 1 to 6.

Abstract: A device for the automated isolation and transfer of at least one microscopic sample from a sample carrier to a collecting system for subsequent automatic analysis is provided. The device comprises a selection unit for selecting at least one sample located on the sample carrier, a controllable isolation unit for the automated isolation of the at least one selected sample, a controllable transfer unit, which has carrier means for the defined receiving and deposition of the at least one selected isolated sample, for an automated and defined transfer of the at least one selected isolated sample from the sample carrier to the collecting system, and a control unit, which has a data link to the selection unit, the isolation unit and the transfer unit, for an automated isolation and transfer operation.

Abstract: A method for detecting radiation during the examination of a sample (1) comprises the steps of generating the radiation, more particularly X-ray radiation or proton radiation, by means of a source device (10), passing the radiation through the sample (1), and detecting the radiation by means of at least one photoelectric solid-state detector (20) containing a photoconduction section having a predetermined response threshold and a potential well section for taking up free charge carriers. The solid-state detector (20) is a GaN- or GaAs-based semiconductor detector and the potential well section contains a two-dimensional electron gas (2DEG). A setting of the radiation is provided in such a way that the solid-state detector (20) is operated separately from the response threshold of the photoconduction section and in a sensitivity range of the potential well section.

Abstract: The invention relates to an X-ray camera (100) for the high-resolution detection of X-rays (1), comprising a plurality of radiation detectors (10), each of which has a carrier substrate (11), a detector layer (12), and contact electrodes (13). The detector layer (12) contains GaN, lies on the carrier substrate (11), and has a thickness of less than 50 ?m. The contact electrodes (13) form ohmic contacts with the detector layer (12). The X-ray camera also comprises a retaining device (20) on which the radiation detectors (10) are arranged along a specified reference line or reference surface (21). The invention also relates to a method for capturing an image of an object (2, 3) being examined using X-rays (1), said X-ray camera (100) being used in the method.

Abstract: The present invention is directed to a method of identifying CD4+ T cell antigens as well as to antigens which were identified by such a method. The present invention further is directed to the application of those identified antigens in medicine.

Abstract: A method of thermoacoustic imaging of an object includes providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component.

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: A device for wetting at least one sample by means of an aerosol, the device has: side walls, a base region which is bounded by the side walls, the base region adapted for receiving or interacting with a positioning device for positioning the sample, a cover region, which sits vertically opposite the base region and is bounded by the side walls. The device forms an exposure chamber and an aerosolizing device for producing an aerosol, which is arranged in the vicinity of the cover region. The aerosolizing device is arranged above the base region in such a way that the aerosolizing device at least partially covers the base region in a vertical plan view. A method for wetting at least one sample by an aerosol is also provided that includes the steps of: providing at least one sample, producing a cloud above the at least one sample in a position which at least partially covers the base region in a vertical plan view, and allowing the cloud to descend in the direction of the sample.

Abstract: In a first aspect, the present invention relates to the use of a TLR 9 agonist and/or a TLR 4 agonist in a prophylactic or therapeutic vaccine. According to the present vaccination strategy, the TLR 9 agonist and/or TLR 4 agonist is adapted or designed for use as a multiplying jump agent to enhance numbers and functionality of CD8 T cells in a prime-jump vaccination strategy for jump T cell expansion. In particular, the TLR 9 agonist and/or TLR 4 agonist is used as a component to be administered after priming of the individual to be vaccinated. The vaccination strategy is particularly useful against acute and chronic infections with intracellular pathogens or for anti-tumor vaccination. In another aspect, the present invention relates to a kit of part containing a prime agent and a multiplying jump agent according to the present invention.

Abstract: An imaging apparatus (100), configured for thermoacoustic tomographic imaging a region of interest (2) in an object (1), comprises a source device (10) being arranged for emitting an electromagnetic energy input into the region of interest (2), a detector device (20) being arranged for detecting mechanical wave response signals generated in the region of interest (2) along multiple angular projection directions in response to the electromagnetic energy input, and an image data acquisition and processing device (30) being arranged for providing tomographic image data representing the image of the region of interest (2) on the basis of the mechanical wave response signals, wherein the source device (10) is adapted for continuously emitting the electromagnetic energy input with a predetermined input modulation, and the image data acquisition and processing device (30) is adapted for converting the mechanical wave response signals into the frequency domain and for performing data processing and image reconstructi

Abstract: The present invention relates to a novel class of gene trap vector (enhanced gene trap vectors, eGTV) for efficiently identifying silent or weakly expressed target genes in mammalian genomes, methods of their production and methods for identifying and mutating target genes by using the enhanced gene trap vectors. The gene trap vectors of the present invention can also be used for inducing the expression of silent genes and enhancing the expression of weakly expressed genes. The use of the enhanced gene trap vectors for creating transgenic organisms to identify gene function and to validate pharmaceutical compounds prior to clinical applications is a further aspect of the present invention.

Abstract: An autostereoscopic display includes a background illumination with a multiplicity of parallel light strip groups with in each case at least two parallel light strips, wherein the individual light strip groups are arranged next to one another with a first grid dimension, and a lens grid arranged before the background illumination and has a multiplicity of parallel lens strips, wherein the lens strips are arranged next to one another with a second grid dimension, as well as a light modulator arranged before the lens grid and displays image information.

Abstract: The invention relates to a vertical agitator for wastewater and the like received in a sedimentation tank, wherein an agitator tool (5) is mounted on a drive shaft (4) extending vertically from a drive (1) mounted above a tank floor (2), wherein a free end (E2) of a shaft section (7) extending from the agitator tool (5) in the direction of the tank floor (2) is held in a safety bearing (14), wherein the safety bearing (14) is held in a retaining device (8) supported on the tank floor (2), wherein the retaining device (8) comprises a receiving section (9) for a receiving device (12) receiving the safety bearing (14). In order to simplify installation, the invention proposes that the receiving section (9) comprises a recess (11) opening in a substantially horizontal direction for laterally inserting the shaft section (7).

Abstract: The present invention discloses an ex vivo method for producing a preparation containing CD4+ T cells specific for EBV structural antigens for use in the prophylaxis and treatment of patients with a reduced T cell activity in order to prevent or treat growth of EBV infected B cells.

Abstract: The invention relates to a horizontal agitator for producing a flow in a clarifier, a propeller being connected to a submersible motor which is axially offset in relation thereto, wherein the propeller and the submersible motor are designed such that a flow in a direction from the propeller towards the submersible motor is produced when the submersible motor is operated, and wherein plate-shaped flow guide elements are provided downstream of the propeller and extend in at least an axial plane that runs substantially parallel to the propeller axis. In order to improve the efficiency of the horizontal agitator, it is proposed in accordance with the invention to support the submersible motor on a bottom of the clarifier via at least two first flow guide elements.

Abstract: The invention relates to a method for operating an electronic terminal (1.1-1.4) comprising an integrated image sensor (2.1-2.4) that has a large number of pixels, in particular for a mobile telephone. According to the invention, a dosage value of ionising radiation striking the image sensor is determined by means of the image sensor (2.1-2.4). The invention further relates to a terminal that operates accordingly (e.g. a smart phone having a corresponding application program).