Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
Type:
Grant
Filed:
November 2, 2017
Date of Patent:
May 25, 2021
Assignees:
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Christopher C. Lindsey, Craig C. Beeson, Yuri Karl Peterson, Rick G. Schnellmann
Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.
Type:
Grant
Filed:
October 17, 2017
Date of Patent:
May 18, 2021
Assignees:
MUSC Foundation For Research Development, United States Government as Represented by the Department of Veterans Affairs
Inventors:
Stephen Tomlinson, DeAnna Adkins, Ali Alawieh
Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
September 30, 2019
Date of Patent:
May 4, 2021
Assignees:
United States Government as Represented by the Department of Veterans Affairs, The University of Pittsburgh—of the Commonwealth of Higher Education, Xiamen University, University of Exeter
Inventors:
Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
Abstract: The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.
Type:
Grant
Filed:
July 9, 2019
Date of Patent:
April 27, 2021
Assignee:
United States Government as represented by the Department of Veterans Affairs
Abstract: The invention provides a catheter and control box apparatus and related methods that are useful in delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the invention provides a catheter that stabilizes fluid flow within a vein to deliver a volume, pressure charge of saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The catheter and control box apparatus and related methods described herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.
Type:
Grant
Filed:
September 2, 2014
Date of Patent:
April 20, 2021
Assignees:
Indiana University Research and Technology Corporation, United States Government as Represented by the Department of Veterans Affairs
Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
Type:
Grant
Filed:
June 6, 2017
Date of Patent:
March 30, 2021
Assignees:
Yale University, The Regents of the University of California, The United States Government Represented by the Department of Veterans Affairs
Inventors:
James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
Abstract: Disclosed are methods for treating pain and tracking response to treatment. Also disclosed are methods for determining pain, including predicting future medical care facility visits for pain.
Type:
Application
Filed:
March 14, 2019
Publication date:
February 18, 2021
Applicants:
Indiana University Research and Technology Corporation, The United States Government as Represented by the Department of Veterans Affairs
Abstract: A wheelchair includes a frame, a seat attached to the frame, a first forward wheel on a first side of the frame and a second forward wheel on a second side of the frame, a first rearward wheel on the first side of the frame and a second rearward wheel on the second side of the frame, a first drive wheel on the first side of the frame positioned intermediate between the first forward wheel and the first rearward wheel and a second drive wheel on the second side of the frame positioned intermediate between the second forward wheel and the second rearward wheel, and actuators to independently control the vertical position of the first forward wheel relative to the frame, the vertical position of the second forward wheel relative to the frame, the vertical position of the first rearward wheel relative to the frame, the vertical position of the second rearward wheel relative to the frame, the vertical position of the first drive wheel relative to the frame and the vertical position of the second drive wheel relati
Type:
Grant
Filed:
September 23, 2016
Date of Patent:
February 9, 2021
Assignees:
The United States Government As Represented By The Department of Veterans Affairs, University of Pittsburgh—Of The Commonwealth System Of Higher Education
Inventors:
Rory Alan Cooper, Hongwu Wang, Cheng-Shiu Chung, Jorge Luis Candiotti, Garrett G. Grindle, Jonathan L. Pearlman, Brandon Joseph Daveler
Abstract: This disclosure relates to nucleobase polymers useful for degrading GATA-3 mRNA. In certain embodiments, this disclosure relates to nucleobase polymers and nanoparticles conjugated to nucleobase polymers disclosed herein. In certain embodiments, the nucleobase polymers or nanoparticles can be used in methods of managing disorders associated with excessive GATA-3 expression in inflammatory disorders and respiratory disorders such as asthma.
Type:
Grant
Filed:
May 24, 2017
Date of Patent:
February 2, 2021
Assignees:
Emory University, The United States Government as represented by the Department of Veterans Affairs
Abstract: EMAPII is a monocyte- and endothelial cell-activating protein with prominent pro-apoptotic activity on endothelial and epithelial cells. Provided herein are compositions and methods for treating or preventing endothelial and epithelial apoptosis induced by EMAPII. More particularly, provided herein are compositions and methods for treating or preventing Influenza A virus (IAV)-induced weight loss, impairment of blood oxygenation, lung edema, and endothelial/epithelial apoptosis associated with IAV infections. In addition, anti-EMAPII therapy provides a novel complementary treatment strategy to existing anti-viral and anti-inflammatory approaches.
Type:
Grant
Filed:
February 23, 2017
Date of Patent:
January 26, 2021
Assignees:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Natalia Bogatcheva, Matthias Alexander Clauss, Keith L. March
Abstract: The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed herein, such as 2,4-diamino-1,3,5-triazine derivatives or salts thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement.
Type:
Grant
Filed:
January 2, 2020
Date of Patent:
January 12, 2021
Assignees:
Emory University, The United States Government as represented by the Department of Veterans Affairs
Abstract: The invention provides methods and compositions for the diagnosis, prognosis and treatment of respiratory tract diseases. Specifically, the invention provides diagnosis, prognosis and treatment of respiratory infections using bitter and sweet taste signal transduction pathways. In one aspect, the invention relates to a method for treating a respiratory infection by administering a composition to the respiratory tract of a subject in an amount capable of activating bitter taste signaling and/or inhibiting sweet taste signaling. The composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract. In another aspect, the invention relates to a composition for treatment of a respiratory infection. Such composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract.
Type:
Grant
Filed:
January 25, 2013
Date of Patent:
January 5, 2021
Assignees:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, MONELL CHEMICAL SENSES CENTER, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Noam A. Cohen, Robert J. Lee, Danielle R. Reed
Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
July 7, 2020
Publication date:
December 31, 2020
Applicants:
Oregon Health & Science University, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Thomas S. Scanlan, Meredith Hartley, Andrew Placzek, Marco Righi, Dennis Bourdette, Gail Marracci, Priya Chaudhary
Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.
Type:
Grant
Filed:
June 18, 2019
Date of Patent:
December 22, 2020
Assignees:
University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans Affairs
Abstract: A portable polysomnography apparatus comprises a unitary flexible structured pillow that is embedded with accelerometers for data collection. The polysomnography apparatus is advantageously sized and shaped to cause the sleeping subject to properly orient the embedded accelerometers for optimal data collection while the subject is asleep. A portable polysomnography system comprises a structured pillow with embedded sensors that are in wireless communication with a companion data collection device that records data from the embedded sensors. In an alternative embodiment, a system may include a structured pillow with an internal pocket into which a single device including embedded sensors and data recording capabilities is inserted.
Type:
Grant
Filed:
June 7, 2013
Date of Patent:
December 8, 2020
Assignee:
United States Government As Represented By The Department of Veterans Affairs
Abstract: Compositions that include one isolated, class I HLA-E trimolecular complex that includes a peptide ligand unique to M. tuberculosis-infected cells are disclosed. Isolated compositions that include the three components of the trimolecular complex and/or a polynucleotide encoding one or more of the three components are also disclosed.
Type:
Grant
Filed:
March 27, 2015
Date of Patent:
December 8, 2020
Assignees:
The Board of Regents of the University of Oklahoma, Oregon Health & Science University, The United States Government as Represented by the Department of Veterans Affairs
Inventors:
William H. Hildebrand, Curtis McMurtrey, David Lewinsohn, Deborah Lewinsohn, Melanie Harriff
Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.
Type:
Grant
Filed:
July 25, 2019
Date of Patent:
December 8, 2020
Assignees:
UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, OREGON HEALTH & SCIENCE UNIVERSITY
Inventors:
Prakash Ambady, Jeffrey Wu, Edward Neuwelt
Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.
Type:
Grant
Filed:
December 11, 2017
Date of Patent:
December 8, 2020
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
Inventors:
James Chang, Hung Pham, Colin Woon, Simon Farnebo, Anais Legrand
Assignees:
The United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh—Of The Commonwealth System of Higher Education
Inventors:
Rory A. Cooper, Garrett Grindle, Zak Anzelone, Aaron Anderson
Assignees:
The United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh—Of The Commonwealth System of Higher Education
Inventors:
Rory A. Cooper, Garrett Grindle, Zak Anzelone, Aaron Anderson